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Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice

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Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 391-400,I0008-I0291页

作者： swapnil Gavhane Chandrakant Gawli sachin Kumar Biswajit Das Gayatri Marathe Vishal s.patil Harun M.Patel Basavaraj Bommanahalli Chanakya Nath Kundu Chandragouda R.patil R.C.Patel Institute of Pharmaceutical Education and Research Karwand NakaShirpurMaharashtra 425405India Department of Pharmacology Delhi Pharmaceutical Sciences and Research UniversityNew Delhi 110017India school of Biotechnology Kalinga Institute of Industrial TechnologyBhubaneshwar 751024India Gadag Institute of Medical sciences GadagKarnataka 582103India

Objective:To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis(IPF)and to explore its underlying mechanisms using network ***:IPF was induced in C57BL/6 mice by a single intratracheal instillation of bleomycin(5 mg/kg).Trigonelline was administered at doses of 25,50,and 100 mg/kg/day orally from the 2nd day post-bleomycin induction up to the 14th *** IPF-induced mice,lung coefficient,immune cell infiltration in bronchoalveolar lavage fluid,and oxidative stress were *** alterations in lung tissues were also ***,network pharmacology approach was conducted to reveal molecular interactions of bleomycin and trigonelline with targets of ***:Trigonelline treatment reduced bleomycin-induced oxidative stress and immune cell infiltration,and mitigated physiological changes in the lung tissues of ***,trigonelline alleviated bleomycin-induced histological alterations in lung *** pharmacology analysis showed that bleomycin and trigonelline interacted with IPF targets,such as NFKB1,HDAC2,HIF1A,and ***:The interaction of trigonelline with key IPF targets and its ameliorative effects on lung damage and oxidative stress highlight its potential in treating *** may be considered an antifibrotic agent for further clinical development.

关键词： Trigonelline Idiopathic pulmonary fibrosis Antifibrotic Bleomycin Network pharmacology

Decoding bovine coronavirus immune targets:an epitope informatics approach

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Animal Diseases 2024年第2期4卷 138-153页

作者： swati Rani Mehnaj Khatoon Jagadish Hiremath Kuralayanapalya Puttahonnappa suresh Jayashree Anandakumar Nagendra Nath Barman sheethal Manjunath Yamini sri s sharanagouda s.patil spatial Epidemiology Lab ICAR-National Institute of Veterinary Epidemiology and Disease InformaticsYelahankaBengaluruKarnataka 560064India College of Veterinary science Assam Agricultural UniversityGuwahatiAssam 785013India Yuvaraja’s College Mysuru University of MysuruMysuruKarnataka 570005India

Bovine coronavirus(BCoV)poses a significant threat to the global cattle industry,causing both respiratory and gastrointestinal infections in cattle *** necessitates the development of efficacious *** several inactivated and live BCoV vaccines exist,they are predominantly limited to *** immunization of adult cattle is imperative for BCoV infection control,as it curtails viral transmission to calves and ameliorates the impact of enteric and respiratory ailments across all age groups within the *** study presents an in silico methodology for devising a multiepitope vaccine targeting *** spike glycoprotein(s)and nucleocapsid(N)proteins,which are integral elements of the BCoV structure,play pivotal roles in the viral infection cycle and immune *** constructed a remarkably effective multiepitope vaccine candidate specifically designed to combat the BCoV *** immunoinformatics technology,B-cell and T-cell epitopes were predicted and linked together using linkers and adjuvants to efficiently trigger both cellular and humoral immune responses in *** in silico construct was characterized,and assessment of its physicochemical properties revealed the formation of a stable vaccine *** 3D modeling of the vaccine construct,molecular docking revealed a stable interaction with the bovine receptor ***,the viability of the vaccine’s high expression and simple purification was demonstrated by codon optimization and in silico cloning expression into the pET28a(+)*** applying immunoinformatics approaches,researchers aim to better understand the immune response to bovine coronavirus,discover potential targets for intervention,and facilitate the development of diagnostic tools and vaccines to mitigate the impact of this virus on cattle health and the livestock *** anticipate that the design will be useful as a preventive treatment for BCoV sickness in cattle,opening the door for furthe

关键词： Immunoinformatics Bovine coronavirus Multiepitope vaccine Molecular docking In silico cloning

Characterization of early maturing elite genotypes based on MTsI and MGIDI indexes:an illustration in upland cotton(Gossypium hirsutum L.)

