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Mast Cell stabilizing,Antianaphylactic and Antihistaminic Activity of Coccinia grandis Fruits in Asthma

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中国天然药物 2011年第5期9卷 359-362页

作者： Dnyaneshwar J Taur Ravindra Y patil Department of Pharmacognosy SVPM's College of PharmacyMalegaon(bk)Baramati-413115MaharashtraIndia Department of Pharmacognosy PDEA's SU College of Pharmaceutical Sciences and Research CenterKharadiPune-411014MaharashtraIndia

Coccinia grandis Linn(Curcubitaceae) is a climber herb cultivated throughout *** traditional medicine fruits have been used to treat leprosy,fever,asthma,bronchitis and *** present study,ethanol extract of *** fruit(ECGF) at 100,125 and 150 mg·kg-1,i.p.,was evaluated for mast cell stabilizing,antianaphylactic and antihistaminic activity using egg albumin induced mast cell degranulation in mice;passive cutaneous anaphylaxis in rats and clonidine induced catalepsy in mice *** at(100-150 mg·kg-1,i.p.) significantly protected egg albumin induced degranulations of mast cells and caused reduction of blue dye leakage in passive cutaneous anaphylaxis in dose *** treatment ECGF also inhibited clonidine induced catalepsy in dose dependent *** studies observed presence of saponin,steroids,alkaloids,flavonoids and *** conclusion ECGF possesses mast cell stabilizing;anti anaphylactic and antihistaminic potential which might be used in treatment of asthma.

关键词： Coccinia grandis Allergy Asthma Clonidine Mast cell degranulations

semiconductor metal oxide compounds based gas sensors： A literature review

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Frontiers of Materials science 2015年第1期9卷 14-37页

作者： sunil Jagannath patil Arun Vithal patil Chandrakant Govindrao DIGHAVKAR Kashinath shravan THAKARE Ratan Yadav BORAsE sachin Jayaram NANDRE Nishad Gopal DEsHPANDE Rajendra Ramdas AHIRE Department of Physics S. G. Patil Arts Science & Commerce College Sakri-424304 Dist. Dhule India Department of Physics L. V. H. College Panchavati Nashik-422003 India Thin and Thick film Laboratory M. S. G. College Malegaon Camp Malegaon-423105 Dist. Nashik India Department of Physics Uttamrao Patil College Dahivel Dist-Dhule India Department of Physics Shivaji University Kolhapur-416004 India

This paper gives a statistical view about important contributions and advances on semiconductor metal oxide （sMO） compounds based gas sensors developed to detect the air pollutants such as liquefied petroleum gas （LPG）, H2s, NH3, CO2, acetone, ethanol, other volatile compounds and hazardous gases. Moreover, it is revealed that the alloy/composite made up of sMO gas sensors show better gas response than their counterpart single component gas sensors, i.e., they are found to enhance the 4s characteristics namely speed, sensitivity, selectivity and stability. Improvement of such types of sensors used for detection of various air pollutants, which are reported in last two decades, is highlighted herein.

关键词： gas sensor semiconductor metal oxide (sMO) sensitivity air pollutant gas response

Mineralogy, Geochemistry and Palaeomagnetism of Mafic Dykes from Kumaun Lesser Himalaya: Implication on Petrogenesis, Tectonic setting and Timing of Mafic Magmatism in Northern Part of Indian Lithosphere

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Acta Geologica sinica(English Edition) 2016年第S1期90卷 120-121页

作者： santosh Kumar N.surdas singh s.K.patil Department of Geology Kumaun University Dr.K.s.Krishnan Geomagnetic Research Laboratory

Occurrence of mafic dykes in Himalaya has been intriguing and debated since long because of its difficulty to ascent and emplacement through a thickened *** dykes in Kumaun Lesser Himalaya(KLH)of central Indian

关键词： Geochemistry and Palaeomagnetism of Mafic Dykes from Kumaun Lesser Himalaya Mineralogy Tectonic setting and Timing of Mafic Magmatism in Northern Part of Indian Lithosphere

Aloin attenuates chronic constriction injury-induced neuropathic pain in rats by inhibiting inflammatory cytokines and oxidative stress

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Asian Pacific Journal of Tropical Biomedicine 2021年第5期11卷 205-213页

作者： Aarti s.Kale Avinash R.Wadkar Umesh B.Mahajan Lalit A.Birari sateesh Belemkar sameer N.Goyal shreesh Ojha sanjay J.surana Chandragouda R.patil Kalpesh R.patil Department of Pharmacology R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia school of Pharmacy&Technology Management SVKM's NMIMSMPTPShirpur-425405Dist-DhuleMaharashtraIndia shri Vile Parle Kelavani Mandal's Institute of Pharmacy Dhule-424001MaharashtraIndia Department of Pharmacology and Therapeutics College of Medicine and Health SciencesUnited Arab Emirates UniversityP.O.Box 17666Al AinAbu DhabiUAE Department of Pharmacognosy R.C.Patel Institute of Pharmaceutical Education and ResearchShirpur-425405Dist.DhuleMaharashtraIndia

