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A novel molecular distance edge vector as applied to chemical modeling of quantitative structure-retention relationships:Various gas chromatographic retention behaviors of polychlorinated dibenzofurans on different polarity-varying stationary phases

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Chinese Science Bulletin 2005年第16期50卷 1683-1687页

作者： DENG Hong HUANG Ping HU Yinyu ye nancy LI Zhiliang College of Chemistry and Chemical Engineering Key Laboratory of Biomedical Engineering of Chongqing Municipality and Center for Molecular Modeling and Drug Designing Chongqing University Chongqing 400044 China Key Laboratory of Biomechanical Engineering of Education Ministry Department of Chemical Biology and Molecular Toxicology Institute of Biomedical Engineering Chongqing University Chongqing 400044 China

Based on the identical group as a pseudo atom instead of a typical atom, a novel modified molecular dis-tance-edge (MDE) vector μ was developed in our laboratory to characterize chemical structure of polychlorinated diben-zofurans (PCDFs) congeners and/or isomers. Quantitative structure-retention relationships (QSRRs) between the new VMDE parameters and gas chromatographic (GC) retention behavior of PCDFs were then generated by multiple linear regression (MLR) method for non-polar, moderately polar, and polar stationary phases. Four excellent models with high correlation coefficients, R=0.984-0.995, were proposed for non-polar columns (DB-5, SE-54, OV-101). For the moder-ately polar columns (OV-1701), the correlation coefficient of the developed good model is only 0.958. For the polar col-umns (SP-2300), the QSRR model is poor with R=0.884. Then cross validation with leave-one out of procedure (CV) is performed in high correlation with the non-polar (Rcv=992-0.974) and weakly polar (Rcv=921) columns and in little cor-relation (Rcv=0.834) with the polar columns. These results show that the new μ vector is suitable for describing the re-tention behaviors of PCDFs on non-polar and moderately polar stationary phases and not for the various gas chroma-tographic retention behaviors of PCDFs on the different po-larity-varying stationary phases.

关键词：分子距离向量 MDE 氧芴分子模型化学结构异构体

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Science Bulletin 2005年第16期 13-17页

作者： ye nancy College of Chemistry and Chemical Engineering Chongqing 400044 Key Laboratory of Biomedical Engineering of Chongqing Municipality and Center for Molecular Modeling and Drug Designing Chongqing University China

关键词： molecular distance-edge vector (MDE) polychlorinated dibenzofurans (PCDFs) molecular modeling quantitative struc-ture-retention relationship (QSRR) chemical structural parame-terization.

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Learning curve for magnetic resonance imaging/ultrasound fusion prostate biopsy in detecting prostate cancer using cumulative sum analysis

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Current Urology 2023年第3期17卷 159-164页

作者： Linhan Xu nancy Yating ye Adrianna Lee Jasleen Chopra Michael Naslund Jade Wong-You-Cheong Amelia Wnorowski Mohummad Minhaj Siddiqui University of Maryland School of Medicine BaltimoreMDUSA Division of Urology Department of General SurgeryKaiser Permanente Los Angeles Medical CenterLos AngelesCAUSA Department of Diagnostic Radiology University of Maryland School of MedicineBaltimoreMDUSA Division of Urology Department of SurgeryUniversity of Maryland School of MedicineUniversity of Maryland Medical CenterBaltimoreMDUSA

