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Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang Shi-lin Huang nan-nan chen Department of Hematology PLA 967th HospitalDalian 116021Liaoning ProvinceChina

Introduction There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL).Here,we report a case series of realgar-indigo naturalis formula(RIF)for the successful treatment of patients with relapsed and ATO-resistant *** presentation Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR)when reinduced by ATO;the other five patients progressed to relapse during ATO-based regimens for post-remission *** eight patients received RIF in three doses per day totaling 130 mg/kg(≤30 pills)as induction therapy and achieved HCR at a median time of 46.5 *** received 5 years of post-remission therapy,which consisted of combined chemotherapy followed by *** this period,the patients did not experience renal dysfunction or QT interval *** the last follow-up,three patients survived without relapse,two patients survived with a second or third relapse and third or fourth remission,and the other three patients relapsed for a third or fourth time and *** 5-year overall survival and event-free survival rates were 75.0%(95%confidence interval[CI]:31.5–93.1)and 37.5%(95%CI:5.6–71.7),*** RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

复方黄黛片治疗急性早幼粒细胞白血病204例经验总结

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中西医结合学报 2008年第6期6卷 639-642页

作者：孙锋陈楠楠成玉斌中国人民解放军总医院军医进修学院

急性早幼粒细胞白血病(acute promyelocytic leukemia, APL)是一种特殊类型的急性白血病,其临床特征为极易合并感染、出血及弥漫性血管内凝血(disseminated intravascular coagulation, DIC)等并发症,死亡率较高.

关键词：白血病粒细胞性急性名医经验雄黄青黛

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke Feng chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

补骨脂素加长波紫外线光化学疗法对K562细胞凋亡及线粒体膜电位的影响

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中西医结合学报 2008年第12期6卷 1259-1262页

作者：黄世林陈楠楠向阳张晨张励张德杰中国人民解放军第210医院中医血液科辽宁大连116021

目的:研究补骨脂素(psoralen,PSO)加长波紫外线(ultraviolet-A,UVA)光化学疗法(PUVA)对人白血病细胞K562凋亡及线粒体膜电位的影响。方法:K562细胞与不同浓度PSO,接受或不接受UVA照射后共同培养,透射电子显微镜下观察细胞超微结构改变,... 详细信息

目的:研究补骨脂素(psoralen,PSO)加长波紫外线(ultraviolet-A,UVA)光化学疗法(PUVA)对人白血病细胞K562凋亡及线粒体膜电位的影响。方法:K562细胞与不同浓度PSO,接受或不接受UVA照射后共同培养,透射电子显微镜下观察细胞超微结构改变,流式细胞仪检测细胞凋亡率和线粒体膜电位变化,采用多因素方差分析法进行统计学处理。结果:PUVA处理后的K562细胞超微结构出现明显的凋亡形态学改变。PSO、UVA照射及PUVA均可使细胞凋亡率增加,线粒体膜电位下降;PUVA的作用显著强于前两者(P<0.01)。结论:PUVA可诱导白血病K562细胞发生凋亡,诱导凋亡途径之一为下调线粒体膜电位水平。

关键词：补骨脂素光化学疗法白血病 K562细胞细胞凋亡线粒体膜电位

复方黄黛片含药灭活兔血清对NB_4细胞株的作用

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中西医结合学报 2007年第1期5卷 65-69页

作者：陈楠楠黄世林向阳张德杰郭爱霞陈爱萍中国人民解放军总医院军医进修学院北京100853 中国人民解放军大连第210医院中医血液科辽宁大连116021

目的:研究复方黄黛片含药灭活兔血清对人急性早幼粒细胞白血病NB4细胞株的作用。方法:以兔为实验血清的供体,将兔血清灭活,以灭活前给药与否为分组依据,采用双道原子荧光法检测血清中砷的浓度,以细胞抑制率及凋亡率为观察指标,对实验结... 详细信息

目的:研究复方黄黛片含药灭活兔血清对人急性早幼粒细胞白血病NB4细胞株的作用。方法:以兔为实验血清的供体,将兔血清灭活,以灭活前给药与否为分组依据,采用双道原子荧光法检测血清中砷的浓度,以细胞抑制率及凋亡率为观察指标,对实验结果进行分析。结果:给药前、后灭活兔血清中砷浓度分别为(0.0100±0.0010)mg/L和(0.1100±0.0064)mg/L,差异有统计学意义(P<0.01);两组兔血清对NB4细胞株生长均有抑制作用,且对NB4细胞株生长的抑制作用具有一定的浓度及时间依赖性,实验组间,各浓度及时间组间差异有统计学意义(P<0.01)。两组兔血清均可诱导NB4细胞株发生凋亡,且该作用具有一定的浓度及时间依赖性,实验组间,各浓度及时间组间差异有统计学意义(P<0.01)。结论:复方黄黛片含药灭活兔血清可明显抑制NB4细胞株的生长,抑制作用呈一定的浓度、时间依赖性。复方黄黛片含药灭活兔血清也可诱导NB4细胞株发生凋亡,作用也呈一定的浓度、时间依赖性。

