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Intravesical instillation of platelet-rich plasma for treatment of interstitial cystitis/bladder pain syndrome:A pilot study

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Current Urology 2024年第1期18卷 49-54页

作者： Ahmed S.el hefnawy Mohamed Attya Ahmed Hasan Esam el Sawy Mohamed Abdel-Razik Nasr el-Tabey Mansoura Urology and Nephrology Center Faculty of MedicineMansoura UniversityMansouraEgypt

Objective:The aim of this study was to evaluate the feasibility of intravesical instillation of platelet-rich plasma(PRP)to treat interstitial cystitis/bladder pain syndrome(IC/BPS).Materials and methods:Twenty PRP samples were tested in vitro for stability after exposure to urine samples with different pH.A pilot study involving 21 female patients with IC/BPS was conducted,and 6 weekly doses of autologous PRP(50 mL)were *** were followed up at the 2nd,4th,8th,and 12th weeks after terminating *** primary endpoint was the visual analog scale(VAS)for pain,and the secondary endpoints included the IC symptom index,IC problem index of the O'Leary-Sant questionnaire and global response assessment,urine culture,and *** was defined as a reduction in VAS by 30%or more compared with basal level,and adverse events were ***:The mean±SD of VAS was significantly reduced compared with basal level(4.4±2.6 vs.8.8±1.1,respectively,p=0.001).Meanwhile,80%of cases were considered successful,with a 50.1%reduction in the mean score compared with the basal *** mean±SD of IC symptom index and IC problem index significantly improved compared with the basal *** response assessment was markedly,moderately,and slightly improved in 2(10%),10(50%),and 5(25%)patients,respectively,and showed no change in 3(15%).Three patients had positive urine cultures at follow-up,but 1 withdrew after 2 sessions because of a lack of ***:Repeated intravesical instillation of PRP could be considered an effective and safe approach for treating IC/BPS.

关键词： Bladder pain syndrome Interstitial cystitis Platelet-rich plasma

Diet variability of snappers(Teleostei:Lutjanidae)in a bay-to-reef ecosystem of the Mexican Caribbean

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Water Biology and Security 2024年第1期3卷 53-59页

作者： Leon Felipe Martínez-Juarez Juan J.Schmitter-Soto nancy Cabanillas-Teran Norman Mercado-Silva el Colegio de la Frontera Sur 77014ChetumalQuintana RooMexico Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos62209CuernavacaMorelosMexico

Fishes use environmental resources *** ontogenic movements among coastal habitats lead to diverse *** investigated the diets of seven snapper species(Lutjanus apodus,***,***,***,***,***,and Ocyurus chrysurus)in three interconnected coastal environments in the western Caribbean:Río Huach channel,Chetumal/Corozal bay,and the adjacent Xcalak reef *** three encompass all habitats used by the seven species in the study *** diets were mostly composed of fish and crustaceans,but dominance of either group varied among the studied habitats;for example,fish were the main prey for *** from the reef lagoon zone,but second in the *** are piscivorous-invertivorous mesopredators;the species that relied the most on fishes were *** and ***,whereas *** preferred *** content results revealed a high degree of dietary overlap among *** findings suggested a tradeoff in relative weight between fish and crustaceans as the main food source of snappers at these connected areas,supporting the hypothesis of niche *** results can be used as a baseline to further our understanding of the ecology and differences in resource use by snapper species in an area undergoing important anthropogenic changes.

关键词： Resource partitioning Chetumal/Corozal bay Quintana Roo Trophic ecology

Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klambt Thomas M.Kitzler Tilman Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif el Desoky Jameela A.Kari Farkhanda Hafeez Maria Szczepanska Loai A.Eid Hazem S.Awad Muna Al-Saffar Neveen A.Soliman Velibor Tasic Camille Nicolas-Frank Kirollos Yousef Luca M.Schierbaum Sophia Schneider Abdul Halawi Izzeldin elmubarak Katharina Lemberg Shirlee Shril Shrikant M.Mane nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative Medicine(ECRRM) Cairo 11511Egypt Medical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

Phytochemical and biological studies of Butia capitata *** cultivated in Egypt

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Asian Pacific Journal of Tropical Biomedicine 2014年第6期4卷 456-462页

作者： Nagwa Mohamed Ammar Mohammed Said hefnawy Sahar Youssef Al-Okbi Doha Abdou Mohamed Nabil Khamis el-Sayed Amira Ahmed el-Anssary Tom Mabry Pharmacognosy Department National Research Centre Pharmacognosy Department Faculty of PharmacyCairo University Food Sciences and Nutrition Department National Research Centre Tanning Materials and Protein Chemistry National Research Centre Molecular Cell and Developmental Biology The School of Biological ScienceBotany DepartmentTaxas State University