Background:Targeted magnetic resonance(MR)with ultrasound(US)fusion-guided biopsy has been shown to improve detection of prostate *** implementation of this approach requires integration of skills from radiologists and *** methods for assessment of learning curves,such as cumulative sum(CUSUM)analysis,may be helpful in identifying the presence and duration of a learning *** aim of this study is to determine the learning curve for MR/US fusion-guided biopsy in detecting clinically significant prostate cancer using CUSUM *** and methods:Retrospective analysis was performed in this institutional review board-approved *** urologists implemented an MR/US fusion-guided prostate biopsy program between March 2015 and September *** primary outcome measure was cancer detection rate(CDR)stratified by Prostate Imaging Reporting and Data System(PI-RADS)scores assigned on the MR *** sum analysis quantified actual cancer detection versus a predetermined target satisfactory CDR of MR/US fusion biopsies in a sequential case-by-case *** this analysis,satisfactory performance was defined as>80%CDR in patients with Pl-RADS 5,>50%in PI-RADS 4,and<20%in Pl-RADS ***:Complete data were available for MR/US fusion-guided biopsies performed on 107 *** CUSUM learning curve analysis demonstrated intermittent underperformance until approximately 50 *** this inflection point,there was consistently good performance,evidence that no further learning curve was being ***:At a new center implementing MR/US fusion-guided prostate biopsy,the learning curve was approximately 50 cases before a consistently high performance for prostate cancer detection.

关键词： Cumulative sum analysis Learning curve Magnetic resonance/ultrasound fusion biopsy Prostate cancer

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溃疡性结肠炎内镜缓解患者的组织学活动度评估对内镜复发的预测价值

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中华病理学杂志 2024年第7期53卷 709-715页

作者：刘敏姚瑶叶菊香李军石雪迎北京大学第三医院病理科北京大学医学部病理学系北京100191 北京大学第三医院消化科北京100191

目的探讨组织学评估对溃疡性结肠炎(ulcerative colitis,UC)内镜缓解患者的内镜复发预测价值,并对不同组织学评估标准进行比较。方法回顾性分析北京大学第三医院2015年1月1日至2021年6月30日61例UC内镜缓解患者的组织学切片,根据在该次... 详细信息

目的探讨组织学评估对溃疡性结肠炎(ulcerative colitis,UC)内镜缓解患者的内镜复发预测价值,并对不同组织学评估标准进行比较。方法回顾性分析北京大学第三医院2015年1月1日至2021年6月30日61例UC内镜缓解患者的组织学切片,根据在该次活检后12~36个月内最近一次内镜复查结果分为内镜随访持续缓解组31例(缓解组,Mayo内镜评分0)和内镜随访复发组(复发组,Mayo内镜评分≥1)30例,采用Geboes评分(GS)及简化版GS(SGS)、nancy指数(NI)和Robarts的组织病理学指数(RHI)进行组织学评估,取每例全部活检组织块组织学评分的中位数值和最高值;采用卡方检验进行组间单个指标比较,二元Logistic回归分析进行多因素分析,受试者工作特征(ROC)曲线分析4种组织学评价体系对内镜缓解UC患者内镜复发的预测价值。结果不同分级系统组织学评分在缓解组和复发组患者间均差异有统计学意义(P0.05)。单因素和多因素分析结果显示上皮和固有层内中性粒细胞数量在组间差异有统计学意义(P<0.05)。结论内镜缓解UC患者的活检组织中可能仍旧存在组织学活动性炎,并与患者内镜复发具有相关性,4种不同的常用组织学指标体系均可应用于内镜缓解UC患者内镜复发风险的评估,当内镜缓解UC患者的组织学评分大于截止值时(组织学可见轻度活动性炎)发生内镜复发的可能性增高,采用评分最高的组织块评分能更好地预测患者内镜复发的风险。各项评分指标中,上皮和固有层内可见中性粒细胞浸润对患者内镜复发具有独立预测价值,考虑到实用性和操作的方便性,推荐日常工作中采用NI作为组织学炎症活动的评级体系。

关键词：结肠炎,溃疡性缓解诱导危险性评估组织学评分体系

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Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair

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Bioactive Materials 2021年第10期6卷 3515-3527页

作者： Ping Wu Zan Tong Lihua Luo Yanan Zhao Feixiang Chen Yinping Li Céline Huselstein Qifa ye Qingsong ye Yun Chen Department of Biomedical Engineering and Hubei Province Key Laboratory of Allergy and Immune Related Diseases School of Basic Medical SciencesWuhan UniversityWuhan430071China School and Hospital of Stomatology Wenzhou Medical UniversityWenzhouZhejiangChina CNRS UMR 7561 and FR CNRS-INSERM 32.09 nancy University Vandoeuvre-lès-NancyFrance Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityWuhanHubei430071China Center of Regenerative Medicine Renmin Hospital of Wuhan UniversityWuhan430060China

