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Productivity analysis of a fractured horizontal well in a shale gas reservoir based on discrete fracture network model

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Journal of Hydrodynamics 2019年第3期31卷 552-561页

作者： Yu-long Zhao nan-ying li lie-hui Zhang Rui-han Zhang State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum University Chengdu 610500 China Southwest Oil and Gas Branch SINOPEC Chengdu 610041 China

The treatment of horizontal wells with massive hydraulic fracturing technology is important for the economical development of shale gas reservoirs, but sometimes is complex because of the induced fractures during the fracturing process. The studies of the fluid flow characteristics in such formations are rare. In this study, a numerical method based on a finite element method (FEM) is developed for the productivity analysis of a horizontal well in a shale gas reservoir with complex fractures. The proposed method takes into account the adsorbed gas and the complex hydraulic fracture branches. To make the problem more tractable, the dimension of the fracture system is reduced from 2-D to 1-D based on the discrete fracture network (DFN) model. The accuracy of the new method is verified by comparing its results with those obtained by the Saphir commercial software. Finally, the productivity of the fractured horizontal wells in shale gas reservoirs with complex fractures systems is evaluated and analyzed. Results show that if a well is produced with a constant bottomhole pressure, the well productivity is much increased due to the existence of fracture branches that can increase the stimulated reservoir volume (SRV). In addition, the number of hydraulic fractures (Nf) and the fracture halMengths (Lf) have an important influence on the well's productivity. The larger the values of Nf,Lf,the greater the well productivity will be. The existence of adsorbed gas can markedly improve the well productivity, and the greater the Langmuir volume, the greater the productivity will be. The conclusions drawn by this study can provide a guidance for the development of unconventional shale gas reservoirs.

关键词： Fractured horizontal well discrete fracture network (DFN) model finite element method (FEM) productivity analysis shale gas reservoir

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The expression of PD-1 and level of CXCL10 in patients with systemic lupus erythematosus

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Journal of Microbiology and Immunology 2005年第3期3卷 182-186页

作者： ying nan li FENG SHAN ZHANG LU LU li HUI MIN YU ying KUN NIE Department of Rheumatology the Second Hospital Affiliated Harbin Medical University HarbinP. R. China

The aim of this study was to investigate the expression of PD-1 on peripheral blood mononuclear cells (PBMCs) and the serum level of CXCL10 and those of roles in the pathogenesis in SLE patients. The expression of PD-1 on PBMCs was tested by flow cytometry and the serum level of CXCL10 was determined by EliSA in 47 SLE patients and 21 healthy controls. The correlation between PD-1, CXCL10 and ANA, anti-dsDNA antibody and SLEDAI (SLE disease activity index) were evaluated. The expression of PD-1 on PBMCs in SLE patients was significantly different from that of controls. The percentage of PD-1 on neutrophiles in SLE patients was decreased compared with that of healthy controls (P<0.01), and that on lymphocyte from inactive SLE was significantly lower than that of controls (P<0.02). However, the PD-1 expression and the level of serum CXCL10 in active SLE were significantly increased (P<0.01) than those of controls. Positive correlations were found between PD-1, CXCL10 and anti-dsDNA antibody, SLEDAI in active SLE. The abnormal expression of PD-1 on PBMCs and serum level of CXCL10 in SLE patients may impair the auto-immunological tolerance, and play an important role in the pathogenesis of SLE.

关键词： Lupus erythematosus systemic PD-1 CXCL10

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Anthocyanins extracted from Chinese blueberry （Vaccinium uliginosum L.） and its anticancer effects on DLD-1 and COLO205 cells

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Chinese Medical Journal 2010年第19期123卷 2714-2719页

作者： ZU Xiao-yan ZHANG Zhen-ya ZHANG Xiao-wen YOSHIOKA Masahiro YANG ying-nan li Ji Graduate School of life and Environmental Sciences Tsukuba University Tsukuba 305-8572 Japan

