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Eco-Environment & Health 2024年第3期3卷 281-289页

作者： Ya'nan guo linsheng Yang li Wang Hairong li Quansheng Ge Key laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

This study innovatively evaluated ecological civilization in china from the perspective of environment and health.A Composite Environmental Health Index(CEHI)was constructed based on the Driving force-Pressure-State-Impact-Response(DPSIR)and Coupling Coordination Degree(CCD)*** showed that significant and sustained improvements were observed in the ecological environment after ecological civilization,while economic development continued to progress at a steady ***,the advancement in population health(impact subsystem),exhibited comparatively modest progress,potentially linked to issues such as demographic aging and the enduring consequences of past exposure to environmental *** the provincial level,the regional development was *** CEHI performance was highest in the eastern regions,followed by the central regions,with the western regions showing the least ***,Guangdong,Jiangsu,shanghai,and Zhejiang emerged as top performers with higher CEHI scores,which can be attributed to their favorable geographical positioning and the response ***,northeastern regions(Heilongjiang,Jilin,and liaoning)and northwestern regions(Shaanxi,Gansu,Ningxia,and Qinghai)experienced limited advancements in post-ecological civilization *** these underperforming regions,there is a pressing need to intensify efforts aimed at enhancing their response *** summary,china's pursuit of ecological civilization has yielded significant successes,potentially offering valuable insights for other nations striving for sustainable *** ecological civilization model's integration of ecological environmental protection into economic,political,cultural,and social constructs may serve as a meaningful reference for the sustainable development of other countries.

关键词： Ecological civilization Environment and health Driving force-Pressure-State-Impact-Response Coupling Coordination Degree Model

Novel heterozygous USH1C mutation impacts hair cell mechanotransduction and causes progressive hearing loss

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Science Bulletin 2024年第2期69卷 167-172页

作者： Yanyan Jia Gaogan Jia Luo guo nan Song Yu-Meng Wang Luoying Jiang Yilai Shu Yan Chen Shujia Zhu Huawei li Wenyan li ENT institute and Otorhinolaryngology Department of Eye&ENT Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceFudan UniversityShanghai 200031China institutes of Biomedical Sciences Fudan UniversityShanghai 200032China NHC Key laboratory of Hearing Medicine(fudan university) Shanghai 200031China The institutes of brain Science and the Collaborative Innovation Center for brain Science Fudan UniversityShanghai 200032China shanghai Center for brain Science and brain-Inspired Intelligence Technology Shanghai 201210China institute of Neuroscience State Key Laboratory of NeuroscienceCAS Center for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Department of Cardiology and Institute for Developmental and Regenerative Cardiovascular MedicineXinhua Hospital Affiliated to Shanghai Jiaotong University School of MedicineShanghai 200092China

Hearing loss is one of the most common sensory disorders worldwide,affecting approximately 466 million people,including 34 million children[1].Genetic mutations accounts for approximately 60%of inherited hearing loss cases[2,3].These genetic changes result in a wide variety of clinical manifestations,ranging from nonsyndromic hearing loss(NSHL)to over 400 syndromes involving hearing loss and from mild adult-onset hearing loss to profound congenital deafness,covering the entire spectrum of Mendelian inheritance.

关键词： mec hearing approximate

An empirical model for high energy density lithium-(ion)batteries with ultra-thick electrodes

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Tungsten 2024年第1期6卷 230-237页

作者： li-ming Jin Guang-Guang Xing nan Qin Yan-Yan Lu Jun-Sheng Zheng Cun-Man Zhang Jim P.Zheng School of Automotive Studies and Clean Energy Automotive Engineering Center Tongji UniversityShanghai 201804China Department of Electrical Engineering University at BuffaloThe State University of New YorkBuffaloNY 14260USA

Increasing the electrode thickness is a significant method to decrease the weight and volume ratio of the inactive components for high energy density of the *** this contribution,we extracted a repeating unit in the configurations and establish the empirical energy density model based on some *** this model,the effects of the electrode thickness on the energy density for lithium-ion batteries(liBs),lithium metal batteries(LMBs),and anode-free lithium batteries(ALBs)are evaluated quantitively with the current parameters of the *** results demonstrate that the structure evolutions from liBs,LMBs to ALBs with the reduction of the anode weight contribution,the energy density can be well improved *** the increase of the thickness of the electrode provide another route to furthe r enhance the energydensity by decreasing the weight contribution of inactive materials;meanwhile the effects for ALBs are higher than LMBs and liBs due to the higher weight ratio of inactive *** empirical energy density model is also applied into the practical system and provide intuitional results to guide the battery design for higher energy density.

