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Autophagy-targeting modulation to promote peripheral nerve regeneration

Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia Deng nannan zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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Strengthening behavior of AlCoCrFeNi(TiN)_(x) high-entropy alloy coatings fabricated by plasma spraying and laser remelting

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Journal of Materials Science & Technology 2022年第26期121卷 163-173页

作者： Bingqian Jin nannan zhang Shuo Yin Department of Material Science and Engineering Shenyang University of TechnologyShenyang 110870China Department of Mechanical Manufacturing and Biomedical EngineeringTrinity College DublinThe University of DublinParsons BuildingDublin 2Ireland

High-entropy alloy(HEA)coatings are of great importance in the fabrication of wear resistance *** coatings containing ceramic particles as reinforcement phase usually have better wear *** this study,AlCoCrFe Ni(TiN)_(x)(x:molar ratio;x=0,0.2,0.4,0.6,0.8,1.0)HEA coatings were fabricated on Q235 steel by plasma spray first and then subjected to laser *** experimental results confirm that plasma spray together with post laser remelting could result in the in-situ formation of TiN-Al_(2)O_(3) ceramic particles and cuboidal B2 phase in the AlCoCrFeNi(TiN)_(x) HEA *** in-situ TiN-Al_(2)O_(3) and nano-cuboidal B2 precipitation phase strengthened the coatings and improved their wearresistance *** to the dispersion of hard phase and nano-particles resulting from second heating,the microhardness of the Al Co Cr Fe Ni(Ti N)coatings significantly increased from 493 to 851 HV after laser *** the same reasons,the wear-resistance performance was also significantly promoted after laser remelting.

关键词： High-entropy alloy Coatings Ceramics Laser remelting Microstructure Wear resistance

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The Application of an Improved Wavelet Threshold Function in De-noising of Heart Sound Signal 32

The Application of an Improved Wavelet Threshold Function in...

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第32届中国控制与决策会议

作者： zhang nannan College of Control Science and Engineering China University of Petroleum

ISBN: (数字)9781728158556

ISBN: (纸本)9781728158563

Heart sound can reflect the pathological characteristics of cardiovascular ***-noising of heart sound is the basis of accurate identifying *** transform is often used to de-noise heart sound *** this paper,by analyzing the advantages and disadvantages of traditional wavelet threshold and two improved threshold functions,a new two parameter adjustable wavelet threshold function is *** function has a transition region which is more consistent with the continuous characteristics of the signal,and improves the signal integrity after *** experimental results show that the improved new function is better than the traditional wavelet threshold de-noising method in SNR and RMSE of heart sound signal,which has a certain practical value.

关键词： Heart sound signal de-noising Wavelet transform Threshold function

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From Fiber to Fabric: Progress Towards Photovoltaic Energy Textile

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Advanced Fiber Materials 2021年第2期3卷 18-48页

作者： Siwei Xiang nannan zhang Xing Fan College of Chemistry and Chemical Engineering Chongqing UniversityChongqing 400044China

Flexible solar cells are one of the most significant power sources for modern on-body electronics ***,fiber-type or fabric-type photovoltaic devices have attracted increasing *** with conventional solar cell with planar structure,solar cells with fiber or fabric structure have shown remarkable flexibility and deformability for weaving into almost any shape and assembling with any portable electronic equipment as a sustainable power *** review comprehensively summarizes the recent progress of wearable fiber-type and fabric-type solar cells as well as its applications in hybrid energy *** solar cells of dye-sensitized type,organic type and perovskite type,the discussion involves working mechanism,structural design,material selection,preparation technology and potential *** addition,challenges and technical difficulties that may hinder its large-scale commercial application are also summarized and *** is hoped that,this review will be of help for future researches on textile-type energy devices,to finally make it an everyday lifestyle in a near future.

关键词： Solar cells Fiber-type Fabric-type Hybrid energy textiles

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Glial cell line-derived neurotrophic factor in brain repair after focal ischemic stroke

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Neural Regeneration Research 2022年第8期17卷 1735-1736页

作者： Zhe zhang nannan zhang Shinghua Ding Department of Biomedical Biological and Chemical EngineeringUniversity of Missouri-ColumbiaMOUSA Dalton Cardiovascular Research Center University of Missouri-ColumbiaMOUSA

Cerebral focal ischemic stroke(FIS)is a leading brain disorder associated with human debilitation and *** is induced by the formation of a thrombus in the arteries that supply blood to the central nervous *** patients may suddenly experience paralysis,impairment of speech and loss of *** patients develop permanent *** the past decades,enormous efforts have been taken to develop FIS treatment strategies,but unfortunately,there is still a lack of effective ones for this ***,tissue plasminogen activator is the only Food and Drug Administration approved drug for FIS treatment,however,this method has limited application since it is only effective within 3-5 hours after the onset of *** of this,the recovery from FIS largely depends on self-brain repair and rehabilitation(Campbell et al.,2019).

关键词： paralysis arteries suddenly

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Mechanism of Gravity Effect on Solidification Microstructure of Eutectic Alloy

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Journal of Materials Science & Technology 2014年第5期30卷 499-503页

作者： nannan zhang Xinghong Luo Shaobo Feng Yuhu Ren Institute of Metal Research Chinese Academy of Sciences

The influence of gravity on the solidification microstructure of Al-Al3Ni eutectic alloy was investigated by using a 50-m-long drop tube. It was found that at different growth rates the average inter-rod spacing was always larger under rnicrogravity （μg） than those under normal gravity （lg）. Moreover, with increasing growth rate, the spacing difference between lg samples and μg samples reduced progressively. Based on the experimental results and analysis, a physical model was proposed to describe the effect of gravity on the solidification process of eutectic alloy.

