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Utility of high-resolution anterior segment optical coherence tomography in the diagnosis and management of sub-clinical ocular surface squamous neoplasia

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Eye and Vision 2019年第1期6卷 229-235页

作者： Ann Q.Tran nandini Venkateswaran Anat Galor Carol L.Karp Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine900 NW 17th StMiamiFL 33136USA

Background:To evaluate the frequency and characteristics of sub-clinical ocular surface squamous neoplasia(OSSN)detected by high-resolution anterior segment tomography(HR-OCT)in patients with clinically unapparent disease following topical ***:A retrospective chart review of patients with OSSN identified through a pharmacy database at the Bascom Palmer Eye Institute from January 2013 to December 2018 was *** undergoing primary therapy with topical 5-fluorouracil 1%(5-FU)(4 times a day for 7 days with a 21-day break)or interferon-alpha-2b(IFN)(4 times a day)were *** were separated into two *** 1 included individuals whose clinical resolution of OSSN aligned with complete resolution on *** 2(sub-clinical OSSN group)included individuals with clinical OSSN resolution but with features of persistent disease on *** excluded included those treated at an outside institution and those who used topical therapy as a surgical ***:A total of 95 patients(95 eyes)were ***-clinical OSSN was detected at a frequency of 17%in our study patients(n=16 patients,9 treated with 5-FU and 7 treated with IFN).In the 16 individuals,the mean time to clinical resolution was 3.6±1.0 cycles for 5-FU and 4.0±0.0 months for *** additional 2.1±0.8 cycles for 5-FU and 1.2±0.4 months for IFN were needed to achieve HR-OCT resolution of *** in Group 1 was noted in 10 patients(12%)while no recurrences occurred in Group 2,the cohort with subclinical disease that received the extended medical *** mean follow-up was 24.0±17.9 ***:We found that at least 17%of individuals with apparent clinical resolution of OSSN have sub-clinical disease detected on *** information can be used to optimize treatment and extend therapy past the point of clinical resolution.

关键词： Ocular surface squamous neoplasia,High-resolution optical coherence tomography,Sub-clinical ocular surface squamous neoplasia,Ocular surface imaging ocular surface lesions

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Role of MgF2 addition on high energy ball milled kalsilite:Implementation as dental porcelain with low temperature frit

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Journal of Advanced Ceramics 2014年第4期3卷 332-338页

作者： Pattem Hemanth KUMAR Abhinav SRIVASTAVA Vijay KUMAR nandini JAISWAL Pradeep KUMAR Vinay Kumar SINGH Department of Ceramic Engineering Indian Institute of Technology(BHU)VaranasiIndia Department of Chemical Engineering Indian Institute of Technology(BHU)VaranasiIndia

Porcelain fused to metal(PFM)has received great attention over the last few years due to its importance in the ***(K_(2)O·Al_(2)O_(3)·SiO_(2))is a high thermal expansion porcelain,suitable for bonding to ***,kalsilite is a metastable phase which gets converted into crystalline leucite upon *** the current work feasibility of developing stable kalsilite phase,dispersion of MgF2 in it as an additive and using mechanochemical synthesis are *** fine dental material has been formulated by mixing prepared kalsilite with low temperature frit(LTF)in different *** crystalline phases evolved in fired powders are characterized by powder X-ray diffraction(XRD)*** with different ratio of LTF has been cold pressed and heat treated to examine its coefficient of thermal expansion(CTE),flexural strength,apparent porosity(AP),bulk density(BD)and *** indicate that MgF_(2) addition and high milling duration help in kalsilite *** also plays an important role in this stabilization,and at 1100℃single phase kalsilite formation is *** outcomes demonstrate that it is easily possible to synthesize a stable single phase kalsilite with desirable properties.

关键词： kalsilite porcelain fused to metal(PFM) dental ceramic mechanochemical synthesis thermal expansion X-ray diffraction(XRD)

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Risk prediction model for cutaneous squamous cell carcinoma in adult cardiac allograft recipients

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World Journal of Transplantation 2021年第3期11卷 54-69页

作者： nandini Nair Zhiyong Hu Dongping Du Enrique Gongora Division of Cardiology Department of Internal MedicineTexas Tech Health Sciences CenterLubbockTX 79430United States Department of Industrial Manufacturing and Systems EngineeringTexas Tech UniversityLubbockTX 79409United States Department of Cardiothoracic Surgery University of Alabama at BirminghamBirminghamAL 35233United States

