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Science China(Life Sciences) 2022年第11期65卷 2205-2217页

作者： Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg naohiro ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong-Hong Kong Joint Laboratory for RNA MedicineBreast Tumor CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Radiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Clinical Research Design Division Clinical Research CenterSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Medical Statistics School of Public HealthSun Yat-sen UniversityGuangzhou 510080China Department of Breast Surgery the Second Affiliated HospitalShandong UniversityJinan 250033China Department of Breast Surgery Key Laboratory of Breast DiseasesThird Hospital of NanchangNanchang 330009China Department of Breast Surgery the First Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510120China Department of Pathology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Experimental and Clinical Pharmacology University of MinnesotaMinneapolisMN 55455USA Department of Surgery College of MedicineUniversity of RzeszówRzeszów 35-959Poland Department of Radiation Oncology O’Neal Comprehensive Cancer CenterUniversity of Alabama at Birmingham School of MedicineBirminghamALUSA Laboratoty of Predictive Oncology Institut Paoli-CalmettesCentre de Recherche en Cancérologie de MarseilleINSERM UMR1068CNRS UMR725MarseilleFrance Department of Drug Development and Innovation(D3i) Institut CurieParis 75005France Comprehensive Cancer Center UOC di Oncologia MedicaFondazione Policlinico Universitario A.Gemelli IRCCSRome 00168Italy Multidisciplinary Breast Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Breast Surgery Department of Surgical OncologyRoswell Park Comprehensive Cancer CenterBuffaloNYUSA Department of Surgery MD Anderson Cancer CenterHoustonTX 77030USA Department of Plastic and Reconstructive Surgery

Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,*** who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer.

关键词： hormone receptor-positive breast cancer micro RNA signature neoadjuvant chemotherapy dynamic contrast-enhanced magnetic resonance imaging nomogram

Study on the Effects of Flow in the Volute Casing on the Performance of a Sirocco Fan

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Journal of Thermal Science 2004年第3期13卷 199-206页

作者： Tsutomu ADACHI naohiro SUGITA Satoshi OHOMORI Faculty of Engineering Osaka Sangyo University 3-1-1 Nakagaito Daito Osaka JapanFaculty of Engineering Osaka Sangyo University 3-1-1 Nakagaito Daito Osaka JapanSanki Engineering Corporation Ltd.

The flow at the exit from the runner blade of a centrifugal fan with forward curved blades (a sirocco fan) sometimes separates and becomes unstable. We have conducted many researches on the impeller shape of a sirocco fan, proper inlet and exit blade angles were considered to obtain optimum performance. In this paper, the casing shape were decided by changing the circumferential angle, magnifying angle and the width, 21 sorts of casings were used. Performance tests, inner flow velocity and pressure distributions were measured as well. Computational fluid dynamic calculations were also made and compared with the experimental results. Finally, the most suitable casing shape for best performance is considered.

关键词： sirocco fan fan flow measurement flow in the casing CFD.

Institutions and accounting standard transformation:Observations from Japan

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China Journal of Accounting Research 2014年第1期7卷 51-64页

作者： naohiro Urasaki Faculty of Business Administration Kinki University

This paper describes the transformation of Japan's accounting standards over the past 2 decades and the driving forces behind this transformation. It also analyzes the current state of Japan's accounting standards, which are characterized by the dichotomy of accounting systems inherited from the country's political, economic and legal institutions. The discussion in this paper emphasizes that a single set of accounting standards is not always effective for every entity.

关键词： Single set of accounting standards IFRS Financial instruments Substance over form Fair value Dichotomy of accounting systems Accounting standards for SMEs

Intra-gastric triacetin alters upper gastrointestinal motility in conscious dogs

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World Journal of Gastroenterology 2014年第4期20卷 1054-1060页

作者： Kazumasa Oosaka Masaaki Tokuda naohiro Furukawa Research and Development Department Fushimi Pharmaceutical Co. Ltd. Department of Cell Physiology Faculty of Medicine Kagawa University Department of Clinical Nutrition Faculty of Health Science and Technology Kawasaki University of Medical Welfare

AIM: To examine the effect of intra-gastric triacetin on both upper gastrointestinal motility and proximal gastric tone in conscious dogs.