关键词： Empirical model High energy density lithium batteries Ultra-thick electrodes

Synthesis of granulated li_(1.33)Mn_(1.67)O_(4) via two antisolvent methods for lithium adsorption from gas-produced water

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Chinese Journal of Chemical Engineering 2024年第5期69卷 34-46页

作者： Jun Qiu Lu-Ri bao Wei guo Ying Yang Shu-Ying Sun National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China

Gas-produced water is an accompanying wastewater in the natural gas extraction process,and it is a potential liquid lithium resource that contains a considerable amount of *** study investigated the feasibility of using manganese-based ion sieves to adsorb and extract lithium from gas-produced *** we focused on the applicability of two different granulation methods,extrusion and droplet,in gas-produced water *** types of H_(1.33)Mn_(1.67)O_(4) particles were prepared by the extrusion method(EHMO)and the droplet method(DHMO).The porosity of DHMO was much higher than that of EHMO,and the adsorption performance of DHMO increased with the decrease of binder *** prepared with a binder concentration of 0.14 g·ml^(-1)exhibited the best adsorption performance in gas-produced water,and the li^(+)adsorption capacity could reach 25.14 mg·g^(-1).In gas-produced water,the adsorption equilibrium of DHMO only took 9 h,and the adsorption process conformed to the Langmuir model and pseudo-second-order kinetic *** pore diffusion model(PDM)could well describe its adsorption ***,DHMO showed a great selectivity to li^(+),and the selectivity order of DHMO in gas-produced water was li^(+)>Ba^(2+)>>Mg^(2+),Ca^(2+),Sr^(2+)>>Na^(+)>>K^(+).After 20 cycles,the li^(+)adsorption capacity was still higher than 17.30 mg·g^(-1),and the rate of manganese dissolution was less than 1%.

关键词： Gas-produced water Granulation li_(1.33)Mn_(1.67)O_(4)

I-DCGAN and TOPSIS-IFP:A simulation generation model for radiographic flaw detection images in light alloy castings and an algorithm for quality evaluation of generated images

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china Foundry 2024年第3期21卷 239-247页

作者： ming-jun Hou Hao Dong Xiao-yuan Ji Wen-bing Zou Xiang-sheng Xia Meng li Ya-jun Yin bao-hui li Qiang Chen Jian-xin Zhou State Key laboratory of Materials Processing and Die&Mould Technology Huazhong University of Science and TechnologyWuhan 430074China Xinjiang Technology(Jiangsu)Co. Ltd.Nantong 226100JiangsuChina Southwest Technique and Engineering Research institute Chongqing 400039China shanghai Spaceflight Precision Machinery institute Shanghai 201600China

The intelligent detection technology driven by X-ray images and deep learning represents the forefront of advanced techniques and development trends in flaw detection and automated evaluation of light alloy ***,the efficacy of deep learning models hinges upon a substantial abundance of flaw *** existing research on X-ray image augmentation for flaw detection suffers from shortcomings such as poor diversity of flaw samples and low reliability of quality *** this end,a novel approach was put forward,which involves the creation of the Interpolation-Deep Convolutional Generative Adversarial Network(I-DCGAN)for flaw detection image generation and a comprehensive evaluation algorithm named TOPSIS-IFP.I-DCGAN enables the generation of high-resolution,diverse simulated images with multiple appearances,achieving an improvement in sample diversity and quality while maintaining a relatively lower computational ***-IFP facilitates multi-dimensional quality evaluation,including aspects such as diversity,authenticity,image distribution difference,and image distortion *** results indicate that the X-ray radiographic images of magnesium and aluminum alloy castings achieve optimal performance when trained up to the 800th and 600th epochs,*** TOPSIS-IFP value reaches 78.7%and 73.8%similarity to the ideal solution,*** to single index evaluation,the TOPSIS-IFP algorithm achieves higher-quality simulated images at the optimal training *** approach successfully mitigates the issue of unreliable quality associated with single index *** image generation and comprehensive quality evaluation method developed in this paper provides a novel approach for image augmentation in flaw recognition,holding significant importance for enhancing the robustness of subsequent flaw recognition networks.

