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Antioxidant activity of polyaniline nanofibers

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Chinese Chemical Letters 2007年第8期18卷 1005-1008页

作者： Jia wang li hua zhu jing li he qing tang Department of Chemistry and Chemical Engineering Hubei Key laboratory of Bioinorganic Chemistry and Materia Medica Huazhong University of Science and Technology Wuhan 430074 China

Well-confined uniform polyaniline （PANI） nanofibers were synthesized by using photo-assisted chemical oxidative polymer- ization of aniline in the presence of different dopant acids, and the radical scavenging ability of the produced PANI nanofibers was determined by the DPPH assay. It was found that the antioxidant activity of PANI nanofibers was higher than conventional PANI, and increased with decreasing of averaged diameter of the nanofibers. The enhanced antioxidant activity was concerned with increased surface area of PANI nanofibers.

关键词： Polyaniline nanofibers Dopant acids Antioxidant activity DPPH radical

Achievement of complete response to nivolumab in a patient with advanced sarcomatoid hepatocellular carcinoma:A case report

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World Journal of Gastrointestinal Oncology 2020年第10期12卷 1209-1215页

作者： Shu-Guang zhu Hai-Bo li Ze-nan Yuan Wei liu qing Yang Ying Cheng Wen-jing wang Guo-Ying wang hua li Department of hepatic Surgery and liver Transplantation The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina liver Transplant Branch of Organ Transplant Center Organ Transplantation Institute of Sun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina Guangdong Key Laboratory of liver Disease Research The Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510000Guangdong ProvinceChina Department of Medicine OrigiMed Inc.Shanghai 201100China

BACKGROUND Sarcomatoid hepatocellular carcinoma(SHC)is a rare subtype of hepatocellular carcinoma(HCC),with a high recurrence rate after *** addition to limited effective treatment for the advanced stage of SHC,the prognosis of patients with this malignancy is worse than that of patients with conventional *** SUMMARY We present the case of a 54-year-old man with SHC who underwent radical segmental hepatectomy,which relapsed 4 mo after surgery due to lymphatic metastasis in the porta *** a second surgery was performed,new metastasis developed in the mediastinal lymph ***,sorafenib and lenvatinib were sequentially administered as first-and second-line systemic therapies,***,progressive disease was confirmed based on a recurrent hepatic lesion and new metastatic lesion in the abdominal *** transhepatic cholangial drainage was performed to alleviate the biliary *** the tumor was strongly positive for programmed death-ligand 1,the patient was started on *** studies revealed that after two cycles of immunotherapy,the metastatic lesions decreased to undetectable *** The patient experienced continuous complete remission for 8 *** checkpoint inhibitors are useful for the treatment of advanced SHC.

关键词： Sarcomatoid hepatocellular carcinoma hepatocellular carcinoma Programmed death-ligand 1 Immunotherapy Nivolumab Case report

Rabies Virus Neutralizing Activity,Safety,and Immunogenicity of Recombinant Human Rabies Antibody Compared with Human Rabies Immunoglobulin in healthy Adults

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Biomedical and Environmental Sciences 2022年第9期35卷 782-791页

作者： ZHANG Jun nan MENG Ya Juan BAI Yun hua li Yu Feng YANG li qing SHI Nian Min HAN Hui Xia GAO Jian zhu li Juan li Shu Ping ZHANG jing ZHAO Qin hua wang Xiu Qin WEI jing Shuang REN Le Min CAO Chen hua CheN Chen ZHAO Wei li li Center for Disease Control and Prevention of Chaoyang District Beijing 100021China NCPC New Drug Research and Development Co. Ltd.State Key Laboratory of Antibody Research&DevelopmentShijiazhuang 050015HebeiChina Beijing Institute of Biological Products Beijing 100021China Xiaohongmen Community healthcare Center Beijing 100023China