BACKGROUND Heart transplant recipients are at higher risk of developing skin cancer than the general population due to the long-term immunosuppression *** has been reported as one of the major causes of morbidity and mortality for patients after heart *** different types of skin cancers,cutaneous squamous cell carcinoma(cSCC)is the most common one,which requires timely screening and better *** To identify risk factors and predict the incidence of cSCC for heart transplant *** We retrospectively analyzed adult heart transplant recipients between 2000 and 2015 extracted from the United Network for Organ Sharing *** whole dataset was randomly divided into a derivation set(80%)and a validation set(20%).Uni-and multivariate Cox regression were done to identify significant risk factors associated with the development of *** operating characteristics curves were generated and area under the curve(AUC)was calculated to assess the accuracy of the prediction *** on the selected risk factors,a risk scoring system was developed to stratify patients into different risk groups.A cumulative cSCC-free survival curve was generated using the Kaplan-Meier method for each group,and the log-rank test was done to compare the intergroup cSCC *** There were 23736 heart-transplant recipients during the study period,and 1827 of them have been reported with *** predictors of post-transplant cSCC were older age,male sex,white race,recipient and donor human leukocyte antigen(HLA)mismatch level,malignancy at listing,diagnosis with restrictive myopathy or hypertrophic myopathy,heart re-transplant,and induction therapy with OKT3 or *** multivariate model was used to predict the 5-,8-and 10-year incidence of cSCC and respectively provided AUC of 0.79,0.78 and 0.77 in the derivation set and 0.80,0.78 and 0.77 in the validation *** risk scoring system assigned each patient with a

关键词： Cutaneous squamous cell carcinoma Heart transplantation Cox proportional hazard model Risk assessment Squamous cell carcinoma Mortality outcomes

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Protection against symptomatic SARS-CoV-2 infection during the second wave among individuals with pre-existing binding antibodies to SARS-CoV-2: A population-based study from Puducherry, India

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Asian Pacific Journal of Tropical Medicine 2023年第10期16卷 476-478页

作者： Premkumar Ramasubramani Dhanajayan Govindan nandini Balakrishnan Krishnan Tamilarasu Kadhiravan Sitanshu Sekhar Kar Department of Preventive and Social Medicine Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)PuducherryIndia Department of General Medicine Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER)PuducherryIndia

During the COVID-19 pandemic,several studies have shown that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection is associated with a substantial reduction in the risk of subsequent reinfection with a... 详细信息

关键词： infection acute respiratory

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Fat,oil,and grease as new feedstock towards bioelectrogenesis in microbial fuel cells:Microbial diversity,metabolic pathways,and key enzymes

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Journal of Energy Chemistry 2023年第10期85卷 418-429,I0011页

作者： Monika Sharma Mohammed Jalalah Saeed AAlsareii Farid AHarraz Abdulrhman AAlmadiy nandini Thakur El-Sayed Salama Xiangkai Li MOE Key Laboratory of Cell Activities and Stress AdaptationsSchool of Life SciencesLanzhou UniversityLanzhou 730000GansuChina Promising Centre for Sensors and Electronic Devices(PCSED) Advanced Materials and Nano-Research CentreNajran UniversityP.O.Box:1988Najran 11001Saudi Arabia Department of Electrical Engineering College of EngineeringNajran UniversityNajran 11001Saudi Arabia Department of Surgery College of MedicineNajran UniversityNajran 11001Saudi Arabia Department of Chemistry Faculty of Science and Arts at SharurahNajran UniversitySharurah 68342Saudi Arabia Department of Biology Faculty of Arts and SciencesNajran University1988 NajranSaudi Arabia Department of Occupational and Environmental Health School of Public HealthLanzhou UniversityLanzhou 730000GansuChina

Microbial fuel cells(MFCs)are a well-known technology used for bioelectricity production from the decomposition of organic waste via electroactive ***,oil,and grease(FOG)as a new substrate in the anode and microalgae in the cathode were added to accelerate the *** effect of FOG concentrations(0.1%,0.5%,1%,and 1.5%)on the anode chamber was *** FOG degradation,volatile fatty acid(VFAs)production,and soluble chemical oxygen demand along with voltage output kinetics were ***,the microbial community analysis and active functional enzymes were also *** maximum power and current density were observed at 0.5%FOG which accounts for 96 mW m^(-2)(8-folds enhancement)and 560 mA m^(-2)(3.7-folds enhancement),*** daily voltage output enhanced upto 2.3-folds with 77.08%coulombic efficiency under 0.5%FOG,which was the highest among all the *** 0.5%FOG was degraded>85%,followed by a 1%FOG-loaded *** chief enzymes inβ-oxidation and electrogenesis were acetyl-CoA C-acetyltransferase,riboflavin synthase,and riboflavin *** identified enzymes symbolize the presence of Clostridium sp.(>15%)and Pseudomonas(>10%)which served as electrochemical active bacteria(EAB).The major metabolic pathways involved in electrogenesis and FOG degradation were fatty acid biosynthesis and glycerophospholipid *** of lipidic-waste(such as FOG)in MFCs could be a potential approach for simultaneous biowaste utilization and bioenergy generation.

