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Science China Chemistry 2024年第1期67卷 351-359页

作者： Long Chen Jia-Heng Cai You-Jun Yu Yang-Kun Qu sheng-Yi Yang sheng-nan Zou Rui-Hong Liu Dong-Ying Zhou Liang-sheng Liao Zuo-Quan Jiang Institute of Functional nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyMacao 999078China

Multi-resonance thermally activated delayed fluorescence(MR-TADF)emitters can enable narrowband emission with high color purity and electroluminescence ***/carbonyl(N/C=O)system is receiving increasing attention while the nitrogen/boron(N/B)system has been widely *** decoration is an effective approach for N/B type MR-TADF system but always leads to broadening and red-shifting of the emission band in N/C=O MR-TADF *** attribute these unfavorable phenomena to the formation of intramolecular charge transfer between the MR-core and peripheral *** address this issue,we have developed a new strategy by decorating DMQAO(a fused N/C=O MR-core)with a triazine acceptor and a neutral terphenyl group to construct MTDMQAO and MBDMQAO,*** introduction of the triazine acceptor not only realizes efficient narrowband emission in MTDMQAO,but also accelerates the reverse intersystem crossing process through enhanced spin-orbital *** a result,MTDMQAO exhibits a significantly higher external quantum efficiency of 29.4%compared to the referent emitters,validating the rationality of our derivation *** study highlights the potential of the N/C=O system for MR-TADF emitters and provides important insights for understanding the difference between N/B and N/C=O systems.

关键词： carbonyl group narrowband acceptor decoration thermally activated delayed fluorescence OLEDs

Improved early diagnosis of cystadenocarcinoma of the pancreas

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Hepatobiliary & Pancreatic Diseases International 2007年第1期6卷 87-91页

作者： Wu, Hong Cheng, nan-sheng Zhang, Yan-Ge Luo, Hong-Zhi Yan, Lu-nan Li, Jin Sichuan Univ W China Hosp Dept Gen Surg Chengdu 610041 Peoples R China

BACKGROUND: Cystadenocarcinoma of the pancreas is insensitive to radiotherapy and chemotherapy, and surgery is at present the definitive treatment. Early and accurate diagnosis of cystadenocarcinoma is crucial for increasing the five-year survival rate and the resectable rate. There is no definitive and effective method of early diagnosis of cystadenocarcinoma of the pancreas in China and other countries. METHODS: We compared endoscopic ultrasonography-guided (EUS-guided) fine needle aspiration biopsy combined with cyst fluid carcinoembryonic antigen (CEA), CA19-9 examination with computed tomography (CT), B-ultrasonography (B-US) and serum CEA and CA19-9, to explore methods of early diagnosis of cystadenocarcinoma of the pancreas. Retrospective analysis was made on the clinical data of 126 cases of benign pancreatic lesion (90 cases) and cystadenocarcinoma (36). RESULTS: The sensitivity of B-US and CT for cystadenocarcinoma was 52.8% and 77.8%, while the specificity was 78.9% and 86.7%, respectively. When measurement of CEA and CA19-9 of cyst fluid was combined with EUS-guided fine needle aspiration biopsy, the sensitivity was 94.4%, higher than that of B-US and CT (P<0.05). The sensitivity of cyst fluid CEA, CA19-9 examinations was considerably higher than that of serum CEA, CA19-9 (P<0.05). Upper gastrointestinal barium meal and endoscopic retrograde cholangiopancreatography (ERCP) had low sensitivity and specificity. CONCLUSIONS: EUS-guided fine needle aspiration biopsy combined with examination of cyst fluid CEA, CA19-9 is a credible means for early diagnosis of cystadenocarcinoma of the pancreas. B-US, CT and serum CEA, CA19-9 measurements are in common use, their findings are also very important.

