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A combined quality evaluation method that integrates chemical constituents, appearance traits and origins of raw Rehmanniae Radix pieces

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Chinese Journal of Natural Medicines 2021年第7期19卷 551-560页

作者： GU Min YUAN Yi-Ping QIN Zi-nan XU Yan shi nan-nan WANG Yan-Ping ZHAI Hua-Qiang QIAN Zhong-Zhi Standardization Research Center of Traditional Chinese Medicine Dispensing Beijing University of Chinese MedicineBeijing 102488China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing 100700China National Pharmacopoeia Commission Beijing 100061China

The quality control of Chinese herbal medicine is a current challenge for the internationalization of traditional Chinese *** quality evaluation methods lack quantitative analysis,while modern quality evaluation methods ignore the origins and appearance ***,an integrated quality evaluation method is urgent in *** Rehmanniae Radix(RRR)is commonly used in Chinese herbal *** present,much attention has been drwan towards its quality control,which however is limited by the existing quality evaluation *** present study was designed to establish a comprehensive and practical method for the quality evaluation and control of RRR pieces based on its chemical constituents,appearance traits and ***-three batches of RRR pieces were collected from six provinces,while high-performance liquid chromatography(HPLC)was applied to determine the following five constituents,including catalpol,rehmannioside A,rehmannioside D,leonuride and verbascoside in RRR *** appearance traits were quantitatively ***,correlation analysis,principal components analysis(PCA),cluster analysis and t-test were performed to evaluate the qualities of RRR *** batches of RRR pieces were divided into three categories:samples from Henan province,samples from Shandong and Shanxi provinces,and those from other ***,the chemical constituents and appearance traits of RRR pieces were significantly different from diverse *** combined method of chemical contituents,appearance traits and origins can distinguish RRR pieces with different qualities,which provides basic reference for the quality control of Chinese herbal medicine.

关键词： Bioactive constituents Raw Rehmanniae Radix Quality evaluation Appearance traits Different origins

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消费文化视阈下产品设计创新研究

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鞋类工艺与设计 2024年第9期4卷 183-185页

作者：彭海波施南韩思佳大连工业大学艺术与信息工程学院辽宁庄河116400

随着社会的发展,人们的消费需求发展着翻天覆地变化,要想在市场中占据竞争优势,需要不断研究消费者需求以实现产品设计创新。其中消费文化对消费者的购买决策有很大影响,因此在创新产品设计时开始从消费文化出发,找寻创新方向,基于此,... 详细信息

随着社会的发展,人们的消费需求发展着翻天覆地变化,要想在市场中占据竞争优势,需要不断研究消费者需求以实现产品设计创新。其中消费文化对消费者的购买决策有很大影响,因此在创新产品设计时开始从消费文化出发,找寻创新方向,基于此,本文研究当前消费文化视阈下产品设计创新存在的问题,并提出相应策略,助力产品设计创新发展。

关键词：消费文化产品设计创新

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Myricetin alleviates ovalbumin-induced allergic rhinitis in mice by regulating Th1/Th2 balance

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Asian Pacific Journal of Tropical Biomedicine 2023年第7期13卷 306-314页

作者： Ya-nan shi Jin-Zhu Su Juan Wang Jiang-Qiao Geng Department of Otolaryngology Sanya Women and Children's HospitalSanya572000China Department of Otolaryngology Hebei Children’s HospitalShijiazhuang050031China

Objective:To evaluate the effect of myricetin on ovalbumin(OVA)-induced allergic rhinitis in ***:Mice were sensitized and challenged using OVA(5%,500 mL)intraperitoneally and intranasally,respectively,on an alternative day for 14 days,followed by administration of myricetin(50,100,and 200 mg/kg)till day *** symptoms,biochemical parameters,protein expressions,and histopathology were ***:OVA-induced increased nasal symptoms including rubbing,sneezing,and discharge were significantly reduced by myricetin(100and 200 mg/kg)(P<0.05).Myricetin also protected against histamine challenge and attenuated elevated serum immunoglobulin E(IgE;total and OVA-specific),total IgG1,andβ-hexosaminidase levels,as well as leukotriene C4 and interleukins levels in nasal lavage fluid(P<0.05).Western blot analysis showed that myricetin significantly upregulated the protein expression of T-box expressed in T cells,while downregulating the protein expression of GATA binding protein 3,NF-κB,and IκB-α(P<0.05).Additionally,OVA-induced histopathological abberations in the nasal mucosa was markedly ameliorated by myricetin treatment(P<0.05).Conclusions:Myricetin exerts anti-allergic effects against OVAinduced allergic rhinitis via regulating Th1/Th2 balance.

