检索结果-南通市图书馆

Green Tea Polyphenols Prevent Early Vascular Aging Induced by High-Fat Diet via Promoting Autophagy in Young Adult Rats

引用

Current Medical Science 2022年第5期42卷 981-990页

作者： Xiang-tian XIAO Shui-qing HE nan-nan wu Xue-chun LIN Jing ZHAO Chong TIAN Medical College of wuhan University of Science and Technology Wuhan430081China Department of Nutrition and Food Hygiene Hubei Key Laboratory of Food Nutrition and SafetySchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China School of Public Health and Management Research Center for Medicine and Social DevelopmentInnovation Center for Social Risk Governance in HealthChongqing Medical UniversityChongqing400016China School of Nursing Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective Epidemiology studies indicate that green tea polyphenols(GTP)perform a protective effect on cardiovascular diseases,but the underlying mechanisms are *** present study aimed to investigate the effect of GTP on high-fat diets(HFD)induced-early vascular *** Six-week young adult Wistar rats were fed with standard chow or HFD in the presence and absence of GTP(200 mg/kg body weight)for 18 *** vitro experiment,human umbilical vascular endothelial cells(HUVECs)were treated with palmitic acid(PA)and *** The results showed that GTP alleviated the disorganized arterial wall and the increased intima-media thickness induced by *** addition,the vascular oxidative injury was suppressed following GTP ***,GTP elevated the ratio of LC3-II/LC3-I and suppressed expression of p62/SQSTM1,and restored SIRT3 expression in the aorta of HFD ***,in cultured HUVECs,GTP inhibited cell senescence indicated by SA-β-gal and promoted endothelial autophagy compared with the PA treatment *** activity of SIRT3 was specifically inhibited by 3-TYP,and the protective effect of GTP was consequently *** The findings indicated that GTP protected against early vascular senescence in young HFD rats via ameliorating oxidative injury and promoting autophagy which was partially regulated by the SIRT3 pathway.

关键词： high-fat diets green tea polyphenols early vascular aging autophagy Sirtuin 3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

NiO nanoparticles-decorated ZnO hierarchical structures for isopropanol gas sensing

引用

Rare Metals 2022年第3期41卷 960-971页

作者： Shi-Chao Wang Xiao-Hu Wang Gao-Qun Qiao Xiao-Yan Chen Xin-Zhen Wang nan-nan wu Jian Tian Hong-Zhi Cui School of Materials Science and Engineering Shandong University of Science and TechnologyQingdao 266590China

In this paper,a three-dimensional(3D)hierar-chical ZnO structure consisting of nanosheets modified with ultrafine NiO particles was synthesized via a facile two-step chemical precipitate *** techniques characterized the as-synthesized ZnO/NiO composites and pure *** p-NiO/n-ZnO junctions formed between adjacent ZnO and NiO nanoparticles,improving the gas sensing *** ZnO/NiO composite with the Ni:Zn atomic ratio of 7.42:100 exhibited the best iso-propanol sensing *** to pure ZnO,it showed high selectivity and sensitivity(R_(a)/R_(g)=221.3 toward 400×10^(-6)isopropanol),fast response rate(less than 10 s),short recovery time,and simultaneously low operating ***,the ZnO/NiO composite exhibited a wide sensing range(1×10^(-6)-1000×10^(-6))to isopropanol and processed good long-term *** experimental results suggested the potential application in fabricating efficient isopropanol sensors using this ZnO/NiO *** enhanced isopropanol sensing mech-anism is also discussed in charge transfer between heterojunctions,surface area,and surface defects.

关键词： ZnO NiO Hierarchical structure Gas sensor Isopropanol

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interaction between adolescent sleep rhythms and gender in an obese population

引用

World Journal of Clinical Cases 2024年第1期12卷 86-94页

作者： nan-nan wu Guo-Li Yan Hong-Yu Zhang Ling Sun Min Hou Guang-Ming Xu Department of Laboratory Medicine Tianjin Chest HospitalTianjin 300222China Mental Health Center of Tianjin Medical University Tianjin Anding HospitalTianjin 300222China Department of Child and Adolescent Psychology Mental Health Center of Tianjin Medical UniversityTianjin 300222China

