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Grounded-source short offset transient electromagnetic method:Theory and applications in deep mineral exploration

Science China Earth Sciences 2025年

作者： Guoqiang XUE Xin WU Weiying CHEN nannan zhou Key Laboratory of Mineral Resources Institute of Geology and Geophysics Chinese Academy of Sciences College of Earth and Planetary Sciences University of Chinese Academy of Sciences

Abstract The Transient Electromagnetic (TEM) method is a critical geophysical technique for subsurface exploration of metal ore bodies, primarily utilizing either loop or grounded transmitters. The Long Offset Transient Electromagnetic(LOTEM) method employs a grounded-source transmitter, relying on a far-source observation mode and plane wave approximation for detection. However, LOTEM’s far-source configuration weakens signal strength, and the plane wave approximation reduces precision, limiting effective detection depth to approximately 1000 m with a comprehensive error of about 15%. Recently, we have developed the grounded-source Short Offset Transient Electromagnetic (SOTEM) method,achieving greater detection depth and accuracy within the 500–2000 m depth range, a crucial interval for mineral resource exploration. This study explores the theoretical framework, instrumentation, data processing, and field applications of SOTEM. Based on a point charge element model, SOTEM accurately computes surface wave effects in EM field calculations,optimized for near-source observation. High-power, high-resolution, wide-bandwidth exploration equipment and an advanced three-dimensional hybrid inversion technique were also developed to enhance the method’s effectiveness. Application of SOTEM to the deep exploration of the zhou’an Ni-Cu-PGE deposit in Henan Province yielded high-resolution imaging of conductivity structures to about 2.5 km depth. These results, consistent with existing drill data, delineated mineralized ore bodies from surrounding formations, identified zones of mineralization potential, and suggested extensive resource prospects in the region.

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A vector hybrid triboelectric sensor(HTS)for motion identification via machine learning

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Nano Research 2023年第7期16卷 10120-10130页

作者： nannan zhou Hongrui Ao Xiaoming Chen Shan Gao Hongyuan Jiang School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China School of Control Engineering Northeastern University at QinhuangdaoQinhuangdao 066004China

Rapidly responding and cost-effective sensors played a crucial role in industrial ***,the lack of versatile strategies for identifying and classifying operating states on various practical behaviors has limited the rapid development of monitoring *** study developed a vector hybrid triboelectric sensor(HTS)with surface nanocrystalline containing triboelectric vibration and rotation units(triboelectric vibration unit(TVU),triboelectric rotation unit(TRU))capable of detecting the vibrational and rotary states of the *** synchronous detection of two sensing signals can be achieved due to the hierarchical structure as the basic unit of the HTS,which contributed to reducing the volume and spatial distribution of the *** on the voltage/current/charge(U-I-Q)signal amplitudes and phase features generated by the TVU,the vibration frequency and orientation of the device can be identified by using a double-layer neural network(D-LNN),in which the accuracy reaches 96.5%and 95.5%***,by combining logistic regression,D-LNN,and linear regression,the accuracy of the TRU for rotary classification exceeds 93.5%in practical *** this study,the great potential application of the HTS combined with the machine learning methods was successfully explored and exhibited and it might speed up the development of industrial detection in the near future.

关键词： vector triboelectric sensor surface nanocrystalline hierarchical structure sensing properties state detection machine learning

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Xylanase improves the intestinal barrier function of Nile tilapia(Oreochromis niloticus)fed with soybean(Glycine max)meal

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Journal of Animal Science and Biotechnology 2023年第5期14卷 2224-2238页

作者： Tong Wang nannan zhou Junyi He Zhenzhen Hao Chentao zhou Yidi Du Zhenyu Du Xiaoyun Su Meiling Zhang Laboratory of Aquaculture Nutrition and Environmental Health(LANEH) School of Life SciencesEast China Normal UniversityShanghai 200241China State Key Laboratory of Animal Nutrition Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China