Objective Preliminary assessment of rabies virus neutralizing activity,safety and immunogenicity of a recombinant human rabies antibody(NM57)compared with human rabies immunoglobulin(HRIG)in Chinese healthy *** Subjects were randomly(1:1:1)allocated to Groups A(20 IU/kg NM57),B(40 IU/kg NM57),or C(20 IU/kg HRIG).One injection was given on the day of *** samples were collected on days-7 to 0(pre-injection),3,7,14,28,and *** events(AEs)and serious AEs(SAEs)were recorded over a period of 42 days after *** All 60 subjects developed detectable rabies virus neutralizing antibodies(RVNAs)(>0.05 IU/mL)on days 3,7,14,28,and *** RVNA levels peaked on day 3 in all three groups,with a geometric mean concentration(GMC)of 0.2139 IU/mL in Group A,0.3660 IU/mL in Group B,and0.1994 IU/mL in Group *** each follow-up point,the GMC in Group B was significantly higher than that in Groups A and *** areas under the antibody concentration curve over 0-14 days and 0-42 days in Group B were significantly larger than those in Groups A and *** AEs were *** for one grade 2 myalgia in Group C,the other 14 were all grade *** SAEs were *** The rabies virus neutralizing activity of 40 IU/kg NM57 was superior to that of 20 IU/kg NM57 and 20 IU/kg HRIG,and the rabies virus neutralizing activity of 20 IU/kg NM57 and 20 IU/kg HRIG were *** was comparable between NM57 and HRIG.

关键词： Recombinant human rabies antibody NM57 Human rabies immunoglobulin Rabies virus neutralizing activity Safety Immunogenicity

Mineralization of the liwu large-scale stratiform copper deposits in Sichuan Province, China: Constraints from fluid inclusions

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China Geology 2023年第2期6卷 252-268页

作者： hua-yun Yuan qing Zhou Yuan-bao Song Wei Zhang Hui-hua Zhang Tong-zhu li Tao Yin Chang-nan wang Gao-lin tang Evaluation and Utilization of Strategic Rare Metals and Rare Earth Resource Key Laboratory of Sichuan Province Sichuan Geological SurveyChengdu 610081China Chengdu Center China Geological SurveyMinistry of Natural ResourcesChengdu 610081China Sichuan liwu Copper Mining Company Ganzi 626200China

The liwu stratiform copper deposit is located in the northwestern Jianglang dome,western *** studies mainly focus on the genetic type and mineralization of this *** fluid inclusion characteristics of metallogenic period quartz veins were studied to reveal the ore-forming fluid *** Raman analysis indicates that the ore-forming fluids is a H_(2)O-NaCl-CH_(4)(-CO_(2))*** inclusions microthermometry shows a homogenization temperature of 181-375°C and a salinity of 5.26%-16.99%for the disseminated-banded Cu-Zn mineralization;but a homogenization temperature of 142-343°C and a salinity of 5.41%-21.19%for the massive-veined Cu-Zn *** features suggest a medium-high temperature and a medium salinity for the ore-forming fluids.H-O isotopic data indicates that the ore-forming fluids were mainly from the metamorphic and magmatic water,plus minor formation *** sulfur isotopic data indicates that sulfur was mainly derived from the formation and magmatic *** of the disseminated-banded mineralization was mainly correlated with fluid mixing and water-rock reaction;whereas that of the massive-veined mineralization was mainly correlated with fluid *** genetic type of the deposit is a medium-high temperature hydrothermal deposit related to magmatism and controlled by shear *** study is beneficial to understand the stratiform copper deposit.

关键词： Stratiform copper deposit Mineralization Fluid inclusion H-O isotopes Hydrothermal deposit Dome structure Middle Proterozoic metamorphic rock Mineral exploration engineering Sichuan Province

DC and analog/RF performance of C-shaped pocket TFET(CSP-TFET)with fully overlapping gate

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Chinese Physics B 2022年第5期31卷 711-719页

作者： Zi-Xin Chen Wei-jing liu Jiang-nan liu Qiu-Hui wang Xu-Guo Zhang Jie Xu qing-hua li Wei Bai Xiao-Dong tang College of Electronics and Information Engineering Shanghai University of Electric PowerShanghai 200090China GTA Semiconductor Corporation limited Shanghai 200123China Key Laboratory of Polar Materials and Devices East China Normal UniversityShanghai 200041China

