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指导性集体锻炼对治疗中的早期乳腺癌妇女的益处:实用性随机对照试验

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英国医学杂志中文版 2007年第4期10卷 210-213页

作者： nanette mutrie Anna M Campbell Fiona Whyte Alex McConnachie Carol Emslie Laura Lee Nora Kearney Andrew Walker Diana Ritchie 方桦（译）王燕（校） Department of Sport Culture and the ArtsStrathclyde UniversityGlasgow G13 1PP Nursing and Midwifery School University of GlasgowGlasgow G12 8LW Robertson Centre for Biostatistics University of Glasgow G12 8QQ MRC Social and Public Health Sciences Unit Glasgow G12 8RZ Cancer Care Research Centre Department of Nursing and MidwiferyUniversity of StirlingStirling FK9 4LA Beatson Oncology Centre Glasgow G11 6NT 不详

目的确定12周指导性集体锻炼对治疗中的早期乳腺癌患者在机体功能和心理上的获益,并随访6个月。设计实用性、前瞻性、随机对照、开放性试验。地点苏格兰3家国家医疗卫生服务体系肿瘤门诊和社区运动设施。参加者共203位妇女参加研究;其中... 详细信息

目的确定12周指导性集体锻炼对治疗中的早期乳腺癌患者在机体功能和心理上的获益,并随访6个月。设计实用性、前瞻性、随机对照、开放性试验。地点苏格兰3家国家医疗卫生服务体系肿瘤门诊和社区运动设施。参加者共203位妇女参加研究;其中177位完成6个月随访。干预与常规护理相对照,干预组予12周指导性集体锻炼加常规护理。主要结果评价癌症治疗功能评价(FACT)问卷、贝克抑郁问卷、正性和负性情绪量表、体重指数、7日体力活动回忆问卷、12分钟步行实验和肩关节活动度评估。结果对基线值、研究中心、基线治疗和参加干预试验时的年龄进行校正后,综合效应模型的评估结果(干预组减对照组)显示第12周时:12分钟步行距离为129米(95%可信区间83～176),1周的中等强度活动时间182分钟(75～289),肩关节活动度2.6(1.6～3.7),乳腺癌特定的生活质量量表2.5(1.0～3.9),正性情绪4.0(1.8～6.3)。初步结果未发现干预锻炼对生活质量综合量表(FACT-G)有影响。随访6个月后,大多数效果维持不变,并且在乳腺癌特定的生活质量上得到改善。尚未有不良反应的报道。结论在12周干预锻炼结束时以及6个月后,指导性集体锻炼均显示出机体功能和心理上的获益。因此临床医生应该鼓励患者活动,决策者们应该考虑把体育锻炼纳入到癌症康复服务中来。试验注册号当前对照试验 ISRCTN12587864[***]。

关键词：随机对照试验早期乳腺癌体育锻炼治疗功能集体妇女生活质量量表医疗卫生服务体系

What do the recent American Heart Association/American College of Cardiology Foundation Clinical Practice Guidelines tell us about the evolving management of coronary heart disease in older adults?

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Journal of Geriatric Cardiology 2013年第2期10卷 123-128页

作者： Daniel Forman nanette K Wenger Harvard Medical School Brigham and Women's Hospital Boston MA 02115USA Emory University School of Medicine Emory Heart and Vascular Center Atlanta GA 30303 USA

Biological aging predisposes older adults to increased cardiovascular disease (CHD) and greater disease complexity. Given the high age-related prevalence of CHDand age-related compounding factors, the recently updatedAmerican HeartAssociation/American College of Cardiology Foundation CHD-related guidelines increased their focus on older patients. These guidelines are predominately evidence-based (using data from quality randomized clinical trials) and are organized to delineate medications and procedures that best treat particular cardiovascular *** such rationale and thought work well in young and middle aged adults, they become problematic in patientswho are very old. Data pertaining to adults aged ≥80 are virtually absent from most randomized clinical trials, and even in the instances when very old patients were included, eligibility criteria typically excluded candidates with co-morbidities and complexities of customary CHD patients. While medications and interventions yielding benefit in clinical trials should theoretically produce the greatest benefits for patients with high intrinsic risk, age-related cardiovascular complexities also increase iatrogenic risks. Navigating between the potential for high benefit and high risk in “evidence-based”cardiovascular management remains a key Geriatric Cardiology challenge. In this review we consider the expanded Geriatric Cardiology content of current guidelines, acknowledging both the progress that has been made, as well as the work that still needs to be accomplished to truly address the patient-centered priorities of older CHDpatients.

