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IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells

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Cellular & Molecular Immunology 2019年第7期16卷 644-651页

作者： ning Liu Yuxue Jiang Jintong Chen He nan yinghua Zhao Xiao Chu Alison Wang Dongjiao Wang Tianxue Qin Sujun Gao ying Yue Siqing Wang Department of Gynecological Oncology The First Hospital of Jilin UniversityChangchun 130061China Department of Cancer Immunology The First Hospital of Jilin UniversityChangchun 130061China Department of Rheumatology and Immunology China-Japan Union Hospital of Jilin UniversityChangchun 130033China Department of Hematology The First Hospital of Jilin UniversityChangchun 130061China and 5 Department of Cancer BiologyLerner Research InstituteCleveland ClinicClevelandOH 44195USA

Dendritic cell(DC)tumor vaccines exert their antitumor effects through the induction of effector T *** recently identified Tc9 cells as a new potent antitumor effector T cell ***,approaches to direct DCs to preferably prime antitumor Tc9 cells should be further ***,we demonstrate that the addition of interleukin(IL)-33 potently promotes the induction of Tc9 cells by DCs in vitro and in ***-33 treatment also drives the cytotoxic activities of DC-induced Tc9 ***,IL-33 treatment enhances cell survival and proliferation of DC-primed CD8+T *** importantly,the addition of IL-33 during in vitro priming of tumor-specific Tc9 cells by DCs increases the antitumor capability of Tc9 *** studies demonstrated that IL-33 treatment inhibits exhaustive CD8+T cell differentiation by inhibiting PD-1 and 2B4 expression and increasing IL-2 and CD127(IL-7 receptor-α,IL-7Rα)expression in CD8+T ***,the addition of IL-33 further promotes the therapeutic efficacy of DC-based tumor vaccines in the OT-I mouse *** study demonstrates the important role of IL-33 in DC-induced Tc9 cell differentiation and antitumor immunity and may have important clinical implications.

关键词： Interleukin-33 Dendritic cells Tc9 Cancer immunology

Non-equilibrium alloy phase formation and transformation driven by ion beam mixing in the Fe-Hf-Nb multilayers

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Science China(Technological Sciences) 2012年第3期55卷 640-645页

作者： LI nan WANG TongLe DING ning DAI Ye BAI Xue LIU BaiXin Advanced Materials Laboratory Department of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

In the ion beam mixing experiments,eight Fe-Hf-Nb multilayered films,with overall compositions of Fe67Hf22Nb11,Fe67Hf11Nb22,Fe54Hf38Nb8,Fe54Hf30Nb16,Fe54Hf11Nb35,Fe25Hf67Nb8,Fe25Hf50Nb25 and Fe25Hf11Nb64,were irradiated by 200 keV xenon ions to doses ranging from 3×1014 Xe+/cm2 to 7×1015 Xe+/*** results showed that unique amorphous phases were obtained at designed alloy compositions,falling in the favored glass-forming region deduced from three binary metal ***,at some alloy compositions,the crystal-amorphous-crystal transformations were observed back and forth while varying the irradiation *** addition,at the alloy composition of Fe25Hf67Nb8,a metastable FCC phase was formed through an HCP-FCC structural phase transformation and it had a large lattice constant identified to be a=4.51 .Besides,the formation mechanism of non-equilibrium alloy phases was also discussed in terms of thermodynamics of solids and atomic collision theory.

关键词： phase transformation ion beam mixing amorphous phase Fe-Hf-Nb system shearing mechanism

A multi-functional binder for high loading sulfur cathode

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Journal of Energy Chemistry 2020年第7期29卷 99-104,I0004页

作者： ying Chu ning Chen Ximing Cui Anmin Liu Liang Zhen Qinmin Pan School of Chemistry and Chemical Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001HeilongjiangChina State Key Laboratory of Fine Chemicals School of Petroleum and Chemical EngineeringDalian University of TechnologyPanjin 124221LiaoningChina

Lithium sulfur(Li-S)batteries are the promising power sources,but their commercialization is significantly impeded by poor energy-storage functions at high sulfur *** we report that such an issue can be effectively addressed by using a mussel-inspired binder comprised of chitosan grafted with catecholic moiety for sulfur *** resulting sulfur cathodes possess a high loading up to 12.2 mg cm-2 but also exhibit one of the best electrochemical properties among their *** excellent performances are attributed to the strong adhesion of the binder to sulfur particles,conducting agent,current collector,and *** versatile adhesion effectively increases the sulfur loading,depresses the shuttle effect,and alleviates mechanical pulverization during cycling *** present investigation offers a new insight into high performance sulfur cathodes through a bio-adhesion viewpoint.

