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Synthesis and antitumor evaluation of fluoroquinolone C3 fused heterocycles(Ⅱ):From triazolothiadiazines to pyrazolotriazoles

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Chinese Chemical Letters 2011年第7期22卷 804-806页

作者： Guo Qiang Hu Li Li Hou Yong Yang Lei Yi Song Qiang Xie Guo Qiang Wang nan nan duan Tie Yao Chao Xiao Yi Wen Wen Long Huang Institute of Chemistry & Biology Henan University Kaifeng 475001 China China Pharmaceutical University Nanjing 210009 China

To further expand an effective modified route for the shift from an antibacterial fluoroquinolone （FQ） to an antitumor FQ, two series of title compounds based on an isostere of the FQ C3 carboxylic group with two fused heterocyclic rings, [ 1,2,4]triazolo[3,4- b][1,3,4]thiadiazine and pyrazolo[5,1-c][1,2,4]triazole, respectively, were designed and synthesized starting from the current antibacterial FQs, and their in vitro antitumor activity against L1210, CHO cell lines were evaluated via their respective IC50 values.

关键词： Fluoroquinolone Triazolothiadiazine Pyrazolotriazole Antitumor evaluation

Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives(Ⅲ):Mono- and bis-Schiff-bases

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Chinese Chemical Letters 2012年第5期23卷 515-517页

作者： Guo Qiang Hu Xiao Kui Wu Guo Qiang Wang nan nan duan Xiao Yi Wen Tie Yao Cao Yin Jun Wang Wei Song Qiang Xie Wen Long Huang Institute of Chemistry&Biology Henan UniversityKaifeng 475001China China Pharmaceutical University Nanjing 210009China

To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized,and their in vitro antitumor activity against CHO,HL60,L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported.

关键词： Fluoroquinolone Schiff base Antitumor evaluation

Overexpression of the peroxidase gene ZmPRX1 increases maize seedling drought tolerance by promoting root development and lignification

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The Crop Journal 2024年第3期12卷 753-765页

作者： Xiuzhen Zhai Xiaocui Yan Tinashe Zenda nan Wang Anyi Dong Qian Yang Yuan Zhong Yue Xing Huijun duan State Key Laboratory of North China Crop Improvement and Regulation Key Laboratory of Crop Germplasm Resources in North China Ministry of EducationCollege of AgronomyHebei Agricultural UniversityBaoding 071001HebeiChina

Drought is a main abiotic stress factor hindering plant growth,development,and crop ***,it is crucial to understand the mechanisms by which plants cope with drought ***,the function of the maize peroxidase gene ZmPRX1 in drought stress tolerance was investigated by measurement of its expression in response to drought treatment both in a ZmPRX1 overexpression line and a mutant *** higher root lignin accumulation and seedling survival rate of the overexpression line than that of the wild type or mutant support a role for ZmPRX1 in maize drought tolerance by regulating root development and ***,yeast one-hybrid,Dule luciferase and ChIP-qPCR assays showed that ZmPRX1 is negatively regulated by a nuclear-localized ZmWRKY86 transcription *** gene could potentially be used for breeding of drought-tolerant cultivars.

关键词： Drought tolerance Maize ZmPRX1 Root development Lignin biosynthesis

Research on pumped storage and complementary energy development models for abandoned mines in China

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Journal of Central South University 2024年第8期31卷 2860-2871页

作者： Yang, Ke Lyu, Xin Xu, Chao-shui Fang, Jue-jing duan, Min-ke Zhang, Zhai-nan State Key Laboratory of Mining Response and Disaster Prevention and Control in Deep Coal Mines Anhui University of Science and Technology Huainan China Institute of Energy Hefei Comprehensive National Science Center Hefei China School of Mining Engineering Anhui University of Science and Technology Huainan China School of Chemical Engineering University of Adelaide Adelaide Australia

Within the framework of achieving carbon neutrality, various industries are confronted with fresh challenges. The ongoing process of downsizing coal industry operations has evolved into a new phase, with the burgeoning proliferation of abandoned mines posing a persistent issue. Addressing the challenges and opportunities presented by these abandoned mines, this paper advocates for a scientific approach centered on the advancement of pumped storage energy alongside gas-oil complementary energy. Leveraging abandoned mine tunnels to establish pumped storage power stations holds significant ecological and economic importance for repurposing these sites. This initiative not only serves as an effective means to restore the ecological balance in mining regions but also provides an environmentally friendly approach to repurposing abandoned mine tunnels, offering a blueprint for economically viable pumped storage power stations. This article delineates five crucial scientific considerations and outlines seven primary models for the utilization of abandoned mine sites, delineating a novel, comprehensive pathway for energy and power development that emphasizes multi-energy complementarity and synergistic optimization within abandoned mines.