关键词： Gastrointestinal motility Barostat Proximal gastric relaxation Short-chain triglycerides

End of the First Demographic Dividend and Possible Labor Market Response in China and Other Asian Countries(Regions)

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China & World Economy 2013年第2期21卷 78-96页

作者： naohiro Ogawa Qiulin Chen Population Research Institute Nihon University Institute of Population and Labor Economics Chinese Academy of Social Sciences

This paper sheds light on the nexus of age compositional shifts and the generation of the first demographic dividend over the past several decades in China, and also discusses how this dividend could be extended. We first estimate how long China ＇s first demographic dividend will last and then compare the computed results for China with those for other selected Asian countries in order to place the Chinese case in a wider perspective. Furthermore, in view of the possibility that China ＇s first demographic dividend will turn negative in 2014, we offer insight into how and to what extent China ＂s labor market needs to adjust and how much labor income must increase for the first demographic dividend to remain positive up to year 2050. For this goal to be achieved, the labor income age profile needs to be shifted to a considerable extent. We conduct an exercise in which the 2007peak labor income age of 32 years is shifted to 40years. In the case of the elderly, this implies an annual labor income growth of 3.1 percent over the period of 39 years. Throughout this paper, we draw on a variety of computed results derived from the Chinese component of the global ＂National Transfer Accounts＂ project.

关键词： consumption first demographic dividend labor income support ratio total dependency ratio

Heavy Ion Beam Probe Measurement in Turbulence Diagnostic Simulator

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Plasma Science and Technology 2011年第3期13卷 326-331页

作者： naohiro KASUYA Seiya NISHIMURA Masatoshi YAGI Kimitaka ITOH Sanae-I ITOH National Institute for Fusion Science 322-60roshi-cho Toki Gifu 509-5292 Japan Research Institute for Applied Mechanics Kyushu University 6-1 Kasuga-kouen KasugaFukuoka 816-8580 Japan Japan Atomic Energy Agency 801-1 Mukoyama Naka Ibaraki 311-0193 Japan

A numerical measurement module simulating a heavy ion beam probe was developed, and numerical measurements of electrostatic potential and density fluctuations are carried out for 3-D turbulent data generated by a global simulation of drift-interchange mode turbulence in helical plasmas. The deviation between measured and local values is estimated. It is found that the characteristic structures can be detected in spite of the screening effect due to the finite spatial resolution.

关键词： turbulence structural formation numerical simulation heavy ion beamprobe fluctuation spatial resolution

Interaction Dynamics in AEC Global Teamwork

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Tsinghua Science and Technology 2008年第S1期13卷 145-150页

作者： Renate Fruchter Shubashri Swaminathan naohiro Matsumura Yukio Ohsawa Department of Civil and Environmental Engineering Stanford University Graduate School of Economics Osaka University Faculty of Engineering The University of Tokyo

Architecture, engineering, and construction (AEC) global project teamwork is communication intensive and relies heavily on synchronous and asynchronous information and collaboration technologies (ICT). We explore in this paper how an asynchronous ICT, called ThinkTank, reshaped the work practice of design-construction global teams, and how the interaction with this ICT reshaped the purpose and benefits of its use. ThinkTank is a web-based asynchronous collaboration and discussion forum. We introduce the influence diffusion model (IDM) that formalizes the process of identifying the influence of people, messages, and terms mathematically. Discovering who the influence leaders in project teams are can be beneficial and critical from a corporate management perspective, since they can guide or motivate the team towards successful actions and outcomes. We present the ThinkTank-IDM integrated system and its validation with a testbed of 53 AEC global team project archived in ThinkTank over 8 years.