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Journal of Cotton Research 2024年第3期7卷 253-265页

作者： D s RAJ supritha patil Rajesh s. patil Bhuvaneshwara R. NAYAK spurthi N. PAWAR Kasu N. Department of Genetics and Plant Breeding College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Agricultural Research station Dharwad 580005India Department of Biotechnology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India Department of Crop Physiology College of AgricultureUniversity of Agricultural SciencesDharwad 580005India

Background Globally,the cultivation of cotton is constrained by its tendency for extended periods of *** maturity plays a potential role in rainfed-based multiple cropping system especially in the current era of climate *** the current study,a set of 20 diverse Gossypium hirsutum genotypes were evaluated in two crop seasons with three planting densities and assessed for 11 morphological traits related to early *** study aimed to identify genotype(s)that mature rapidly and accomplish well under diverse environmental conditions based on the two robust multivariate techniques called multi-trait stability index(MTsI)and multi-trait genotype-ideotype distance index(MGIDI).Results MTsI analysis revealed that out of the 20 genotypes,three genotypes,viz.,NNDC-30,A-2,and s-32 accomplished well in terms of early maturity traits in two ***,three genotypes were selected using MGIDI method for each planting densities with a selection intensity of 15%.The strengths and weaknesses of the genotypes selected based on MGIDI method highlighted that the breeders could focus on developing early-maturing genotypes with specific traits such as days to first flower and boll *** selected genotypes exhibited positive genetic gains for traits related to earliness and a successful harvest during the first and second ***,there were negative gains for traits related to flowering and boll *** The study identified three genotypes exhibiting early maturity and accomplished well under different planting *** multivariate methods(MTsI and MGIDI)serve as novel approaches for selecting desired genotypes in plant breeding programs,especially across various growing *** methods offer exclusive benefits and can easily construe and minimize multicollinearity issues.

关键词： Cotton MTsI MGIDI Genotype environment interaction Early maturity Multi-trait Multi-environment

Progress in metal oxide-based electrocatalysts for sustainable water splitting

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Materials Reports(Energy) 2024年第3期4卷 19-34页

作者： Aasiya s.Jamadar Rohit sutar susmita patil Reshma Khandekar Jyotiprakash B.Yadav Vacuum Techniques and Thin Film Laboratory USICShivaji UniversityKolhapur416004MaharashtraIndia

Metal oxide-based electrocatalysts are promising alternatives to platinum group metals for water splitting due to their low cost,abundant raw materials,and impressive *** review covers recent progress in various metal oxides tailored for hydrogen and oxygen evolution reactions,discussing their crystal structure,composition,and surface modification influence on *** like surface engineering,doping,and nanostructuring are evaluated for enhancing catalytic activity and *** key considerations for commercialization are highlighted,emphasizing ongoing research,innovation,and future scope to drive widespread adoption of water-splitting technology for a cleaner and sustainable future.

关键词： Metal oxide HER OER Electrocatalyst Overall water spilling

Improved region growing segmentation for breast cancer detection:progression of optimized fuzzy classifier

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International Journal of Intelligent Computing and Cybernetics 2020年第2期13卷 181-205页

作者： Rajeshwari s.patil Nagashettappa Biradar Department of Electronics and Communication BLDEA’s V P Dr PG Halakatti College of Engineering and TechnologyBijapurIndia Department of Electronics and Communication Bheemanna Khandre Institute of TechnologyBidarIndia

Purpose-Breast cancer is one of the most common malignant tumors in women,which badly have an effect on women’s physical and psychological health and even danger to ***,mammography is considered as a fundamental criterion for medical practitioners to recognize breast ***,due to the intricate formation of mammogram images,it is reasonably hard for practitioners to spot breast cancer ***/methodology/approach-Breast cancer is one of the most common malignant tumors in women,which badly have an effect on women’s physical and psychological health and even danger to ***,mammography is considered as a fundamental criterion for medical practitioners to recognize breast ***,due to the intricate formation of mammogram images,it is reasonably hard for practitioners to spot breast cancer ***-The performance analysis was done for both segmentation and *** the analysis,the accuracy of the proposed IAP-CsA-based fuzzy was 41.9%improved than the fuzzy classifier,2.80%improved than PsO,WOA,and CsA,and 2.32%improved than GWO-based fuzzy ***,the accuracy of the developed IAP-CsA-fuzzy was 9.54%better than NN,35.8%better than sVM,and 41.9%better than the existing fuzzy ***,it is concluded that the implemented breast cancer detection model was efficient in determining the normal,benign and malignant ***/value-This paper adopts the latest Improved Awareness Probability-based Crow search Algorithm(IAP-CsA)-based Region growing and fuzzy classifier for enhancing the breast cancer detection of mammogram images,and this is the first work that utilizes this method.

关键词： Mammogram Breast cancer detection Optimized region growing Membership optimized-fuzzy classifier Improved crow search algorithm

Health Monitoring of Milling Tool Inserts Using CNN Architectures Trained by Vibration spectrograms

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Computer Modeling in Engineering & sciences 2023年第7期136卷 177-199页

作者： sonali s.patil sujit s.Pardeshi Abhishek D.Patange Department of Mechanical Engineering College of Engineering PunePune411005India

In-process damage to a cutting tool degrades the surface􀀀nish of the job shaped by machining and causes a signi􀀀cant􀀀nancial *** stimulates the need for Tool Condition Monitoring(TCM)to assist detection of failure before it extends to the worse *** Learning(ML)based TCM has been extensively explored in the last ***,most of the research is now directed toward Deep Learning(DL).The“Deep”formulation,hierarchical compositionality,distributed representation and end-to-end learning of Neural Nets need to be explored to create a generalized TCM framework to perform eciently in a high-noise environment of cross-domain *** this motivation,the design of dierent CNN(Convolutional Neural Network)architectures such as AlexNet,ResNet-50,LeNet-5,and VGG-16 is presented in this ***-time spindle vibrations corresponding to healthy and various faulty con􀀀gurations of milling cutter were *** data was transformed into the time-frequency domain and further processed by proposed architectures in graphical form,i.e.,*** model is trained,tested,and validated considering dierent datasets and showcased promising results.