关键词： abandoned mines pumped storage underground reservoir energy systems carbon neutrality

Wide-color-gamut, high-purity, and high-brightness thin film structural colors based on modified Fano resonant structure

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CHINESE OPTICS LETTERS 2024年第8期22卷 082601-082601页

作者： Chen, Weijie He, Zexiang duan, Zhenzhen Yang, Jian Wang, Ning Wang, Dan Hu, Zexiong Chen, nan Luo, Zhengqian Bu, Yikun Xiamen Univ Sch Elect Sci & Engn Natl Model Microelect Coll Xiamen 361005 Peoples R China Xiamen Univ Fujian Key Lab Ultrafast Laser Technol & Applicat Xiamen 361005 Peoples R China

Recently, the Fano resonance has played an increasingly important role in improving the color performance of structural colors. In this study, we further elucidate the asymmetric spectral shape generated by Fano resonance from a phase perspective and explore four distinct continuum state structures. By integrating the proposed cavity-like structure with a metal-dielectric-metal discrete state, multilayered thin-film structural colors with minimal background reflection, as low as 8%, were successfully achieved. The reflection peak of this structure exhibits a bandwidth of approximately 50 nm and reaches up to 80%, indicating heightened saturation and color brightness. Moreover, by adjusting the thickness, we effortlessly obtained a broader color gamut compared to Adobe ROB (45.2%), covering 56.7% of the CIE color space. Even adjusting a single layer can achieve a color gamut of 47.1%. In experiments, by deliberately choosing low oxygen- dependent materials, excellent ROB colors with high brightness and in high consistency with simulation results were successfully achieved. Therefore, the scheme's simple process for structural color creation, along with its excellent color performance and the ability to effectively replicate simulation characteristics makes it highly valuable in fields like anti- counterfeiting, decoration, display devices, and solar cell panels.

关键词： Fano resonance structural colors full color thin films high saturation

Molecular Mechanism of Polysaccharides Extracted from Chinese Medicine Targeting Gut Microbiota for Promoting Health

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Chinese Journal of Integrative Medicine 2024年第2期30卷 171-180页

作者： ZHAO Wen-xiao WANG Tong ZHANG Ya-nan CHEN Qian WANG Yuan XING Yan-qing ZHENG Jun duan Chen-chen CHEN Lijun ZHAO Hai-jun WANG Shijun School of Nursing Shandong University of Traditional Chinese MedicineShandong University of Traditional Chinese MedicineJi'nan(250355)China Shandong Co-innovation Center of Classic Traditional Chinese Medicine Formula Shandong University of Traditional Chinese MedicineJi'nan(250355)China College of Traditional Chinese Medicine Shandong University of Traditional Chinese MedicineJinan(250355)China

The accumulating evidence revealed that gut microbiota plays an important role in pathological process of disease including obesity,type 2 diabetes mellitus,heart failure,and non-alcoholic fatty liver *** extracted from Chinese medicine(CM)can not only alleviate pathological status but also promote health by anti-inflammatory,regulating immunity,lowering blood glucose and lipids,anti-cancer,and *** alterations of gut microbiota composition and metabolism pathways are the potential mechanisms of CM polysaccharides *** addition,they exert functions through gut-organ axis or play an indirect role by synergistic actions with other drugs or components mediated by gut *** review summarizes the molecular mechanisms of CM polysaccharides interacted with intestinal microbial inhabitants as potential prebiotics forpromoting health.