Peripheral nerve regeneration requires stepwise and well-organized establishment of *** local delivery of VEGF-A in peripheral nerve repair is expected to promote angiogenesis in the microenvironment and Schwann cells(SCs)play critical role in nerve repair,combination of VEGF and Schwann cells may lead to efficient peripheral nerve ***-A overexpressing Schwann cells were established and loaded into the inner wall of hydroxyethyl cellulose/soy protein isolate/polyaniline sponge(HSPS)*** HSPS is mechanically distorted,it still has high durability of strain strength,thus,can accommodate unexpected strain of nerve tissues in motion.A 10 mm nerve defect rat model was used to test the repair performance of the HSPS-SC(VEGF)conduits,meanwhile the HSPS,HSPS-SC,HSPS-VEGF conduits and autografts were worked as *** immunofluorescent co-staining of GFP/VEGF-A,Ki67 and MBP showed that the VEGF-A overexpressing Schwann cells could promote the proliferation,migration and differentiation of Schwann cells as the VEGF-A was secreted from the VEGF-A overexpressing Schwann *** nerve repair performance of the multifunctional and flexible conduits was examined though rat behavioristics,electrophysiology,nerve innervation to gastrocnemius muscle(GM),toluidine blue(TB)staining,transmission electron microscopy(TEM)and NF200/S100 double staining in the regenerated *** results displayed that the effects on the repair of peripheral nerves in HSPS-SC(VEGF)group was the best among the conduits groups and closed to ***-SC(VEGF)group exhibited notably increased CD31+endothelial cells and activation of VEGFR2/ERK signaling pathway in the regenerated nerve tissues,which probably contributed to the improved nerve ***,the comprehensive strategy including VEGF overexpressing Schwann cells-mediated and HSPS conduit-guided peripheral nerve repair provides a new avenue for nerve tissue engineering.

关键词： Angiogenesis Nerve regeneration Endogenous secretion Schwann cells Vascular endothelial growth factor-A(VEGF-A)

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妊娠期糖尿病孕妇孕期血糖代谢情况与新生儿血糖、肾功能及胆红素代谢的相关性

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分子诊断与治疗杂志 2024年第3期16卷 578-581页

作者：叶远飞李亚林汪丹丹宣城市人民医院新生儿科安徽宣城242000

目的分析妊娠期糖尿病(GDM)孕妇孕期糖代谢情况与新生儿血糖、肾功能及胆红素代谢的相关性。方法选取宣城市人民医院在2021年1月至2023年3月期间收治的95例GDM患者及所分娩的新生儿进行研究,GDM产妇根据分娩完成时的血糖水平分为血糖... 详细信息

目的分析妊娠期糖尿病(GDM)孕妇孕期糖代谢情况与新生儿血糖、肾功能及胆红素代谢的相关性。方法选取宣城市人民医院在2021年1月至2023年3月期间收治的95例GDM患者及所分娩的新生儿进行研究,GDM产妇根据分娩完成时的血糖水平分为血糖控制理想组与血糖控制不佳组;另选取同期妊娠的100名健康产妇及所分娩的新生儿为对照组。比较三组产妇妊娠完成时的血糖水平;比较三组新生儿入住新生儿科时的血糖值、血红蛋白及血钙水平;比较三组新生儿入住新生儿科时的肾功能指标[血尿素氮(BUN)、血肌酐(SCr)];比较三组新生儿入住新生儿科时的胆红素代谢情况[总胆红素(TBil)、直接胆红素(DBil)以及间接胆红素(IBil)];分析新生儿血糖水平、肾功能、胆红素水平与GDM产妇血糖代谢的相关性。结果 95例患者中,有54例患者血糖控制理想(血糖控制理想组),41例患者血糖控制不佳(血糖控制不佳组)。血糖控制不佳组的空腹血糖、糖化血红蛋白、餐后2 h血糖均高于对照组、血糖控制理想组,差异均有统计学意义(P血糖控制理想组>血糖控制不佳组,血红蛋白、SCr、TBil、IBil水平:对照组<血糖控制理想组<血糖控制不佳组,差异均有统计学意义(P<0.05);新生儿血糖、血钙水平与GDM产妇血糖代谢呈负相关,血红蛋白、SCr、TBil、IBil水平与GDM产妇血糖代谢呈正相关(P<0.05)。结论 GDM对胎儿及新生儿影响较大,应加强妊娠期血糖控制,密切关注GDM产妇所生新生儿血糖、肾功能及胆红素代谢情况,防止并发症的发生。

