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Hepatic decompensation/serious adverse events in post-liver transplantation recipients on sofosbuvir for recurrent hepatitis C virus

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World Journal of Gastroenterology 2016年第9期22卷 2844-2854页

作者： Neal Patel Kian Bichoupan Lawrence Ku Rachana Yalamanchili Alyson Harty Donald Gardenier Michel Ng David Motamed Viktoriya Khaitova nancy bach Charissa Chang Priya Grewal Meena Bansal Ritu Agarwal Lawrence Liu Gene Im Jennifer Leong Leona Kim-Schluger Joseph Odin Jawad Ahmad Scott Friedman Douglas Dieterich Thomas Schiano Ponni Perumalswami Andrea Branch Division of Liver Diseases Icahn School of Medicine at Mount Sinai Recanati Miller Transplant Institute Icahn School of Medicine at Mount Sinai

AIM: To determine the safety profile of new hepatitis C virus (HCV) treatments in liver transplant (LT) recipients with recurrent HCV ***: Forty-two patients were identified with recurrent HCV infection that underwent LT at least 12 mo prior to initiating treatment with a Sofosbuvir-based regimen during December 2013-June 2014. Cases were patients who experienced hepatic decompensation and/or serious adverse events (SAE) during or within one month of completing treatment. Controls had no evidence of hepatic decompensation and/or SAE. HIV-infected patients were excluded. Cumulative incidence of decompensation/SAE was calculated using the Kaplan Meier method. Exact logistic regression analysis was used to identify factors associated with the composite ***: Median age of the 42 patients was 60 years [Interquartile Range (IQR): 56-65 years], 33% (14/42) were female, 21% (9/42) were Hispanic, and 9% (4/42) were Black. The median time from transplant to treatment initiation was 5.4 years (IQR: 2.1-8.8 years). Thirteen patients experienced one or more episodes of hepatic decompensation and/or SAE. Anemia requiring transfusion, the most common event, occurred in 62% (8/13) patients, while 54% (7/13) decompensated. The cumulative incidence of hepatic decompensation/SAE was 31% (95%CI: 16%-41%). Risk factors for decompensation/SAE included lower pre-treatment hemoglobin (OR = 0.61 per g/dL, 95%CI: 0.40-0.88, P 2, 95%CI: 0.90-0.99, P = 0.01), and higher baseline serum total bilirubin (OR = 2.43 per mg/dL, 95%CI: 1.17-8.65, P < 0.01). The sustained virological response rate for the cohort of 42 patients was 45%, while it was 31% for ***: Sofosbuvir/ribavirin will continue to be used in the post-transplant population, including those with HCV genotypes 2 and 3. Management of anemia remains an important clinical challenge.

关键词： Hepatitis C virus Sofosbuvir Ribavirin Anemia Hepatic decompensation Serious adverse event Liver transplant

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The organic geochemistry of crude oil in the Saltpond Basin(Ghana):Organic source input,depositional environment,and thermal maturity

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Acta Geochimica 2024年第3期43卷 424-440页

作者： Kojo Amoako Ningning Zhong nancy Pearl Osei-Boakye Ebenezer Apesegah Research Group for Marine Geochemistry(ICBM-MPI Bridging Group) Institute for Chemistry and Biology of the Marine Environment(ICBM)School of Mathematics and ScienceCarl von Ossietzky UniversitäOldenburgAmmerläder HeerstraВ114-11826129 OldenburgGermany State Key Laboratory of Petroleum Resources and Prospecting College of GeosciencesChina University of PetroleumBeijing 102249China Petroleum Corporation GNPCPMBPetroleum HouseTemaGhana

The Saltpond Basin,situated within the South Atlantic margin of Ghana,is a significant area for petro-leum exploration but has received relatively limited research *** studies have examined source rock com-position,but data on crude oil organic chemistry are lack-ing,hindering understanding of the basin’s petroleum system and *** address this gap,we analyzed biomarkers and stable carbon-isotope ratios in Saltpond Basin crude oil using gas chromatography–mass spectrometry and gas chromatography–isotope ratio mass spectrometry to eluci-date organic matter source,depositional environment,and thermal *** were compared with oils from the West African segment of the South Atlantic margin,namely the Tano Basin and the Niger Delta Basin,to iden-tify potential correlations and gain insights into regional *** and isotopic results unveiled a sig-nificant prevalence of organic matter derived from lower marine *** of organic matter deposition and preservation in Saltpond oil samples suggested a suboxic marine transitional environment,contradicting conventional understanding of terrestrial dominance in such ***,the potential for degradation processes to obscure differentiation between terrestrial and marine organic mat-ter origins underscores the complex nature of organic mat-ter dynamics in transitional marine *** of molecular thermal maturity indices suggested Saltpond oils were expelled from source rocks exhibiting thermal maturity at the early maturity *** analysis unveiled genetic disparities among crude oils sourced from the Saltpond Basin and those from the Tano and Niger Delta Basin,primarily due to variations in source input and depo-sitional environment *** oil exhibits lower terrestrial organic input than Tano Basin’s crude oils,which also have less terrestrial input than Niger Delta Basin crude ***,its paleodepositional envi

