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Acta Geologica Sinica(English Edition) 2014年第2期88卷 380-393页

作者： Birendra P. Singh Kapesa Lokho Naval Kishore nancy Virmani Center of Advanced Study in Geology Panjab University Wadia Institute of Himalayan Geology

A new locality bearing ichnofossils of the Cruziana Assemblage Zone-Ⅲ from the Mussoorie syncline,Lesser Himalaya,is located in rocks of Member-B of the Dhaulagiri Formation,Tal Group,exposed along the Maldewta-Chhimoli fresh road cut *** site yielded ichnofossils Bergaueria perata,Cochlichnus anguineus,？Diplocraterion isp.,Dimorphichnus obliquus,diplichnitiform Cruziana bonariensis,Diplichnites gouldi,Glockeria isp.,Helminthopsis isp.,Monomorphichnus lineatus,Phycodes palmatum,Palaeophycus striatus,Planolites beverleyensis,Planolites montanus,Treptichnus ***,scratch marks and an undetermined worm *** Early Cambrian age （Cambrian Series 2） is assigned to the ichnofossil-bearing strata based on the stratigraphic position between the Drepanuroides and Palaeoolenus trilobite zones.A revised Cambrian ichnofossil zonation is presented for the Tal Group of the Mussoorie *** with their occurrence on rippled surfaces,and the lateral displacement of some trackways （due to current action）,a sub-aqueous shallow-marine depositional setting is proposed for the rocks of Member-B.

关键词： Ichnology Cruziana Assemblage Zone Cambrian Series 2 shallow-marine northern India

Thymoma and autoimmunity

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Cellular & Molecular Immunology 2011年第3期8卷 199-202页

作者： Shahar Shelly nancy Agmon-Levin Arie Altman Yehuda Shoenfeld The Zabludovicz Center for Autoimmune Diseases Sheba Medical CenterTel-Hashomeraffiliated with Sackler Faculty of MedicineTel Aviv UniversityIsrael Department of Medicine‘B’ Sheba Medical CenterTel-HashomerIsrael Sackler Faculty of Medicine Incumbent of the Laura Schwarz-Kip Chair for Research of Zabludowitz Center for Autoimmune DiseasesTel-Aviv UniversityTel-AvivIsrael

The thymus is a central lymphatic organ that is responsible for many immunological functions,including the production of mature,functional T cells and the induction of *** or malignant tumors may originate from the thymus gland,with thymoma being the most common and accounting for 50% of anterior mediastinal *** linked to thymoma include the loss of self-tolerance and the presence of *** this review,we compiled the current scientific evidence detailing the various interactions between thymoma and autoimmune diseases,including myasthenia gravis,systemic lupus erythematosus,inappropriate antidiuretic hormone secretion,pure red cell aplasia,pernicious anemia,pemphigus and autoimmune thyroid *** recent years,several mechanisms have been proposed to explain these *** are based on the assumption that the‘sick’thymus,like the‘normal’thymus,can generate mature T cells;however,the T cells generated by the sick thymus are impaired and thus may exert cellular ***,we present several theories that may shed light on the loss of self-tolerance associated with this epithelial tumor of the thymus.

关键词： autoimmune diseases autoimmunity self-tolerance thymoma thymus

Temporal trends in the relative prevalence of dysphagia etiologies from 1999-2009

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World Journal of Gastroenterology 2012年第32期18卷 4335-4341页

作者： Trilokesh Kidambi Erin Toto nancy Ho Tiffany Taft Ikuo Hirano Division of Gastroenterology Northwestern University Feinberg School of MedicineChicagoIL 60611United States Department of Medicine University of California at San FranciscoSan FranciscoCA 94143United States Department of Medicine Northwestern University Feinberg School of MedicineChicagoIL 60611United States