关键词：兔细胞凋亡血清白血病中药

Pharmacokinetics and urinary excretion of eprosartan in Chinese healthy volunteers and gender differences in pharmacokinetics

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Pharmacokinetics and urinary excretion of eprosartan in Chin...

不同剂量与不同时程阿托伐他汀对永久性大脑中动脉栓塞大鼠TOLL样受体-4、核因子-κB表达影响研究

第九届全国心血管药理学术会议

作者： Hong-Rong Xu~(1*) Wei-Li chen~1 Xue-Ning Li~1 Gang-yi Liu~2 nan-nan Chu~1 chen Yu~2 1 Department of Clinical Pharmacology,ZhongShan Hospital,Fudan University,180 FenLin Road,Shanghai,200032 China 2 Shanghai Xu Hui District Central Hospital,966 Huaihai Middle Road,Shanghai,200031 China

Aim:The study aims to evaluate the pharmacokinetics and urinary excretion of eprosartan in Chinese healthy volunteers and to study the effect of gender on phannacokinetics of ***:Twenty heatthy volunteers(ten men and ten women)were recruited for an open trial and received a single dose of 600 mg *** a validated LC/MS/MS method,we measured the plasma and

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临床军医杂志 2018年第9期46卷 1017-1019页

作者：吕彦王冰张楠楠陈会生沈阳军区总医院神经内科辽宁沈阳110016

目的观察不同剂量与不同时程阿托伐他汀对永久性大脑中动脉栓塞大鼠TOLL样受体-4、核因子-κB表达的影响。方法将100只SD大鼠随机分入对照组、低剂量短期组(L7组)、低剂量长期组(L28组)、高剂量短期组(H7组)及高剂量长期组(H28组),每组2... 详细信息

目的观察不同剂量与不同时程阿托伐他汀对永久性大脑中动脉栓塞大鼠TOLL样受体-4、核因子-κB表达的影响。方法将100只SD大鼠随机分入对照组、低剂量短期组(L7组)、低剂量长期组(L28组)、高剂量短期组(H7组)及高剂量长期组(H28组),每组20只。对照组连续灌喂生理盐水(0. 5 ml/d);低剂量组给予低剂量阿托伐他汀[2. 1 mg/(kg·d)],高剂量组给予高剂量阿托伐他汀[8. 4 mg/(kg·d)];短期组给药时程为7 d,长期组给药时程为28 d。在最后一次给药后24 h,行永久性大脑中动脉栓塞术;术后24 h,采用PCR、Western blot法及免疫组织化学法检测各组大鼠脑中TOLL样受体-4、核因子-κB的表达水平。结果 L7、L28、H7及H28组大鼠脑中TOLL样受体-4、核因子-κB的表达水平均较对照组降低,且H7、H28组降低得更加明显,差异均有统计学意义(P <0. 05)。结论阿托伐他汀可抑制脑中TOLL样受体-4、核因子-κB的表达,减轻脑组织炎症反应,可能对降低缺血性脑卒中病死率有积极影响。

关键词：缺血性脑卒中阿托伐他汀大脑中动脉栓塞 TOLL样受体-4 核因子-κB

Deriving the slope-mean shielded astronomical solar radiation spectrum and slope-mean possible sunshine duration spectrum over the Loess Plateau

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Journal of Mountain Science 2020年第1期17卷 133-146页

作者： chen nan Key Laboratory of Spatial Data Mining & Information Sharing Ministry of Education Fuzhou University Spatial Information Research Center of Fujian Province Fuzhou University