关键词： Cardiovascular disease Elderly patient Guidelines

Science and the practice of cardiovascular medicine in the geriatric population

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Journal of Geriatric Cardiology 2011年第2期8卷 67-71页

作者： nanette K Wenger Emory University School of Medicine Emory Heart and Vascular Center Atlanta GA 30303 USA

1 Why is the demograpy important? In the half century 2000-2050,there will be a virtual tsunami of aging in the United *** anticipated increase in the population older than age 65 is 140%,and for the population older than age 85,389%.More than half of the current *** can anticipate living to age 80,with a contemporary life expectancy at age 75 of 11 years,and at age 85 of 6 years.

关键词： cardiovascular medicine the aged clinical trials

Geriatric cardiology and the Great Wall International Congress of Cardiology 2015

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Journal of Geriatric Cardiology 2016年第4期13卷 279-281页

作者： nanette K Wenger Chang-Sheng MA Emory University School of Medicine Atlanta GA USA Department of Cardiology Beij'ing Anzhen Hospital Capital Medical University Beijing China

The burgeoning geriatric population worldwide has resulted in an unprecedented challenge to the cardiology community. Cardiovascular disease is the major cause of morbidity and mortality in the elderly population, but its recognition and management are characteristically confounded by substantial comorbidities, polypharmacy, and other complexities of care, not encountered in younger cardiac patients.

关键词： Acute coronary syndrome GWICC 2015 ST- elevation myocardial infarction The elderly

Cardiovascular Care for Older Adults Aortic valve disease in the older adult

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Journal of Geriatric Cardiology 2016年第12期13卷 941-944页

作者： Neal Bhatia Sukhdeep S Basra Adam H Skolnick nanette K Wenger Emory University School of Medicine Atlanta GA USA The Heart Hospital Baylor Piano Dallas TX USA Leon H Charney Division of Cardiology New York University Langone Medical Center NY USA

As the population continues to age, aortic stenosis re- mains as the most prevalent valvular disease in Western countries. The number of elderly patients with aortic ste- nosis continues to pose both a diagnostic and therapeutic challenge. Despite new advances such as transcatheter aortic valvular replacement （TAVR）, there is still much pa- tient-provider decision making that needs to take place giv- en the comorbidities and complex goals of care in an elderly patient population.

关键词： Aortic stenosis The elderly Valve disease

Concomitant atopic dermatitis and narcolepsy type 1:psychiatric implications and challenges in management

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General Psychiatry 2019年第5期32卷 279-282页

作者： Justin Chin Craig Bearison nanette Silverberg Mary Lee Wong Department of Primary Care Touro College of Osteopathic MedicineNew York CityNew YorkUSA Department of Internal Medicine Beth Israel Medical CenterNew York CityNew YorkUSA Department of Pediatric Dermatology Mount Sinai Health SystemNew York CityNew YorkUSA Department of Allergy and Immunology Beth Israel Medical CenterNew York CityNew YorkUSA Department of Medicine Icahn School of Medicine at Mount SinaiNew York CityNew YorkUSA

Atopic dermatitis(AD)and narcolepsy type 1(NT1)are two distinct diseases that have not been classically shown to be *** potential connection between the known immunological aetiology of AD and the proposed autoimmune pathophysiology of dysregulation in NT1;however,is the subject of ongoing speculation and debate with advances in gene sequencing and ***,we present a case of a patient with concomitant refractory AD and NT1 and review the current research on their immunological relationship and the challenges in management relative to disease burden and psychiatric comorbidities.

关键词： dermatitis psychiatric diseases

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Slip,Slide,Swoosh!

小学生时代（大嘴英语） 2019年第1期 44-45页

作者： nanette Regan(图) 不详

Four friends are ready to slide down the hill! Who will reach the bottom? Who will stop to play?

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Essentials of cardiovascular care for older adults： extending a US-based educational resource for collaboration with our China colleagues

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Journal of Geriatric Cardiology 2015年第3期12卷 191-191页

作者： Daniel E Forman nanette K Wenger University of Pittsburgh Medical Center Pittsburgh PA USA Emory University School of Medicine Atlanta GA USA.

1 The rationale for a geriatric cardiology skillset Throughout most of the world, people are living substantially longer. As a result, there is a rapidly expanding population of older adults who did not previously survive into old age. These adults are exposed to advanced aging processes that did not previously occur. Physiological changes of age predispose to cardiovascular diseases. Ironically, coronary heart disease, heart failure, valvular heart disease, peripheral artery disease, arrhythmias and other cardiovascular problems all soar with survival into senior years.

关键词：老年人教育资源心血管合作中国护理美国心脏病

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Pumpkin,Pumpkin

小学生时代（大嘴英语） 2020年第10期 42-43页

作者： Della Ross Ferreri nanette Regan(图) 不详

Hooray!收获的季节到了,瞧,南瓜大丰收啦,地里一派忙碌的景象!来一起"寻宝"吧。

关键词： Pump 寻宝南瓜