A C-shaped pocket tunnel field effect transistor(CSP-TFET)has been designed and optimized based on the traditional double-gate TFETs by introducing a C-shaped pocket region between the source and channel to improve the device performance.A gate-to-pocket overlapping structure is also examined in the proposed CSP-TFET to enhance the gate *** effects of the pocket length,pocket doping concentration and gate-to-pocket overlapping structure on the DC and analog/RF characteristics of the CSP-TFET are estimated after calibrating the tunneling model in double-gate *** DC and analog/RF performance such as on-state current(Ion),on/off current ratio(Ion/Ioff),subthreshold swing(SS)transconductance(g;),cut-off frequency(f_(T))and gain-bandwidth product(GBP)are *** optimized CSPTFET device exhibits excellent performance with high I_(off)(9.98×10^(-4)A/μm),high I_(on)/I_(off)(~10^(11)),as well as low SS(~12 m V/dec).The results reveal that the CSP-TFET device could be a potential alternative for the next generation of semiconductor devices.

关键词： tunnel field effect transistor double gate pocket

eGPS 1.0: comprehensive software for multi-omic and evolutionary analyses

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National Science Review 2019年第5期6卷 867-869页

作者： Dalang Yu lili Dong Fangqi Yan Hailong Mu Bixia tang Xiao Yang Tao Zeng qing Zhou Feng Gao Zhonghuang wang Ziqian Hao Hongen Kang Yi Zheng Hongwei huang Yuzhang Wei Wei Pan Yaochen Xu Junwei zhu Shilei Zhao Ciran wang Pengyu wang Long Dai Mushan li li Lan Yiwei wang hua Chen Yi-Xue li Yun-Xin Fu Zhen Shao Yiming Bao Fangqing Zhao Luo-nan Chen Guo-qing Zhang Wenming Zhao Haipeng li CAS Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of Sciences Chinese Academy of Sciences University of Chinese Academy of Sciences BIG Data Center Beijing Institute of GenomicsChinese Academy of Sciences Shanghai Center for Bioinformation Technology Key Laboratory of Systems Biology Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences CAS Laboratory of Genomic and Precision Medicine Beijing Institute of Genomics Chinese Academy of Sciences Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Department of Biostatistics and Data Science School of Public Health University of Texas Health Science Center at Houston Computational Genomics Lab Beijing Institutes of Life Science Chinese Academy of Sciences Shanghai Research Center for Brain Science and Brain-Inspired Intelligence

It has become increasingly challenging for researchers to analyze the exponentially expanding amount of multi-omic ***, we describe multi-functional software named evolutionary GenotypePhenotype Systems (eGPS) that en... 详细信息

关键词： GPS eGPS 1.0 comprehensive software for multi-omic and evolutionary analyses

CBX7 reprograms metabolic flux to protect against meningioma progression by modulating the USP44/c-MYC/LDHA axis

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Journal of Molecular Cell Biology 2023年第10期15卷 10-25页

作者： Haixia Cheng lingyang hua Hailiang tang Zhongyuan Bao Xiupeng Xu Hongguang zhu Shuyang wang Zeyidan Jiapaer Roma Bhatia Ian FDunn Jiaojiao Deng Daĳun wang Shuchen Sun Shihai Luan jing Ji qing Xie Xinyu Yang Ji Lei Guoping li Xianli wang Ye Gong Department of Pathology School of Basic Medical SciencesFudan UniversityShanghai 200032China Department of Neurosurgery Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200040China Department of Neurosurgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210000China Xinjiang Key Laboratory of Biology Resources and Genetic Engineering College of Life Science and TechnologyXinjiang UniversityUrumqi 830046China Beth Israel Deaconess Medical Center Harvard Medical SchoolBostonMA 02215USA Department of Neurosurgery University of Oklahoma Health Sciences CenterOklahoma CityOK 73117USA Fangshan Hospital of Beĳing University of Traditional Chinese MedicineBeĳing 102400China Center for Transplantation Science Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114USA Cardiovascular Research Center Massachusetts General Hospital and Harvard Medical SchoolBostonMA 02114USA School of Public health Shanghai Jiao Tong University School of MedicineShanghai 200025China Department of Critical Care Medicine Huashan HospitalShanghai Medical CollegeFudan UniversityShanghai 200032China