Background Vaccinium uliginosum L. is a type of blueberry found in the Chinese Changbai Mountains. We extracted Vaccinium uliginosum Anthocyanins （***） to investigate its bioactivity on suppressing cancer cells. Methods *** was extracted under different conditions of temperature （10℃-35℃）, pH 1.0-3.0, and diatomaceous earth （1.0 g-3.0 g）, followed by a HPLC analysis for the determination of the ingredients. Its anticancer bioactivities on human colon and colorectal cancer cells （DLD-1 and COLO205） were compared with those on Lonicera caerulea Anthocyanins （***） and Vaccinium myrtillus Anthocyanins （***）, using cell viability assays, DNA electrophoresis and nuclear morphology assays. Results The optimum process of *** extraction involved conditions of temperature 20℃, pH 2.0, and diatomaceous earth 1.0 g/50 g of fruit weight. *** contained 5 main components： delphinidin （40.70±1.72）%, cyanidin （3.40±0.68）%, petunidin （17.70±0.54）%, peonidin （2.90±0.63）% and malvidin （35.50±1.11）%. The malvidin percentage was significantly higher （P 〈0.05） than it in ***. *** complied with a dose-dependent repression of cancer cell proliferation with an IC50 （50% inhibitory concentration） value of 50 μg/ml, and showed greater anticancer efficiency than AL. cae and Av. myr under the same cell treatment conditions. These observations were further supported by the results of nuclear assays. Conclusions The extraction protocol and conditions we used were effective for anthocyanin extraction. *** could be a feasible practical research tool and a promising therapeutic source to suppress human colon or colorectal cancers.

关键词： vaccinium uliginosum anthocyanin extraction cancer cell suppression

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang nan Mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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nanostructured ZnO/BiVO_(4)I-scheme heterojunctions for piezocatalytic degradation of organic dyes via harvesting ultrasonic vibration energy

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 488-497页

作者： Yiling li Xiaoyao Yu yingjie Zhou Yao lin ying Wu Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004China

BiVO_(4)porous spheres modified by ZnO were designed and synthesized using a facile two-step *** resulting ZnO/BiVO_(4)composite catalysts have shown remarkable efficiency as piezoelectric catalysts for degrading Rhodamine B(RhB)unde mechanical vibrations,they exhibit superior activity compared to pure *** 40wt%ZnO/BiVO_(4)heterojunction composite displayed the highest activity,along with good stability and *** enhanced piezoelectric catalytic activity can be attributed to the form ation of an I-scheme heterojunction structure,which can effectively inhibit the electron-hole ***,hole(h+)and superoxide radical(·O_(2)^(-))are proved to be the primary active ***,ZnO/BiVO_(4)stands as an efficient and stable piezoelectric catalyst with broad potential application in the field of environmental water pollution treatment.

关键词： piezoelectric catalytic heterojunction dye degradation ultrasonic vibration

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Normalized Solutions of Nonlinear Choquard Equations with Nonconstant Potential

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应用数学 2025年第1期38卷 14-29页

作者： li nan XU liping School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang 471000China

In this paper,we mainly focus on a type of nonlinear Choquard equations with nonconstant *** appropriate hypotheses on potential function and nonlinear terms,we prove that the above Choquard equation with prescribed 2... 详细信息

关键词： Nonlinear Choquard equation Potential function Variational method Normalized solution

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高速柴油机燃油系低速喷射特性的研究

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内燃机工程 1985年第4期6卷 59-70页

作者：郭英男李善祯吉林工业大学

本文分析了高速柴油机燃油系低速范围内针阀波形变化的特点和原因,提出了确定波动喷射边界和单波喷射区边界的计算方法,并进行了试验验证。

关键词：柴油机燃油系边界单波喷射特性阀升程柴油机喷嘴针阀低速

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Preparation of YBa_2Cu_3O_(7-δ) superconducting thick film on Ni-W tapes via electrophoretic deposition

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Transactions of Nonferrous Metals Society of China 2014年第1期24卷 120-125页

作者：罗清威李英楠李凤华樊占国东北大学材料与冶金学院沈阳110819

The preparation of La0.4Sr0.6TiO3 （LSTO） buffer layer and YBa2Cu3O7-δ（YBCO） superconducting thick film by a low cost technology was studied. The crystal orientation of LSTO and YBCO films was detected by X-ray diffraction, the conductivity of LSTO film and superconductivity of YBCO coating were investigated by standard four-probe method. Excellent in-plane alignment, smooth and dense LSTO buffer layer was successfully prepared on textured Ni-W taps by metal organic deposition （MOD）. YBCO thick film was fabricated by electrophoretic deposition （EPD）. The effects of applied voltage and deposition time on the YBCO coatings properties were studied. The results show that the critical current density of the YBCO coating deposited under 138 V for 35 min was about 600 A/cm2 （0 T, 77 K）.