关键词： Chinese medicine polysaccharides gut microbiota short-chain fatty acids lipopolysaccharides gut-organaxis synergistic actions

Design, synthesis and antitumor activity of C3/C3 bis-fluoroquonolones cross-linked with [1,2,4]triazolo[3,4-b] [1,3,4]thiadiazole

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Acta Pharmaceutica Sinica B 2011年第3期1卷 172-177页

作者： Guo-qiang Hu Yong Yang Lei Yi Guo-qiang Wang nan-nan duan Xiao-yi Wen Tie-yao Cao Song-qiang Xie Wen-Long Huang Institute of Chemistry&Biology Henan UniversityKaifeng 475001China Center of Drug Discovery China Pharmaceutical UniversityNanjing 210009China

To contribute to the development of an efficient method for the conversion of antibacterial fluoroquinolones to antitumor fluoroquinolones,a series of C3/C3 bis-fluoroquinolone fused heterocycles cross-linked with a[1,2,4]-triazolo[3,4-b][1,3,4]-thiadiazole core as a common bioisostere of two carboxylic acid groups was designed and synthesized as their hydrochloride *** were characterized by elemental analysis and spectral data and their in vitro antitumor activity against L1210,CHO and HL60 cell lines was screened by determination of their IC50 values in the methylthiazole trazolium(MTT)*** compounds were highly potent against the HL60 cell line and represent promising lead compounds for future development.

关键词： Fluoroquinolone Triazolothiadiazole Synthesis Antitumor evaluation

长期护理保险的劳动力市场化配置效应——基于女性劳动参与行为的分析

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北京社会科学 2024年第8期 76-88页

作者：殷俊段亚男武汉大学社会保障研究中心中共武汉市委党校

以长期护理保险政策试点作为准自然实验,利用CHARLS2011—2018年的数据实证检验了长期护理保险政策试点实施对子代女性劳动参与行为的影响,结果显示:长期护理保险试点显著提高了子代女性进入劳动力市场的概率,且主要通过改善老年人健康... 详细信息

以长期护理保险政策试点作为准自然实验,利用CHARLS2011—2018年的数据实证检验了长期护理保险政策试点实施对子代女性劳动参与行为的影响,结果显示:长期护理保险试点显著提高了子代女性进入劳动力市场的概率,且主要通过改善老年人健康水平和增加正式照护行为两条路径产生影响;异质性分析发现,多主体筹资、比例给付和服务给付的政策细则对子代女性劳动参与产生了更好的促进效果,这一促进效果在农村地区更为明显。因此,需要从认可家庭照护劳动价值、扩大长期护理保险制度覆盖面和提高长期护理保险待遇水平等方面做出努力,以支持女性根据个人比较优势在家庭—市场场域进行有序流动,改进女性劳动力要素配置效率。

关键词：长期护理保险劳动力市场化配置女性劳动参与劳动力市场家庭照护

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Sclerodermus alternatusi(Hymenoptera:Bethylidae),a new species from China,parasitizing Monochamus alternatus(Coleoptera:Cerambycidae)

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Zoological Systematics 2024年第3期49卷 258-266页

作者： Zhongqi Yang Xiaoyi Wang Zhaoyao duan Yanlong Zhang Yi’nanZhang Liangming Cao Ke Wei Key Lab of Forest Protection National Forestry and Grassland AdministrationEcology and Nature Conservation InstituteChinese Academy of ForestryBeijing 100091China Research Institute of Biological Control Beijing Vocational College of AgricultureBeijing 102442China Research Institute of Forest Protection Yunnan Academy of Forestry and GrasslandKunming 650201China

A new species,Sclerodermus alternatusi Yang,***.(Hymenoptera:Bethylidae),is described and *** cerambycid host,Monochamus alternatus Hope,a severe wood borer attacking many pine trees(Pinus spp.),is also a vector of pine wood nematode,Bursaphelencus xylophilus,which cause severe damages to pine forests in *** new species is a gregarious ectoparasitoid of junior larva of *** number of adult wasps reared from a single host larva ranges from 6 to *** ratio of female to male is 20:*** new parasitoid species has a high potential in using as a biocontrol agent for the wood *** of the new species with comparisons to its related species,*** Yang&Yao and a key to known species of Sclerodermus from China is provided.

关键词： Ectoparasitoid larval parasitoid taxonomy biological control