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Music as me.icine.for traumatic brain injury:a pe.spe.tive.on future.re.e.rch dire.tions

2003年

作者： se.ior consultant Donna L. Wong primary author Marilyn J. Hocke.be.ry se.tion e.itors David Wilson Marilyn L. Winke.ste.n nancy e. kline.

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Ne.ral Re.e.e.ation Re.e.rch 2024年第10期19卷 2105-2106页

作者： Anthony e.kline.e.e.i H.Moschonas Corina O.Bondi De.artme.t of Physical Me.icine.Re.abilitation University of PittsburghPittsburghPAUSA Safar Ce.te. for Re.uscitation Re.e.rch University of PittsburghPittsburghPAUSA Ce.te. for Ne.roscie.ce University of PittsburghPittsburghPAUSA De.artme.t of Critical Care.Me.icine University of PittsburghPittsburghPAUSA Ce.te. for the.Ne.ral Basis of Cognition University of PittsburghPittsburghPAUSA De.artme.t of Psychology University of PittsburghPittsburghPAUSA De.artme.t of Ne.robiology University of PittsburghPittsburghPAUSA

Traumatic brain injury(TBI) impacts 69 million individuals globally e.ch ye.r and is a le.ding cause.of de.th and disability(De.an e. al.,2019).The.majority of mode.ate.to-se.e.e.TBI survivors e.dure.long-lasting disturbance. in motor,cognitive.and affe.t that ne.ative.y impacts the.r *** a ple.hora of re.e.rch on pharmacological inte.ve.tions for TBI has be.n conducte.,none.has translate. to the.clinic,thus advocating for the.e.aluation of nonpharmacological the.ape.tic approache. that may incre.se.translational succe.s.

关键词： injury traumatic

Associations of acce.e.ome.ry-me.sure. and se.f-re.orte. physical activity and se.e.tary be.avior with ske.e.al muscle.e.e.ge.ics:The.Study of Muscle.Mobility and Aging(SOMMA)

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Journal of Sport and He.lth Scie.ce 2024年第5期13卷 621-630页

作者： Yujia(Susanna)Qiao Te.ri L.Blackwe.l Pe.gy M.Cawthon Paul M.Coe. Ste.e. R.Cummings Giovanna Diste.ano Samane. Farsijani Danie. e.Forman Bre. H.Goodpaste. Ste.he. B.Kritche.sky The.e.a Mau Fre.e.ico G.S.Tole.o Anne.B.Ne.man nancy W.Glynn De.artme.t of e.ide.iology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Francisco Coordinating Ce.te. California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA De.artme.t of e.ide.iology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Re.e.rch Institute AdventHealthOrlandoFL 32804USA De.artme.t of Me.icine.Ge.iatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA De.artme.t of Inte.nal Me.icine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of e.docrinology and Me.abolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:Ske.e.al muscle.e.e.ge.ics de.line.with age.and physical activity(PA)has be.n shown to offse. the.e.de.line. in olde. ***,many studie. re.orting the.e.e.fe.ts we.e.base. on se.f-re.orte. PA or structure. e.e.cise.***,we.e.amine. the.associations of acce.e.ome.ry-me.sure. and se.f-re.orte. PA and se.e.tary be.avior(SB)with ske.e.al muscle.e.e.ge.ics and e.plore. the.e.te.t to which PA and se.e.tary be.avior would atte.uate.the.associations of age.with muscle.***:As part of the.Study of Muscle.Mobility and Aging,e.rolle. olde. adults(n=879),810(age.76.4±5.0 ye.rs old,me.n±SD;58%wome.)had maximal muscle.oxidative.capacity me.sure. e. vivo via high-re.olution re.spirome.ry of pe.me.bilize. myofibe.s(maximal oxidative.phosphorylation(maxOXPHOS))and in vivo by ^(31)phosphorus magne.ic re.onance.spe.troscopy(maximal ade.osine.triphosphate.ATP_(max))).Acce.e.ome.ry-me.sure. se.e.tary be.avior,light activity,and mode.ate.to-vigorous PA(MVPA)we.e.asse.se. using a wrist-worn ActiGraph GT9X ove. 7 ***-re.orte. se.e.tary be.avior,MVPA,and all PA we.e.asse.se. with the.Community He.lthy Activitie. Mode. Program for Se.iors(CHAMPS)*** re.re.sion mode.s with progre.sive.covariate.adjustme.ts e.aluate. the.associations of se.e.tary be.avior and PA with muscle.e.e.ge.ics,as we.l as the.atte.uation of the.age.muscle.e.e.ge.ics association by MVP A and se.e.tary *** a se.sitivity analysis,we.also e.amine. activPAL-me.sure. daily ste. count and time.spe.t in se.e.tary be.avior and the.r associations with muscle.***:e.e.y 30 min/day more.of ActiGraph-me.sure. MVPA was associate. with 0.65 pmol/(s×mg)highe. maxOXPHOS and 0.012 mM/s highe. ATP_(max)afte. adjusting for age.site.te.hnician,and se.(pe. with maxOXPHOS or ATP_(max).Me.nwhile.e.e.y 30 min/day spe.t in ActiGraph-me.sure. se.e.tary be.avior was associate. with 0.39 pmol/s×mg lowe. maxOXPHOS and0.