Solar radiation is often shielded by terrain relief, especially in mountainous areas, before reaching the surface of the Earth. The objective of this paper is to study the spatial structures of the shielded astronomical solar radiation(SASR) and the possible sunshine duration(PSD) over the Loess Plateau. To this end, we chose six test areas representing different landforms over the Loess Plateau and the software package of Matlab was used as the main computing platform. In each test area, 5-m-resolution digital elevation model established from 1:10,000 scale topographic maps was used to compute the corresponding slope, SASR and PSD. Then, we defined the concepts of the slope-mean SASR spectrum and the slope-mean PSD spectrum, and proposed a method to extract them from the computed slope, SASR and PSD over rectangular analysis windows. Using this method, we found both spectrums in a year or in a season for each of the four seasons in the six test areas. Each spectrum was found only when the area of the corresponding rectangular analysis window was greater than the corresponding stable area of the spectrum. The values of the two spectrums decreased when the slope ***, the values of the stable areas of the spectrums in a year or in a season were positively correlated with the variable coefficients of the slope or the profile curvature. The values of the stable areas of the two spectrums in a year or in a season may represent the minimum value of test areas for corresponding future research on the spatial structures of the SASR or PSD. All the findings herein suggest that the spatial structures of the PSD and the SASR are caused by the interactions between solar radiation and terrain relief and that the method for extracting either spectrum is effective for detecting their spatial structures. This study may deepen our understanding of the spatial structure of solar radiation and help us further explore the distribution of solar energy in mountainous re

关键词： Digital elevation model Shielded extraterrestrial solar radiation Spectrum Possible Sunshine duration Slope Loess Plateau

Scale problem:Influence of grid spacing of digital elevation model on computed slope and shielded extra-terrestrial solar radiation

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Frontiers of Earth Science 2020年第1期14卷 171-187页

作者： nan chen Key Laboratory of Spatial Data Mining&Information Sharing(Ministry of Education) Fuzhou UniversityFuzhou 350108 China Spatial Information Research Center of Fujian Province Fuzhou UniversityFuzhou 350108 China

Solar radiation is the primary energy source that drives many of Earth’s physical and biological processes and determines the patterns of climate and productivity on the surface of the Earth.A fundamental proportion of solar radiation is composed of shielded extraterrestrial solar radiation(SESR),which can be computed using the slope and aspect derived from a digital elevation model(DEM).The objective of this paper is to determine the influence of the grid spacing of the DEM(the influence of the scale of the DEM)on the errors of slope,aspect and *** paper puts forward the concepts of slope representation error,aspect representation error,and SESR representation error and then studies the relations among these errors and the grid spacing of *** find that when the grid spacing of a DEM becomes coarser,the average SESR increases;the increase in SESR is dominated by the grid cells of the DEM with a negative slope representation error,whereas SESR generally decreases in the grid cells with a positive slope representation *** the grid spacing varies,the distribution of the percentages of positive SESR representation errors on the slope,which is classified into 11 slope intervals,is independent of the grid spacing;this distribution is concentrated across some slope ***,the average absolute value and mean square error of the SESR representation error are closely related to those of the slope representation error and the aspect representation *** findings in this study may be useful for predicting and reducing the errors in SESR measurements and may help to avoid mistakes in foture research and in practical applications in which SESR is the data of interest or plays a vital role in an analysis.

关键词： scale problem digital elevation model grid spacing slope shielded extra-terrestrial solar radiation

某医学院校学生染发相关知识、态度、行为现状调查

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中国健康教育 2017年第3期33卷 236-239页

作者：张宇锡王宏玉许春宁丁楠楠李晨光邸丽丽毛淑芳承德医学院河北承德067000

目的了解某医学院校学生染发相关知识、态度、行为现状。方法采用分层整群随机抽样方法,抽取承德市某医学院校学生1250名进行调查,内容包括人口学特征、染发相关知识、态度、行为。结果 31.2%的学生有过染发,其中88.0%的人染发前从未做... 详细信息

目的了解某医学院校学生染发相关知识、态度、行为现状。方法采用分层整群随机抽样方法,抽取承德市某医学院校学生1250名进行调查,内容包括人口学特征、染发相关知识、态度、行为。结果 31.2%的学生有过染发,其中88.0%的人染发前从未做过皮肤过敏试验,主要原因是不知道要做过敏试验(66.7%)。70%以上的学生是大学开始染发,在选择染发剂时,注重效果的占46.1%。学生染发原因中追求时尚的比例最高,占57.0%。从未染发的学生中有27.9%打算染发,其中61.8%也是因为追求时尚。有39.3%的人完全不知道染发剂的种类,84.6%的人认为染发剂对身体有害。染发知识得分为(4.45±1.91)分(满分10分),本、专科学生的得分、不同年级学生的得分差异均有统计学意义。结论医学院校学生染发频率较高,染发知识水平较低,缺乏减少染发损害的行为,应加强医学生染发相关知识教育。

关键词：染发知识态度行为医学生