关键词：妊娠期糖尿病孕期糖代谢情况新生儿血糖肾功能胆红素代谢

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经阴道超声诊断早期异位妊娠准确性影响因素分析

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中国计划生育学杂志 2024年第1期32卷 154-157页

作者：叶秀琴陈阳边焕杰谢乐燕浙江省诸暨市妇幼保健院 311800 浙江省绍兴市妇幼保健院

目的:分析经阴道超声诊断早期异位妊娠相关影响因素.方法:回顾性分析2020年1月-2022年12月本院就诊经阴道超声诊断为疑似早期异位妊娠213例临床资料,根据手术病理结果分析诊断准确率,利用logistic回归模型分析影响诊断准确率相关因素.结... 详细信息

目的:分析经阴道超声诊断早期异位妊娠相关影响因素.方法:回顾性分析2020年1月-2022年12月本院就诊经阴道超声诊断为疑似早期异位妊娠213例临床资料,根据手术病理结果分析诊断准确率,利用logistic回归模型分析影响诊断准确率相关因素.结果:213例疑似病例病理检查确诊167例,诊断准确率78.4%.其中不均质包块型(孕囊破裂)为12例(5.6%),输卵管环型98例(46.0%),孕囊型33例(15.5%),胚芽型24例(11.3%).单因素分析显示,不同体质指数、盆腔积液、血清绒毛膜促性腺激素(β-hCG)检查情况以及不明部位妊娠情况者超声诊断准确率有差异(P<0.05);多因素logistic回归模型分析显示,体质指数≥28.0kg/m^(2)、有盆腔积液、血清β-hCG检查以及不明部位妊娠是影响经阴道超声诊断准确性的独立影响因素(均P<0.05).结论:对疑似异位妊娠进行超声诊断时,对肥胖患者以及有盆腔积液、不明部位妊娠情况的患者,应尽量结合血清β-hCG检查,以提高超声诊断准确率.

关键词：异位妊娠经阴道超声检查诊断影响因素

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Developing a conceptual model and conducting a preliminary risk assessment for a former chemical manufacturing site in Nanjing City,China

Developing a conceptual model and conducting a preliminary r...

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中国毒理学会第六届全国毒理学大会

作者： Ralph G.STAHL ye Shu-jun MA Jun nancy GROSSO E Erin MACK Jennifer WANG Calvin CHIEN REN Li-jing DuPont Company Corporate Remediation Group Nanjing University School of Earth Sciences and Engineering BCEG Environmental Remediation Co.Ltd

＜正＞Recently DuPont,Nanjing University and BCEG began collaborative work at a former chemical manufacturing site in Nanjing City,*** goal was to use this as a pilot ortest site to conduct a remediation *** relatively small former chemical manufacturing site is located adjacent to other chemical manufacturing operations,roadways,a housing development,and community vegetable *** the project began,old buildings have been razed,several phases of soil and groundwater sampling have been completed,and that work has provided data sufficient to build apreliminary conceptual model and to conduct a screening-level human health risk *** contamination in surficial and sub-surface soils appears to be relatively limited,some contaminants have been found in groundwater *** of the contaminants in groundwater are found at levels above risk-based screening levels suggesting the need for additional investigation to identify source material and understand fate and transport within the subsurface soil and *** addition,further sampling is underway in the small community gardens to determine if vegetables are being grown in contaminated soil. These current data indicate there will likely be a need to evaluate remedial options that will prevent migration of contaminants through the subsurface,and which will mitigate potential human exposures to contaminants. In this presentation we will discuss the development of the conceptual model,initial results of the risk assessment,and steps to begin evaluating potential remedial options.

