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Successful endovascular treatment of endoscopically unmanageable hemorrhage from a duodenal ulcer fed by a renal artery: A case report

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World Journal of Clinical Cases 2018年第15期6卷 1012-1017页

作者： Shimpei Anami Hiroki Minamiguchi naoaki shibata Takao Koyama Hirotatsu Sato Akira Ikoma Motoki Nakai Takuji Yamagami Tetsuo Sonomura Department of Radiology Wakayama Medical University Department of Radiology Kochi Medical School Kochi University Department of Emergency and Critical Care Medicine Wakayama Medical University

A 52-year-old woman was admitted with hypovolemic shock. Emergency endoscopy revealed three hemorrhagic duodenal ulcers(all stage A1) with exposed vessels. Two ulcers were successfully treated by endoscopic clipping; however, the remaining ulcer on the posterior wall of the horizontal portion of the duodenum could not be clipped. Because her vital signs were rapidly worsening, we performed transcatheter arterial embolization(TAE) as it is less invasive than surgery. Computed tomography aortography showed that the duodenal hemorrhage was sourced from the lower branch of the right renal artery. In general, the duodenum is fed by branches from the gastroduodenal artery or superior mesenteric artery. However, this patient had three right renal arteries. The lower branch of the right renal artery at the L3 vertebral level was at the same level as the horizontal portion of the duodenum. Complete hemostasis was achieved by TAE using metallic coils and n-butyl-2-cyanoacrylate. After TAE, she recovered from the hypovolemic shock and was discharged from hospital. She has had no recurrence of the hemorrhagic duodenal ulcer for over 1 yr, and followup endoscopy showed no necrosis or stricture of the duodenum. Although she developed a small infarct of her right kidney, her renal function was satisfactory. In summary, the present case is the first reported case of hemorrhagic duodenal ulcer in which the culprit vessel was a renal artery that was successfully treated by TAE. Computed tomography aortography before TAE provides valuable information regarding the source of a duodenal hemorrhage.

关键词： Transcatheter arterial embolization Metallic coils N-butyl-2-cyanoacrylate Renal artery Emergency radiology Case report Duodenal ulcer

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Exploration of organic superionic glassy conductors by process and materials informatics with lossless graph database

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npj Computational Materials 2022年第1期8卷 1622-1629页

作者： Kan Hatakeyama-Sato Momoka Umeki Hiroki Adachi naoaki Kuwata Gen Hasegawa Kenichi Oyaizu Department of Applied Chemistry Waseda University3-4-1 OkuboShinjukuTokyo169-8555Japan National Institute for Materials Science(NIMS) 1-1 NamikiTsukuba305-0044Japan

Data-driven material exploration is a ground-breaking research style;however,daily experimental results are difficult to record,analyze,and *** report a data platform that losslessly describes the relationships of structures,properties,and processes as graphs in electronic laboratory *** a model project,organic superionic glassy conductors were explored by recording over 500 different *** data analysis revealed the essential factors for a remarkable room temperature ionic conductivity of 10^(−4)–10^(−3) S cm^(−1) and a Li^(+) transference number of around *** contrast to previous materials research,everyone can access all the experimental results,including graphs,raw measurement data,and data processing systems,at a public *** data sharing will improve scientific communication and accelerate integration of material knowledge.

关键词： ionic glassy breaking

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Hyperpigmentation after surgery for a deep dermal burn of the dorsum of the hand:partial-thickness debridement followed by medium split-thickness skin grafting vs full-thickness debridement followed by thick split-thickness skin grafting

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Burns & Trauma 2016年第2期4卷 123-133页

作者： Yoshitaka Kubota Nobuyuki Mitsukawa Kumiko Chuma Shinsuke Akita Yoshitaro Sasahara naoaki Rikihisa Kaneshige Satoh Department of Plastic Surgery Chiba University1-8-1InohanaChuo-kuChibaChiba 260-8677Japan Department of Plastic Surgery Tokyo Rosai Hospital4-13-21OmoriminamiOta-kuTokyo 143-0013Japan Department of Plastic Surgery Chiba Rosai Hospital2-16TatsumidaihigashiIchiharaChiba 290-0003Japan

