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Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy

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Cellular & Molecular Immunology 2020年第3期17卷 227-236页

作者： Dongli Cai Jiaming Li Dingfeng Liu Shanjuan Hong Qin Qiao Qinli Sun Pingping Li nanan lyu Tiantian Sun Shan Xie Li Guo Ling Ni Liping Jin Chen Dong Obstetrics&Gynecology Hospital Fudan UniversityShanghai 200011China Institute for Immunology and School of Medicine Tsinghua UniversityBeijing 100084China Suzhou Kanova Biopharmaceutical Co. LtdSuzhou 215000China Clinical and Translational Research Center Shanghai First Maternity and Infant HospitalTongji University School of MedicineShanghai 201204China Department of Gynecologic Oncology Beijing Obstetrics and Gynecology HospitalCapital Medical UniversityBeijingChina Beijing Key Lab for Immunological Research on Chronic Diseases Beijing 100084China

Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers,the majority of patients with solid tumors do not respond well,but the underlying reason remains ***,we studied ovarian cancer(OvCa),a tumor type generally resistant to current immunotherapies,to investigate PD-1-independent *** found that PD-L1 was not highly expressed in the tumor microenvironment(TME)of human ***,B7-H3,another checkpoint molecule,was highly expressed by both tumor cells and tumor-infiltrating antigen-presenting cells(APCs),which correlated with T-cell exhaustion in *** ID8 OvCa mouse models,we found that B7-H3 expressed on tumor cells,but not host cells,had a dominant role in suppressing antitumor ***,B7-H3 blockade,but not PD-1 blockade,prolonged the survival of ID8 tumorbearing ***,our results demonstrate that tumor-expressed B7-H3 inhibits the function of CD8^(+)T cells and suggest that B7-H3 may be a target in patients who are not responsive to PD-L1/PD-1 inhibition,particularly OvCa patients.

关键词： Antitumor immunity Immune checkpoint B7-H3 T-cell exhaustion Ovarian cancer

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从肝脾论治小儿咳嗽的研究进展

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医学综述 2025年第1期31卷 113-117页

作者：梁潇予郝南南张学青新疆医科大学第四临床医学院乌鲁木齐830000

小儿咳嗽是一种以咳嗽、咳痰为主要临床表现的儿科常见病,近年其发病率显著升高,严重影响儿童的健康成长。中医理论认为小儿脏腑娇嫩,形气未充,其中“肝常有余,肺常不足”的生理特点尤为显著。肝火旺盛、脾气亏虚,则肺魄不宁,因此,在小... 详细信息

小儿咳嗽是一种以咳嗽、咳痰为主要临床表现的儿科常见病,近年其发病率显著升高,严重影响儿童的健康成长。中医理论认为小儿脏腑娇嫩,形气未充,其中“肝常有余,肺常不足”的生理特点尤为显著。肝火旺盛、脾气亏虚,则肺魄不宁,因此,在小儿咳嗽治疗中协调肝、脾、肺三脏气机尤为重要。中医治疗小儿咳嗽注重整体观念,从肝脾论治目前已取得良好疗效。未来,深入研究从肝脾论治小儿咳嗽的干预策略,可以为疾病的治疗提供新思路。

关键词：咳嗽小儿肝旺脾虚经方经验方

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A brief review of equatorial ionization anomaly and ionospheric irregularities

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Earth and Planetary Physics 2018年第4期2卷 257-275页

作者： nanan Balan LiBo Liu HuiJun Le Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences Institutions of Earth Science Chinese Academy of Sciences College of Earth and Planetary Sciences University of the Chinese Academy of Sciences