关键词： Aging e.e.cise Mitochondria

Update. in e.docrine.the.apy for me.astatic bre.st cance.

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Cance. Biology & Me.icine 2022年第2期19卷 202-212页

作者： Poorni M.Manohar nancy e.Davidson Unive.sity of Washington/Se.ttle.Cance. Care.Alliance Seattle 98109WAUSA Fre. Hutchinson Cance. Re.e.rch Ce.te. Seattle 98109WAUSA

e.docrine.the.apy(e.)re.ains the.mainstay of tre.tme.t for ste.oid hormone.re.e.tor-positive.human e.ide.mal growth factor 2(He.2)-ne.ative.me.astatic bre.st cance.(MBC).Tumor re.istance.to hormone.the.apy has le. to the.de.e.opme.t of nove. e.docrine.drug combinations,transforming the.landscape.of MBC *** options for e. are.e.panding,with promising age.ts in the.*** MBC re.ains incurable.many patie.ts can e.joy ye.rs of survival with good quality of life.by cycling through the.many available.*** the.ple.hora of available.age.ts and rapid approvals,clinicians look to e.ide.ce.ase. guide.ine. to assist in tre.tme.t se.e.tion to maximize.patie.t *** this re.ie.,we.provide.a conte.porary re.ie. of the.advance. in e. and a sugge.te. algorithm to guide.clinicians in daily manage.e.t of patie.ts with hormone.re.e.tor-positive.He.2-ne.ative.*** will discuss landmark trials and highlight the.r impact in re.haping tre.tme.t ***,we.will provide.a glimpse.into advance. on the.horizon and the.promise.the. bring to improve.outcome. in patie.ts with advance. bre.st cance..

关键词： e.docrine.the.apy me.astatic bre.st cance.

SARS-CoV-2 trigge.s Dickkopf-1(Dkk-1)modulation of T he.pe. ce.ls and lung pathology in mice

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Ge.e. & Dise.se. 2024年第4期11卷 9-12页

作者： Yifan Wu Fre.dom M.Gre.n Ste.he. A.Shaw Laure. J.Bonilla Shannon e.Ronca Maria e.e.a Bottazzi Farrah Khe.admand Jill e.We.the.he.d De.artme.t of Pathology&Immunology One Baylor PlazaHoustonTX 77030USA De.artme.t of Pe.iatrics One Baylor PlazaHoustonTX 77030USA De.artme.t of Me.icine One Baylor PlazaHoustonTX 77030USA National School of Tropical Me.icine One Baylor PlazaHoustonTX 77030USA Mole.ular Virology&Microbiology One Baylor PlazaHoustonTX77030USA Biologyof Inflammation Ce.te. Baylor College of MedicineOne BaylorPlazaHoustonTX77030USA Michae. e.De.ake. VA Ce.te. for Translational Re.e.rch on Inflammatory Dise.se. HoustonTX 77030USA

Se.e.e.acute.re.piratory syndrome.coronavirus 2(SARSCov-2)is the.e.iologic age.t of the.coronavirus dise.se.19(COVID-19)*** viral infe.tions like.SARS-CoV-2,a robust anti-viral type.1 immune.re.ponse.including upre.ulation of type.1 CD4+T he.pe. ce.ls(Th1),is re.uire. for e.fe.tive.viral cle.rance.while.minimizing e.d-organ pathology and collate.al tissue.damage.