Background:Early excision and skin grafting are commonly used to treat deep dermal burns(DDBs)of the dorsum of the ***-thickness debridement(PTD)is one of the most commonly used procedures for the excision of burned tissue of the dorsum of the *** contrast,full-thickness debridement(FTD)has also been ***,it is unclear whether PTD or FTD is ***:In this hospital-based retrospective study,we compared the outcomes of PTD followed by a medium split-thickness skin graft(STSG)with FTD followed by a thick STSG to treat a DDB of the dorsum of the hand in Japanese *** evaluate postoperative pigmentation of the skin graft,quantitative analyses were performed using the red,green,and blue(RGB)and the hue,saturation,and brightness(HSB)color *** have organized the manuscript in a manner compliant with the Strengthening the Reporting of Observational Studies in Epidemiology(STROBE)***:Data from 11 patients were *** hands(five patients)received grafts in the PTD group and eight hands(six patients)received grafts in the FTD *** take was significantly better in the FTD group(median 98%,interquartile range 95–99)than in the PTD group(median 90%,interquartile range 85–90)(P<0.01).Quantitative skin color analyses in both the RGB and HSB color spaces showed that postoperative grafted skin was significantly darker than the adjacent control area in the PTD group,but not in the FTD ***:There is a possibility that FTD followed by a thick STSG is an option that can reduce the risk of hyperpigmentation after surgery for DDB of the dorsum of the hand in Japanese *** investigation is needed to clarify whether the FTD or the thick STSG or both are the factor for the control of hyperpigmentation.

关键词： thick grafting split

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Inhibitory effects of methanolic Olea europaea and acetonic Acacia laeta on growth of Babesia and Theileria

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Asian Pacific Journal of Tropical Medicine 2019年第9期12卷 425-434页

作者： Amany Magdy Beshbishy Gaber El-Saber Batiha Oluyomi Stephen Adeyemi naoaki Yokoyama Ikuo Igarashi Natonal Research Certer for Protocron Diseases Obihiro Uninersity of Agricnuture and Veterinary MedicineNishi 2-13Inada-choObihiroHolkkaido 080-8555Japan Department of Pharmacology and Therapeutics Faculy of Velerinary MedicineDamanhour UniersitDamonhour 22511Al BeheiraEgpt Medicinal Biochemistry Infectious DiseasesNanomedicine and Toricology LaboratoryDepurtment of BiochenmistryLandmarks UniversityOmu Aran 251101Kiuarc StateNigeria

Objective:To evaluate the antipiroplasmic activities of methanolic extract of Olea europaea(MOE)and acetonic extract of Acacia laeta(AAL)against Babesia and Theileria parasites in vitro and evaluate the chemotherapeutic effects of these extracts against Babesia(B.)microti in ***:Fluorescence assay using SYBR Green 1 nucleic acid stain was used to detect inhibitory effects of the two extracts as well as the combination effects of the two extracts with diminazene aceturate and atovaquone on four Babesia species and Theileria equi in vitro while for in vivo experiments,8-weekold female BALB/c mice were injected intraperitoneally with 1× 107 ***-iRBCs and treated orally at a dose of 150 mg/kg of both ***:The half maximal inhibitory concentration(IC50)values of AAL against ***,***,***,***,and Theileria equi were lower than those of MOE *** assay on Madin-Darby bovine kidney,mouse embryonic fibroblast(NIH/3T3),and human foreskin fibroblast cell lines showed that MOE and AAL affected only the viability of Madin-Darby bovine kidney cell line with half maximal effective concentrations(EC50)of(794.7±41.9)and(873.9±17.5)μg/mL,*** oral treatments of MOE and AAL at 150 mg/kg inhibited the growth of *** in mice by 80.4% and 64.4%,*** MOE and diminazene aceturate combination showed a higher chemotherapeutic effect than that of ***:MOE and AAL have the potential to be an alternative remedy for treating ***,the combination therapy of MOE + DA was more potent against *** infection in mice than their monotherapies.