Following a brief history and progress of ionospheric research, this paper presents a brief review of the recent developments in the understanding of two major phenomena in low and mid latitude ionosphere—the equatorial ionization anomaly(EIA) and involved equatorial plasma fountain(EPF) and ionospheric irregularities. Unlike the easy-to-understand misinterpretations, the EPF involves field perpendicular E×B plasma drift and field-aligned plasma diffusion acting together and plasma flowing in the direction of the resultant at all points along the field lines at all altitudes. The EIA is formed mainly from the removal of plasma from around the equator by the upward E×B drift creating the trough and consequently the crests with small accumulation of plasma at the crests when the crests are within ~±20° magnetic latitudes and no accumulation when they are beyond ~±25° magnetic latitudes. The strong EIA under magnetically active conditions arises from the simultaneous impulsive action of eastward prompt penetration electric field and equatorward neutral wind. Intense ionospheric irregularities develop in the post-sunset bottom-side equatorial ionosphere when it rises to high altitudes, and evolve nonlinearly into the topside. Pre-reversal enhancement(PRE) of the vertical upward E×B drift and its fluctuations amplified during PRE provide the driving force and seed, with neutral wind and gravity waves being the primary sources. At low solar activity especially in summer when fast varying PRE is absent, the slow varying gravity waves including large scale waves(LSW)seem to act as both driver and seed for weak irregularities. At mid latitudes, the irregularities are weak and associated with medium scale traveling ionospheric disturbances(MSTIDs). A low latitude minimum in the occurrence of the irregularities at March equinox predicted by theoretical models is identified. The minimum occurs on the poleward side of the EIA crest and shifts equatorward from ~25° magnetic latit

关键词： equatorial ionization anomaly ionospheric irregularities

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Thermohydraulics of Turbulent Flow Through Heat Exchanger Tubes Fitted with Circular-rings and Twisted Tapes

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Chinese Journal of Chemical Engineering 2013年第6期21卷 585-593页

作者： Smith Eiamsa-ard Vichan Kongkaitpaiboon Kwanchai nanan Department of Mechanical Engineering Faculty of Engineering Mahanakom University of Technology Bangkok10530 Thailand

The influences of circular-ring turbulators （CRT） and twisted tape （TT） swirl generators on the heat transfer enhancement, pressure drop and thermal performance factor characteristics in a round tube are reported. The circular-ring turbulators were individually employed and together with the twisted tape swirl generators in the heated section of the tube. Three different pitch ratios （I/D = 1.0, 1.5, and 2.0） of the CRT and three different twist ratios （y/W= 3, 4, and 5） of the TT were introduced. The experiments were conducted using air as the working fluid under a uniform wall heat flux condition, for the Reynolds number between 6000 and 20000. The experimental results reveal that the heat transfer rate, friction factor and thermal performance factor of the combined CRT and qT are considerably higher than those of CRT alone. For the range examined, the Sncreases of mean Nusselt number, friction factor and thermal performance, in the tube equipped with combined devices, respectively, are 25.8%, 82.8% and 6.3% over those in the tube with the CRT alone. The highest thermal performance factor of 1.42 is found for the combined device consisting of the CRT with l/D = 1.0 and TT with y/W= 3. The correlations of the Nusselt number, friction factor and thermal performance factor of the tubes with combined devices are also developed in terms of Reynolds number, Prandtl number, twist ratio and pitch ratio.

关键词： heat transfer enhancement circular-ring twisted tape swirl generator turbulator heat exchanger

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Formation mechanisms and resource potential of carbonate geothermal reservoirs in the Beijing-Tianjin-Hebei plain

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Energy Geoscience 2024年第3期5卷 175-188页

作者： Xinwei Wang Tinghao Wang nanan Gao Xiang Mao Lu Luo Xingchen Lu Haiquan Li New Energy Research Institute Sinopec Star Petroleum Co.Ltd.Beijing100083China School of Energy Resources China University of Geosciences(Beijing)Beijing100083China

Investigating the formation mechanisms of carbonate geothermal reservoirs is of theoretical and practical significance for summarizing the formation pattern of geothermal resources and further guiding their effective *** Beijing-Tianjin-Hebei Plain(BTHP),predominantly located within the Jizhong Depression and Cangxian Uplift in the Bohai Bay Basin,serves as the primary region for geothermal exploitation and utilization in *** than 1500 geothermal wells have been drilled therein,with water temperature at the wellhead ranging from 55 to 110°C,single-well flow rate ranging between 80 and 120 m^(3)/h,and cumulative heating area exceeding 100×10^(6)m^(3).However,the exploration and research in the region remain limited *** per the previous geothermal and petroleum exploration results and the latest geothermal drilling data,this study comprehensively evaluated the geothermal resources of karst geothermal *** results show that two suites of carbonate karst reservoirs,namely the Jxw Formation and the Ordovician strata,have primarily developed in the BTHP,and their formation and evolution can be divided into four stages:the Mesoproterozoic-Early Paleozoic stage with carbonate sedimentation and the development of interlayer karst,the Late Paleozoic stage with the development of direct sedimentary cover,the Mesozoic stage with compressional uplifting and development of buried hill karst,and the Cenozoic stage with regional cover deposition and the modification and finalization of karst geothermal ***,the porosity evolution history of the geothermal reservoirs is composed of three stages,namely a significant decrease followed by a minor increase,a gradual decline,and then a small fluctuation from increase to decrease before slowly rising *** karstification in geothermal reservoirs can be summarized into quasi-syngenetic karstification,epigenetic karstification,and burial karstification,which can be subdivided into s