关键词： light alloy casting flaw detection image generator discriminator comprehensive evaluation index

Aloe emodin promotes mucosal healing by modifying the differentiation fate of enteroendocrine cells via regulating cellular free fatty acid sensitivity

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Acta Pharmaceutica Sinica B 2024年第9期14卷 3964-3982页

作者： Weilian bao Jiaren Lyu Guize Feng linfeng guo Dian Zhao Keyuan You Yang liu Haidong li Peng Du Daofeng Chen Xiaoyan Shen Department of Pharmacology&the Key laboratory of Smart Drug Delivery Ministry of Education School of PharmacyFudan UniversityShanghai 201210China Department of Natural Medicine School of PharmacyFudan UniversityShanghai 201210China Department of Colorectal and Anal Surgery Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghai 200092China shanghai Colorectal Cancer Research Center Shanghai 200092China

The proper differentiation and reorganization of the intestinal epithelial cell population is critical to mucosal regeneration post *** retaining cells(LRCs)expressing SRY-box transcription factor 9(SOX9)promote epithelial repair by replenishing LGR5 t intestinal stem cells(ISCs).While,LRCs are also considered precursor cells for enteroendocrine cells(EECs)which exacerbate mucosal damage in inflammatory bowel disease(IBD).The factors that determine LRC-EEC differentiation and the effect of intervening in LRC-EEC differentiation on IBD remain *** this study,we investigated the effects of a natural anthraquinone called aloe emodin(derived from the Chinese herb rhubarb)on mucosal healing in IBD *** findings demonstrated that aloe emodin effectively interfered with the differentiation to EECs and preserved a higher number of SOX9t LRCs,thereby promoting mucosal ***,we discovered that aloe emodin acted as an antagonist of free fatty acid receptors(FFAR1),suppressing the FFAR1-mediated Gbg/serine/threonine-protein kinase(AKT)pathway and promoting the translocation of forkhead box protein O1(FOXO1)into the nucleus,ultimately resulting in the intervention of differentiation *** findings reveal the effect of free fatty acid accessibility on EEC differentiation and introduce a strategy for promoting mucosal healing in IBD by regulating the FFAR1/AKT/FOXO1 signaling pathway.

关键词： LRCs ISCs EECs IBD SOX9 Aloe emodin FFAR1 FOXO1

β-Adrenergic activation enhances NMDA-induced current in pyramidal cells of the basolateral nucleus of amygdala

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Science Bulletin 2005年第17期 152-154页

作者： liU Xinqiu, CAO Xiaohua & li bao-ming laboratory of higher brain functions, institute of neurobiology, Insti-tute of brain Science, fudan university, shanghai 200433, china

NMDA receptor (NMDA-R) in the amygdala complex is critical for both long-term potentiation (LTP) and formation of conditioned fear memory. It is reported that activation of β-adrenoceptors (β-AR) in the amygdala facili-tates LTP and enhances memory consolidation. The present study examined the regulatory effect of β-AR activation on NMDA-R mediated current in pyramidal cells of the baso-lateral nucleus of amygdala (BLA), using whole-cell re-cording technique. Bath application of the β-AR agonist iso-proterenol enhanced NMDA-induced current, and this fa-cilitatory effect was blocked by co-administered propranolol, a β-AR antagonist. The facilitatory effect of isoproterenol on NMDA-induced current could not be induced when the pro-tein kinase A (PKA) inhibitor Rp-cAMPs was added in elec-trode internal *** present results suggest that β-AR activation in the BLA could modulate NMDA-R activity di-rectly and positively, probably via PKA.

关键词： β-adrenoceptor NMDA receptor amygdala basolateral nucleus of amygdala rat.

Nickel-modified In_(2)O_(3) with inherent oxygen vacancies for CO_(2) hydrogenation to methanol

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Science china Chemistry 2024年第5期67卷 1715-1728页

作者： Zixuan Zhou Yuchen Wang Yuanjie bao Haiyan Yang Jiong li Chunran Chang Shenggang li Peng Gao CAS Key laboratory of Low-Carbon Conversion Science and Engineering Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201210China university of Chinese Academy of Sciences Beijing 100049China School of Physical Science and Technology ShanghaiTech UniversityShanghai 201210China shanghai Synchrotron Radiation Facility Shanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China Shaanxi Key laboratory of Low Metamorphic Coal Clean Utilization School of Chemistry and Chemical EngineeringYulin UniversityYulin 719000China