关键词： Olea europaea Acacia laeta Babesia Theileria In vitro In vivo Inhibition

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Efficient Stabilization of Na Storage Reversibility by Ti Integration into O′3-Type NaMnO_(2)

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Energy Material Advances 2021年第1期2021卷 143-154页

作者： Takuro Sato Kazuki Yoshikawa Wenwen Zhao Tokio Kobayashi Hongahally Basappa Rajendra Masao Yonemura naoaki Yabuuchi Department of Chemistry and Life Science Yokohama National University79-5 TokiwadaiHodogaya-kuYokohamaKanagawa 240-8501Japan Department of Applied Chemistry Tokyo Denki UniversityAdachiTokyo 120-8551Japan Elements Strategy Initiative for Catalysts and Batteries Kyoto Universityf1-30 Goryo-OharaNishikyo-kuKyoto 615-8245Japan Institute of Materials Structure Science High Energy Accelerator Research OrganizationTsukubaIbaraki 305-0801Japan Department of Materials Structure Science Sokendai(The Graduate University for Advanced Studies)203-1 ShirakataTokaiIbaraki 319-1106Japan Advanced Chemical Energy Research Center Yokohama National University79-5 TokiwadaiHodogaya-kuYokohamaKanagawa 240-8501Japan

The development of an energy storage system with abundant elements is a key challenge for a sustainable society,and the interest of Na intercalation chemistry is extending throughout the research ***,the impact of Ti integration into NaMnO2 in a binary system of x NaMnO2–(1–x)TiO2(0:5≤x≤1)is systematically examined for rechargeable Na battery *** NaMnO2,which is classified as an in-plane distorted O′3-type layered structure,delivers a large initial discharge capacity of approximately 200 mAhg-1,but insufficient capacity retention is observed,most probably associated with dissolution of Mn ions on electrochemical ***-substituted samples show highly improved electrode performance as electrode ***,the appearance of a sodium-deficient phase,Na4Mn4Ti5O18 with a tunnel-type structure,is observed for Ti-rich *** the samples in this binary system,Na0.8Mn0.8Ti0.2O2(x=0:8),which is a mixture of a partially Ti-substituted O′3-type layered oxide(Na0.88Mn0.88Ti0.12O2)and tunnel-type Na4Mn4Ti5O18 as a minor phase elucidated by Rietveld analysis on both neutron and X-ray diffraction patterns,shows good electrode performance on the basis of energy density and *** phases are electrochemically active as evidenced by in situ X-ray diffraction study,and the improvement of reversibility originates from the suppression of Mn dissolution on electrochemical *** these results,the feasibility of Mn-based electrode materials for high-energy rechargeable Na batteries made from only abundant elements is discussed in detail.

关键词： electrode system Storage

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Clinical efficacy of a combination of Percoll continuous density gradient and swim-up techniques for semen processing in HIV-1 serodiscordant couples

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Asian Journal of Andrology 2017年第2期19卷 208-213页

作者： Osamu Inoue naoaki Kuji Hiroe Ito Mitsutoshi Yamada Toshio Hamatani Aimi Oyadomari Shingo Kato Hideji Hanabusa Keiichi Isaka Mamoru Tanaka Department of Obstetrics and Gynecology Keio University School of Medicine Tokyo 1608582 Japan Department of Obstetrics and Gynecology Tokyo Medical College Tokyo 1600023 Japan Department of Microbiology Keio University School of Medicine Tokyo 1608582 Japan Department of Hematology Ogikubo Hospital Tokyo 1670035 Japan

To evaluate the clinical efficacy of a procedure comprising a combination of Percoll continuous density gradient and modified swim-up techniques for the removal of human immunodeficiency virus type 1 （HIV-1） from the semen of HIV-1 infected males, a total of 129 couples with an HIV-1 positive male partner and an HIV-1 negative female partner （serodiscordant couples） who were treated at Keio University Hospital between January 2002 and April 2012 were examined. A total of 183 ejaculates from 129 HIV-1 infected males were processed. After swim-up, we successfully collected motile sperms at a recovery rate as high as 100.0% in cases of normozoospermia （126/126 ejaculates）, oligozoospermia （6/6）, and asthenozoospermia （36/36）. The recovery rate of oligoasthenozoospermia was 86.7% （13/15）. In processed semen only four ejaculates （4/181：2.2%） showed viral nucleotide sequences consistent with those in the blood of the infected males. After using these sperms, no horizontal infections of the female patients and no vertical infections of the newborns were observed. Furthermore, no obvious adverse effects were observed in the offspring. This protocol allowed us to collect HIV-1 negative motile sperms at a high rate, even in male factor cases. We concluded that our protocol is clinically effective both for decreasing HIV-1 infections and for yielding a healthy child.