BACKGROUND The obesity rate of adolescents is gradually increasing,which seriously affects their mental health,and sleep plays an important role in adolescent *** To investigate the relationship between sleep rhythm and obesity among adolescents and further explores the interactive effect of sleep rhythm and gender on adolescent obesity,providing a theoretical basis for developing interventions for adolescent *** Research data source Tianjin Mental Health Promotion Program for *** April to June 2022,this study selected 14201 students from 13 middle schools in a certain district of Tianjin as the research subject using the convenient cluster sampling *** these students,13374 accepted and completed the survey,with an effective rate of 94.2%.The demographic data and basic information of adolescents,such as height and weight,were collected through a general situation *** sleep rhythm of adolescents was evaluated using the reduced version of the morningness-eveningness *** A total of 13374 participants(6629 females,accounting for 49.56%;the average age is 15.21±1.433 years)were *** them,the survey showed that 2942 adolescent were obesity,accounting for 22%and 2104 adolescent were overweight,accounting for 15.7%.Among them,1692 male adolescents are obese,with an obesity rate of 25.1%,higher than 18.9%of female *** is a statistically significant difference between the three groups(χ2=231.522,P<0.000).The obesity group has the smallest age(14.94±1.442 years),and there is a statistical difference in age among the three groups(F=69.996,P<0.000).Obesity rates are higher among individuals who are not-only-child,have residential experience within six months,have family economic poverty,and have evening-type sleep(P<0.05).Logistic regression analysis shows a correlation between sleep rhythm and adolescent ***-type sleep rhythm can increase the risk of obesity in male adoles

关键词： Adolescent Obesity Sleep rhythm Gender Interaction

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

引用

Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali wu Yu Wang Hanlin Huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Near-infrared brain functional characteristics of mild cognitive impairment with sleep disorders

引用

World Journal of Psychiatry 2025年第1期15卷 106-116页

作者： Heng Liao Sha Liao Yu-Jiao Gao Xi Wang Li-Hong Guo Su Zheng wu Yang Yi-nan Dai Sleep Psychosomatic Medicine Center Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Integrated Chinese and Western Medicine Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Orthopaedics Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Rehabilitation Taihe Hospital of Shiyan CityAffiliated Hospital of Hubei University of MedicineShiyan 442000Hubei ProvinceChina

BACKGROUND Mild cognitive impairment(MCI)has a high risk of progression to Alzheimer’s *** disease is often accompanied by sleep disorders,and whether sleep disorders have an effect on brain function in patients with MCI is *** To explore the near-infrared brain function characteristics of MCI with sleep *** A total of 120 patients with MCI(MCI group)and 50 healthy subjects(control group)were *** subjects underwent the functional near-infrared spec-troscopy *** baseline data,Mini-Mental State Examination,Montreal Cognitive Assessment scale,fatigue severity scale(FSS)score,sleep parameter,and oxyhemoglobin(Oxy-Hb)concentration and peak time of functional near-infrared spectroscopy test during the task *** relationship between Oxy-RESULTS Compared with the control group,the FSS score of the MCI group was higher(t=11.310),and the scores of Pittsburgh sleep quality index,sleep time,sleep efficiency,nocturnal sleep disturbance,and daytime dysfunction were higher(Z=-10.518,-10.368,-9.035,-10.661,-10.088).Subjective sleep quality and total sleep time scores were lower(Z=-11.592,-9.924).The sleep efficiency of the MCI group was lower,and the awakening frequency,rem sleep latency period,total sleep time,and oxygen desaturation index were higher(t=5.969,5.829,2.887,3.003,5.937).The Oxy-Hb concentration at T0,T1,and T2 in the MCI group was lower(t=14.940,11.280,5.721),and the peak time was higher(t=18.800,13.350,9.827).In MCI patients,the concentration of Oxy-Hb during T0 was negatively correlated with the scores of Pittsburgh sleep quality index,sleep time,total sleep time,and sleep efficiency(r=-0.611,-0.388,-0.563,-0.356).It was positively correlated with sleep efficiency and total sleep time(r=0.754,0.650),and negatively correlated with oxygen desaturation index(r=-0.561)and FSS score(r=-0.526).All comparisons were P<*** Patients with MCI and sleep disorders have lower near-infrared brain function than norm

关键词： Mild Cognitive impairment Sleep disorders Near-infrared Brain functional Characteristics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Electrical Power Generation Using Dynamic Piezoelectric Shear Deformation Under Friction

引用

Acta Mechanica Solida Sinica 2021年第6期34卷 977-988页

作者： Peng Wang Yu Xiao nan wu Department of Mechanical Engineering Northeastern UniversityShenyang 110819China Department of Mechanical Engineering University of ManitobaWinnipeg R3T 2N2Canada

A new electrical power generation device based on high-frequency dynamic piezoelectric shear deformation under friction is *** the operation of a moving plate compressed and sliding on the top of a piezoelectric patch with constant velocity,dynamic shear deformation of the elastic piezoelectric patch is excited by periodic friction force and status(sliding and stick)*** dynamic piezoelectric shear strain can then generate continuous electrical power for energy absorbing and harvesting *** design of the piezoelectric couple device is first provided,and its mechanism,dynamic response and electric power generation under friction are described by a detailed iteration *** comparing with previous experimental results,the accuracy of the proposed model is *** numerical studies,the influences of the equivalent mass of the system,the velocity of the sliding object,the static friction coefficient and its lower limit,as well as the friction force delay rate on the power generation are obtained and *** numerical results show that with the proposed design,up to 50-Watt maximum electrical power could be generated by a piezoelectric patch with a dimension of 20×2×6 cm under continuous friction with the moving plate at the velocity of 15 m/*** possible bi-linear elastic stiffness variation of the system is also introduced,and the threshold of bi-linear elastic deformation,where the system stiffness changes,can be optimized for obtaining the highest power generation.