关键词： Biomarkers Carbon isotopes Crude oil Saltpond Basin Ghana

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Use of Patient-Specific “4D” Tele-Education to Enhance Actual and Perceived Knowledge in Congenital Heart Disease (CHD) Patients

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Congenital Heart Disease 2024年第1期19卷 5-17页

作者： Molly Clarke Karin Hamann nancy Klein Laura Olivieri Yue-Hin Loke Department of Inpatient Cardiology Boston Children’s HospitalBoston02115USA Department of Cardiology Children’s National HospitalWashington20001USA Department of Cardiology Noninvasive Cardiac ImagingUniversity of Pittsburgh Medical Center Children’s Hospital of PittsburghPittsburgh15224USA

Background:Patients with congenital heart disease(CHD)will transition to lifelong adult congenital cardiac ***,their structural heart disease is challenging to convey via two-dimensional *** study utilized a tele-educational environment,with personalized three-dimensional(3D)modeling and health Details(3D+Details=“4D”),to improve actual and perceived knowledge,both important components of transition readiness in CHD ***:Participants aged≥13 years with a history of CHD and cardiac magnetic resonance imaging(MRI)studies were *** MRI datasets were then used to segment and create 3D heart models(using Mimics,Materialize Inc.).Participantsﬁrst completed the MyHeart Questionnaire,a validated survey of actual knowledge.A tele-educational session was then scheduled,during which participants were shown a 3D model of a normal heart,followed by their personal 3D heart model and speciﬁc health *** then repeated the actual knowledge survey,in addition to questionnaires assessing perceived knowledge pre-and post-session,as well as a satisfaction ***:Twenty-two patients were *** knowledge increased from 75%±15%to 89%±20%(p=0.00043)and perceived knowledge increased inﬁve of seven *** knowledge correlated with perceived knowledge(r=0.608,p<0.0001).Ninety-one percent of participants ranked the 3D model as“very satisfactory”and ninety-ﬁve percent ranked the educational session as“very help-ful”or“extremely helpful.”Conclusions:The use of“4D”tele-education increased both actual and perceived knowledge and may help improve transition readiness in CHD patients.

关键词： Congenital heart disease tele-education transition

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Refinement Mechanism of Microstructure of Undercooled Nickel Based Alloys

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 1041-1047页

作者：杜文华 HOU Kai XU Xuguang Ismal Saad Willey Liew Yun Hsien AN Hongen nancy Julius Siambun Bih-Lii Chuab 王洪福 College of Mechanical Engineering North University of ChinaTaiyuan 030051China Faculty of Engineering University Malaysia SabahKota Kinabalu 88400Malaysia

Through the use of purification and recirculation superheating techniques on molten glass,the Ni65Cu33Co2 alloy was successfully undercooled to a maximum temperature of 292 ***-speed photography was employed to capture the process of interface migration of the alloy liquid,allowing for an analysis of the relationship between the morphological characteristics of the alloy liquid solidification front and the degree of ***,the microstructure of the alloy was examined using metallographic microscopy,leading to a systematic study of the microscopic morphological characteristics and evolution laws of the refined structure during rapid *** research reveals that the grain refining mechanism of the Ni-Cu-Co ternary alloy is consistent with that of the binary alloy(Ni-Cu).Specifically,under low undercooling conditions,intense dendritic remelting was found to cause grain refinement,while under high undercooling conditions,recrystallization driven by accumulated stress and plastic strain resulting from the interaction between the liquid flow and the primary dendrites caused by rapid solidification was identified as the main factor contributing to grain ***,the study highlights the significant role of the Co element in influencing the solidification rate and reheat effect of the *** addition of Co was also found to facilitate the formation of non-segregated solidification structure,indicating its importance in the overall solidification process.