关键词： Li-S batteries Sulfur cathode Mussel-inspired binder Bio-adhesion High loading High performance

NUMERICAL SIMULATION OF GAS TURBULENCE ENHANCEMENT BY PARTICLE-WAKE EFFECT

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Journal of Hydrodynamics 2007年第2期19卷 155-159页

作者： ZENG Zhuo-zhi ZENG Zhuo-xiong nan ying HAN Shou-lei Aeronautic and Mechanical Engineering college Nanchang University of Aeronautics Nanchang 330063 China

A new turbulence enhancement model was incorporated into the second-order moment two-phase turbulence model and was used to simulate gas-particle flows in swirling chambers and channels with different wall roughness. The results show that compared with the turbulence modification model not accounting for the wake effect, this model, together with the conventional particle source term, gives simulation results in better agreement with the experimental data.

关键词： gas-particle flows turbulencemodification numerical simulation

Dynamically reconfigurable topological edge state in phase change photonic crystals

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Science Bulletin 2019年第12期64卷 814-822页

作者： Tun Cao Linhan Fang ying Cao nan Li Zhiyou Fan Zhiguo Tao School of Optoelectronic Engineering and Instrumentation Science Dalian University of TechnologyDalian 116024China China North Vehicle Research Institute Beijing 100072China

The observation of topological edge states(TESs) revolutionized our understanding of scattering and propagation of electromagnetic(EM) waves. Supported by topological robustness, the TES at the interface between trivial and non-trivial insulators was not reflected from the structural disorders and imperfections. Recently topological photonic crystals(PhCs) were demonstrated to obtain remarkable one-way propagation of the TES, having the advantages of lossless propagation, dense integration, and high fabrication tolerance over conventional PhCs. Nevertheless, the lack of reversible switching of TES possesses significant limitations in helicity/spin filtering and tunable photonic devices. We proposed a topological PhC based on a prototypical phase-change material, Ge2 Sb2 Te5(GST225) to solve the problem. We find that at a particular frequency, the TES within the structure can be reversibly switched between "on"and "off" by transiting the GST225 structural state between amorphous and crystalline. Moreover, the topology of the PhC was maintained since the tuning of TES was achieved by varying the refractive index of GST225 instead of the structural geometry. This provides a continuous change of the spectral position of the photonic bandgap and TES by gradually crystallising the GST225. We show that the phase change of GST225 from amorphous to crystalline and vice versa can be engineered in nanoseconds. Our proof of concept may offer a platform for dynamically tuning the TESs that might otherwise be challenging to attain in photonic systems. We expect it to have potential applications for photonic devices in topological optical circuits and scatter-free one-way light propagation.

关键词： Phase change materials Photonic crystals Topological edge states Tunability Reconfigurability

Simultaneous denoising and resolution enhancement of seismic data based on elastic convolution dictionary learning

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Petroleum Science 2023年第4期20卷 2127-2140页

作者： nan-ying Lan Fan-Chang Zhang Kai-Heng Sang Xing-Yao Yin School of Geosciences China University of Petroleum(East China)QingdaoShandong266580China

Enhancing seismic resolution is a key component in seismic data processing, which plays a valuable role in raising the prospecting accuracy of oil reservoirs. However, in noisy situations, existing resolution enhancement methods are difficult to yield satisfactory processing outcomes for reservoir characterization. To solve this problem, we develop a new approach for simultaneous denoising and resolution enhancement of seismic data based on convolution dictionary learning. First, an elastic convolution dictionary learning algorithm is presented to efficiently learn a convolution dictionary with stronger representation capability from the noisy data to be processed. Specifically, the algorithm introduces the elastic L1/2 norm as a sparsity constraint and employs a steepest gradient descent strategy to efficiently solve the frequency-domain linear system with substantial computational cost in a half-quadratic splitting framework. Then, based on the learned convolution dictionary, a weighted convolutional sparse representation paradigm is designed to encode the noisy data to acquire an optimal sparse approximation of the effective signal. Subsequently, a high-resolution dictionary with a broadband spectrum is constructed by the proposed parameter scaling strategy and matched filtering technique on the basis of atomic spectrum modeling. Finally, the optimal sparse approximation of the effective signal and the constructed high-resolution dictionary are used for data reconstruction to obtain the seismic signal with high resolution and high signal-to-noise ratio. Synthetic and field dataset examples are executed to check the effectiveness and reliability of the developed method. The results indicate that this method has a more competitive performance in seismic applications compared with the conventional deconvolution and spectral whitening methods.

