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Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1514-1531页

作者： Yong Pan Yi-ru Zhang Ling-Yun Wang Li-Na Wu Ying-Qiu ma Zhou Fang Shi-Bo Li Department of Infectious Disease Zhoushan HospitalWenzhou Medical UniversityZhoushan 316021Zhejiang ProvinceChina State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Infectious Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Competitive endogenous RNA(ceRNA)is an innovative way of gene expression modulation,which plays a crucial part in ***,the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma(HCC)remain *** To establish a cyclin dependent kinase inhibitor 2A(CDKN2A)-related ceRNA network and recognize potential prognostic indicators for *** The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal *** expression analysis was implemented between CDKN2Ahigh and CDKN2Alow expression HCC *** targeted microRNAs were predicted by lncBasev3.0,and the targeted mRNAs were predicted by miRDB,and Targetscan *** univariate and multivariate analysis were utilized to identify independent prognostic *** CDKN2A was frequently mutated and deleted in *** single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle *** CDKN2A-related ceRNA network-growth arrest specific 5(GAS5)/miR-25-3p/SRY-box transcription factor 11(SOX11)was successfully ***5 was recognized as an independent prognostic biomarker,whose overexpression was correlated with a poor prognosis in HCC *** association between GAS5 expression and methylation,immune infilt-ration was ***,traditional Chinese medicine effective components targeting GAS5 were *** This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and ***,GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.

关键词： Hepatocellular carcinoma Competitive endogenous RNA Molecular mechanism Prognosis Biomarker

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Arbitrary topological charge vortex beams from carbon dots random lasers

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Rare Metals 2024年第8期43卷 3844-3853页

作者： Xiang-Dong Wang Xiao-Bo Mi Jiu-ru He Feng-Ying ma Jun-Qiao Wang Li Song Yong-Qiang Zhang Si-Yu Lu Yong-Sheng Hu School of Physics and Microelectronics Zhengzhou UniversityZhengzhou 450001China State Key Laboratory of Reliability and Intelligence of Electrical Equipment and Tianjin Key Laboratory of Electronic materials and Devices School of Electronics and Information EngineeringHebei University of TechnologyTianjin 300401China Green Catalysis Center College of ChemistryZhengzhou UniversityZhengzhou450001China

Vortex beams have attracted great attention due to their promising applications in the fields of high-capacity optical communication,optical micromanipulation,and quantum information ***,we demonstrate vortex beams with flexible control of the topological charge and modes in a carbon dots random laser for the first *** beams with different types,including the Laguerre-Gaussian(LG),Bessel-Gaussian(BG),LG-superposition,and polarized vortex beams with topological charges up to 50,have been successfully ***,vortex beams can be well realized in carbon dots random lasers with different emission wavelengths covering from 465 to 612 *** work would not only enrich the types of vortex laser,especially for solution-processable lasers,but also provide a new route to realizing multicolor and wavelength-tunable vortex lasers.

关键词： Carbon dots Random lasers Vortex beam Topological charge Spatial light modulator

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magnetocaloric effect and phase transition critical behavior of La0.75Sr0.25Mn0.9Co0.1O3 compound synthesized under the high pressure

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Tungsten 2024年第3期6卷 621-632页

作者： Jing Zhao Lei Gao Jian-Jun Zhao Wei Wei Hui-Qin Yun ru Xing Huai-Jin ma Xiang Jin Luo-Meng Chao School of Physical Science and Technology Key Laboratory of Magnetism and Magnetic Materials for Higher Education in Inner Mongolia Autonomous Region Baotou Teachers' College National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths School of Physics and Electronic Information Inner Mongolia Normal University College of Science Inner Mongolia University of Science and Technology

In this study,a novel method is proposed for producing perovskite rare-earth manganese oxide magnetic refrigeration materials that exhibit superior properties compared to similar *** maximum magnetic entropy change values for this sample are 1.44 and 3.75 J·kg-1·K-1for magnetic fields of 2 and 7 T,***,its relative cooling power has been calculated to be 101.96 and 404.78 J·kg-1,indicating good *** results were obtained using the sample synthesized under a pressure of 4 GPa,and the sample has undergone a second phase *** critical behavior of the sample fits well with the mean field *** different magnetic fields,there is a significant overlap between the values of the maximum magnetic entropy change and the temperature-averaged entropy change,indicating that the refrigeration performance of the sample after high pressure can approach its maximum capability.