Objective:To study the antioxidant and anti-inflammatory activity of Butia capitata(***)leaf extracts along with phytochemical analysis of the proposed bioactive ***:Different successive extracts of *** *** were prepared with selective organic solvents and screened for their anti-inflammatory activities in tested animals and invitro antioxidant *** extensive phytochemical investigation of the bioactive extracts through paper chromatography,thin layer chromatography,column chromatography,gasliquid chromatography(GLC),high pressure liquid chromatography and spectral ***,ultraviolet,hydrogen and carbon nuclear magnetic resonance,electron ionization-mass spectrometry,heteronuclear multiple bond correlation and heteronuclear multiple quantum correlation were carried out Results:Results showed that different extracts possess promising antioxidant effect and significant anti-inflammatory activity with variable *** results of the phytochemical investigation of the bioactive extracts revealed the presence of volatile substances,lipoidal matter,α-tocopherol,free sugars,polysaccharides and flavonoidal ***:*** leaf extracts were shown to possess variable antioxidant effect,the most promising was methanol extract Both polar and non polar extracts were proved to have anti-inflammatory activity,the non polar extract was superior in this respect The bioactivity of the extracts was ascribed to the presence of flavonoids,sterols andα-tocopherol.

关键词： Butia capitata leaves antioxidant effect anti-inflammatory activity bioactive constituents rats.

Cordial Labeling of Corona Product of Path Graph and Second Power of Fan Graph

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Open Journal of Discrete Mathematics 2021年第2期11卷 31-42页

作者： Ashraf Ibrahim hefnawy elrokh Shokry Ibrahim Mohamed Nada Eman Mohamed el-Sayed el-Shafey Department of Math Faculty of Science Menoufia University Shebeen El-Kom Egypt Department of Math Faculty of Science El-Azhar University Cairo Egypt

A graph is said to be cordial if it has 0 - 1 labeling which satisfies particular conditions. In this paper, we construct the corona between paths and second power of fan graphs and explain the necessary and sufficie... 详细信息

关键词： Corona Second Power of Fan Cordial Graph

Performance Analysis of an Artificial Intelligence Nanosystem with Biological Internet of Nano Things

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Computer Modeling in Engineering & Sciences 2022年第10期133卷 111-131页

作者： Saied M.Abd el-atty nancy A.Arafa Atef Abouelazm Osama Alfarraj Konstantinos A.Lizos Farid Shawki Department of electronics and electrical Communications Engineering Faculty of Electronic EngineeringMenoufia UniversityMenoufEgypt Computer Science Department Community CollegeKing Saud UniversityRiyadhSaudi Arabia Department of Informatics Faculty of Mathematics and Natural SciencesUniversity of Oslo(UiO)OsloNorway

Artificial intelligence(AI)has recently been used in nanomedical applications,in which implanted intelligent nanosystems inside the human body were used to diagnose and treat a variety of ailments with the help of the Internet of biological Nano Things(IoBNT).Biological circuit engineering or nanomaterial-based architectures can be used to approach the *** nanomedical applications,the blood vascular medium serves as a communication channel,demonstrating a molecular communication system based on flow and *** paper presents a performance study of the channel capacity for flow-based-diffusive molecular communication nanosystems that takes into account the ligand-receptor binding *** earlier studies,we take into account the effects of biological physical characteristics such as blood pressure,blood viscosity,and vascular diameter on channel ***,in terms of drug transmission error probability,the inter-symbol interference(ISI)phenomenon is applied to the proposed *** numerical results show that the proposed AI nanosystems-based IoBNT technology can be successfully implemented in future nanomedicine.

关键词： Nanosystem AI Internet of biological Nano Things(IoBNT) channel capacity

Analyzing Customer Reviews on Social Media via Applying Association Rule

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Computers, Materials & Continua 2021年第8期68卷 1519-1530页

作者： nancy Awadallah Awad Amena Mahmoud Department of Computer and Information Systems Sadat Academy for Management SciencesCairo11742Egypt Faculty of computers and Information Department of Computer ScienceKafr el Sheikh UniversityKafr El Sheikh33511Egypt