关键词： Simultaneous denoising and resolution enhancement Elastic convolution dictionary learning Weighted convolutional sparse representation Matched filtering

Compute extremely low-frequency electromagnetic field exposure by 3-D impendance method

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The Journal of China Universities of Posts and Telecommunications 2007年第3期14卷 113-116页

作者： HAN Yu-nan LV ying-hua ZHANG Hong-xin Beijing University of Posts and Telecommunications Beijing 100876 ChinaAerospace Science and Technology Group Beijng 100076 China

A 3-D impedance method has been introduced to compute the electric currents induced in a human body exposed to extremely low-frequency electromagnetic field. The 3-D impedance method has been deduced from Maxwell equations and is put into the computation and simulation effectively to the visible human body model, which has 196×114×626 cells and more than 40 types of tissues. As the result, two representative cases are investigated. One is exposure of the human body to 100 μT （1 000 mG）, the limit recommended by the International Commission on Non-Ionizing Radiation Protection for the public and the other one is the exposure of human body to 0.4 laT （4 mG）, the level at which a statistical link appears with a doubled risk of development of childhood leukaemia. The distribution of induced current density can be obtained and the maximum of induced current are found to be 16 mA/m^2 and 0.07 mA/m^2.

关键词： 3-D impedance method induced current magnetic flux density visible human body model extremely low frequency (ELF)

Hemophagocytic lymphohistiocytosis caused by STAT1 gain-offunction mutation is not driven by interferon-γ:A case report

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World Journal of Clinical Cases 2020年第23期8卷 6130-6135页

作者： nan Liu Fen-ying Zhao Xiao-Jun Xu Department of Hematology-oncology Children’s HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a life-threatening hyperinflammatory syndrome caused by many genetic ***1 is a DNAbinding factor that regulates gene *** caused by STAT1 gain-offunction(GOF)mutations has rarely been reported and its clinical manifestations and mechanisms are not clearly *** SUMMARY A 2-year-old boy presented to our hospital with recurrent fever for>20 *** patient had a personal history of persistent oral candidiasis and inoculation site infection during the past 2 *** was *** blood cell count showed severe anemia,thrombocytopenia and *** laboratory tests showed liver dysfunction,hypertriglyceridemia and decreased *** was found in the bone *** computed tomography showed a cavitary *** for fungal infection were *** T helper(Th)1/Th2 cytokine determination demonstrated moderately elevated levels of interleukin(IL)-6 and IL-10 with normal interferon(IFN)-γ*** bovis was identified in bronchoalveolar lavage fluid by polymerase chain *** testing identified a heterozygous mutation of c.1154C>T causing a T385M amino acid substitution in *** antibacterial and antifungal therapy,the febrile disease was not *** signs of HLH were relieved after HLH-94 protocol administration,except *** was not resolved until he received anti-tuberculosis *** stem cell transplantation was refused and the patient died six months later due to severe *** Patients with STAT1 GOF mutation have broad clinical manifestations and may develop *** form of HLH presents with normal IFN-γlevel without cytokine storm.

关键词： Hemophagocytic lymphohistiocytosis Signal transducer and activator of transcription 1 Gain-of-function Interferon gamma Mycobacterial disease Case report

Transcriptional mechanism of IRF8 and PU.1 governs microglial activation in neurodegenerative condition

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Protein & Cell 2019年第2期10卷 87-103页

作者： nan Zhou Kaili Liu Yue Sun ying Cao Jing Yang State Key Laboratory of Membrane Biology Peking UniversityBeijing 100871China IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Center for Life Sciences Peking UniversityBeijing 100871China School of Life Sciences Peking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China School of Medicine Tsinghua UniversityBeijing 100084China

Microglial activation occurs in divergent neuropathological *** microglial event has the key involvement in the progression of CNS ***,the transcriptional mechanism governing microglial activation remains poorly ***,we investigate the microglial response to traumatic injuryinduced neurodegeneration by the 3D fluorescence imaging *** show that transcription factors IRF8 and PU.1 are both indispensible for microglial activation,as their specific post-developmental deletion in microglia abolishes the ***,we reveal that IRF8 and PU.1 directly target the gene transcription of each other in a positive feedback to sustain their highly enhaneed expression during microglial ***,IRF8 and PU.1 dictate the microglial response by cooperatively acting through the composite IRF-ETS motifs that are specifically enriched on microglial activation-related *** action of cooperative transcription can be further verified bio chemically by the synergetic binding of IRF8 and PU.1 proteins to the composite-motif *** study has therefore elucidated the central transcriptional mechanism of microglial activation in response to neurodegenerative condition.

关键词： microglia 3D fluorescence imaging technique neurodegeneration IRF8 PU.1