关键词： Carbonate geothermal reservoir Formation mechanism Karstification type Resource assessment Beijing-Tianjin-Hebei plain(BTHP)

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Manifestations of Abuse of Women in Childbirth in Public Hospitals in Ivory Coast: Case of Hospital Center Regional from Divo

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Open Journal of Emergency Medicine 2022年第4期10卷 194-209页

作者： nanan Doh N’guessan Gerard Abidjan C&#244 te d’Ivoire

The aim of this study is to describe the manifestations of abuse of women in childbirth. The techniques and tools for collecting data are documentary research, observation, questionnaire and interview. The study was based on a sample of 72 people determined according to the method of reasoned choice. As for data analysis, the method of processing is qualitative and quantitative. In terms of results, it should be noted that the average age of women in childbirth is 23 and those aged 16 - 24 represent the largest segment of the survey population. Most of these women are illiterate or drop out very early. They belong to several religious communities and are of various nationalities. Regarding the manifestations of mistreatment, we retain that they are of several types the most significant of which are verbal abuse, physical abuse, neglect and psychological abuse. These abuses have taken place for some women at their first or last delivery, at all their deliveries or at a single delivery. In general, young women between the ages of 16 and 25 are the most victims of mistreatment in childbirth. Various authors are at the origin of the mistreatment of women in childbirth. They are young midwives often single and childless.

关键词： Abuse Woman in Childbirth Midwife Manifestations Divo Ivory Coast

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数码饕餮

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中国西部科技 2004年第3期3卷 73-74页

作者： nanan

数码饕餮 HS73P Clear Bright LCD Sony出品的HS73P Clear Bright LCD是HS系列的升级之作.在外形上既有跳跃感、又轻盈洒脱的动感造型.以及高光泽的金属银色质感表面.风格上典雅灵动.达到与生活空间的完美融合。带有硅涂层的液晶面板.... 详细信息

数码饕餮 HS73P Clear Bright LCD Sony出品的HS73P Clear Bright LCD是HS系列的升级之作.在外形上既有跳跃感、又轻盈洒脱的动感造型.以及高光泽的金属银色质感表面.风格上典雅灵动.达到与生活空间的完美融合。带有硅涂层的液晶面板.可以提供颜色对比方面更大的动态范围.从而将亮度提升了进22％.即使在明亮的房间.它也能具有高达400 c d/m2的亮度.这在市场上的17’液晶显示器中极为罕见.这样的技术指标意味着HS73P不仅可以应用于图像显示.

关键词：颜色对比图像显示液晶显示器跳跃感动态范围硅涂层 Bright 技术指标运算速度卡西欧

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Human Skeleton Detection, Modeling and Gesture Imitation Learning for a Social Purpose

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Engineering（科研） 2020年第2期12卷 90-98页

作者： Linda nanan Vallée Sao Mai Nguyen Christophe Lohr Ioannis Kanellos Olivier Asseu Ecole Supérieure Africaine des TIC LASTIC Abidjan Cte d’Ivoire Institut Mines Telecom Atlantique de Bretagne Lab-STICC Brest France.

Gesture recognition is topical in computer science and aims at interpreting human gestures via mathematical algorithms. Among the numerous applications are physical rehabilitation and imitation games. In this work, we suggest performing human gesture recognition within the context of a serious imitation game, which would aim at improving social interactions with teenagers with autism spectrum disorders. We use an artificial intelligence algorithm to detect the skeleton of the participant, then model the human pose space and describe an imitation learning method using a Gaussian Mixture Model in the Riemannian manifold.

