检索结果-南通市图书馆

Glycine Attenuates Myocardial Fibrosis in Myocardial Infarction in Rats Partly through Modulating Signal Transducer and Activator of Transcription 3/Nuclear Factor-κB/Transforming Growth Factor-β axis

引用

World Journal of Traditional Chinese Medicine 2024年第2期10卷 263-270页

作者： Ning Li Yong Wang Chun Li Xu Chen Xue-Feng Zhang nan nan tan Yi-Qin Hong Ming-Yan Shao Bing-Hua tang Dong-Qing Guo School of Life Science Beijing University of Chinese MedicineBeijingChina College of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Modern Research Center of Traditional Chinese Medicine School of Traditional Chinese Material MedicaBeijing University of Chinese MedicineBeijingChina

Objective: Inflammation and fibrosis are strongly associated with each other. Glycine is present in various traditional Chinese medicines and exhibits anti-inflammatory activity. However, the effects of glycine on myocardial fibrosis(MF) in rats with myocardial infarction(MI) have not been reported. The purpose of this study is to investigate the effects of glycine therapy on MF and comprehend its underlying mechanisms. Materials and Methods: Left anterior descending artery ligation-induced MI in Sprague Dawley rats was leveraged to assess the therapeutic effects of Glycine. Rats received either normal saline or glycine(0.5 mg/g bodyweight) for 7 days. Results: Glycine upregulated cardiac ejection fraction and fractional shortening to improve cardiac function, as evaluated by echocardiography. Histological and immunohistochemical analyses demonstrated that glycine could decrease inflammatory cell infiltration and alleviate collagen deposition. Western blotting revealed that nuclear factor-κB(NF-κB)-mediated inflammatory signaling was also downregulated by glycine treatment. The expression of signal transducer and activator of transcription 3(STAT3), tumor necrosis factor-α, and transforming growth factor-β(TGF-β) was decreased significantly in the glycine-treated group compared to the model group. Thus, glycine plays a protective role against myocardial ischemia and subsequent MF. Conclusion: The protective effects of glycine were achieved partly through STAT3/NF-κB/TGF-β signaling pathway.

关键词： Glycine myocardial fibrosis signal transducer and activator of transcription 3/nuclear factor-κB/transforming growth factor-β

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nomogram model including LATS2 expression was constructed to predict the prognosis of advanced gastric cancer after surgery

引用

World Journal of Gastrointestinal Surgery 2024年第2期16卷 518-528页

作者： nan Sun Bi-Bo tan Yong Li Department of Blood Transfusion The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hubei ProvinceChina Third Department of General Surgery the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Gastric cancer is a leading cause of cancer-related deaths *** assessments are typically based on the tumor-node-metastasis(TNM)staging system,which does not account for the molecular heterogeneity of this ***2,a tumor suppressor gene involved in the Hippo signaling pathway,has been identified as a potential prognostic biomarker in gastric *** To construct and validate a nomogram model that includes LATS2 expression to predict the survival prognosis of advanced gastric cancer patients following ra-dical surgery,and compare its predictive performance with traditional TNM *** A retrospective analysis of 245 advanced gastric cancer patients from the Fourth Hospital of Hebei Medical University was *** patients were divided into a training group(171 patients)and a validation group(74 patients)to deve-lop and test our prognostic *** performance of the model was determined using C-indices,receiver operating characteristic curves,calibration plots,and decision *** The model demonstrated a high predictive accuracy with C-indices of 0.829 in the training set and 0.862 in the validation *** under the curve values for three-year and five-year survival prediction were significantly robust,suggesting an excellent discrimination *** plots confirmed the high concordance between the predictions and actual survival *** We developed a nomogram model incorporating LATS2 expression,which significantly outperformed conven-tional TNM staging in predicting the prognosis of advanced gastric cancer patients *** model may serve as a valuable tool for individualized patient management,allowing for more accurate stratification and im-proved clinical *** validation in larger patient cohorts will be necessary to establish its generaliza-bility and clinical utility.