Objective:To investigate the effect of aloin against chronic constriction injury(CCI)-induced neuropathic pain in ***:Rats were randomly divided into 7 groups:GroupⅠ(normal control),GroupⅡ(sham-operated),GroupⅢ(CCI control)and GroupⅣ,Ⅴ,Ⅵ,andⅦ,which underwent CCI surgery and then were administered with aloin(5 mg/kg,p.o.;25 mg/kg,p.o.;125 mg/kg,p.o.)and gabapentin(50 mg/kg,p.o.),respectively for 14 *** neuropathy was induced by silk ligatures(4-0)loosely placed around the sciatic *** thresholds against mechanical stimuli(Von-Frey filaments)and thermal stimuli(12℃and 40℃)were measured at midplantar paw region ipsilateral to the compressed nerve on day-3,7,11,and *** concentration of cytokines including tumor necrosis factor-α(TNF-α),interleukin-6,and interleukin-1βwas estimated at *** day 14,motor nerve conduction velocity was determined under urethane anesthesia(1.25 g/kg).Oxidative stress parameters(malondiadehyde,glutathione,catalase,and superoxide dismutase)were estimated in sciatic nerve homogenates at day *** nerve samples were processed for histological ***:Aloin significantly reduced CCI-induced mechanical and thermal *** also improved motor nerve conduction velocity and decreased oxidative stress in nerve *** addition,it decreased pro-inflammatory cytokine levels and restored the histoarchitecture of compressed sciatic ***:Aloin mitigates CCI-induced neuropathic pain in rats by inhibiting oxidative stress and pro-inflammatory cytokines in the afflicted sciatic nerve.

关键词： Aloin Chronic constriction injury Antioxidant Neuropathic pain

Optimization of microwave-assisted extraction for picroside I and picroside II from Picrorrhiza kurroa using Box-Behnken experimental design

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Frontiers of Chemical science and Engineering 2014年第4期8卷 445-453页

作者： Pravin WAKTE Ajit patil Bhusari sACHIN Munnaza QUAZI shraddha JABDE Devanand sHINDE Pharmaceutical Technology Division Department of Chemical Technology Dr. Babasaheb Ambedkar Marathwada University Aurangabad 431004 India

The response surface methodology was employed to study the optimization of microwave-assisted extraction of picroside I and picroside II from Picrorrhiza kurroa Royle rhizomes. The effects of solid to solvent ratio, and extraction temperature, time and solvent on the yields ofpicroside I and picroside II have been investigated using Box-Behnken experimental design. The experimen- tal data were fitted to second-order polynomial equations using multiple regression analysis and analyzed using the appropriate statistical method. By solving the regression equation and analyzing 3-D plots, the optimum extraction conditions were found to be： solid to solvent ratio, 10 ： 90 （w/v）; temperature, 60 ~C; and extraction time, 60 s. Under the optimal conditions, the yields of picroside I and picroside II are 41.23 and 6.12 *** feed respectively, which are in good agreement with the predicted values. The ratio of solid to solvent significantly affects the yields of picroside I and picroside II. Application of microwave- assisted extraction of picroside I and picroside II from P kurroa would dramatically reduce extraction time and solvent consumption.

关键词： microwave-assisted extraction picroside I,picroside II Picrorrhiza kurroa Box-Behnken design

Micropropagation of yellow mangosteen:a valuable endemic tree of India

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Journal of Forestry Research 2016年第1期27卷 161-165页

作者： Lalita Mahantagouda patil Hosakatte Niranjana Murthy Vijayalaxmi s.Dandin sunita P.Koli shirugumbi Hanamanthagouda Manohar shivanand D.Payamalle Department of Botany Karnatak University

We developed a method for in vitro regenera- tion of Garcinia xanthochymus （yellow mangosteen） from matured seed segments. Multiple shoots were induced on woody plant （WP） medium supplemented with cytokinins. An average of 11 shoots per explant were regenerated from mature seed segments on WP medium containing 20 μM 6-benzylaminopurine. Histological analysis revealed that hypodermal cells of seed segments were initially involved in active division, which later developed into meriste- moids, subsequently leading to the formation of shoot buds. shoot elongation was achieved by repeated subculturing of seed explants in shoot regeneration medium. Rooting of shoots was achieved on WP medium supplemented with indole-3-butyric acid or s-naphthalene acetic acid. Plant- lets were transplanted to pots containing soil： compost （1：1） and survival rate was 90 %.