关键词： Allergic rhinitis GATA3 Interleukins Myricetin Montelukast Ovalbumin Th1/Th2 balance

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Realgar-indigo naturalis formula for the treatment of patients with relapsed and arsenic trioxide-resistant acute promyelocytic leukemia:A case series

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Journal of Integrative Medicine 2024年第5期22卷 614-620页

作者： Yong-guang Fang shi-lin Huang nan-nan Chen Department of Hematology PLA 967th Hospital

Introduction: There is currently no standard treatment for relapsed and arsenic trioxide(ATO)-resistant acute promyelocytic leukemia(APL). Here, we report a case series of realgar-indigo naturalis formula(RIF) for the successful treatment of patients with relapsed and ATO-resistant *** presentation: Two patients in the first relapse and one in the second relapse failed to achieve hematologic complete remission(HCR) when reinduced by ATO; the other five patients progressed to relapse during ATO-based regimens for post-remission therapy. These eight patients received RIF in three doses per day totaling 130 mg/kg(≤ 30 pills) as induction therapy and achieved HCR at a median time of46.5 days. They received 5 years of post-remission therapy, which consisted of combined chemotherapy followed by RIF. During this period, the patients did not experience renal dysfunction or QT interval prolongation. At the last follow-up, three patients survived without relapse, two patients survived with a second or third relapse and third or fourth remission, and the other three patients relapsed for a third or fourth time and died. The 5-year overall survival and event-free survival rates were 75.0%(95% confidence interval [CI]: 31.5–93.1) and 37.5%(95% CI: 5.6–71.7), ***: RIF for induction therapy and RIF combined with chemotherapy for post-remission therapy may represent an effective and safe protocol for the treatment of patients with relapsed and ATO-resistant APL.

关键词： Acute promyelocytic leukemia Realgar-indigo naturalis formula Arsenic Trioxide Resistant Case report

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Application of near-infrared fluorescence imaging in theranostics of gastrointestinal tumors

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Gastroenterology Report 2023年第1期11卷 159-170页

作者： nan-Qing shi Xin-Yuan Cui Cheng Zhou Ning Tang Da-Xiang Cui Department of Sensing Science and Engineering School of Electronic Information and Electrical EngineeringInstitute of Nano Biomedicine and EngineeringShanghai Jiao Tong UniversityShanghaiP.R.China Department of Radiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiP.R.China National Engineering Center for nanotechnology ShanghaiP.R.China

Gastrointestinal cancers have become an important cause of cancer-related death in *** the early diagnosis rate of gastrointestinal tumors and improving the effect of surgical treatment can significantly improve the survival rate of *** conventional diagnostic method is high-definition white-light endoscopy,which often leads to missed *** surgical treatment,intraoperative tumor localization and post-operative anastomotic state evaluation play important roles in the effect of surgical *** a new imaging method,near-infrared fluorescence imaging(NIRFI)has its unique advantages in the diagnosis and auxiliary surgical treatment of gastrointestinal tumors due to its high sensitivity and the ability to image deep *** this review,we focus on the latest advances of NIRFI technology applied in early diagnosis of gastrointestinal tumors,identification of tumor margins,identification of lymph nodes,and assessment of anastomotic *** addition,we summarize the advances of NIRFI systems such as macro imaging and micro imaging systems,and also clearly describe the application process of NIRFI from system to clinical application,and look into the prospect of NIRFI applied in the theranostics of gastrointestinal tumors.