关键词： Gastric cancer LATS2 Column line graph Prognosis Advanced gastric cancer survival Molecular biomarkers Predictive analytics in oncology Survival analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Weizmannia coagulans:an ideal probiotic for gut health

引用

Food Science and Human Wellness 2024年第1期13卷 16-26页

作者： Shiqi Zhang Pinglan Li Suwon Lee Yu Wang Chunming tan nan Shang Key Laboratory of Functional Dairy Ministry of EducationCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China Coree Beijing Co. Ltd.Beijing 101312China Key Laboratory of Precision Nutrition and Food Quality Department of Nutrition and HealthChina Agricultural UniversityBeijing 100083China College of Engineering China Agricultural UniversityBeijing 100083China

Weizmannia coagulans(formerly Bacillus coagulans)is a spore-forming and lactic acid-producing *** has recently attracted much attention from researchers and food manufacturers due to its probiotic functions and stability in processing and *** is capable of improving gut health through the regulation of gut microbiota,modulation of immunity,and improving digestibility and ***,germinated cells and metabolites of *** modulate the gut micro-environment and further affect other *** is an environment-friendly probiotic since it can contribute to the host by reconstructing the balance of gut microbiota and only temporarily resides in the intestine after *** has been generally recognized as safe(GRAS)by the US Food and Drug Administration(FDA),thus it is an ideal probiotic for improving gut *** merit of its stability in processing and storage provides *** spores many possibilities for its use in various types of functional *** review presents an overview of the characteristics of *** that make it an ideal probiotic candidate and highlights the proposed health benefits with scientific evidence conferred by the administration of ***.

关键词： Weizmannia coagulans Spore former Probiotics Microbiota Gut disorders

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An indicator model for assessing community resilience to the COVID-19 pandemic and its validation: A case study in Hong Kong

引用

Journal of Safety Science and Resilience 2024年第2期5卷 222-234页

作者： nan Liao Muhammad Nawaz Departnent of Geography Faculty Art and Social SciencesSingapore 65166666Singapore

The COVID-19 outbreak had a significant negative impact on the world,and the fifth wave of COVID-19 in Hong Kong brought a considerable shock to Chinese *** is a growing call for more resilient ***,empirical evidence and validation of modeling studies of resilience indicators for urban community responses to the COVID-19 pandemic still need to be *** this study,a resilience assessment indicator model comprising 4 subsystems,7 indicators,and 12 variables was developed to assess the resilience of Hong Kong communities in response to COVID-19(i.e.,Resilience Index).Furthermore,this study utilized regression models such as geographically weighted regression(GWR)and multiscale GWR(MGWR)to validate the resilience model proposed in this study at the model and variable *** the regression model,the Resilience Index and the individual variables in the resilience model are explanatory variables,and the outcomes of the COVID-19 pandemic(confirmed cases,confirmation rate,discharged cases,discharge rate)are dependent *** results showed that:(i)the resilience of Hong Kong communities to the COvID-19 pandemic was not strong in general and showed some clustered spatial distribution characteristics;(i)the validation results at the model level showed that the Resilience Index did not explain the consequences of the COvID-19 pandemic to a high degree;(ii)the validation results at the variable level showed that the MGWR model was the best at identifying the relationships between explanatory variables and the dependent variable;and(iv)compared with the model-level assessment results,the variable-level assessment explained the consequences of the COvID-19 pandemic better than the model level assessment *** above analysis and the spatial distribution maps of the resilience variables can provide empirically based and targeted insights for policymakers.

关键词： Resilience Community resilience CoVID-19pandemic Resilience assessment indicator model Resilience model validation MGWR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Data-Driven Direct Adaptive Risk-Sensitive Control of Stochastic Systems

引用

Journal of Systems Science & Complexity 2024年第4期37卷 1446-1469页

作者： QIAO nan LI Tao School of Mathematical Sciences East China Normal UniversityShanghai 200241China Shanghai Key Laboratory of Pure Mathematics and Mathematical Practice School of Mathematical SciencesEast China Normal UniversityShanghai 200241China