关键词： Milling tool inserts health monitoring vibration spectrograms deep learning convolutional neural network

Comparative Analysis of Execution of CNN-Based sanguine Data Transmission with LsB-ss and PVD-ss

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Computer systems science & Engineering 2023年第8期46卷 1707-1721页

作者： Alaknanda s.patil G.sundari Arun Kumar sivaraman Department of Electronics and Communication Sathyabama Institute of Science and TechnologyChennaiTamil Nadu600119India school of Computer science and Engineering Vellore Institute of TechnologyChennai600127India

The intact data transmission to the authentic user is becoming crucial at every moment in the current ***;is a technique for concealing the hidden message in any cover media such as image,video;and audio to increase the protection of *** resilience and imperceptibility are improved by choosing an appropriate embedding *** paper gives a novel system to immerse the secret information in different videos with different *** audio and video steganography with novel amalgamations are implemented to immerse the confidential auditory information and the authentic user’s face image.A hidden message is first included in the audio from the multimedia file;using LsB *** stego-video is created in the second stage by merging the authorized user’s face into the frame of the video;by using PVD ***-audio is linked again with the stego-video in the third *** incorporated perspective techniques(LsB-ss and PVD-ss algorithms)with more significant data immersing capacity,good robustness and imperceptibility are proposed in this research *** spread spectrum approach is used to increase the complexity of secret data *** different video files are tested with different voice files with the results such as PsNR,ssIM,RMsE and MsE as 52.3,0.9963,0.0024 and 0.0000059,respectively.

关键词： Audio steganography data hiding information security pixel value differencing

Nonmetric Traits in Permanent Teeth as Clues to Ethnicity in Vidarbha subpopulation to Aid Forensic Profiling:Pilot study

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Journal of Forensic science and Medicine 2024年第1期10卷 11-19页

作者： Vaishali Amarlal sadhwani Nilima Prakash GLPradeep Rekha patil shubhechha Anand Khivsara sabiha Mokashi Khan MGV’s KBH Dental College NashikMaharashtraIndia Oral Cancer screening and Awareness in Cancer screening Vertical Indian Cancer SocietyMumbaiMaharashtraIndia

Introduction:Nonmetric dental traits have a crucial role in ethnic classification of populations that help in forensic racial *** studies have demonstrated the differences in the expression and frequency of dental traits between various ethnic groups for ancestry determination in the context of forensic dental *** present study is an attempt to assess the frequency and variation in nonmetric traits for establishing ethnicity in the Vidarbha ***:The aim of the study was to assess the frequency and variation of nonmetric traits in permanent teeth for establishing ethnicity in the Vidarbha *** and Methods:Participants of the Vidarbha subpopulation were selected by random sampling ***,premolars,and incisors were evaluated for frequency of nonmetric traits,and variations were graded according to Dentoanthropological system of state University of Arizona *** statistics,Chi-square test,and student’s t-test were used for analysis of ***:The most common occlusal morphology in mandibular first and second molar was 5 cusp and 4 cusp,respectively,with the“+”groove *** 3 and cusp 4 were observed frequently in the maxillary *** lingual cusp was most commonly seen in mandibular premolars show while incisors showed faint ***:Our study concludes that nonmetric traits were present and showed variation in permanent maxillary and mandibular teeth among the Vidarbha *** 5 and Cusp 4 in first and second mandibular molars,respectively,groove pattern“+”and grade 1 protostylid were the most frequent grades observed in permanent mandibular *** lingual cusp was most commonly seen in mandibular premolars and faint shoveling was a notable feature in incisors of this population.

关键词： Cusp number ethnicity forensic anthropology molar protostylid

CsF mediated rapid condensation of 1,3-cyclohexadione with aromatic aldehydes:Comparative study of conventional heating *** temperature

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Chinese Chemical Letters 2011年第7期22卷 777-780页

作者： Kamalakar P.Nandre Vijay s.patil sidhanath V.Bhosale Department of Organic Chemistry North Maharashtra UniversityJalgaon 425 001India

A mild, efficient and high yielding protocol for the synthesis of 2,2＇-arylmethelene dicyclohexane- 1,3-dione derivatives at room temperature and 9-aryl-1,8-dihydrooctahydroxanthene at conventional heating using cesium fluoride as a catalyst is reported. The major advantages of this reaction are excellent yield, very short reaction time and use of inexpensive catalyst.

关键词： Aromatic aldehydes 1,3-Cyclohexadione Cesium fluoride