Meningioma is one of the most common primary neoplasms in the central nervous system,but no specific molecularly targeted therapy has been approved for the clinical treatment of aggressive *** is hence an urgent demand to decrypt the biological and molecular landscape of malignant ***,through the in-silica prescreening and 10-year follow-up studies of 445 meningioma patients,we uncovered that CBX7 expression progressively decreases with malignancy grade and neoplasia stage in meningioma,and a high CBX7 expression level predicts a favorable prognosis in meningioma ***7 restoration significantly induces cell cycle arrest and inhibits meningioma cell ***-based proteomics analysis indicated that CBX7 restoration triggers the metabolic shift from glycolysis to oxidative *** mechanistic study demonstrated that CBX7 promotes the proteasome-dependent degradation of c-MYC protein by transcriptionally inhibiting the expression of a c-MYC deubiquitinase,USP44,consequently attenuates c-MYC-mediated transactivation of LDHA transcripts,and further inhibits glycolysis and subsequent cell *** importantly,the functional role of CBX7 was further confirmed in subcutaneous and orthotopic meningioma xenograft mouse models and meningioma ***,our results shed light on the critical role of CBX7 in meningioma malignancy progression and identify the CBX7/USP44/c-MYC/LDHA axis as a promising therapeutic target against meningioma progression.

关键词： CBX7 meningioma glycolysis USP44 c-MYC LDHA malignancy glucose metabolism

Feasibility of controlling hepatitis E in Jiangsu Province, China: a modelling study

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Infectious Diseases of Poverty 2021年第3期10卷 116-117页

作者： Meng Yang Xiao-qing Cheng Ze-Yu Zhao Pei-hua li Jia Rui Sheng-nan lin jing-Wen Xu Yuan-Zhao zhu Yao wang Xing-Chun liu li Luo Bin Deng Chan liu Jie-Feng huang Tian-Long Yang zhuo-Yang li Wei-Kang liu Wen-Dong liu Ben-hua Zhao Yue he Qi Yin Si-Ying Mao Yan-hua Su Xue-Feng Zhang Tian-Mu Chen State Key Laboratory of Molecular Vacci no logy and Molecular Diagnostics School of Public HealthXiamen University4221-117 South Xiang'an RoadXiang'an DistrictXiamen City 361102Fujian ProvincePeople's Republic of China Jiangsu Center for Disease Control and Prevention Nanjing CityJiangsu ProvincePeople's Republic of China

Background:hepatitis E,an acute zoonotic disease caused by the hepatitis E virus(heV),has a relatively high burden in developing *** current research model on hepatitis E mainly uses experimental animal models(such as pigs,chickens,and rabbits)to explain the transmission of *** studies have developed a multi-host and multiroute transmission dynamic model(MHMRTDM)to explore the transmission feature of ***,this study aimed to explore its transmission and evaluate the effectiveness of intervention using the dataset of Jiangsu Province.

关键词： hepatitis E Transmission dynamic model Meteorological factor Intervention Transmissibility

Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang Sheng-Quan Yan Ming he qing-Zhang Zhao Wen-Hui Zhang Chao-Xin Kan Jian-Ming Zhou Kang-Ning li Xiao-Fei wang Jian-Cheng liu Zhao-hua Peng zhuo liang Ai-ling li Jian Zheng Qi-Wen Fan Yun-Ju li You-Bao wang Zhi-Hong li Yang-Ping Shen Ding nan Wei nan Yu-Qiang Zhang Jia-Ying-Hao li Jun-Wen Tian Jiang-lin Hou Chang-Xin Guo Zhi-Cheng Zhang Ming-Hao zhu Yu-Wen Chen Yu-Chen Jiang Tao Tian Jin-Long Ma Yi-Hui liu jing-Yu Dong Run-Long liu Mei-Yue-nan Ma Yong-Shou Chen Wei-Ping liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples