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Current therapeutic strategies for recurrent hepatitis B virus infection after liver transplantation

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World Journal of Gastroenterology 2010年第20期16卷 2468-2475页

作者： Jiang, Li yan, Lu-nan Sichuan Univ W China Hosp Dept Liver & Vasc Surg Liver Transplantat Ctr Chengdu 610041 Sichuan Prov Peoples R China

Hepatitis B virus (HBV)-related liver disease is the leading indication for liver transplantation (LT) in Asia,especially in *** the introduction of hepatitis B immunoglobulin (HBIG) and oral antiviral drugs,the recurrent HBV infection rate after LT has been evidently ***,complete eradication of recurrent HBV infection after LT is almost *** graft infection may lead to rapid disease progression and is a frequent cause of death within the fi rst year after *** present,the availability of new oral medications,especially nucleoside or nucleotide analogues such as adefovir dipivoxil,entecavir and tenofovir disoproxil fumarate,further strengthens our ability to treat recurrent HBV infection after ***,since combined treatment with HBIG and antiviral agents after liver re-transplantation may play an important role in improving the prognosis of recurrent HBV infection,irreversible graft dysfunction secondary to recurrent HBV infection in spite of oral medications should no longer be considered an absolute contraindication for liver *** reviews focusing on the therapeutic strategies for recurrent HBV infection after LT are very *** this article,the current therapeutic strategies for recurrent HBV infection after LT and evolving new trends are reviewed to guide clinical doctors to choose an optimal treatment plan in different clinical settings.

关键词： Therapy Hepatitis B virus Recurrent hepatitis B virus infection Antiviral drugs Liver transplantation

D-CONVERGENCE OF RUNGE-KUTTA METHODS FOR STIFF DELAY DIFFERENTIAL EQUATIONS

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Journal of Computational Mathematics 2001年第3期19卷 259-268页

作者： Cheng-ming Huang Hong-yuan fu Shou-fu Li Guang-nan Chen Institute of Applied Mathematics Academy of Mathematics and Systems SciencesChinese Academy of SciencesBeijing 100080China Graduate School China Academy of Engineering PhysicsBeijing 100088China Institute for Computational and Applied Mathematics Xiangtan UniversityXiangtan 411105China Graduate School China Academy of Engineering PhysicsBeijing 100088China

Focuses on a study which examined the numerical solution of delay differential equations (DDE). Information on the Runge-Kutta methods for DDE; Results of the D-convergence analysis of Runge-Kutta methods; Details on ... 详细信息

关键词： delay differential equations Runge-Kutta methods D-convergence

Current status of intrahepatic cholangiocarcinoma

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World Journal of Gastroenterology 2008年第41期14卷 6289-6297页

作者： Jian yang Lu-nan yan Liver Transplantation Division Department of Surgery West China Hospital Sichuan University Chengdu 610041 Sichuan Province China

Intrahepatic cholangiocarcinoma (ICC) is a rare primary liver cancer with a global increasing trend in recent years. Symptoms tend to be vague and insidious in development, often are diagnosed at an advanced stage when only palliative approaches can be used with a median survival rate of months. Comparing with HCC, ICC tends to spread to lymph nodes early, and is rarely limited to the regional lymph nodes, with a frequent postoperative recurrence. Surgery is the only choice of curative therapy for ICC, but recently no consensus has been established for operation. Thus, more data from multiple centers and more cases are needed. Generally speaking, current adjunctive therapy cannot clearly improve survival. further research is needed to find more effective radio- and chemotherapeutic regimens.