Background Soybean(Glycine max)meal is one of the important protein sources for fish,but the non-starch polysaccharides(NSP)in soybean meal impair the intestinal barrier *** we aimed to investigate whether xylanase can alleviate the adverse effects on the gut barrier induced by soybean meal in Nile tilapia and to explore the possible *** Nile tilapia(Oreochromis niloticus)(4.09±0.02 g)were fed with two diets including SM(soybean meal)and SMC(soybean meal+3,000 U/kg xylanase)for 8 *** characterized the effects of xylanase on the gut barrier,and the transcriptome analysis was performed to investigate the underlying *** xylanase improved intestinal morphology and decreased the concentration of lipopolysaccharide(LPS)in *** results of transcriptome and Western blotting showed that dietary xylanase up-regulated the expression level of mucin2(MUC2)which may be related to the inhibition of protein kinase RNA-like endoplasmic reticulum kinase(perk)/activating transcription factor 4(atf4)signaling *** analysis showed that addition of xylanase in soybean meal altered the intestinal microbiota composition and increased the concentration of butyric acid in the ***,dietary sodium butyrate was supplemented into the soybean meal diet to feed Nile tilapia,and the data verified that sodium butyrate mirrored the beneficial effects of *** Collectively,supplementation of xylanase in soybean meal altered the intestinal microbiota composition and increased the content of butyric acid which can repress the perk/atf4 signaling pathway and increase the expression of muc2 to enhance the gut barrier function of Nile *** present study reveals the mechanism by which xylanase improves the intestinal barrier,and it also provides a theoretical basis for the application of xylanase in aquaculture.

关键词： Butyrate Exogenous enzymes Intestinal health Intestinal microbiota Mucin Xylanase

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The effects of water depth on the growth and reproduction of Potamogeton crispus in an in situ experiment

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Journal of Plant Ecology 2017年第3期10卷 546-558页

作者： nannan zhou Weiping Hu Jiancai Deng Jinge Zhu Weiwei Xu Xin Liu State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and LimnologyChinese Academy of Sciences73 East Beijing RoadNanjing 210008JiangsuChina College of Environmental Science and Engineering Anhui Normal University189 South Jiuhua RoadWuhu 241000AnhuiChina University of the Chinese Academy of Sciences 19 Yuquan RoadBeijing 100049China

Aims Water level is one of the most important determinants of the distri-bution and composition of submersed aquatic vegetation in shal-low *** changes in nutrient loading,large-scale declines in submerged macrophytes in shallow lakes are largely attributed to strong external or internal forces,including changes in water *** a winter-active submerged macrophyte,Potamogeton crispus has important functions in aquatic *** objec-tives of our study were to reveal the effects of water depths on the germination,growth,reproduction and morphological changes of *** under natural environmental conditions;identify the optimum water depth range for colonization of ***;and pre-dict the succession course for *** in Lake *** A long-term in situ experiment was performed to study the effects of water depth on the growth and morphology of *** across the entire life *** were grown in the improved cross type of rhizotrons for 30 weeks at three different water depths(60,120 and 200 cm)in Dongtaihu Bay of Lake *** measured the plant height,root length,the length and width of leaves and counted the numbers of leaves,ramets,turion spikes and roots of each plant on each observation day during the *** Findings Water depths ranging from 60 to 120 cm were favourable for above-ground vegetation growth,root tissue growth and the reproductive ability of *** water depth of 200 cm or beyond,the distri-bution of *** will be limited in the following year because of the lack of turion formation and the severe inhibition of ramet *** relationship between above-ground biomass and growth time at three different water depths fits a logistic growth curve well(P<0.001).The rapid growth and distribution with high density of *** at water depth near 60 cm during the reproductive stage is not favourable for growth of other submerged *** a continuous water depth of~60-120 cm is the op

关键词： influence strength morphology responses rhizotron shallow lakes submerged plant

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Probiotic Pediococcus pentosaceus restored gossypol-induced intestinal barrier injury by increasing propionate content in Nile tilapia