The authors propose a data-driven direct adaptive control law based on the adaptive dynamic programming(ADP) algorithm for continuous-time stochastic linear systems with partially unknown system dynamics and infinite horizon quadratic risk-sensitive *** authors use online data of the system to iteratively solve the generalized algebraic Riccati equation(GARE) and to learn the optimal control law *** the case with measurable system noises,the authors show that the adaptive control law approximates the optimal control law as time goes *** the case with unmeasurable system noises,the authors use the least-square solution calculated only from the measurable data instead of the real solution of the regression equation to iteratively solve the *** authors also study the influences of the intensity of the system noises,the intensity of the exploration noises,the initial iterative matrix,and the sampling period on the convergence of the ADP ***,the authors present two numerical simulation examples to demonstrate the effectiveness of the proposed algorithms.

关键词： Adaptive dynamic programming direct adaptive control generalized algebraic Riccati equation risk-sensitive control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure

引用

Journal of Environmental Sciences 2024年第2期136卷 270-278页

作者： Tingting Ku Jindong Hu Mengmeng Zhou Yuanyuan Xie Yutong Liu Xin tan Lin Guo Guangke Li nan Sang College of Environmental Science and Resources Research Center of Environment and HealthShanxi UniversityTaiyuan 030006China

Tebuconazole exposure has been described as an increasing hazard to human *** increasing number of recent studies have shown a positive association between tebuconazole exposure and cardiovascular disease risk,which is characterized by the reduction of adenosine triphosphate(ATP)***,researches on the damage of tebuconazole exposure to energy metabolism and the related molecular mechanisms are *** the present study,male C57BL/6 mice were treated with tebuconazole at different low concentrations for 4 *** results indicated that tebuconazole could accumulate in the heart and further induce the decrease of ATP content in the mouse ***,tebuconazole induced an obvious shift in substrate utilization of fatty acid and glucose by disrupting their corresponding transporters(GLUT1,GLUT4,CD36,FABP3 and FATP1)expression,and significantly repressed the expression of mitochondrial biogenesis(Gabpa and Tfam)and oxidative phosphorylation(CS,Ndufa4,Sdhb,Cox5a and Atp5b)related genes in a dosedependent *** investigation revealed that these alterations were related to the IRS1/AKT and PPARγ/RXRα*** findings contribute to a better understanding of triazole fungicide-induced cardiovascular disease by revealing the key indicators associated with this phenomenon.

关键词： Tebuconazole Cardiotoxicity Energy metabolic disorders Energy substrate Mitochondrial damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bending results of graphene origami reinforced doubly curved shell

引用

Defence Technology（防务技术） 2024年第5期35卷 198-210页

作者： nan Yang Yunhe Zou Mohammad Arefi School of Architecture and Civil Engineering Qiqihar UniversityQiqihar 161006HeilongjiangChina School of Mechanical Engineering Inner Mongolia University of TechnologyHohhot 010051Inner MongoliaChina Inner Mongolia Key Laboratory of Special Service Intelligent Robotics Hohhot 010051Inner MongoliaChina Faculty of Mechanical Engineering Department of Solid MechanicsUniversity of KashanKashan87317-51167Iran

The present work investigates higher order stress,strain and deformation analyses of a shear deformable doubly curved shell manufactures by a Copper(Cu)core reinforced with graphene origami auxetic metamaterial subjected to mechanical and thermal *** effective material properties of the graphene origami auxetic reinforced Cu matrix are developed using micromechanical models cooperate both material properties of graphene and Cu in terms of temperature,volume fraction and folding *** principle of virtual work is used to derive governing equations with accounting thermal *** numerical results are analytically obtained using Navier's technique to investigate impact of significant parameters such as thermal loading,graphene amount,folding degree and directional coordinate on the stress,strain and deformation responses of the *** graphene origami materials may be used in aerospace vehicles and structures and defence technology because of their low weight and high stiffness.A verification study is presented for approving the formulation,solution methodology and numerical results.