关键词： Al-Al3Ni eutectic Drop tube Microgravity Solidification Eutectic

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AC magnetic trap for cold paramagnetic molecules

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Communications in Theoretical Physics 2023年第11期75卷 92-98页

作者： Shengqiang Li Jing Lin nannan zhang Xue Chen School of physics and electronic engineering Yancheng Teachers UniversityYancheng Jiangsu 224007China

Strong-field-seeking states are the lowest-energy configurations for paramagnetic molecules in the magnetic *** in strong-field-seeking states cannot be trapped in a magnetostatic field because a magnetostatic maximum in free space is not *** this paper,we propose an AC magnetic trap composed of two pairs of Helmholtz *** spatial magnetic field distribution is numerically calculated and the time-sequential control is *** investigate the influence of the switching frequency and the electric current in the coils on the performance of our *** of the location and phase-space distribution during a whole switching cycle are ***,we study the impact of time during which the field is switched off on the number of captured molecules in a switching cycle.

关键词： cold paramagnetic molecules AC magnetic trap Monte Carlo simulation

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Fault diagnosis of rolling bearings with noise signal based on modified kernel principal component analysis and DC‐ResNet

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CAAI Transactions on Intelligence Technology 2023年第3期8卷 1014-1028页

作者： Yunji Zhao Menglin Zhou Xiaozhuo Xu nannan zhang School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuoChina Henan Key Laboratory of Intelligent Detection and Control of Coal Mine Equipment Henan Polytechnic UniversityJiaozuoChina

In view of the influence of aliasing noise on the effectiveness and accuracy of bearing fault diagnosis,a bearing fault diagnosis algorithm based on the spatial decoupling method of modified kernel principal component analysis(MKPCA)and the residual network with deformable convolution(DC‐ResNet)is innovatively ***,the Gaussian noise with different signal‐to‐noise ratios(SNRs)is added to the data to simulate the different degrees of noise in the actual data acquisition *** MKPCA is used to project the fault signal with different SNRs in the kernel space to reduce the data dimension and eliminate some noise ***,the DC‐ResNet model is used to further filter the noise effects and fully extract the fault features through the training of the preprocessed *** proposed algorithm is tested on the Case Western Reserve University(CWRU)and Xi'an Jiaotong University and Changxing Sumyoung Technology Co.,Ltd.(XJTU‐SY)bearing data sets with different SNR *** fault diagnosis accuracy can reach 100%within 30 min,which has better performance than most of the existing *** experimental results show that the algorithm has an excellent effect on accuracy and computation complexity under different noise levels.

关键词： artificial intelligence classification deep learning fault feature extraction

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Nanosilver resonance scattering spectral method for determination of hydroxyl radical and its application

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Science China Chemistry 2008年第3期51卷 226-232页

作者： LIANG AiHui zhang nannan JIANG ZhiLiang LIU RongJin Department of Material and Chemical Engineering Key Laboratory of New Processing Technology for Nonferrous Metals and Ma-terials of Education MinistryGuilin University of TechnologyGuilin 541004China

Silver nanoparticles were prepared under a microwave high-pressure condition using citric acid sodium as a reducer while the excess citrate was removed under high speed centrifugation. There is a resonance scattering (RS) peak at 470 nm for silver nanoparticles. In a pH 4.0 HAc-NaAc buffer solution, hydroxyl radicals from the Fenton reaction can oxidize silver nanoparticles to Ag+, resulting in the RS intensity decreasing. The decreased RS intensity at 470 nm (△I 470 nm) is linear with respect to the concentration of H2O2 (C) in the range of 0.27-7.56 μmol/L with a detection limit of 0.23 μmol/L. Its regression equation is △I 470 nm = 24.3 C + 13.8 with a correlation coefficient of 0.9959. This method was applied to screening the antioxidants with satisfactory results.

关键词： microwave high pressure nanosilver hydroxyl radical Fenton reaction resonance scattering

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Bearing fault diagnosis with cascaded space projection and a CNN

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Control Theory and Technology 2022年第1期20卷 103-113页

作者： Yunji Zhao Menglin Zhou Li Wang Xiaozhuo Xu nannan zhang School of Electrical Engineering and Automation Henan Polytechnic UniversityJiaozuo454003HenanChina Henan Key Laboratory of Intelligent Detection and Control of Coal Mine Equipment Henan Polytechnic UniversityJiaozuo454003HenanChina

Fault diagnosis is essential for the normal and safe operation of dynamic *** improve the spatial resolution among multiple channels and the discriminability among categories of the original data collected from actual operating equipments and to further achieve high diagnostic accuracy,this paper proposes a method for fault diagnosis by cascaded space projection(CSP)and a convolutional neural network(CNN)***,one of every kind of sample is selected from the original data to calculate the PCA transformation ***,the original data are expanded to 10 dimensions by the W2C projection matrix provided by Google-image searching,which is the main part of ***,the ten-dimensional matrix is multiplied by the PCA transformation matrix,which corresponds to its fault type,to make the data more representative by reducing unnecessary ***,the processed data are converted into images to input into a CNN,the backbone structure for fault *** verify the effectiveness and reliability of the proposed method,the Case Western Reserve University(CWRU)and Xi’an Jiaotong University(XJTU-SY)rolling bearing datasets are used to perform *** with other methods is carried out to show the superiority of the proposed *** experimental results demonstrate that the method proposed in this paper can effectively achieve 100%accuracy.

关键词： Color names Fault diagnosis Principal component analysis CNN

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