关键词： YBCO conductive buffer layer YBCO superconducting thick film electrophoretic deposition

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Deciphering Water Oxidation Catalysts:The Dominant Role of Surface Chemistry over Reconstruction Degree in Activity Promotion

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nano-Micro Letters 2025年第3期17卷 340-354页

作者： li An Jianyi li Yuanmiao Sun Jiamin Zhu Justin Zhu Yeow Seow Hong Zhang nan Zhang Pinxian Xi * Zhichuan JXu Chun‑Hua Yan State Key Laboratory of Applied Organic Chemistry Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu ProvinceFrontiers Science Center for Rare IsotopesCollege of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000People’s Republic of China School of Materials Science and Engineering Nanyang Technological UniversitySingapore 639798Singapore Faculty of Materials Science and Energy Engineering Institute of Technology for Carbon NeutralityShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055People’s Republic of China Key Laboratory of Electromagnetic Materials and Devices National Center for International Research On Photoelectric and Energy MaterialsSchool of Materials and EnergyElectron Microscopy CenterYunnan UniversityKunming 650091People’s Republic of China State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030People’s Republic of China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsPKU‑HKU Joint Laboratory in Rare Earth Materials and Bioinorganic ChemistryPeking UniversityBeijing 100871People’s Republic of China

Water splitting hinges crucially on the availability of electrocatalysts for the oxygen evolution *** surface reconstruction has been widely observed in perovskite catalysts,and the reconstruction degree has been often correlated with the activity ***,a systematic study on the roles of Fe substitution in activation of perovskite LaNiO_(3)is *** substituting Fe content influences both current change tendency and surface reconstruction ***_(0.9)Fe_(0.1)O_(3)is found exhibiting a volcano-peak intrinsic activity in both pristine and reconstructed among all substituted perovskites in the LaNi_(1-x)Fe_(x)O_(3)(x=0.00,0.10,0.25,0.50,0.75,1.00)*** reconstructed LaNi_(0.9)Fe_(0.1)O_(3)shows a higher intrinsic activity than most reported NiFe-based ***,density functional theory calculations reveal that Fe substitution can lower the O 2p level,which thus stabilize lattice oxygen in LaNi0.9Fe0.1O3 and ensure its long-term ***,it is vital interesting that activity of the reconstructed catalysts relied more on the surface chemistry rather than the reconstruction *** effect of Fe on the degree of surface reconstruction of the perovskite is decoupled from that on its activity enhancement after surface *** finding showcases the importance to customize the surface chemistry of reconstructed catalysts for water oxidation.

关键词： Oxygen evolution reaction Perovskite oxides Doping Activation and reconstruction

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Improving lithographic masks with the assistance of indentations

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Chinese Physics B 2012年第5期21卷 577-582页

作者：郭英楠李旭峰潘石王乔王硕吴永宽 School of Physics and Optoelectronic Technology Dalian University of Technology School of Applied Science Taiyuan University of Science and Technology

Indentations etched on the output surface of a metallic mask are proposed to produce fine lithographic patterns with a resolution of 500 nm using the finite-difference time domain （FDTD） method. Such a designed mask is capable of enhancing near field lithography （NFL） resolution more than three times compared with the structure without indentations. The simulation results show that the interference disturbance between the adjacent lithographic channels can be eliminated efficiently by employing the indentations. As a straightforward consequence, the channel-to-channel interspaces can be shortened significantly, maintaining a uniform field distribution and high contrast.

关键词： surface plasmons lithography finite-difference time domain (FDTD) method

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