关键词： Graphene origami Copper matrix Doubly curved Shear deformable Auxetic metamaterial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Toward understanding the microstructure characteristics,phase selection and magnetic properties of laser additive manufactured Nd-Fe-B permanent magnets

引用

International Journal of Extreme Manufacturing 2024年第1期6卷 277-294页

作者： Bo Yao nan Kang Xiangyu Li Dou Li Mohamed EL Mansori Jing Chen Haiou Yang Hua tan Xin Lin State Key Laboratory of Solidiffcation Processing Northwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Arts et Metiers Institute of Technology MSMPHESAM UniversitéF-51006 Chˆalons-en-ChampagneFrance Key Laboratory of Metal High Performance Additive Manufacturing and Innovative Design MIIT ChinaNorthwestern Polytechnical UniversityXi’anShaanxi 710072People’s Republic of China Texas A&M Engineering Experiment Station Institute for Manufacturing SystemsCollege StationTX 77843United States of America

Nd-Fe-B permanent magnets play a crucial role in energy conversion and electronic *** essential magnetic properties of Nd-Fe-B magnets,particularly coercivity and remanent magnetization,are significantly infuenced by the phase characteristics and *** this work,Nd-Fe-B magnets were manufactured using vacuum induction melting(VIM),laser directed energy deposition(LDED)and laser powder bed fusion(LPBF)*** evolution and phase selection of Nd-Fe-B magnets were then clarified in *** results indicated that the solidification velocity(V)and cooling rate(R)are key factors in the phase *** terms of the VIM-casting Nd-Fe-B magnet,a large volume fraction of theα-Fe soft magnetic phase(39.7 vol.%)and Nd2Fe17Bxmetastable phase(34.7 vol.%)areformed due to the low R(2.3×10-1?C s-1),whereas only a minor fraction of the Nd2Fe14B hard magnetic phase(5.15 vol.%)is *** the LDED-processed Nd-Fe-B deposit,although the Nd2Fe14B hard magnetic phase also had a low value(3.4 vol.%)as the values of V(10-2m s-1)and R(1.45×106?C s-1)in the LPBF process resulted in the substantial formation of the Nd2Fe14B hard magnetic phase(55.8 vol.%)directly from the liquid,while theα-Fe soft magnetic phase and Nd2Fe17Bxmetastable phase precipitation are suppressed in the LPBF-processed Nd-Fe-B ***,crystallographic texture analysis reveals that the LPBF-processedNd-Fe-B magnets exhibit isotropic magnetic ***,the LPBF-processed Nd-Fe-B deposit,exhibiting a coercivity of 656 k A m-1,remanence of 0.79 T and maximum energy product of 71.5 k J m-3,achieved an acceptable magnetic perfor

关键词： laser additive manufacturing(LAM) Nd-Fe-B permanent magnets numerical simulation microstructure magnetic properties

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spin-orbit interaction induced Casimir-Lifshitz torque between two-dimensional electron gases

引用

Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 134-142页

作者： Jia-nan Rong Liang Chen Kai Chang State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China School of Physics Zhejiang UniversityHangzhou 310027China College of Materials Science and Opto-electronic Technology University of Chinese Academy of SciencesBeijing 100049China

We investigate theoretically the Casimir interaction between two parallel two-dimensional electron gases(2DEGs)with Rashba and Dresselhaus spin-orbit interactions(SOIs),based on the quantum field *** derive an analytical expression for the polarization tensor and obtain the solution to the motion equation of the electromagnetic(EM)*** calculate the CasimirLifshitz torque(CLT)between two parallel 2DEGs with Rashba and Dresselhaus SOIs,which can be tuned by changing the relative strength between two *** anisotropic Casimir energy between 2DEGs caused by the interplay between the SOIs of 2DEGs offers a new origin of CLT and a new type of optoelectronic device.

关键词： Casimir torque two-dimensional electron gas spin-orbit interaction

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Growth and development of children in China:achievements,problems and prospects

引用

World Journal of Pediatrics 2024年第2期20卷 97-104页

作者： Xin-nan Zong Hui Li Department of Growth and Development Capital Institute of PediatricsBeijing 100020China

Growth reflects the general condition of society,and is a measure of the nutritional and hygienic status of a population[1,2].Nutrition is one of the most important components of children’s well-being[3].The Chinese government attaches great importance to children’s health and development,with a clear statement and consistent practice for“Children are the future and hope of the motherland”.

关键词： mother statement children

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：