关键词： Lipidic-waste Microalgae Electrogenesis Microbial community Functional enzymes

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IOT Assisted Biomedical Monitoring Sensors for Healthcare in Human

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Computer Systems Science & Engineering 2023年第6期45卷 2853-2868页

作者： S.Periyanayagi V.nandini K.Basarikodi V.Sumathy Department of ECE Ramco Institute of TechnologyRajapalayam626117India Department of CSE Sona College of TechnologySalem636005India Department of Mathematics Ramco Institute of TechnologyRajapalayamIndia Government College of Engineering DharmapuriIndia

The Internet of Things(IoT)is a concept that refers to the deployment of Internet Protocol(IP)address sensors in health care systems to monitor patients’*** has the ability to access the Internet and collect data from *** decisions are made after evaluating the information of illness people ***’health and well-being can be monitored through IoT medical *** is possible to trace the origins of biological,medical equipment and *** reliability is a major concern in user activity and fitness trackers in day-to-day *** fundamental challenge is to measure the efficiency of the human system *** to maintain tabs on the well-being of humans;this paper recommends the use of wireless body area networks(WBANs)and artificial neural networks(ANN)to create an IoT-based healthcare framework for hospital information systems(IoT-HF-HIS).Our evaluation system uses a server to estimate how much computing power is needed for modeling,and simulations of the framework have been done using data rate and latency requirements are implementing the energy-aware technology presented in this *** proposed framework implements several hospital information system case studies by building a time-saving simulation *** the world’s population ages,more and more people suffer from physical and emotional *** the recommended strategy regularly has been proven user-friendly,reliable,and cost-effective,with an overall performance of 95.2%.

关键词： IoT WBANs ANN healthcare biomedical sensors humans

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Metaheuristic Based Clustering with Deep Learning Model for Big Data Classification

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Computer Systems Science & Engineering 2023年第1期44卷 391-406页

作者： R.Krishnaswamy Kamalraj Subramaniam V.nandini K.Vijayalakshmi Seifedine Kadry Yunyoung Nam Department of Electronics and Communication Engineering University College of Engineering AriyalurAriyalur621704India Department of Biomedical Engineering Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore641021India Department of Computer Science and Engineering Sona College of TechnologySalem636005India Department of Electronics and Communication Engineering Saveetha School of EngineeringSaveetha Institute of Medical and Technical SciencesChennai600077India Deparmtent of Applied Data Science Noroff University CollegeKristiansandNorway Department of Computer Science and Engineering Soonchunhyang UniversityAsanKorea

Recently,a massive quantity of data is being produced from a distinct number of sources and the size of the daily created on the Internet has crossed two *** the same time,clustering is one of the efficient techniques for mining big data to extract the useful and hidden patterns that exist in ***-based clustering techniques have gained significant attention owing to the fact that it helps to effectively recognize complex patterns in spatial *** data clustering is a trivial process owing to the increasing quantity of data which can be solved by the use of Map Reduce *** this motivation,this paper presents an efficient Map Reduce based hybrid density based clustering and classification algorithm for big data analytics(MR-HDBCC).The proposed MR-HDBCC technique is executed on Map Reduce tool for handling the big *** addition,the MR-HDBCC technique involves three distinct processes namely pre-processing,clustering,and *** proposed model utilizes the Density-Based Spatial Clustering of Applications with Noise(DBSCAN)techni-que which is capable of detecting random shapes and diverse clusters with noisy *** improving the performance of the DBSCAN technique,a hybrid model using cockroach swarm optimization(CSO)algorithm is developed for the exploration of the search space and determine the optimal parameters for density based ***,bidirectional gated recurrent neural network(BGRNN)is employed for the classification of big *** experimental validation of the proposed MR-HDBCC technique takes place using the benchmark dataset and the simulation outcomes demonstrate the promising performance of the proposed model interms of different measures.