关键词： grain refinement recalescence recrystallization undercooling

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Utility of the low-accelerating-dose regimen in 182 liver recipients with recurrent hepatitis C virus

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World Journal of Gastroenterology 2015年第20期21卷 6236-6245页

作者： Kieron BL Lim Hamid R Sima M Isabel Fiel Viktoriya Khaitova John T Doucette Maria Chernyiak Jawad Ahmad nancy bach Charissa Chang Priya Grewal Leona Kim-Schluger Lawrence Liu Joseph Odin Ponni Perumalswami Sander S Florman Thomas D Schiano Division of Liver Diseases Icahn School of Medicine at Mount Sinai Division of Gastroenterology and Hepatology National University Center for Organ TransplantationNational University Hospital Lillian and Henry M Stratton-Hans Popper Department of Pathology Icahn School of Medicine at Mount Sinai Recanati-Miller Transplantation Institute Icahn School of Medicine at Mount Sinai Department of Preventive Medicine Icahn School of Medicine at Mount Sinai

AIM: To describe our experience using a low-acceleratingdose regimen(LADR) with pegylated interferon alpha-2a and ribavirin in treatment of hepatitis C virus(HCV) recurrence. METHODS: From 2003, a protocolized LADR strategy was employed to treat liver transplant(LT) recipients with recurrent HCV at our institution. Medical records of 182 adult patients with recurrent HCV treated with LADR between 1/2003 and 1/2011 were reviewed. Histopathology from all post-LT liver biopsies were reviewed in a blinded fashion. Paired recipient and donor IL28 B status were assessed. A novel technique was employed to ascertain recipient and donor IL28B(rs12979860) Gt data using DNA extracted from archival FFPE tissue from explanted native livers and donor gallbladders respectively. The primary endpoint was SVR; secondary endpoints examined include(1) patient and graft survival;(2) effect of anti-viral therapy on liver histology(fibrosis and inflammation);(3) incidence of on-treatment development of ACR, CDR, or PCH;(4) association of recipient and donor IL28 B genotype with SVR; and(5) incidence of antiviral therapy-associated adverse events(anemia, leukopenia, thrombocytopenia, depression) and hepatic ***: The overall SVR rate was 38%(29% Gt1, 67% Gt2, 86% Gt3 and 58% Gt4). HCV Gt(P < 0.0001), donor age(P = 0.003), cytomegalovirus mismatch(P = 0.001), baseline serum bilirubin(P = 0.002), and baseline viral load(P = 0.04) were independent predictors for SVR. SVR rates were significantly higher in the recipient-CC/donor-non CC pairs(P = 0.007). Neither baseline fibrosis nor change in fibrosis stage after anti-viral therapy were associated with SVR. Fibrosis progressed in 72% of patients despite SVR. Median graft survival was 91 mo. Five-year patient survival was superior in patients who achieved SVR(97% vs 82%, P = 0.001). Pre-treatment ALP ≥ 150 U/L(P = 0.01), total bilirubin ≥ 1.5 mg/d L(P = 0.001) and creatinine ≥ 2 mg/d L(P = 0.001) were independently associated

关键词： Hepatitis C recurrence Liver transplant Low accelerating dose regimen Peginterferon α-2a IL28B

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Changes in call properties of Boana pulchella (Anura, Hylidae) in response to different noise conditions

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Current Zoology 2024年第4期70卷 548-556页

作者： Pablo Grenat Maria Ferrero Mariana Baraquet Favio Pollo Manuel Otero Zulma Salinas nancy Salas Adolfo Martino Ecologia Departamento de Ciencias NaturalesFacultad de Ciencias ExactasFisico-Quimicas y NaturalesUniversidad Nacional de Rio CuartoRutaNacional N°36-km601X5804BYARioCuartoArgentina lnstituto de Ciencias de la Tierra Biodiversidad y Ambiente(ICBIA)UNRC-CONICETRuta Nacional N°36-km 601X5804BYARio CuartoArgentina Cátedra de Botanica General Departamento de Recursos Naturales y AmbienteFacultad de AgronomiaUniversidad de Buenos AiresAv.San Martin 4453Buenos AiresArgentina