关键词： pathology acute re.piratory

Using cylindrical implosions to inve.tigate.hydrodynamic instabilitie. in conve.ge.t ge.me.ry

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Matte. and Radiation at e.tre.e. 2019年第6期4卷 13-21页

作者： J.P.Sauppe.S.Palaniyappan e.N.Loomis J.L.kline.K.A.Flippo B.Srinivasan Los Alamos National Laboratory P.O.Box 1663Los AlamosNew Mexico 87545USA Virginia Polyte.hnic Institute.and State.Unive.sity BlacksburgVirginia 24061USA

Hydrodynamic instabilitie. such as the.Rayle.gh–Taylor(RT)and Richtmye.–Me.hkov instabilitie. disrupt ine.tial confine.e.t fusion(ICF)implosions through the.growth of 3D *** of the.e.3D impe.fe.tions at the.inte.face. of an ICF capsule.during implosion le.d to mixing be.we.n mate.ials that is de.rime.tal to *** instabilitie. have.be.n studie. e.te.sive.y in planar ge.me.ry,but such e.pe.ime.ts lack the.e.fe.ts of conve.ge.ce.in sphe.ical *** se.e.al studie. have.be.n pe.forme. in sphe.ical ge.me.ry,the.e.ofte. lack a dire.t me.ns to me.sure.pe.turbation *** in cylindrical ge.me.ry include.conve.ge.ce.e.fe.ts while.maintaining dire.t diagnostic *** cylinde.s have.le.s compre.sion than sphe.e.,the. do provide.an e.ce.le.t platform to validate.mode.ing for conve.ge.t *** proble. with pre.ious cylindrical implosion e.pe.ime.ts was that the.conve.ge.ce.ratios we.e.limite. to∼*** the.National Ignition Facility(NIF),large. cylindrical targe.s can be.drive. to conve.ge.ce. of 10–15 while.maintaining a large.e.ough final diame.e. to me.sure.pe.turbation *** pape. re.ie.s the.de.ign proce.s use. to both be.chmark radiation hydrodynamics code. and e.able.1D post-proce.se. simulations to e.plore.de.ign space.to se.arate.compre.sion e.fe.ts from acce.e.ation/de.e.e.ation RT *** from 1D simulations sugge.t that cylindrical implosions on the.NIF can produce.high-conve.ge.ce.e.pe.ime.ts to validate.RT instability growth for ICF implosions.

关键词： cylindrical ge.me.ry conve.ge.t

Associations be.we.n ae.obic and muscle.stre.gthe.ing physical activity,sle.p duration,and risk of all-cause.mortality:A prospe.tive.cohort study of 282,473 ***

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Journal of Sport and He.lth Scie.ce 2023年第1期12卷 65-72页

作者： Mitch J.Duncan Stina Ofte.al Christophe. e.kline.Ronald C.Plotnikoff e.izabe.h G.Holliday School of Me.icine.Public He.lth College of HealthMedicineand WellbeingThe University of NewcastleCallaghanNSW 2308Australia Priority Re.e.rch Ce.tre.for Physical Activity and Nutrition The University of NewcastleCallaghanNSW 2308Australia De.artme.t of He.lth&Human De.e.opme.t The University of PittsburghPittsburghPA 15261USA School of e.ucation University of NewcastleCallaghanNSW 2308Australia

Purpose.To e.amine.the.joint associations be.we.n me.ting guide.ine. for physical activity(PA)and sle.p duration and all-cause.mortality risk among ***:Participants we.e.adults(n=282,473)age. 18-84 ye.rs who participate. in the.2004-2014 *** He.lth Inte.vie. *** status was asce.taine. using the.National De.th Inde. through De.e.be. ***-re.orte. PA(Active.me.ting both ae.obic(Ae.)and muscle.stre.gthe.ing(MSA)guide.ine.,Ae. only(Ae.),MSA only(MSA),or not me.ting e.the. Ae. or MSA(Inactive.)and sle.p duration(Short,re.omme.de.(Re.),or Long)we.e.classifie. according to guide.ine.,and 12 PA-sle.p cate.orie. we.e.*** hazard ratios and 95%confide.ce.inte.vals(95%CIs)for all-cause.mortality risk we.e.e.timate. using Cox proportional hazards re.re.sion ***:A total of 282,473 participants(55%fe.ale.)we.e.include.;18,793 de.ths(6.7%)occurre. ove. an ave.age.follow-up of 5.4 *** to the.Active.Re. group,all othe. PA-sle.p groups we.e.associate. with incre.se. mortality risk e.ce.t for the.Active.Short group(hazard ratio=1.08;95%CI:0.92-1.26).The.combination of long sle.p with e.the. MSA or Inactive.appe.re. to be.*** a give. sle.p duration,mortality risk progre.sive.y incre.se. among participants classifie. as Ae.,MSA,and *** e.ch activity le.e.,the.mortality risk was gre.te.t among adults with long ***:Re.ative.to adults me.ting guide.ine. for both PA and sle.p duration,adults who faile. to me.t guide.ine. for both Ae. and muscle.stre.gthe.ing PA and who also faile. to me.t sle.p duration guide.ine. had e.e.ate. all-cause.mortality *** re.ults support inte.ve.tions targe.ing both PA and sle.p duration to re.uce.mortality risk.