关键词： gastrointestinal cancers early diagnosis near-infrared fluorescence imaging tumor margins clinical application

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The mitigation of pitch-derived carbon with different structures on the volume expansion of silicon in Si/C composite anode

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Journal of Energy Chemistry 2023年第9期84卷 292-302页

作者： Xin Xue Xiao Liu Bin Lou Yuanxi Yang nan shi FuShan Wen Xiujie Yang Dong Liu State Key Laboratory of Heavy Oil Processing China University of PetroleumQingdao 266580ShandongChina Department of Chemical Engineering University College London Torrington Place London WC1E7JEUK

The microstructures of carbon precursors significantly affect the electrochemical performance of Si/C composite ***,the interaction between Si and carbon materials with different structures is still ***-based materials undergoing different thermal treatments are superior sources for synthesizing carbons with different ***,different types of mesophase pitch(domain,flow-domain and mosaic structure) obtained from controllable thermal condensation are utilized to prepare Si/C composite materials and the corresponding models are established through finite element simulation to explore the correlation between the lithium storage properties of Si/C composites and the structures of carbon *** results indicate that the flow-domain texture pitch P2 has a better ability to buffer the volume expansion of silicon particles for its highly ordered arrangement of carbon crystallites inside could disperse the swelling stress uniformly alongside the particle *** sample Si@P2 exhibits the highest capacity of 1328 mA h/g after 200 cycles at a current density of 0.1 A/g as well as the best rate performance and *** sample Si@P3 in which the mosaic texture pitch P3 composed of random orientation of crystallites undergoes the fastest capacity *** findings suggest that highly ordered carbon materials are more suitable for the synthesis of Si/C composite anodes and provide insights for understanding the interaction between carbon and silicon during the charging/discharging process.

关键词： Si/C composite materials Mesophase pitch Finite element simulation Volume expansion

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Convolutional Neural Networks of Whole Jujube Fruits Prediction Model Based on Multi-Spectral Imaging Method

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Chinese Journal of Electronics 2023年第3期32卷 655-662页

作者： WANG Jing FAN Xiaofei shi nan ZHAO Zhihui SUN Lei SUO Xuesong College of Mechanical and Electrical Engineering Hebei Agricultural University Key Laboratory of Microbial Diversity Research and Application of Hebei Province College of Life Sciences Hebei University Research Center of Chinese Jujube Hebei Agricultural University

Soluble sugar is an important index to determine the quality of jujube, and also an important factor to influence the taste of jujube. The acquisition of the soluble sugar content of jujube mainly relies on manual chemical measurement which is time-consuming and labor-intensive. In this study, the feasibility of multispectral imaging combined with deep learning for rapid nondestructive testing of fruit internal quality was analyzed. Support vector machine regression model, partial least squares regression model, and convolutional neural networks(CNNs) model were established by multispectral imaging method to predict the soluble sugar content of the whole jujube fruit, and the optimal model was selected to predict the content of three kinds of soluble sugar. The study showed that the sucrose prediction model of the whole jujube had the best performance after CNNs training, and the correlation coefficient of verification set was 0.88, which proved the feasibility of using CNNs for prediction of the soluble sugar content of jujube fruits.

关键词： Training Support vector machines Codes Multispectral imaging Nondestructive testing Predictive models Mathematical models

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cis-Nitenpyram Analogues Bearing Acyloxy Segments Anchored on the Tetrahydropyrimidine Ring： Synthesis, Insecticidal Activities and Molecular Docking Studies

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Chemical Research in Chinese Universities 2013年第3期29卷 477-482页

作者： SUN Chuan-wen WU Ying CHEN Yan-xia nan shi-bin ZHANG Wang-geng College of Life and Environment Sciences Shanghai Normal University Shanghai 200234 P. R. China Jiangsu Institute of Eeomones Co. Ltd. Jintan 213200 P. R. China

A series of novel cis-nitenpyram analogues bearing acyloxy segments anchored on the tetrahydropyrimi-dine ring was designed and synthesized. Preliminary bioassays indicate that all the nitenpyram analogues 3a--3n exhibit good insecticidal activities against Nilaparvata lugens and Aphis medicaginis at 100 mg/L, while analogue 3k affords the best activity in vitro and the lethal concentration 50（LC50） values（0.187, 0.214 mg/L） are close to that of nitenpyram. The structure activity relationships（SARs） suggest that their insecticidal potency is influenced by the species of acyloxy segments. The docking results reveal that analogue 3k forms stronger hydrogen-bonding with the nAChR, which explain the structure activity relationships（SARs） observed in vitro and imply that the strategies of our designed nitenpyram analogues are feasible.