AIM:To examine the relative prevalence and temporal variation of dysphagia etiologies in patients undergoing upper endoscopy(EGD) over the past ***:EGDs with the indication of dysphagia at an urban,university medical center in 1999,2004 and 2009 were retrospectively identified from the electronic medical *** entire patient chart,including EGD,pathology,manometry,radiographic and clinician reports,was reviewed for demographic and clinical data and to determine the etiology of *** number of EGDs in which an esophageal biopsy was performed was also *** reflux disease(GERD) as a cause of dysphagia independent of peptic stricture was defined by symptoms with erosive esophagitis or symptom response to proton pump inhibition(PPI).Cases of eosinophilic esophagitis(EoE) were defined by an appropriate clinical history and histological criteria of ≥ 15 eosinophils per high powered ***-responsive esophageal eosinophilia was not routinely reported prior to *** analysis was performed using one-way analysis of variance to analyze for trends between 1999,2004 and 2009 and a post-hoc Tukey analysis was performed following a significant main ***:A total of 1371 cases(mean age 54 years,43% male) met pre-specified inclusion criteria with 191,504 and 675 cases in 1999,2004 and 2009,*** were older in 2004 compared to 2009(mean ± SD,54.0 ± 15.7 years vs 52.3 ± 16.8 years,P = 0.02) and there were more males in 1999 compared to 2004(57.5% vs 40.8%,P = 0.005).Overall,GERD(27.6%) and EoE(7.7%) were the most common identifiable causes of *** unspecified diagnosis accounted for 21% of overall *** were no significant differences in the relative prevalence of achalasia or other motility disorders,peptic stricture,Schatzki's ring,esophageal cancer or unspecified diagnoses over the 10-year time *** was,however,a decrease in the relative prevalence of GERD(39.3% vs 24.1%,P < 0.001

关键词： Eosinophilic esophagitis Gastroesophageal reflux disease Dysphagia Endoscopy Esophagitis Esophageal diseases

Nitrogen deposition and reduction of terrestrial biodiversity:Evidence from temperate grasslands

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Science China(Life Sciences) 2005年第Z2期48卷 720-728页

作者： nancy B.Dise Carly J.Stevens Department of Earth Sciences Open University Milton KeynesMK7 6AAUK Department of Biology Villanova UniversityVillanovaPA 19085USA Department of Agricultural Science Imperial College at WyeWyeAshfordTN25 4NJUK

Biodiversity is thought to be essential for ecosystem stability, function and long-term sustainability. Since nitrogen is the limiting nutrient for plant growth in many terrestrial ecosystems, reactive nitrogen has the potential to reduce the diversity of terrestrial vegetation and associated biota through favouring species adapted to quickly exploiting available nutrients. Although the potential has long been recognised, only recently has enough evidence come together to show beyond reasonable doubt that these changes are already occurring. Linked together, experimental, regional/empirical, and time-series research provide a powerful argument that enhanced deposition of reactive nitrogen across Great Britain, and potentially the rest of Europe, has resulted in a significant and ongoing decline in grassland species richness and diversity.

关键词： nitrogen deposition, terrestrial biodiversity, temperate grasslands.

Biomass derived porous nitrogen doped carbon for electrochemical devices

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Green Energy & Environment 2017年第2期2卷 84-99页

作者： Litao Yan Jiuling Yu Jessica Houston nancy Flores Hongmei Luo Department of Chemical and Materials Engineering New Mexico State University Extension Family Consumer Science New Mexico State University

Biomass derived porous nanostructured nitrogen doped carbon(PNC) has been extensively investigated as the electrode material for electrochemical catalytic reactions and rechargeable batteries. Biomass with and without containing nitrogen could be designed and optimized to prepare PNC via hydrothermal carbonization, pyrolysis, and other methods. The presence of nitrogen in carbon can provide more active sites for ion absorption, improve the electronic conductivity, increase the bonding between carbon and sulfur, and enhance the electrochemical catalytic reaction. The synthetic methods of natural biomass derived PNC, heteroatomic co-or tri-doping into biomass derived carbon and the application of biomass derived PNC in rechargeable Li/Na batteries, high energy density Li-S batteries, supercapacitors, metal-air batteries and electrochemical catalytic reaction(oxygen reduction and evolution reactions, hydrogen evolution reaction) are summarized and discussed in this review. Biomass derived PNCs deliver high performance electrochemical storage properties for rechargeable batteries/supercapacitors and superior electrochemical catalytic performance toward hydrogen evolution, oxygen reduction and evolution, as promising electrodes for electrochemical devices including battery technologies, fuel cell and electrolyzer.

关键词： Biomass Nitrogen doped carbon Batteries Fuel cell Electrolyzer

Traditional Taxation Systems in Western Tibet:A Comparative Perspective

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中国藏学 1992年第S1期 322-345页

作者： nancy E.Levine

This paper focuses on traditional systems of taxation in Ngari, or Western Tibet, and their in-tegration with the system of land tenure and related features of social structure. These systems dis-play tremendous regional diversity, due, no doubt, to particularities of history and idiosyncratic e-conomic and geographical factors. Despite some noteworthy differences, they share

关键词：留级洛阳义山

One man’s trash-another man’s treasure: fecal transplantation

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Hepatobiliary Surgery and Nutrition 2019年第6期8卷 623-625页