关键词： High-pressure synthesis magnetocaloric effect Relative cooling power magnetic phase transition

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Targeting lncRNA16 by GalNAc-siRNA conjugates facilitates chemotherapeutic sensibilization via the HBB/NDUFAF5/ROS pathway

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Science China(Life Sciences) 2024年第4期67卷 663-679页

作者： Yanfang Liu Yan Wang Bing Liu Wenzhong Liu Yuanyuan ma Yiren Cao Shi Yan Panpan Zhang Lixin Zhou Qimin Zhan nan Wu Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Surgery IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Laboratory of Molecular OncologyPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Department of Thoracic Oncology IIPeking University Cancer Hospital and InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of PathologyPeking University Cancer Hospital and InstituteBeijing 100142China Peking University International Cancer Institute Beijing 100191China Institute of Cancer Research Shenzhen Bay LaboratoryShenzhen 518132China

Chemoresistance is a significant barrier to effective cancer *** mechanisms for chemoresistance include reactive oxygen species(ROS)accumulation and expression of chemoresistance-promoting ***,we report a novel function of lncRNA16 in the inhibition of ROS generation and the progression of *** analyzing the serum levels of lncRNA16 in a cohort of 35 patients with non-small cell lung cancer(NSCLC)and paired serum samples pre-and post-treatment from 10 NSCLC patients receiving neoadjuvant platinum-based chemotherapy,performing immunohistochemistry(IHC)assays on 188 NSCLC tumor samples,using comprehensive identification of RNA-binding proteins by mass spectrometry(ChIRP-MS)assays,as well as RNA immunoprecipitation(RIP)and RNA pull-down analyses,we discovered that patients with increased serum levels of lncRNA16 exhibited a poor response to platinum-based *** expression of hemoglobin subunit beta(HBB)and NDUFAF5 significantly increases with the development of ***16 binds to HBB and promotes HBB accumulation by inhibiting ***16 can also inhibit ROS generation via the HBB/NDUFAF5 axis and function as a scaffold to facilitate the colocalization of HBB and NDUFAF5 in the ***,preclinical studies in mouse models of chemo-resistant NSCLC have suggested that lncRNA16 targeting by trivalent N-acetylgalactosamine(GalNAc)-conjugated siRNA restores chemosensitivity and results in tumor growth inhibition with no detectable toxicity in ***,lncRNA16 is a promising therapeutic target for overcoming chemoresistance,and the combination of first-line platinum-based chemotherapy with lncRNA16 intervention can substantially enhance anti-tumor efficacy.

关键词： chemoresistance lncRNARNA interference ROs chemosensitizer

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Simultaneous type III congenital esophageal atresia and patent ductus arteriosus in a low-weight patient: A case report

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World Journal of Clinical Cases 2024年第3期12卷 560-564页

作者： Yong-Yu ma Jun-ru Chen Shi-Wu Yang Shu-Yu Wang Xin Cao Jun Wu Faculty of Pediatrics Children’s Hospital Affiliated to Kunming Medical UniversityKunming 650103Yunnan ProvinceChina Department of Cardiothoracic Surgery Kunming Children’s HospitalKunming 650103Yunnan ProvinceChina

BACKGROUND We report a low-birth-weight child(1.8 kg)with neonatal type III congenital esophageal atresia(CEA)combined with symptomatic patent ductus arteriosus(PDA).After comprehensive evaluation,esophageal anastomosis was performed on postnatal day 11 after excluding surgical contraindications,and arterial catheter ligation was performed at the same *** surgery for CEA combined with PDA has not been clearly reported in the *** SUMmaRY We report a 6-day-old female child with type III CEA and *** patient presented with foam at the mouth after birth,cough and shortness of breath after *** another hospital,she was considered to have neonatal pneumonia,neonatal jaundice and congenital heart disease and transferred to our *** iodine oil radiography of the esophagus and echocardiography we con-firmed diagnosis of CEA and *** diameter of the PDA was 8 mm,with obvious left to right *** performed right rear extrapleural orificium fistula ligation and esophageal anastomosis,and ligation of PDA via left axilla straight incision after 5 d of *** operations were successful,and the incision healed after 12 d,and the patient was *** re-examined the patient 1 mo after *** did not vomit when she ate rice *** angiography showed no stricture of the anastomotic *** patient weighed 3.2 *** For CEA patients with multiple risk factors,comprehensive,timely and accurate diagnosis and evaluation,and early treatment may improve prognosis.