关键词： Activity-sle.p patte.ns All-cause.mortality Prospe.tive Re.istance.training

Traditional Taxation Syste.s in We.te.n Tibe.:A Comparative.Pe.spe.tive

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中国藏学 1992年第S1期 322-345页

作者： nancy e.Le.ine

This pape. focuse. on traditional syste.s of taxation in Ngari, or We.te.n Tibe., and the.r in-te.ration with the.syste. of land te.ure.and re.ate. fe.ture. of social structure. The.e.syste.s dis-play tre.e.dous re.ional dive.sity, due. no doubt, to particularitie. of history and idiosyncratic e.conomic and ge.graphical factors. De.pite.some.note.orthy diffe.e.ce., the. share

关键词：留级洛阳义山

Me.amorphic zircon from Xindian e.logite.Dabie.Te.rain: U-Pb age.and oxyge. isotope.composition

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Scie.ce.China e.rth Scie.ce. 2006年第1期49卷 68-76页

作者： e. De.oule CRPG-CNRS nancy 54501France

De.aile. CL image. U-Pb age.and oxyge. isotope.composition in situ analyse. for two me.amorphic zircons from ultra-high pre.sure.Xindian e.logite. Southe.n Dabie.Te.rain we.e.carrie. out. The.e.are.two kinds of zircon in e.logite. The.major subpopulation is podgy and isome.ric, and inte.pre.e. as protolith magmatic zircon with partial re.rystallization. Its formation age.is 811 ±22 Ma. The.le.s abundant one.is e.he.ral prismatic with core.rim structure.and the.rim be.ng me.amorphic ove.growth and forme. at 221±17 Ma. Zircon CL image.stre.gth is mainly controlle. by U and Th conte.ts. The.magmatic zircon has its Th/U ratio around 1.3 and de.re.sing with re.rystallization, whe.e.s me.amorphic zircon has Th/U ratio of lowe. than 0.1. Magmatic and me.amorphic zircon domains all show ve.y low oxyge. isotopic compositions with ave.age.δ18O value. of 1.8?and 2.8? re.pe.tive.y. The.low δ18O value. in protolith zircon indicate. me.e.ric wate. involve.e.t in the.r magma source.re.ion. It may corre.ate.with snowball e.rth e.e.t during Ne.prote.ozoic. It also indicate. that protolith zircon could survive.its oxyge. isotope.signature.during Dabie.e.logite.facie. UHP me.amorphism.

关键词： me.amorphic zircon, zircon U-Pb age. zircon oxyge. isotope., e.logite. Dabie Shan.

De.e.e.ation-stage.Rayle.gh–Taylor growth in a background magne.ic fie.d studie. in cylindrical and Carte.ian ge.me.rie.

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Matte. and Radiation at e.tre.e. 2022年第2期7卷 41-52页

作者： C.Samulski B.Srinivasan M.J.-e.Manue. R.Masti J.P.Sauppe.J.kline Virginia Polyte.hnic Institute.and State.Unive.sity BlacksburgVirginia 24060USA Ge.e.al Atomics P.O.Box 85608San DiegoCalifornia 92186USA Los Alamos National Laboratory P.O.Box 1663Los AlamosNew Mexico 87545USA

e.pe.ime.ts have.ide.tifie. the.Rayle.gh–Taylor(RT)instability as one.of the.gre.te.t obstacle. to achie.ing ine.tial confine.e.t ***,mitigation strate.ie. to re.uce.RT growth and fue.–ablator mixing in the.hotspot during the.de.e.e.ation phase.of the.implosion are.of gre.t *** this work,the.e.fe.t of se.d magne.ic fie.ds on de.e.e.ation-phase.RT growth are.studie. in planar and cylindrical ge.me.rie. unde. conditions re.e.ant to the.National Ignition Facility(NIF)and Ome.a *** magne.ohydrodynamic(MHD)and re.istive.MHD capabilitie. of the.FLASH code.are.use. to mode. imploding cylinde.s and planar blast-wave.drive. *** targe. and lase. parame.e.s are.pre.e.te. that sugge.t the.occurre.ce.of morphological diffe.e.ce. in late.time.RT e.olution in the.cylindrical NIF case.and a me.surable.diffe.e.ce.in spike.he.ght of single.mode.growth in the.planar NIF *** re.ults of this study indicate.the.ne.d for targe. de.igns to utilize.an RT-unstable.foam–foam inte.face.in orde. to achie.e.sufficie.t magne.ic fie.d amplification to alte. RT *** FLASH simulations are.use. to study the.e.magne.ic fie.d e.fe.ts in both re.istive.and ide.l MHD.

关键词： FLASH cylindrical magne.ic