作者： nancy Gupta Stephen B.Hanauer Digestive Health Center University of Iowa Hospitals and ClinicsIowa CityIAUSA Digestive Health Center Northwestern University Feinberg School of MedicineChicagoILUSA

Discovery of immune checkpoint inhibitors has revolutionized the field of *** checkpoints play a key role in maintaining immune homeostasis and preventing *** normal situation,immune responses are regulated by a balance between co-stimulatory and inhibitory signals referred to as"immune checkpoints".Activated T cells express multiple co-inhibitory receptors such as lymphocyte-activation gene 3(LAG-3),programmed cell death protein 1(PD-1)and cytotoxic T-lymphocyte-associated protein 4(CTLA-4)that are primary mediators of immune effector responses to self-proteins,chronic infections and tumor *** tumors these immune checkpoints allow the tumor cells to dodge anti-tumor response(1).Checkpoint inhibitors(CPI)block these immune checkpoints allowing the immune system to attack tumor cells(2).Although the immune system has the inherent ability to distinguish self from non-self and thus typically mount an attack on the non-self-cancer cells;over-activation of the immune response can lead to serious adverse events collectively called immune-related adverse events(irAEs)(3).While activation of the immune system and development of irAEs has been associated with better outcomes for underlying cancer(4),the associated side effects increase morbidity and mortality in addition to having a negative impact on patient’s quality of *** associated with CPI therapy can have delayed manifestation and present after the CPI have been discontinued(5).

关键词： homeostasis mortality collective

Highlights in applications of nanotechnology in radiation research

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Chinese Journal of Cancer Research 2013年第5期25卷 613-614页

作者： nancy Q.Zhong Molly J.Wang Editorial Office Translational Cancer Research

Translational Cancer Research （Transl Cancer Res; TCR; Print ISSN： 2218-676X; Online ISSN 2219-6803; www. ***） launched in August 2013 a special issue on Applications of Nanotechnology in Radiation Research inviting Prof. Rao V.L. Papineni from University of Kansas Medical Center, Pataje G.S. Prasanna from National Cancer Institute and Mansoor M. Ahmed, National Cancer Institute to serve as the Guest Editors.

关键词： ISSN Highlights in applications of nanotechnology in radiation research

Murine neurofibroma reversion by antisense RNA for HTLV-I tax

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Science China(Life Sciences) 1999年第1期42卷 8-16页

作者：李昌本 Mark C.Horowitz nancy H.Ruddle Department of Orthopaedics and Rehabilitation Yale University Schcol of Medicine New Haven Connecticut 06520 USA Department of Epidemiology and Public Health Yale University School of Medicine New Haven Connecticut 06520 USA

Neurofibroma cell lines derived from mice transgenic for HTLV-I LTR tax express high levels of HTLV-I tax mRNA and protein and exhibit a transformed phenotype. A retrovirus vector carrying HTLV-I tax cDNA in reversed transcriptional orientation was stably transfected into the neurofibroma cells. Antisense RNA inhibited expression of the tax gene with a decrease of more than 40 % in both tax mRNA and protein. Tax antisense RNA reversed the transformed phenotype as exhibited by dramatic changes in cell morphology and growth characteristics. Expression of several cellular genes which are activated by Tax protein including GM-CSF, IL-6, LT/TNF, c-myc and LIF was down-regulated, while M-CSF and c-src proto-oncogene expressions were up-regulated. Accumulation of β-actin mRNA was not affected. The changes that occurred in the tax antisense expressing neurofibroma cells could be the consequence of the decreased concentration of Tax protein. These results also indicate that HTLV-I Tax protein is crucial for maintaining the transformed cell morphology, growth and proliferation of murine neurofibroma cells and suggest that deregulation of endogenous cellular genes by Tax protein is the mechanism through which neurofibromas occur in tax mice.

关键词： neurofibroma antisense RNA HTLV-I tax cytokine proto-oncogene.

Impact of medical therapy on patients with Crohn's disease requiring surgical resection

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World Journal of Gastroenterology 2014年第33期20卷 11808-11814页

作者： YT nancy Fu Thomas Hong Andrew Round Brian Bressler Division of Gastroenterology Department of Medicine University of British Columbia St. Paul’s Hospital Vancouver BC V6Z 1Y6 Canada Faculty of Medicine University of British Columbia Vancouver BC V6T 1Z3 Canada GI Clinic and Gastrointestinal Research Institute Vancouver BC V6Z 2K5 Canada

AIM: To evaluate the impact of medical therapy on Crohn’s disease patients undergoing their first surgical resection.

关键词： Crohn's disease Surgery Medication Phe-notype Biologics Anti-tumor necrosis factor Immuno-modulators Inflammatory bowel disease