关键词： Intrahepatic cholangiocarcinoma Lymph node metastasis Liver transplantation Adjunctive therapy

Bidirectional coupling between the Earth and human systems is essential for modeling sustainability

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National Science Review 2016年第4期3卷 397-398页

作者： Bojie fu yan Li State Key Laboratory of Earth Surface Processes and Resource Ecology Faculty of Geographical ScienceBeijing Normal University Department of Natural Resources and Environmental Sciences University of Illinois at Urbana Champaign

The remarkably fast and recent growth of the human system has introduced tremendous changes in both the natural and social systems of our *** have dramatically modified the Earth system and are playing an increasingly... 详细信息

关键词： Bidirectional coupling between the Earth and human systems is essential for modeling sustainability cycle

In situ observation of the effect of Al N particles on bainitic transformation in a carbide-free medium carbon steel

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International Journal of Minerals,Metallurgy and Materials 2020年第5期27卷 620-629页

作者： Xiao-jie Zhao Zhi-nan yang fu-cheng Zhang State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao 066004China

The bainitic transformation of the steels with different mass fractions of N, ~0.002% and 0.021%, was observed in situ by using high-temperature metalloscope. Micrometer-and nanometer-sized aluminum nitride(AlN) particles were found in the steel with 0.021% *** boundaries, the interior of the grains, and Al N particles were used as initial nucleation sites of bainitic ferrite, and bainitic ferrite subunits served as new nucleation sites to induce secondary nucleation. The lengthening rate of bainitic ferrite varied at different nucleation sites, which was controlled by the repeated nucleation and growth of bainitic subunits. The Al N particles not only provided several nucleation sites, but also increased the autocatalytic effect on the transformation, further shortening the incubation period, promoting the bainitic transformation, and refining the bainitic microstructure.

关键词： bainitic steel In situ observation phase transformation aluminum nitride

基于二氧化铈/羟基氧化铁纳米酶的比色分析法快速检测泡椒凤爪中过氧化氢

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食品科学 2025年第1期46卷 166-175页

作者：岳晓月闫曙亮符龙赵电波郑州轻工业大学食品与生物工程学院河南郑州450001 冷链食品加工与安全控制教育部重点实验室河南郑州450001 河南省冷链食品质量安全控制重点实验室河南郑州450001

采用水热法合成二氧化铈(CeO_(2))修饰的羟基氧化铁(FeOOH),得到纳米材料CeO_(2)/FeOOH。CeO_(2)/FeOOH具有类过氧化物酶活性,可以催化过氧化氢(H_(2)O_(2))分解产生羟自由基(·OH)和超氧阴离子自由基(O2-·),将3,3’,5,5’-四甲基联苯... 详细信息

采用水热法合成二氧化铈(CeO_(2))修饰的羟基氧化铁(FeOOH),得到纳米材料CeO_(2)/FeOOH。CeO_(2)/FeOOH具有类过氧化物酶活性,可以催化过氧化氢(H_(2)O_(2))分解产生羟自由基(·OH)和超氧阴离子自由基(O2-·),将3,3’,5,5’-四甲基联苯胺(3,3’,5,5’-tetramethylbenzidine,TMB)氧化为蓝色的氧化TMB(oxidized TMB,ox-TMB)。基于此,构建基于CeO_(2)/FeOOH纳米酶的H_(2)O_(2)比色传感器。结果表明:该比色传感器对H_(2)O_(2)显示出高灵敏度响应,检测限为3.92μmol/L,检测范围为10~1000μmol/L。此外,该传感器可用于泡椒凤爪中H_(2)O_(2)的快速检测,其中,H_(2)O_(2)加标回收率为90.59%~93.42%,相对标准偏差≤4.25%,具有灵敏、准确、快速和简便等优势。

关键词：泡椒凤爪过氧化氢快速检测比色法纳米酶

Comparison on wear resistance of nanostructured bainitic bearing steel with and without residual cementite

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Journal of Iron and Steel Research International 2022年第2期29卷 339-349页

作者： Yu-man Qin Chang-bo Liu Chun-sheng Zhang Xu-biao Wang Xiao-yan Long yan-guo Li Zhi-nan yang fu-cheng Zhang State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao066004HebeiChina National Engineering Research Center for Equipment and Technology of Cold Rolled Strip Yanshan UniversityQinhuangdao066004HebeiChina