The rapid growth of the use of social media opens up new challenges and opportunities to analyze various aspects and patterns in ***-text mining,several techniques are available such as information clustering,extraction,summarization,*** this study,a text mining framework was presented which consists of 4 phases retrieving,processing,indexing,and mine association rule *** is applied by using the association rule mining technique to check the associated term with the Huawei P30 Pro *** reviews are extracted from many websites and Facebook groups,such as ***,*** and *** technology,where customers from all over the world placed their notes on cell *** this analysis,a total of 192 reviews of Huawei P30 Pro were collected to evaluate them by text mining *** findings demonstrate that Huawei P30 Pro,has strong points such as the best safety,high-quality camera,battery that lasts more than 24 hours,and the processor is very *** paper aims to prove that text mining decreases human efforts by recognizing significant *** will lead to improving the awareness of customers to choose their products and at the same time sales managers also get to know what their products were accepted by customers suspended.

关键词： Machine learning text mining social media big data association rule document clustering

Improving Reconstructed Image Quality via Hybrid Compression Techniques

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Computers, Materials & Continua 2021年第3期66卷 3151-3160页

作者： nancy Awadallah Awad Amena Mahmoud Department of Computer and Information Systems Sadat Academy for Management SciencesCairo11742Egypt Department of Computer Science Kafr el Sheikh University33511Egypt

Data compression is one of the core fields of study for applications of image and video *** raw data to be transmitted consumes large bandwidth and requires huge storage space as a result,it is desirable to represent the information in the data with considerably fewer bits by the mean of data compression techniques,the data must be reconstituted very similarly to the initial *** this paper,a hybrid compression based on Discrete Cosine Transform(DCT),DiscreteWavelet Transform(DWT)is used to enhance the quality of the reconstructed *** techniques are followed by entropy encoding such as Huffman coding to give additional *** coding is optimal prefix code because of its implementation is more simple,faster,and easier than other *** needs less execution time and it is the shortest average length and the measurements for analysis are based upon Compression Ratio,Mean Square Error(MSE),and Peak Signal to Noise Ratio(PSNR).We applied a hybrid algorithm on(DWT–DCT 2×2,4×4,8×8,16×16,32×32)***,we show that by using a hybrid(DWT–DCT)compression technique,the PSNR is reconstructed for the image by using the proposed hybrid algorithm(DWT–DCT 8×8 block)is quite high than DCT.

关键词： Image compression discrete cosine transform PSNR discrete wavelet transform hybrid algorithm

Patterns and Changes in the Treatment of Patients with Type II Diabetes Mellitus in Egypt: The DISCOVER Program

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International Journal of Clinical Medicine 2020年第12期11卷 731-742页

作者： Salah Shelbaya Mohamed Khattab Khalifa Abdallah Yehia Ghanem Hesham el hefnawy Enas Shaltout Eman Roshdy Emad R. Issak Endocrinology Department Ain Shams University Cairo Egypt Internal Medicine Department Cairo University Giza Egypt Internal Medicine Department Alexandria University Alexandria Egypt Endocrinology Department National Institute of Diabetes & Endocrinology Cairo Egypt Internal Medicine Department Diabetes Unit Cairo University Giza Egypt Internal Medicine Department Ain Shams University Cairo Egypt

The DISCOVER study is a three-year, non-interventional prospective study conducted in 37 countries, including Egypt, to assess the treatment patterns and outcomes in patients with type 2 diabetes mellitus initiating a second-line antidiabetic therapy (add-on or switch). In this report of the Egyptian cohort of DISCOVER, baseline data were collected according to routine clinical practice at 38 study sites, using a standardized electronic case report form, in the period from December-2014 to November-2019. We enrolled 583 patients (mean age: 52.9 ± 9.8 years and median duration since diagnosis: median 36.5, IQR 18.1, 70.4 months). The mean HbA1c value at baseline was 8.6 ± 1.4%, indicating poor glycemic control. The most commonly prescribed first-line medications were metformin or sulfonylurea monotherapy. For second line-therapy, the majority of patients switched to dual therapy with metformin plus sulfonylureas or DPP-4 inhibitors. Fewer patients switched to triple therapy, treatment by four or more medications, or insulin treatment (15, 12, and 35 patients, respectively). The most commonly cited reasons for switching to second-line therapy were lack of efficacy, weight gain, hypoglycemic events, and side effects (549, 54, 25, and 21 patients, respectively). The set treatment target of enrolled patients at the initiation of second-line therapy was an HbA1c level of 6.9%. Follow-up data will assess the outcomes of such changes in the Egyptian population.

关键词： Diabetes Mellitus Glucose Control Metformin Patient-Reported Outcomes Egypt HbA1c Medication