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East Asian monsoon intensification promoted weathering of the magnesium-rich southern China upper crust and its global significance

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Science China Earth Sciences 2021年第7期64卷 1155-1170页

作者： Yibo YANG Albert GALY Xiaomin FANG Christian FRANCE-LANORD Shiming WAN Rongsheng YANG Jian ZHANG Ran ZHANG Song YANG Yunfa MIAO Yudong LIU Chengcheng ye Key Laboratory of Continental Collision and Plateau Uplift Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China Centre de Recherches Pétrographiques et Géochimiques UMR7358CNRS-Universitéde LorraineVandoeuvre les Nancy 54500France University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Marine Geology and Environment Institute of OceanologyChinese Academy of SciencesQingdao 266071China Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Climate Change Research Center Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Tibetan Environment Changes and Land Surface Processes Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

The Oligocene-Miocene boundary Asian climatic reorganization linked to the northward migration of the East Asian monsoon into subtropical China is a potentially important but poorly constrained atmospheric CO_(2) consumption ***,we performed a first-order estimate of the CO_(2) consumption induced by silicate chemical weathering and organic carbon burial in subtropical China related to this climatic *** results show that an increase in long-term CO_(2 )consumption by silicate weathering varies from 0.06×10^(12)to 0.87×10^(12)mol yr^(-1)depending on erosion flux reconstructions,with an~50%contribution of Mg-silicate weathering since the late *** organic carbon burial flux is approximately 25%of the contemporary CO_(2) consumption by silicate *** results highlight the significant role of weathering of the Mg-rich upper continental crust in East China,which would contribute to the rapid decline in atmospheric CO_(2) during the late Oligocene and the Neogene rise in the seawater Mg *** this climatic reorganization was mainly induced by the Tibetan Plateau uplift,our study suggests that the growth of the Himalayan-Tibetan Plateau can lead to indirect modification of the global carbon and magnesium cycles by changing the regional hydrological cycle in areas of East Asia that are tectonically less active.

关键词： Tibetan Plateau Late Oligocene Silicate weathering Carbon cycle Oceanic Mg cycle

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一叶萩生物碱类成分研究

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中草药 2007年第2期38卷 163-167页

作者：王英李茜叶文才叶翠芬叶玉如赵守训中国药科大学天然药物化学教研室暨南大学中药及天然药物研究所广东广州510632 香港科技大学生物化学系

目的对一叶萩的生物碱类成分进行研究。方法采用各种色谱技术对一叶萩的总生物碱部位进行分离,应用理化常数和波谱技术(NMR、MS等)鉴定化合物的结构。结果自一叶萩枝叶的总碱部位中分离得到2个新的生物碱类化合物,分别命名为叶下珠碱B(p... 详细信息

目的对一叶萩的生物碱类成分进行研究。方法采用各种色谱技术对一叶萩的总生物碱部位进行分离,应用理化常数和波谱技术(NMR、MS等)鉴定化合物的结构。结果自一叶萩枝叶的总碱部位中分离得到2个新的生物碱类化合物,分别命名为叶下珠碱B(phyllanthidine B,4α-methoxy-phyllanthidine,Ⅰ)和一叶萩醇D(securi-nolD,14β-hydroxyviroallosecurinine,Ⅱ)。结论化合物和均为新化合物。

关键词：一叶萩生物碱一叶萩型生物碱 4α-methoxy-phyllanthidine 14β-hydroxyviroallosecurinine

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