The increasing expansion of urban areas leads to the emergence of new noisy environments that can affect animal *** play a crucial role in the mating displays of anurans,and the negative impact of anthropogenic noise-induced auditory masking has been reported in several *** investigated the acoustic variation in 96 males(n=971 calls)of the treefrog Boana pulchella across acoustically undis-turbed sites and different noise conditions,associated with urban areas(URBAN)and roads(ROAD),in Central *** analyzed the effect of anthropogenic noise conditions on 6 temporal(call duration[CD],intercall interval,first and second note duration,internote interval,and call rate)and 3 spectral(dominant frequency of first and second note,frequency difference between them)call *** effects of temperature and size on acoustical variables were *** observed differences in all call attributes among the noise conditions,except for intercall *** exposed to URBAN and ROAD exhibited significant changes in CD,dominant frequency of the second note,and fre-quency difference between *** males had longest internote interval,while ROAD individuals displayed increased first and second note duration and call ***,ROAD males exhibited immediate changes in call rate in direct response to passing heavy *** study emphasizes the impact of anthropogenic noise on the acoustic characteristics of *** *** how animals adapt to noisy environments is crucial in mitigating the adverse effects of urbanization on their communication *** investigations should explore whether the observed call adjustments are effective in avoiding or mitigating the negative consequences of anthropogenic noise on reproductive success.

关键词： acoustic communication advertisement call auditory masking noise pollution road traffic noise.

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Multi-disciplinary Pathways to Computing:A Scalable and Col aborative Approach to Capitalize on the Demand for Computer Science Education

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计算机教育 2024年第3期 10-12页

作者： nancy M.Amato Department of Computer Science University of Illinois at Urbana-Champaign 201 N.Goodwin Ave. UrbanaIL 61801

The number of students demanding computer science(CS)education is rapidly rising,and while faculty sizes are also growing,the traditional pipeline consisting of a CS major,a CS master’s,and then a move to industry or a *** is simply not *** address this problem,the Department of Computing at the University of Illinois has introduced a multidisciplinary approach to computing,which is a scalable and collaborative approach to capitalize on the tremendous demand for computer science *** key component of the approach is the blended major,also referred to as“CS+X”,where CS denotes computer science and X denotes a non-computing *** CS+X blended degrees enable win-win partnerships among multiple subject areas,distributing the educational responsibilities while growing the entire *** meet the demand from non-CS majors,another pathway that is offered is a graduate certificate program in addition to the traditional minor *** accommodate the large number of students,scalable teaching tools,such as automatic graders,have also been developed.

关键词： Multi-disciplinary Pathways A Scalable and Collaborative Approach Computer Science Education CS+X

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Geochemical fingerprints and hydrocarbon potential of Paleocene mudrocks in the Tano Basin, Ghana: insights from biomarkers and stable carbon isotopes

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Acta Geochimica 2024年第2期43卷 255-279页

作者： Kojo Amoako nancy Pearl Osei-Boakye Ningning Zhong N’Guessan Francois De Sales Konan Gordon Foli Prince Opoku Appau Clifford Fenyi Ebenezer Apesegah Research Group for Marine Geochemistry(ICBM-MPI Bridging Group) Institute for Chemistry and Biology of the Marine Environment(ICBM)Carl von Ossietzky University OldenburgAmmerlander Heerstr.26129 OldenburgGermany State Key Laboratory of Petroleum Resources and Prospecting College of GeosciencesChina University of PetroleumBeijing 102249China Department of Geological Engineering Faculty of Civil and Geo-EngineeringKwame Nkrumah University of Science and TechnologyKumasiGhana Ghana National Gas Company 225 Osibisa CloseAirport WestAccraGhana Petroleum Corporation GNPCPMBPetroleum HouseTemaGhana

The Paleocene mudrocks in Ghana’s Tano Basin have received limited attention despite ongoing efforts to explore hydrocarbon resources.A thorough geochemical analysis is imperative to assess these mudrocks’petroleum generation potential and formulate effective exploration *** this study,a comprehensive geochemical analysis was carried out on ten Paleocene rock cuttings extracted from TP-1,a discovery well within the Tano *** analytical techniques,including total organic carbon(TOC)analysis,Rock–Eval pyrolysis,gas chromatography-mass spectrometry,and isotope ratio-mass spectrometry,were employed to elucidate their hydrocar-bon potential and organic ***ﬁndings in this study were subsequently compared to existing geochemical data on Paleocene source rocks in the South Atlantic marginal *** results indicated that the Paleocene samples have TOC content ranging from 0.68 to 2.93 wt%.The prevalent kerogen types identiﬁed in these samples were Type Ⅱ and Type Ⅲ.Molecular and isotope data suggest that the organic matter found in the Paleocene mudrocks can be traced back to land plants and lower aquatic *** mudrocks were deposited in a transi-tional environment withﬂuctuating water salinity,charac-terized by sub-oxic redox *** indices,both bulk and molecular,indicated a spectrum of maturity levels within the Paleocene mudrocks,spanning from immature to marginally mature,with increasing maturity observed with greater *** comparison,the organic composition and depositional environments of Paleocene source rocks in the Tano Basin closely resemble those found in the Niger Delta Basin,Douala,and Kribi-Campo Basins,the Kwanza Formation in Angola,and certain Brazilian marginal ***,it is worth noting that Paleocene source rocks in some of the basins,such as the Niger Delta and Brazilian marginal basins,exhibit rela-tively higher thermal maturity levels compared to those observed in the current Paleocene samp