关键词： Big data data classification clustering mapreduce dbscan algorithm

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Pregnancy-associated glycoproteins as a potential marker for diagnosis of earlypregnancy in goats: A scoping reviewing

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Asian pacific Journal of Reproduction 2020年第6期9卷 255-260页

作者： nandini Sharma Shiva Pratap Singh Alok Bharadwaj Ramachandran Natesan Department of Biotechnology GLA(Ganeshi Lal Agrawal Charitable Trust)UniversityP.O.ChaumuhanMathuraUttar Pradesh281406India Animal Physiology and Reproduction Division ICAR-Central Institute for Research on GoatsMakhdoomFarahMathuraUttar Pradesh281122India

Early diagnosis of pregnancy plays an important role to minimize reproductive losses in farm *** are several methods for pregnancy diagnosis like profiling of reproductive hormones(such as progesterone and estrone sulfate),but sometimes they provide false-positive *** specific pregnancy markers,which delineate the presence and viability of the embryo,are considered as perfect for pregnancy ***-associated glycoproteins are distinguished as the best indicator for the determination of early pregnancy,fetal number,and birth weight of ***-associated glycoproteins are structurally correlated to aspartic proteinase and are communicated in the external epithelial cell layer of the *** have been found to share about half amino acid sequence identity with pepsinogen,pepsin,cathepsin D and *** different individuals from aspartic proteinase family,numerous pregnancy-associated glycoproteins appear to be latent compound as a result of amino acid substitutions in and around the catalytic *** review is to discuss the scope and prospects of pregnancy-associated glycoproteins as a pregnancy marker in farm animals,more specifically in goats.

关键词： Pregnancy-associated glycoproteins Early pregnancy Farm animals Placenta Goats

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Update on pharmacotherapy for ocular surface squamous neoplasia

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Eye and Vision 2019年第1期6卷 201-212页

作者： Ghada Al Bayyat Dan Arreaza-Kaufman nandini Venkateswaran Anat Galor Carol L.Karp Bascom Palmer Eye Institute University of Miami900 NW 17th StreetMiamiFL 33136USA Miami Veterans Hospital MiamiFL 33125USA

The most frequently encountered non-pigmented tumor of the ocular surface is ocular surface squamous neoplasia(OSSN).Over the past two decades,the pharmacological management of OSSN has grown,with topical 5-fluorouracil,mitomycin,and interferon alpha 2b all being successfully used to treat this *** agents,such as anti-vascular endothelial growth factor(VEGF),retinoic acid,cidofovir and Aloe vera,have less frequently been used in the treatment of *** review will discuss these pharmacologic agents,summarizing available data and presenting the approach to the treatment of these tumors.

关键词： Ocular surface squamous neoplasia(OSSN) Mitomycin-C Interferon alpha 2b 5-fluorouracil Conjunctival neoplasia Corneal neoplasia

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Adherence to self-care practices, glycemic status and influencing factors in diabetes patients in a tertiary care hospital in Delhi

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World Journal of Diabetes 2018年第5期9卷 72-79页

作者： Saurav Basu Suneela Garg nandini Sharma M Meghachandra Singh Sandeep Garg Department of Community Medicine Maulana Azad Medical College Department of Medicine Maulana Azad Medical College

AIM To assess the adherence to self-care practices,glycemic status and influencing factors in diabetes *** This was a cross-sectional observational analysis of baseline data from a quasi-experimental study conducted among 375 diabetic patients aged between 18 to 65years at a major public tertiary care centre in New Delhi,India during February-September’*** Summary of Diabetes Self-care activities measure was used to assess medical adherence in diabetic *** ended questions were used to identify facilitators and inhibitors of medical *** Mean age of the study subjects was 49.7±10.2 years.A total of 201 men and 174 women were enrolled in the *** hundred nine(82.4%)subjects were adherent to their intake of anti-diabetic *** binary logistic regression,education level below primary school completion and absence of hypertensioncomorbidity were found to be independent predictors of medication *** resistance was an important factor impeding outdoor exercise among younger *** of diabetes in the study subjects was low with mean score of 3.1±2(maximum score=10).Suboptimal glycemic control was found in259(69%)subjects which was significantly more likely in patients on Insulin therapy compared to those on Oral Hypoglycemic agents alone(P<0.006).DISCUSSION Our study found a large gap existed between selfreported medication adherence and glycemic *** suggests the need for enhanced physician focus for diabetic patient management.

关键词： Diabetes Adherence Glycemic control Insulin India

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