关键词： Electrical power generation Friction Piezoelectric shear deformation Sliding and stick Bi-linear

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Variations in the oxytocin receptor gene and prosocial behavior:moderating effects of situational factors

引用

Integrative Zoology 2018年第6期13卷 687-697页

作者： nan wu Yanjie SU Teachers College of Beijing Union University Peking UniversityBeijingChina School of Psychological and Cognitive Sciences and Beijing Key Laboratory of Behavior and Mental Health Peking UniversityBeijingChina

Humans are the most prosocial primate species and they often exhibit high levels of prosocial behavior toward genetically unrelated *** evolutionary theories are not sufficient to explain the individual differences and mechanisms related to *** this study,we focused on the gene–situation interaction in prosocial behaviors,and the patterns of genotype variance related to cooperation and comforting in different *** explored the interaction between the oxytocin receptor(OXTR)gene and situations,and the genotype variance under low and high prosociality situations between outgroup and ingroup recipients in a sample of 422 Chinese *** was tested by measuring the prosocial tendencies,and prosocial behaviors were tested in cooperation and comforting *** single nucleotide polymorphisms(SNPs)were genotyped using polymerase chain reaction–restriction fragment length polymorphism *** results suggested that the relationship between OXTR SNPs(specifically rs13316193,rs1042778 and rs237887)and prosocial behavior varied across different situations,and that the associations were moderated by the recipient’s identity and the prosocial *** findings indicate the action of a moderating mechanism between the OXTR gene and prosocial behaviors according to situational factors.

关键词： group membership oxytocin receptor gene prosocial behavior prosocial cost

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A HIGHLY ACCURATE NUMERICAL METHOD FOR FLOW PROBLEMS WITH INTERACTIONS OF DISCONTINUITIES

引用

Journal of Computational Mathematics 2002年第1期20卷 1-14页

作者： Xiao-nan wu You-lan Zhu Department of Mathematics Hong Kong Baptist UniversityKowloon TongHong Kong Department of Mathematics University of North Carolina at CharlotteCharlotteNC 28223

Focuses on a study wherein a type of shock fitting method has been used to solve dimensional flow problems with interactions of various discontinuities. Discretization of the transformed equations; Numerical results; ... 详细信息

关键词： interaction of discontinuity shock-fitting shock-capturing

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Resonance System Reliability and Sensitivity Analysis Method for Axially FGM Pipes Conveying Fluid with Adaptive Kriging Model

引用

Acta Mechanica Solida Sinica 2022年第6期35卷 1021-1029页

作者： Xin Fan nan wu Yongshou Liu Qing Guo School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi’an710129China

This paper aims to solve the resonance failure probability and develop an effective method to estimate the effects of variables and failure modes on failure probability of axially functionally graded material(FGM)pipe conveying ***,the natural frequency of axially FGM pipes conveying fluid is calculated using the differential quadrature method(DQM).A variable sensitivity analysis(VSA)is introduced to measure the effect of each random variable,and a mode sensitivity analysis(MSA)is introduced to acquire the importance ranking of failure ***,an active learning Kriging(ALK)method is established to calculate the resonance failure probability and sensitivity indices,which greatly improves the application of resonance reliability analysis for pipelines in engineering *** on the resonance reliability analysis method,the effects of fluid velocity,volume fraction and fluid density of axially FGM pipe conveying fluid on resonance reliability are *** results demonstrate that the proposed method has great performance in the anti-resonance analysis of pipes conveying fluid.

关键词： Resonance reliability analysis Simply supported pipe conveying fluid Differential quadrature method Variable sensitivity analysis Mode sensitivity analysis Active learning Kriging model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comments on National guidelines for diagnosis and treatment of esophageal carcinoma 2022 in China(English version)

引用

Chinese Journal of Cancer Research 2022年第6期34卷 633-634页

作者： Yuan Feng nan wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic SurgeryⅡPeking University Cancer Hospital&InstituteBeijing 100142China

Esophageal cancer has always been one of the most common malignant tumors in the world, and China is one of the regions with the highest incidence. Although the incidence and mortality of esophageal cancer in China have shown a downward trend in recent years, according to the statistics of the prevalence of malignant tumor in China in2015, its morbidity and mortality rate still rank 6th and 4th among all malignant tumors, respectively.

关键词： esophageal mortality diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：