Methanol synthesis is one of the most important industrially-viable approaches for carbon dioxide(CO_(2)) utilization, as the produced methanol can be used as a platform chemical for manufacturing green fuels and chemicals. The In_(2)O_(3) catalysts are ideal for sustainable methanol synthesis and have received considerable attention. Herein, Co-, Ni-and Cu-modified In_(2)O_(3) catalysts were fabricated with high dispersion and high stability to improve the hydrogenation performance. The Ni-promoted In_(2)O_(3) catalyst in the form of high dispersion possessed the largest amount of oxygen vacancies and the strongest ability for H_(2) activation, leading to the highest CO_(2) conversion and space time yield of methanol of 0.390 g_(Me OH)g_(cat)^(-1)h^(-1) with CH_(3)OH selectivity of 68.7%. In addition, the catalyst exhibits very stable performance over 120 h on stream, which suggests the promising prospect for industrial applications. Further experimental and theoretical studies demonstrate that surface Ni doping promotes the formation of oxygen defects on the In_(2)O_(3) catalyst, although it also results in lower methanol selectivity. Surprisingly, subsurface Ni dopants are found to be more beneficial for methanol formation than surface Ni dopants, so the Nipromoted In_(2)O_(3)catalyst with a lower surface Ni content at the similar Ni loading can reach higher methanol selectivity and productivity. This work thus provides theoretical guidance for significantly improving the CO_(2) reactivity of In_(2)O_(3)-based catalysts while maintaining high methanol selectivity.

关键词： carbon dioxide hydrogenation methanol synthesis indium oxides Ni doping sites transition metal promoters

GATIS score for predicting the prognosis of rectal neuroendocrine neoplasms:A Chinese multicenter study of 12-year experience

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World Journal of Gastroenterology 2024年第28期30卷 3403-3417页

作者： Xin-Yu Zeng ming Zhong guo-Le lin Cheng-guo li Wei-Zhong Jiang Wei Zhang li-Jian Xia Mao-Jun Di Hong-Xue Wu Xiao-Feng liao Yue-ming Sun Min-Hao Yu Kai-Xiong Tao Yong li Rui Zhang Peng Zhang Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430074Hubei ProvinceChina Department of Gastrointestinal Surgery Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of General Surgery Peking Union Medical College HospitalPeking Union Medical CollegeBeijing 100730China Department of Colorectal Surgery Fujian Medical UniversityFuzhou 350401Fujian ProvinceChina Department of Colorectal Surgery Changhai HospitalShanghai 200433China Department of Gastrointestinal Surgery The First Affiliated Hospital of Shandong First Medical UniversityJinan 250118Shandong ProvinceChina Department of Gastrointestinal Surgery Taihe HospitalHubei University of MedicineShiyan 442099Hubei ProvinceChina Department of Gastrointestinal Surgery I Section Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of General Surgery Xiangyang Central HospitalAffiliated Hospital of Hubei University of Arts and ScienceXiangyang 441021Hubei ProvinceChina Department of Colorectal Surgery Jiangsu Province HospitalNanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Gastrointestinal Surgery School of MedicineShanghai Jiao Tong UniversityShanghai 200127China Department of General Surgery Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina Department of Colorectal Surgery Liaoning Cancer HospitalShenyang 110042Liaoning ProvinceChina

BACKGROUND There is currently a shortage of accurate,efficient,and precise predictive instruments for rectal neuroendocrine neoplasms(NENs).AIM To develop a predictive model for individuals with rectal NENs(R-NENs)using data from a large *** Data from patients with primary R-NENs were retrospectively collected from 17 large-scale referral medical centers in *** forest and Cox proportional hazard models were used to identify the risk factors for overall survival and progression-free survival,and two nomograms were *** A total of 1408 patients with R-NENs were *** grade,T stage,tumor size,age,and a prognostic nutritional index were important risk factors for *** GATIS score was calculated based on these five *** overall survival prediction,the respective C-indexes in the training set were 0.915(95%confidence interval:0.866-0.964)for overall survival prediction and 0.908(95%confidence interval:0.872-0.944)for progression-free survival *** to decision curve analysis,net benefit of the GATIS score was higher than that of a single *** time-dependent area under the receiver operating characteristic curve showed that the predictive power of the GATIS score was higher than that of the TNM stage and pathological grade at all time *** The GATIS score had a good predictive effect on the prognosis of patients with R-NENs,with efficacy superior to that of the World Health Organization grade and TNM stage.

关键词： Rectal neuroendocrine neoplasm Nomogram Random forest Prognosis Overall survival Progression-free survival