关键词： Imitation Learning Artificial Intelligence Gesture Recognition Autism Spectrum Disorders (ASD) Gaussian Mixture Model (GMM)

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A New Perspective on Time and Gravity

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 346-362页

作者： Ittipat Roopkom Wirote Jongchanachavawat Chermdhong Prattanaruk Kwanchai nanan Pichet Wisartpong Thawatchai Mayteevarunyoo Paramote Wardkein Faculty of Engineering and Industrial Technology Phetchaburi Rajabhat University Phetchaburi Thailand School of Electrical and Electronic Engineering Mahanakorn University of Technology Bangkok Thailand Department of Electrical and Computer Engineering Faculty of Engineering Naresuan University Phitsanulok Thailand Department of Telecommunications Engineering School of Engineering King Mongkut’s Institute of Technology Ladkrabang Bangkok Thailand

This paper presents a hypothesis regarding the existence of time fused in spacetime, assuming that time possesses the properties of both a particle and a field. This duality is referred to as the field-particle of time (FPT). The analysis shows that when the FPT moves through matter, it causes time dilation. The FPT is also a significant element that appears in relativistic kinetic energy (KE = (γ - 1) · mc2). Accelerating matter to near the speed of light requires relativistic energy approaching infinity, which corresponds to the relativistic kinetic energy. Meanwhile, the potential energy (PE = mc2) from the rest mass remains constant. Then, the mass-energy equation can be rearranged in terms of PE and KE, as shown in E = (1 + (γ - 1)) · mc2. The relativistic energy of the FPT also directly affects the gravitational attraction of matter. It transfers energy to each other through spacetime. The analysis demonstrates that the gravitational force is inversely proportional to the distance squared, following Newton’s law of gravity, and it varies with the relative velocity of matter. The relationship equation between relative time and the gravitational constant indicates that a higher intensity of the gravitational field leads to a slower reference time for matter, in accordance with the general theory of relativity. A thought experiment presents a comparison of two atomic clocks placed in different locations. The first one is placed in a room temperature, around 25°C, on the surface of the Earth, and the second one is placed in high-density areas. The analysis, considering the presence of the FPT, shows that the reference time slows down in high-density areas. Therefore, the second clock must be noticeably slower than the first one, indicating the existence of the FPT passing through both atomic clocks at different speeds.

关键词： Field-Particle of Time (FPT) Reference Time Relativistic Mass and Energy of FPT Gravity

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Formation of polar ionospheric tongue of ionization during minor geomagnetic disturbed conditions

Formation of polar ionospheric tongue of ionization during m...

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中国科学院地质与地球物理研究所2015年度（第15届）学术年会

作者： Jing Liu Takuji Nakamura Libo Liu Wenbin Wang nanan Balan Takanori Nishiyama Marc R.Hairston E.G.Thomas Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of Sciences High Altitude Observatory National Center for Atmospheric Research National Institute of Polar Research Center for Space Sciences University of Texas at Dallas Bradley Department of Electrical and Computer Engineering Virginia Tech

Previous investigations of ionospheric storm-enhanced density(SED) and tongue of ionization(TOI)focused mostly on the behavior of TOI during intense geomagnetic *** attention has been paid to the spatial and temporal variations of TOI during weak to moderate geomagnetic disturbed *** this paper we investigate the source and development of TOI during a moderate geomagnetic storm on 14 October ***-instrumental observations including GPS total electron content(TEC),Defense Meteorological Satellite Program(DMSP) in situ measured total ion concentration and ion drift velocity,Super DARN measured polar ion convection patterns,and electron density profiles from the Poker Flat Incoherent Scatter Radar(PFISR) have been utilized in the current *** TEC maps show salient TOI structures persisting for about 5 h over high latitudes of North America on 14 October 2012 in the later recovery phase of the storm when the magnitudes of IMF By and Bz were less than 5 n *** PFISR electron density profiles indicate that the extra ionization for TEC enhancements mainly occurred in the topside ionosphere with no obvious changes in the bottomside ionosphere and vertical plasma ***,there were no signatures of penetration electric fields in the equatorial electrojet data and upward ion drifts at high *** the same time,strong subauroral polarization streams with ion drift speeds exceeding 2.5 km/s carried sunward fluxes and migrated toward lower latitudes for about 5° based on the DMSP cross-track drift *** on those measurements,we postulate that the combined effects of initial build-up of ionization at midlatitudes through daytime production of ionization and equatorward(or less poleward than normal daytime) neutral wind reducing downward diffusion along the inclined filed lines,and an expanded polar ion convection pattern and its associated horizontal plasma transport are important in the formation of the TOI.

关键词： Appearance of SED/TOI structures in the geomagnetic storm late recovery phase UT dependency of the SED/TOI strength TEC enhancements mainly occurred in the topside ionosphere

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