关键词： Congenital esophageal atresia Patent ductus arteriosus Low weight One-stage operation Case report

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Data-driven systematic analysis of waterborne viruses and health risks during the wastewater reclamation process

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Environmental Science and Ecotechnology 2024年第3期19卷 80-90页

作者： Jia-Xin ma Xu Wang Yi-Rong Pan Zhao-Yue Wang Xuesong Guo Junxin Liu nan-Qi Ren David Butler Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing100085China State Key Laboratory of UrbanWater Resource and Environment School of Civil and Environmental EngineeringHarbin Institute of TechnologyShenzhenShenzhen518055China University of Chinese Academy of Sciences Beijing100049China Centre for Water Systems College of EngineeringMathematics and Physical SciencesUniversity of ExeterExeterEX44QFUnited Kingdom

Waterborne viral epidemics are a major threat to public *** interest in wastewater reclamation highlights the importance of understanding the health risks associated with potential microbial hazards,particularly for reused water in direct contact with *** study focused on identifying viral epidemic patterns in municipal wastewater reused for recreational applications based on long-term,spatially explicit global literature data during 2000e2021,and modelled human health risks from multiple exposure pathways using a well-established quantitative microbial risk assessment *** median viral loads in municipal wastewater ranged from 7.92×10^(4)to 1.4×10^(6)GC L^(-1)in the following ascending order:human adenovirus(HAdV),norovirus(NoV)GII,enterovirus(EV),NoV GI,rotavirus(RV),and severe acute respiratory syndrome coronavirus 2(SARSCoV-2).Following secondary or tertiary wastewater treatment,NoV GI,NoV GII,EV,and RV showed a relatively higher and more stable log reduction value with medians all above 0.8(84%),whereas SARSCoV-2 and HAdV showed a relatively lower reduction,with medians ranging from 0.33(53%)to 0.55(72%).A subsequent disinfection process effectively enhanced viral removal to over 0.89-log(87%).The predicted event probability of virus-related gastrointestinal illness and acute febrile respiratory illnesses in reclaimed recreational water exceeded the World Health Organization recommended recreational risk benchmark(5%and 1.9%,respectively).Overall,our results provided insights on health risks associated with reusing wastewater for recreational purposes and highlighted the need for establishing a regulatory framework ensuring the safety management of reclaimed waters.

关键词： Reclaimed water Waterborne virus Recreational Human health Data-driven analysis

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Exploring the complex trade-offs and synergies of global ecosystem services

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Environmental Science and Ecotechnology 2024年第5期21卷 141-148页

作者： Jinnan Wang Wenjun Wu Meng Yang Yueming Gao Jiacheng Shao Weishan Yang Guoxia ma Fang Yu nan Yao Hongqiang Jiang State Environmental Protection Key Laboratory of Environmental Planning and Policy Simulation Chinese Academy of Environmental PlanningBeijing100041China The Center for Eco-Environmental Accounting Chinese Academy of Environmental PlanningBeijing100041China The Innovation Center for Eco-environment-Oriented Development Chinese Academy of Environmental PlanningBeijing100041China School of Environment Beijing Normal UniversityBeijing100875China College of Environmental&Resource Sciences Zhejiang UniversityHangzhou310058China College of Economics&management Northwest A&F UniversityYangling712100China

The trade-off and synergy relationship of ecosystem services is an important topic in the current *** value of each service provided by the ecosystem is substantially affected by human activities,and conversely,its changes will also affect the relevant human *** to varying tradeoffs among ecosystem services and synergies between them that can either increase or decrease,it is difficult to optimize multiple ecosystem services simultaneously,making it a huge challenge for ecosystem *** study firstly develops a global Gross Ecosystem Product(GEP)accounting *** uses remote sensing data with a spatial resolution of 1 km to estimate the ecosystem services of forests,wetlands,grasslands,deserts,and farmlands in 179 major countries in *** results show that the range of global GEP values is USD 112e197 trillion,with an average value of USD 155 trillion(the constant price),and the ratio of GEP to gross domestic product(GDP)is *** tradeoffs and the synergies among different ecosystem services in each continent and income group have been further *** found a correspondence between the income levels and the synergy among ecosystem services within each *** specific ecosystem services,there are strong synergies between oxygen release,climate regulation,and carbon sequestration services.A trade-off relationship has been observed between flood regulation and other services,such as water conservation and soil retention services in low-income *** results will help clarify the roles and the feedback mechanisms between different stakeholders and provide a scientific basis for optimizing ecosystem management and implementing ecological compensation schemes to enhance human well-being.

