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Development of polyurethane foam dressing containing silver and asiaticoside for healing of dermal wound

Asian Journal of Pharmaceutical Sciences 2019年第1期14卷 40-51页

作者： Nantaporn Namviriyachote Vimolmas Lipipun Yada Akkhawattanangkul Phingphol Charoonrut Garnpimol C.Ritthidej Faculty of Pharmaceutical Sciences Chulalongkorn UniversityBangkok 10330Thailand Faculty of Veterinary Science Mahidol UniversityNakhon Pathom 73170Thailand

Polyurethane foam dressings for dermal wounds were formulated with natural polyols in order to improve the foam characteristics and the release of 2 active agents,silver and asiaticoside(AS)as an antimicrobial agent and an herbal wound healing agent,respectively.The foam was instantly formed by interaction of polyols and diisocyanate.Hydroxypropyl methylcellulose,chitosan and sodium alginate were individually mixed with themain polyols,polypropylene glycol,in the formulation while the active componentswere impregnated into the obtained foam dressing sheets.Although the type and amount of the natural polyols slightly affected the pore size,water sorption-desorption profile and compression strength of the obtained foam sheets,a prominent effect was found in the release of both active components.Among natural polyols formulations,foam sheets with alginate showed the highest silver and AS release.Non-cytotoxicity of these foam sheets to human fibroblast cells was confirmed.Antimicrobial testing on four bacteria strains showed that 1mg/cm^2 silver in formulations with 6%of natural polyols and without natural polyols had sufficient content of the silver release with comparable inhibition zone and significantly larger zone than other formulations.In pig study,the foam dressing with 6%alginate,1mg/cm^2 silver and 5%AS could improve wound healing in both the percentage of the wound closure and histological parameters of the dermal wound without any dermatologic reactions.In conclusion,this innovative foam dressing had potential to be a good candidate for wound treatment.

关键词： Polyurethane foam dressing Natural polyols Silver nanoparticles Asiaticoside Wound healing

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Physico-mechanical characterization of polyurethane foam dressings containing natural polyols

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Asian Journal of Pharmaceutical Sciences 2016年第1期11卷 114-115页

作者： Nantaporn Namviriyachote Kitipun Manosittisak Garnpimol C.Ritthidej Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkok 10330Thailand Bangkok Botanica Co. Ltd.Bangkok 10600Thailand

Advanced wound dressings are replaced traditional dressings in order to provide appropriate environment for healing and also to promote cell migration[1].The key characteristics of wound dressings are non-toxic,highly absorbed,air permeable,biocompatible and have good mechanical properties[2].Due to providing moist environment and also protecting maceration at the wound edge area,foam dressings are used in various clinical applications[3].They are mostly prepared from polyurethane between polyols and isocyanate polymerization.

关键词： Polyurethane foam Natural polyols Starch Physico-mechanical properties

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