The sliding wear property of high-carbon nanostructured bainitic bearing steel with the equal initial hardness and different microstructures was investigated,and the reasons for the difference of wear resistance between the cementite-bearing(CB)and cementite-free(CF)specimens were *** results show that CF specimens have lower mass loss and surface roughness and shallower wear depth than CB specimens during wear *** with CB specimen,CF specimen presents superior wear *** is due to two reasons:(1)a lot of retained austenite in CF specimen is easy to produce TRIP effect and be transformed into martensite during wear process,which notably increased the surface hardness of worn specimen;(2)there is a nondestructive oxide layer in the surface of cementite-free worn specimen,which can protect the surface of worn specimen from *** the combined effect of retained austenite and oxide layer,the loss of matrix is ***,CF specimen exhibits high wear *** reveals that the wear mechanism of high-carbon nanostructured bainitic bearing steel with different microstructures can provide a reference for improving the wear resistance in high-carbon nanostructured bainitic bearing steel in future.

关键词： Cementite nanostructured bainite Bearing steel Microstructure Wear resistance

Simulation Investigation on Optical and Electrical Properties of Carbon nanotube in Terahertz Region

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Communications in Theoretical Physics 2009年第1期51卷 161-164页

作者： HE Xiao-Yong fu Xiao-nan School of Science Henan University of Technology Zhengzhou 450001 China

Under the framework of Maxwell-Garnett （M-G） model, the optical and electrical properties of singlewalled carbon naotube （SWCNT）, double-walled carbon nanotube （DWCNT） and hydrogen-doped carbon nanotube （H-doped GNT） in terahertz （THz） region have been investigated. It has been found that as frequency increases the loss tangent and conductivity show a peak. The loss tangent and conductivity of SWCNT is larger than that of DWCNT and H-doped CNT. The loss tangent and conductivity increase with the increases of filling factor and the decreases of geometrical factor.

关键词： terahertz nanotube Maxwell- Garnett model

Purification and Characterization of the Catalytic Domain of Protein Tyrosine Phosphatase SHP-1 and the Preparation of Anti-ΔSHP-1 Antibodies

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Chemical Research in Chinese Universities 2008年第5期24卷 592-596页

作者： LI Wan-nan ZHUANG yan LI He SUN Ying fu Yao WU Xiao-xia ZHAO Zhi-zhuang fu Xue-qi Edmond H. Fischer Signal Transduction Laboratory College of Life Sciences Key Laboratory for Molecular Enzymology ＆ Engineering Ministry of Education dilin UniversilT Changchun 130021 P. R. China Department of Pathology The University of Oklahoma Health Science Center OK 73104 USA

This study is focused on the expression of an SH2 domain-truncated form of protein tyrosine phosphatase SHP-1（designated ΔSHP-1） and the preparation of its polyclonal antibodies. A cDNA fragment encoding ΔSHP-1 was amplified by PCR and then cloned into the pT7 expression vector. The recombinant pT7-ΔSHP-1 plasmid was used to transform Rosetta（DE3） E. coli cells. ΔSHP-1 was distributed in the exclusion body of E. coli cell extracts and was purified through a two-column chromatographic procedure. The purified enzyme exhibited an expected molecular weight on SDS-gels and HPLC gel filtration columns. It possesses robust tyrosine phosphatase activity and shows typical enzymatic characteristics of classic tyrosine phosphatases. To generate polyclonal anti-ΔSHP-1 antibodies, purified recombinant ΔSHP-1 was used to immunize a rabbit. The resultant anti-serum was subjected to purification on ΔSHP-1 antigen affinity chromatography. The purified polyclonal antibody displayed a high sensitivity and specificity toward ΔSHP-1. This study thus provides the essential materials for further investigating the biological function and pathological implication of SHP-1 and screening the inhibitors and activators of the enzyme for therapeutic drug development.

关键词： SHP-1 Protein tyrosine phosphatase Polyclonal antibodies