关键词： assisted reproductive technology human immunodeficiency virus type 1 serodiscordant couPle viral nucleotide sequence

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Comparison of Damages on Tungsten Surface Exposed to Noble Gas Plasmas

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Plasma Science and Technology 2013年第3期15卷 282-286页

作者： Miyuki YAJIMA Masato YAMAGIWA Shin KAJITA Noriyasu OHNO Masayuki TOKITANI Arimichi TAKAYAMA Seiki SAITO Atsushi M.ITO Hiroaki NAKAMURA naoaki YOSHIDA Department of Energy Engineering and Science Graduate School of EngineeringNagoya University EcoTopia Science Institute Research Institute for Applied Mechanics Kyushu University International Research Center for Nuclear Material Science Institute for Material ResearchTohoku University

Tungsten was exposed to pure Ar or Ne plasmas over 1550 K at several incident ion energies. Even under the irradiation condition that the tungsten nanostructure is formed by He plasma irradiation, holes/bubbles and fiberform nanostructures were not formed on the surface by exposure to Ar or Ne plasmas. In addition, the results from energy dispersive X-ray spectroscopy supported the facts that Ar and Ne did not remain in the sample. We will discuss the reason for the differences in the damage to the tungsten surface exposed to noble gas plasmas.

关键词： plasma-material interaction tungsten noble gas plasmas

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The Role of Oxidative Stress from Mitochondria on Aging

The Role of Oxidative Stress from Mitochondria on Aging

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The 8th Asia/Oceania Regional Congress of Gerontology and Geriatrics

作者： naoaki Ishii Department of Molecular Life Science Tokai University School of Medicine IseharaKanagawa 259-1193Japan

A mutation in a subunit,cytochrome b large subunit(***:CYT-1;mouse and human:SDHC),of complex Ⅱ in electron transport system,results in increasing O- production and therefore lead to premature aging in *** patients with an inherited propensity for vascularized head and neck tumors(i.e., paragangliomas)have been found to have one of several mutations in this gene.

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Utility of co-transplanting mesenchymal stem cells in islet transplantation

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World Journal of Gastroenterology 2011年第47期17卷 5150-5155页

作者： naoaki Sakata Masafumi Goto Gumpei Yoshimatsu Shinichi Egawa Michiaki Unno Division of Hepato-Biliary-Pancreatic Surgery Department of Surgery Tohoku University Graduate School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai Miyagi 980-8574 Japan Division of Advanced Surgical Science and Technology Tohoku University Graduate School of Medicine 1-1 Seiryo-machi Aoba-ku Sendai Miyagi 980-8574 Japan New Industry Creation Hatchery Center Tohoku University Graduate School of Medicine 1-1 Seiryomachi Aoba-ku Sendai Miyagi 980-8574 Japan

Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. Themechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function.

关键词： Mesenchymal stem cell Islet transplanta-tion Bone marrow Immunomodulatory Regulatory Tcell Angiogenesis Vascular endothelial growth factor Diabetes mellitus

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采用软化学法制备WO_3和其锂化物及其结构稳定性的研究(英文)

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复旦学报（自然科学版） 2004年第4期43卷 530-536,544页

作者：余爱水 KUMAGAI naoaki LEE Jim-yang Excellatron Solid State LLC Atlanta GA 30312 USA Department of Applied Chemistry Iwate UniversityMorioka 020 Japan Department of Chemical Engineering National University of Singapore Singapore 119260

通过两种方法合成了六方形和单斜氧化钨的水化物WO3·yH2O(y=0.50～1.20):(1)用强酸(1～3mol/LHCl)将0.25mol/LLi2WO4在100℃进行酸化;(2)将1mol/LLi2WO4置于高压反应釜中,控制pH为1.5,在100℃进行水热合成.对于水热法,温度较高时(125～200℃),得到组分为LixWO3+x/2·yH2O(x=0.10～0.50,y=0.50～0.90)的锂化氧化钨.合成产物的结构和组分与酸的浓度和后处理(加热、超声波)有关.在350℃加热时六方形氧化钨完全转化为单斜氧化钨.将温度在150℃以上时通过水热法合成的氧化钨前驱体进行超声波处理,产物的含锂量恒定为每单元0.18摩尔.锂的引入有利于锂化氧化钨的结构和组分的稳定.

关键词：软化学法 WO3 结构稳定性六方型锂化氧化钨水热法锂离子电池

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