关键词： global teamwork asynchronous collaboration technology interaction dynamics influence leader influence topic

Successful Treatment of Life-Threatening Cerebral Bleeding Associated with Disseminated Intravascular Coagulation Using Recombinant Human Soluble Thrombomodulin in a Patient with Mixed Phenotype Acute Leukemia with t (9;22) (q34;q11.2);<i>Bcr-Abl1</i>

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International Journal of Clinical Medicine 2013年第1期4卷 52-57页

作者： Naoki Takezako Takashi ishii Akihisa Nagata naohiro Sekiguchi Satoshi Noto Akiyoshi Miwa Department of Hematol- ogy National Center for Global Health and Medicine Tokyo Japan Department of Hematology National Hospital Organization Disaster Medical Center Tachikawa Tokyo Japan

Recently, mixed phenotype acute leukemia (MPAL) with t (9;22) (q34;q11.2);bcr-abl1 was described as one kind of acute leukemia of ambiguous lineage in the 2008 World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues. However, treatment strategy remains difficult for this uncommon MPAL. In addition, this type of MPAL is at high risk of tumor lysis syndrome (TLS) because of high chemo-sensitivity. Here, we report a MPAL with t (9;22) (q34;q11.2);bcr-abl1 case that suffered from life-threatening cerebral bleeding associated with disseminated intravascular coagulation (DIC) with TLS after bcr-abl positive acute lymphoblastic leukemia (ALL) type induction therapy who was successfully treated with recombinant human thrombomodulin (rhTM). This case reached complete remission without additive cerebral bleeding. In conclusion, bcr-abl positive ALL type induction therapy was effective for MPAL with t (9;22) (q34;q11.2);bcr-abl1 and rhTM was effective against DIC with TLS.

关键词： Mixed Phenotype Acute Leukemia with t (9 22) (q34 q11.2) Bcr-Abl1 Recombinant Human Soluble Thrombomodulin Imatinib Disseminated Intravascular Coagulation

Successful Treatment of Low-Dose Lenalidomide Maintenance Therapy Followed by Second Autologous Peripheral Blood Stem Cell Transplantation in Heavily Treated Multiple Myeloma

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International Journal of Clinical Medicine 2012年第2期3卷 106-109页

作者： naohiro Sekiguchi Naoki Takezako Takashi ishii Akihisa Nagata Satoshi Noto Akiyoshi Miwa Hematology Division National Center for Global Health and Medicine Tokyo Japan Hematology Division National Hospital Organization Disaster Medical Center Tokyo Japan

Recently, the prognosis of multiple myeloma has been improved by using high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (ASCT), bortezomib, and immunomodulatory drugs including thalidomide and lenalidomide. On the other hand, treatment strategy remains difficult for refractory and relapse cases. Here, we report the successful treatment of low-dose lenalidomide maintenance therapy followed by salvage ASCT in a heavily treated patient with multiple myeloma. This 58-year-old woman with IgG-λ multiple myeloma had a 5th recurrence in June, 2011. It was 7 years post-diagnosis, and she had received conventional therapies such as VAD, MP therapy. Furthermore, the patient had already been treated with ASCT, bortezomib, and thalidomide therapy. At the 5th recurrence, she had extramedullary plasmacytoma in the left orbit. She initially received bortezomib and dexamethasone therapy as induction therapy. After peripheral blood stem cell collection, radiation therapy was performed. The patient then received a second ASCT. Three months later, the response was very good partial response. Finally, the patient was treated with 5 mg/day lenalidomide orally as a maintenance therapy, and she achieved stringent complete response after 2 months according to International Myeloma Working Group response criteria. Low-dose lenalidomide maintenance therapy might be also useful for ASCT as salvage therapy, although further studies are warranted.

关键词： Multiple Myeloma Stem Cell Transplantation Lenalidomide Maintenance Therapy