关键词： Paleocene source rocks Source input Depositional environment Thermal maturity Hydrocarbon potential Tano Basin West Africa

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Better use of experience from other reservoirs for accurate production forecasting by learn-to-learn method

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Petroleum Science 2024年第1期21卷 716-728页

作者： Hao-Chen Wang Kai Zhang nancy Chen Wen-Sheng Zhou Chen Liu Ji-Fu Wang Li-Ming Zhang Zhi-Gang Yu Shi-Ti Cui Mei-Chun Yang China University of Petroleum(East China) 66 Changjiang West RoadQingdao West Coast New AreaQingdao266580ShandongChina University of Calgary 2500 University Dr NWCalgaryT2N 1N4AlbertaCanada Qingdao University of Technology Qingdao266071ShandongChina State Key Laboratory of Offshore Oil Exploitation Beijing100028China CNOOC Research Institute Ltd. Beijing100028China CNPC Tarim Oilfield Branch Company Korla841000XinjiangChina National Engineering Laboratory for Exploration and Development of Low-Permeability Oil and Gas Fields Xi'an710000ShaanxiChina Sinopec Matrix Co. LTDQingdao266000ShandongChina

To assess whether a development strategy will be profitable enough,production forecasting is a crucial and difficult step in the *** development history of other reservoirs in the same class tends to be studied to make predictions ***,the permeability field,well patterns,and development regime must all be similar for two reservoirs to be considered in the same *** results in very few available experiences from other reservoirs even though there is a lot of historical information on numerous reservoirs because it is difficult to find such similar *** paper proposes a learn-to-learn method,which can better utilize a vast amount of historical data from various ***,the proposed method first learns how to learn samples before directly learning rules in ***,by utilizing gradients from networks with independent parameters and copied structure in each class of reservoirs,the proposed network obtains the optimal shared initial parameters which are regarded as transferable information across different *** on that,the network is able to predict future production indices for the target reservoir by only training with very limited samples collected from reservoirs in the same *** cases further demonstrate its superiority in accuracy to other widely-used network methods.

关键词： Production forecasting Multiple patterns Few-shot learning Transfer learning

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Diet variability of snappers(Teleostei:Lutjanidae)in a bay-to-reef ecosystem of the Mexican Caribbean

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Water Biology and Security 2024年第1期3卷 53-59页

作者： Leon Felipe Martínez-Juarez Juan J.Schmitter-Soto nancy Cabanillas-Teran Norman Mercado-Silva El Colegio de la Frontera Sur 77014ChetumalQuintana RooMexico Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos62209CuernavacaMorelosMexico

Fishes use environmental resources *** ontogenic movements among coastal habitats lead to diverse *** investigated the diets of seven snapper species(Lutjanus apodus,***,***,***,***,***,and Ocyurus chrysurus)in three interconnected coastal environments in the western Caribbean:Río Huach channel,Chetumal/Corozal bay,and the adjacent Xcalak reef *** three encompass all habitats used by the seven species in the study *** diets were mostly composed of fish and crustaceans,but dominance of either group varied among the studied habitats;for example,fish were the main prey for *** from the reef lagoon zone,but second in the *** are piscivorous-invertivorous mesopredators;the species that relied the most on fishes were *** and ***,whereas *** preferred *** content results revealed a high degree of dietary overlap among *** findings suggested a tradeoff in relative weight between fish and crustaceans as the main food source of snappers at these connected areas,supporting the hypothesis of niche *** results can be used as a baseline to further our understanding of the ecology and differences in resource use by snapper species in an area undergoing important anthropogenic changes.

关键词： Resource partitioning Chetumal/Corozal bay Quintana Roo Trophic ecology

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