关键词： Ecosystem services Biophysical quantity Monetary value Trade-off Synergy

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质子滴线核^(17)F在近库仑势垒能区的反应机制研究进展

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科学通报 2021年第27期66卷 3544-3552页

作者：杨磊林承键贾会明马南茹王东玺杨峰温培威中国原子能科学研究院核物理研究所北京102413 广西师范大学物理科学与技术学院桂林541004

质子滴线核在近库仑势垒能区的反应机制研究是当前核物理领域的热点问题.本文对国内外开展的^(17)F在近库仑势垒能区的实验研究进行了回顾和总结.为了深入探索^(17)F的反应机制,本课题组相继开展了^(17)F+^(12)C,89Y和^(208)Pb的弹性散... 详细信息

质子滴线核在近库仑势垒能区的反应机制研究是当前核物理领域的热点问题.本文对国内外开展的^(17)F在近库仑势垒能区的实验研究进行了回顾和总结.为了深入探索^(17)F的反应机制,本课题组相继开展了^(17)F+^(12)C,89Y和^(208)Pb的弹性散射研究以及^(17)F+^(58)Ni的全反应道研究.目前的弹性散射研究表明,在大范围的靶区内,^(17)F的破裂连续态对弹性散射的耦合效应并不显著.对于破裂反应,在近垒能区只有^(17)F+^(58)Ni体系的细致研究.研究表明,去弹破裂是主要的^(16)O产生机制.而对于熔合反应,目前只有^(17)F+^(58)Ni和^(208)Pb两个体系的实验结果.^(17)F+^(58)Ni体系在垒下表现出明显的总熔合截面增强现象.理论计算表明,这种增强主要是由^(17)F连续态的耦合效应导致.而对于^(17)F+^(208)Pb,其总熔合激发函数与^(19)F+^(208)Pb基本相同.^(17)F+^(58)Ni和^(208)Pb体系熔合激发函数的差异还需要进一步研究.

关键词：质子滴线核^(17)F 近库仑势垒能区弹性散射破裂反应熔合反应

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-Xiao Li Hong-nan Mo Yan-Tong Zhou Dan Lv Jing-Tong Zhai Hai-Li Qian Fei ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor *** the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment *** evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully *** Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of *** investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo *** signaling pathway components were evaluated using multi-omics *** were performed to elucidate the regulation of lipid metabolic reprogramming of *** We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic ***,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain *** Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of ***2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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Experimental study of the influencing factors and mechanisms of the pressure-reduction and augmented injection effect by nanoparticles in ultra-low permeability reservoirs

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Petroleum Science 2024年第3期21卷 1915-1927页

作者： Pan Wang Yu-Hang Hu Liao-Yuan Zhang Yong Meng Zhen-Fu ma Tian-ru Wang Zi-Lin Zhang Ji-Chao Fang Xiao-Qiang Liu Qing You Yan Zhang Beijing Key Laboratory of Unconventional Natural Gas Geological Evaluation and Development Engineering China University of Geosciences(Beijing)Beijing100083China School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Petroleum Engineering Technology Research Institute Sinopec Shengli Oilfield CompanyDongying257000ShandongChina Hekou Oil Production Plant Sinopec Shengli Oilfield CompanyDongying257200ShandongChina Petroleum Exploration and Production Research Institute SINOPECBeijing102206China CNPC Engineering Technology R&D Company Limited Beijing102206China

nanoparticles(NPs)have gained significant attention as a functional material due to their ability to effectively enhance pressure reduction in injection processes in ultra-low permeability *** are typically studied in controlled laboratory conditions,and their behavior in real-world,complex environments such as ultra-low permeability reservoirs,is not well understood due to the limited scope of their *** study investigates the efficacy and underlying mechanisms of NPs in decreasing injection pressure under various injection conditions(25—85℃,10—25 MPa).The results reveal that under optimal injection conditions,NPs effectively reduce injection pressure by a maximum of 22.77%in core *** pressure reduction rate is found to be positively correlated with oil saturation and permeability,and negatively correlated with temperature and ***,particle image velocimetry(PIV)experiments(25℃,atmospheric pressure)indicate that the pressure reduction is achieved by NPs through the reduction of wall shear resistance and wettability *** work has important implications for the design of water injection strategies in ultra-low permeability reservoirs.

关键词： nanoparticle Pressure reduction Augmented injection Ultra-low permeability reservoir

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