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1688-1703页

作者： Feifei Ding nannan zhou Yuan Luo Tong Wang Weijie Li Fang Qiao Zhenyu Du Meiling Zhang Laboratory of Aquaculture Nutrition and Environmental Health(LANEH) School of Life SciencesEast China Normal UniversityShanghai 200241China

Background Intestinal barrier is a dynamic interface between the body and the ingested food components, however, dietary components or xenobiotics could compromise intestinal integrity, causing health risks to the host. Gossypol, a toxic component in cottonseed meal(CSM), caused intestinal injury in fish or other monogastric animals. It has been demonstrated that probiotics administration benefits the intestinal barrier integrity, but the efficacy of probiotics in maintaining intestinal health when the host is exposed to gossypol remains unclear. Here, a strain(YC) affiliated to Pediococcus pentosaceus was isolated from the gut of Nile tilapia(Oreochromis niloticus) and its potential to repair gossypol-induced intestinal damage was *** A total of 270 Nile tilapia(2.20 ± 0.02 g) were allotted in 3 groups with 3 tanks each and fed with 3 diets including CON(control diet), GOS(control diet containing 300 mg/kg gossypol) and GP(control diet containing 300 mg/kg gossypol and 10^(8) colony-forming unit(CFU)/g P. pentosaceus YC), respectively. After 10 weeks, addition of P. pentosaceus YC restored growth retardation and intestinal injury induced by gossypol in Nile tilapia. Transcriptome analysis and si RNA interference experiments demonstrated that NOD-like receptors(NLR) family caspase recruitment domain(CARD) domain containing 3(Nlrc3) inhibition might promote intestinal stem cell(ISC) proliferation, as well as maintaining gut barrier integrity. 16S r RNA sequencing and gas chromatography-mass spectrometry(GC-MS) revealed that addition of P. pentosaceus YC altered the composition of gut microbiota and increased the content of propionate in fish gut. In vitro studies on propionate's function demonstrated that it suppressed nlrc3 expression and promoted wound healing in Caco-2 cell *** The present study reveals that P. pentosaceus YC has the capacity to ameliorate intestinal barrier injury by modulating gut microbiota composition and elevating

关键词： Gut barrier injury Gossypol ISCs proliferation Nlrc3 Propionate

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YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation

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Research 2024年第2期6卷 401-415页

作者： Jiadi Lv Xiaohan Liu Yabo zhou Feiran Cheng Haoran Chen Shunshun Li Dianheng Wang Li zhou Zhenfeng Wang nannan zhou Jie Chen Bo Huang Department of Immunology&State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical College(PUMC)Beijing100005China Department of Histology and Embryology Basic Medical CllegeChina Medical UniversityShenyangLiaoning 11122China Department of Immunology Basic Medical Cllege China Medical UniversityShenyangLiaoning 110122China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China

Solid tumor cells live in a highly dynamic mechanical *** the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an ***,we show that a low mechanical force generated from the soft matrix induces dedifferentiation of moderately stiff tumor cells to soft stem-cell-like ***,integrin?was identified to transduce mechano-signaling to trigger tumor cell dedifferentiation by recruiting RhoGDI1 to inactivate RhoA and subsequently Yes-associated protein(YAP).YAP inactivation relieved the inhibition of v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G(MAFG),allowing MAFG to transactivate the stemness genes NANOG,SOX2,and *** also restoredβ8 expression,thereby forming a closed mechanical ***,MAFG expression is correlated with worse *** findings provide mechanical insights into the regulation of tumor cell dedifferentiation,which has therapeutic implications for exploring innovative strategies to attack malignancies.