关键词： cis-Nitenpyram analogue Acyloxy segment Hydrogen-bonding action Insecticidal activity Molecular docking

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Evidence-Based Chinese Medicine Clinical Practice Guideline for Stomach Pain in Hong Kong

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Chinese Journal of Integrative Medicine 2017年第10期23卷 793-800页

作者： ZHONG Linda LD shi nan-nan DAI Liang ZIEA Tat Chi NG Bacon TANG Xu-dong BIAN Zhao-xiang LU Ai-ping Hong Kong Chinese Medicine Study Centre Hong Kong Baptist University Hong Kong SAR China School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR China Institute of Basic Research in Clinical Medicine China Academy of Traditional Chinese Medicine Beijing (100091) China Department of Chinese Medicine Hong Kong Hospital Authority Hong Kong SAR China Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing (100091) China

Stomach pain in Chinese medicine（CM） is a very common disorder in clinical practice and it has been listed as one of the pilot three conditions in Hong Kong to develop evidence-based CM clinical practice guidelines（CM CPGs）. The aim of this stomach Pain CPG is to summarize the treatment methods of stomach pain with CM and evaluate reasonably, then to guide local licensed CM practitioners and provide beneficial reference for social medical decision makers and patients. In this manuscript, we defined stomach pain in CM and the category of chronic gastritis in Western medicine. The clinical manifestation, CM pattern classification, and CM intervention including herbal medicine treatment based on pattern differentiation, symptomatic treatment, acupuncture treatment, regulation and nursing were illustrated.

关键词： clinical practice guideline Chinese medicine pattern Chinese herbal medicine stomach pain

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吐哈盆地丘东洼陷碱泉子沟断裂描述及致密油气控藏分析

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断块油气田 2024年第5期31卷 786-794页

作者：阴学彬石楠林煜杨斌郭翔孙博王兵牟克勋王梓骅中国石油东方物探公司研究院乌鲁木齐分院新疆乌鲁木齐830000 中国石油吐哈油田分公司勘探事业部新疆哈密839009 三亚学院外国语学院海南三亚572000

走滑断裂在油气成藏中具有重要的控制作用,其识别、判断和对油气藏控制要素的研究分析是当前勘探的热点。文中首次在吐哈盆地台北凹陷丘东洼陷中部发现碱泉子沟断裂,为了落实其空间展布特征、成因机制及其对油气藏的控制作用,开展了进... 详细信息

走滑断裂在油气成藏中具有重要的控制作用,其识别、判断和对油气藏控制要素的研究分析是当前勘探的热点。文中首次在吐哈盆地台北凹陷丘东洼陷中部发现碱泉子沟断裂,为了落实其空间展布特征、成因机制及其对油气藏的控制作用,开展了进一步研究。结果表明:碱泉子沟断裂在露头上水平错动、在剖面上断面陡直且发育“花状构造”、在平面上呈“雁列式”展布,并具有“四层构造”特征,走滑特征明显;碱泉子沟断裂是照壁山大断裂的派生次级走滑断裂,沿Sylveser简单剪切模式中的R′剪切面发育,结合流体包裹体均一温度推测其形成于晚印支期,早—中燕山期活动强烈,晚燕山期活动减弱;碱泉子沟断裂具有控圈、控储、控运和控藏作用,其空间结构、活动期次和与成藏期次的匹配关系决定油气运聚的流体相态、油气排替顺序和聚集位置,尤其是断裂中下层结构在中燕山期活动,后续静止封闭,这是导致下侏罗统致密油气藏大面积分布的重要原因。研究成果对吐哈盆地致密油气勘探具有非常重要的指导意义。

关键词：走滑断裂形成机制控藏作用丘东洼陷吐哈盆地

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