关键词： Adventitious shoots Garcinia xanthochymus.In vitro propagation Tissue culture WP medium

some medicinal plants with antiasthmatic potential:a current status

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Asian Pacific Journal of Tropical Biomedicine 2011年第5期1卷 413-418页

作者： Dnyaneshwar J Taur Ravindra Y patil Department of Pharmacognosy SVPM's College of PharmacysMalegaon(bk) Department of Pharmacognosy PDEA's Shankarrao Ursal College of Pharmaceutical Sciences and Research Center

Asthma is a common disease that is rising in prevalence worldwide with the highest prevalence in industrialized *** affect about 300 million people worldwide and it has been estimated that a further 100 million will be affected by *** the ancient times,plants have been exemplary sources of *** asthma therapy lack satisfactory success due to adverse effect,hence patients are seeking complementary and alternative medicine to treat their *** and other Indian literature mention the use of plants in various human *** has about 43 000 plant species and among them several thousand are claimed to possess medicinal *** conducted in the last few decades on the plants mentioned in ancient literature or used traditionally for asthma have shown antiasthmatic,antihistaminic and antiallergic *** review reveals that some plants and their extract have antiasthmatic,antihistaminic,anticholinergic and antiallergic activity.

关键词： Asthma Antiasthmatic plants Ayurveda Herbal medicines Antiallergic activity Medicinal property

Metal nanoparticles as inhibitors of enzymes and toxins of multidrug-resistant staphylococcus aureus

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Infectious Medicine

Infectious Medicine 2023年第4期2卷 294-307页

作者： Amruta A.Joshi Ravindra H.patil Department of Microbiology and Biotechnology R.C.Patel ArtsCommerce and Science CollegeShirpurMaharashtra 425405India

staphylococcus aureus is an aerobic Gram-positive spherical bacterium known to cause a broad range of infections *** is a major cause of infective skin and soft infections and severe and life-threatening conditions,such as pneumonia,bloodstream infections,and *** emergence of drug-resistant strains of s aureus,par-ticularly methicillin-resistant s aureus(MRsA),has become a significant concern in the healthcare ***-resistant s aureus is commonly acquired in hospitals and long-term care *** often affects pa-tients with weakened immune systems,those undergoing invasive medical procedures,or those who have been hospitalized for extended *** the Us,s aureus is known to cause potentially fatal illnesses,such as toxic shock syndrome(Tss)and acute-onset toxic shock syndrome(Tss),which are characterized by fever and *** develops resistance to antibiotics through several mechanisms,such as the production of enzymes that inactivate antibiotics,target site modification,efflux pumps,and plasmid-mediated ***,preventing the spread of drug-resistant s aureus is needed,and there is an urgent need to explore novel ap-proaches in the development of anti-staphylococcal *** article reviews the principal infections caused by s aureus,major virulence factors,mechanisms of resistance development,and nanotechnology-based solutions for the control of drug-resistant s aureus.

关键词： staphylococcus aureus Drug resistance Efflux pumps Plasmid Nanotechnology Inhibitors

Progeny evaluation of Jatropha curcas and Pongamia pinnata with comparison to bioproductivity and biodiesel parameters

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Journal of Forestry Research 2015年第1期26卷 137-142页

作者： Vinod Kumar patil Prithviraj Bhandare Pramod B. Kulkarni G.R.Naik Department of Biotechnology Gulbarga University

Progeny studies of Jatropha curcas and Pongamia pinnata were carried with respect to bioproductivity,pod and seed characters which is one of the selection methods in tree improvement programmes. Variations in bioproductivity and biodiesel parameters of both the plants were compared every 6 months for 4 years of investigation and analyzed by analysis of variance and correlation coefficient by Pearson＇s method using software Graphpad instat 3.06（for Windows and Mac）. P. pinnata has better germination rate（71.4 %）, 100 pod weight（PW）（311.59 g） and 100 seed weight（sW）（173.46 g） as compared to J. curcas for germination rate（43.2 %）, 100 PW（111.29 g） and 100 sW（67.46 g）. P. pinnata has strong correlation for plant height to canopy growth（CG）（0.948）, collar diameter（CD）（0.994）, number of branches per plant（NBP）（0.995） and to number of leaves per branch（NLB）（0.862） as compared to *** which showed good correlation among plant height to CG（0.976）, CD（0.970）, NBP（0.988）, NLB（0.920） and to number of pods per branch（0.657）. However, J. curcas depicted negative correlation for pod breadth to seed length（sL）（-0.447）, seed breadth（-0.248） and to seed thickness（sT）（-0.364） and among the 100 PW to sL（-0.199）, sT（-0.220） and to 100 sW（-0.704）. About 4 kg of P. pinnata seeds were required for each liter of crude oil which yields896 ml of biodiesel on transesterification as compared to5.66 kg of J. curcas seeds for a liter of crude oil, producing about 663 ml of biodiesel. The quality of biodiesel meets the major specification of American society for Testing and Materials（AsTM） standards for biodiesel. The crude glycerin and seed cake obtained as byproduct during biodiesel production were also measured which can be purified and used in composting, animal feeds, pharmaceuticals and cosmetic industries.

关键词： Biodiesel Biofuel plants Bioproductivity Jatropha curcas Pongamia pinnata