关键词： activation thereby MAF

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Visualization of perforin/gasdermin/complement-formed pores in real cell membranes using atomic force microscopy

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Cellular & Molecular Immunology 2019年第6期16卷 611-620页

作者： Yuying Liu Tianzhen Zhang Yabo zhou Jiping Li Xiaoyu Liang nannan zhou Jiadi Lv Jing Xie Feiran Cheng Yiliang Fang Yunfeng Gao Ning Wang Bo Huang Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijing 100005China Clinical Immunology Center Chinese Academy of Medical SciencesBeijing 100005China Beijing SOJO Electric Company Limited BeijingChina Department of Mechanical Science and Engineering College of EngineeringUniversity of Illinois at Urbana-ChampaignUrbanaIllinois 61801USA Laboratory for Cellular Biomechanics and Regenerative Medicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhanHubei 430074China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China

Different types of pores ubiquitously form in cell membranes,leading to various types of cell death that profoundly influence the fate of inflammation and the disease ***,these pores have never truly been visualized to *** force microscopy(AFM),which is emerging as a powerful tool to analyze the mechanical properties of biomolecules and cells,is actually an excellent imaging platform that allows biological samples to be visualized by probing surface roughness at the level of atomic ***,membrane pore structures were clearly visualized using *** visualization not only describes the aperture and depth of the pore complexes but also highlights differences among the pores formed by perforin and gasdermins in tumor cell membranes and by complement in immune cell ***,this type of visualization also reveals the dynamic process of pore formation,fusion,and repair.

关键词： membrane pore formation AFM perforin GSDMD/GSDME complement

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The ratio apparent resistivity definition of rectangular-loop TEM

The ratio apparent resistivity definition of rectangular-loo...

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中国科学院地质与地球物理研究所2014年度（第14届）学术年会

作者： zhou nannan Xue GuoQiang Key Laboratory of Mineral Resources Institute of Geology and GeophysicsChinese Academy of Science

The conventional method for computing the apparent resistivity of any location within a rectangular loop is to use the associated vertical magnetic field or its time derivative by a well-developed central-loop *** central part of the loop,this definition of apparent resistivity is accurate,and the survey configuration is designated as modified central-loop ***,when applied to the non-central part of the rectangular loop that often demonstrates uneven distribution of magnetic field the use of this equation runs the risk of producing computational *** of the uneven distribution of vertical magnetic field,ratio response of the orthogonal horizontal field components has a uniform field ***,the decay curves of ratio response reveal the properties of translation and *** examining the decay curves for different resistivity,a new definition of ratio apparent resistivity is proposed,which is applicable for any point in a loop with the uniform distribution of ratio *** the proposed explicit function between ratio response and apparent resistivity,our new algorithm avoids the time-consuming iteration by solving a non-linear *** theoretical modeling and real data example indicate the added value of our method on computational efficiency and accuracy.

关键词： Rectangular loop Uniform distribution Ratio response Translation and scaling Apparent resistivity Time domain

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ACE2 expression is regulated by AhR in SARS-CoV-2-infected macaques

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Cellular & Molecular Immunology 2021年第5期18卷 1308-1310页

作者： Jiadi Lv Pin Yu Zhenfeng Wang Wei Deng Linlin Bao Jiangning Liu Fengli Li Qiangqiang Zhu nannan zhou Qi Lv Guanpeng Wang Shunyi Wang Yabo zhou Jiangping Song Wei-Min Tong Yuying Liu Chuan Qin Bo Huang Department of Immunology and National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences(CAMS)and Peking Union Medical CollegeBeijingChina NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceCAMS and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesCAMS and Peking Union Medical CollegeBeijingChina Department of Pathology Institute of Basic Medical SciencesCAMS and Peking Union Medical CollegeBeijingChina Clinical Immunology Center CAMSBeijingChina Department of Biochemistry and Molecular Biology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

During the current outbreak of coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),more than 115 million people have been infected,and 2.5 million have died.1,2 Despite such great harm to human health,the pathogenesis of COVID-19 remains *** the first step in the pathogenetic process,viral entry is mediated by the binding of the SARS-CoV-2 surface spike(S)protein to angiotensin-converting enzyme 2(ACE2)on host cells,such as lung epithelial *** an alternative to S protein-blocking strategies,manipulating host cell ACE2 expression may exert an inhibitory effect on SARS-CoV-2 ***,the molecular mechanism regulating ACE2 expression remains unclear.

关键词： ACE2 infected acute

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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan Chen Hongxia Deng nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

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