关键词： cystadenocarcinoma cystadenoma early diagnosis

A review on chemical oxygen supply technology within confined spaces: Challenges, strategies, and opportunities toward chemical oxygen generators(COGs)

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International Journal of Minerals,Metallurgy and Materials 2019年第8期26卷 925-937页

作者： Jian-guo Liu Long-zhe Jin Na Gao sheng-nan Ou Shu Wang Wei-xiang Wang School of Civil and Resource Engineering University of Science and Technology BeijingBeijing 100083China Key Laboratory of High-Efficient Mining and Safety of Metal Mines of the Ministry of Education University of Science and Technology BeijingBeijing 100083China Mine Emergency Technology Research Center University of Science and Technology BeijingBeijing 100083China

Chemical oxygen generators(COGs)have been used worldwide in confined spaces as an emergency oxygen supply technology,mainly because they are independent and have a long shelf ***,a number of challenges related to COGs remain unsolved,and a literature review of the current state of the technology is ***,the present article summarizes the basic information and applications of COGs,including their oxygen production mechanism,components,forming technology,and ignition *** current challenges encountered in applying COGs are discussed,along with the strategies adopted thus far to solve these problems,as found in the published *** literature survey reveals that,although much effort has been devoted to controlling the oxygen production rate and the heat output of COGs,the mechanism of producing toxic gases remains unclear and a reliable and safe ignition system has not been fully ***,future opportunities in the development of COGs are briefly listed.

关键词： chemical oxygen generators oxygen supply technology thermal decomposition catalytic metal fuel combustion

Early intervention with Di-Dang Decoction prevents macrovascular fibrosis in diabetic rats by regulating the TGF-β1/Smad signalling pathway

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Chinese Journal of Natural Medicines 2020年第8期18卷 612-619页

作者： ZHOU sheng-nan ZHANG Jian REN Qiu-Yue YAO Rong-Fei LIU Peng CHANG Bai Nutritional Department TEDA International Cardiovascular HospitalTianjin 300457China Key Laboratory of Cancer Prevention and Therapy Tianjin Medical University Cancer Institute and HospitalTianjin Medical UniversityTianjin 300060China Graduate School of Tianjin University of Traditional Chinese Medicine Tianjin 300070China Key Laboratory of Hormones and Development(Ministry of Health) Tianjin Key Laboratory of Metabolic DiseasesTianjin Metabolic Diseases Hospital&Tianjin Institute of EndocrinologyTianjin Medical UniversityTianjin 300070China 不详

Macroangiopathy is a complication of Type II Diabetes Mellitus(T2 DM),which is mainly caused by fibrosis of blood *** T2 DM rat models,we investigated whether the traditional Chinese medicine,Di-Dang Decoction(DDD),exhibited antifibrotic actions on great vessels.T2 DM rats were randomly divided into non-intervention group,early-,middle-,late-stage DDD intervention groups and control groups,including pioglitazone group and aminoguanidine *** administration of DDD to T2 DM rats at different times,we detected the amount of extracellular matrix(ECM)deposition in the thoracic *** results showed that early-stage intervention with DDD could effectively protect great vessels from ECM *** that TGF-β1 is the master regulator of fibrosis,we further validated at the molecular level that,compared to middle-and late-stage intervention with DDD,early-stage intervention with DDD could significantly decrease the expression levels of factors related to the activated TGF-β1/Smad signalling pathway,as well as the expression levels of downstream effectors including CTGF,MMP and TIMP family proteins,which were directly involved in ECM ***,early-stage intervention with DDD can reduce macrovascular fibrosis and prevent diabetic macroangiopathy.

关键词： Di-Dang Decoction Macroangiopathy Fibrosis Diabetes TGF-β1 CTGF MMP TIMP

Study on Mutations in ALS for Resistance to Tribenuron-Methyl in Galium aparine L.

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Agricultural Sciences in China 2011年第1期10卷 86-91页

作者： SUN Jian WANG Jin-xin ZHANG Hong-jun LIU Jun-liang BIAN sheng-nan College of Plant Protection Shandong Agricultural University Tai＇an 271018 PR.China Institute for the Control of Agrochemicals Ministry of Agriculture Beijing 100125 P.R.China

In recent years, Galium aparine L. has not been controlled by tribenuron-methyl in major Chinese winter wheat fields. The objective of this study is to understand the molecular basis of the resistance mechanism to tribenuron-methyl in G. aparine and to find the specific mutation sites in amino acid sequence of acetolactate synthase （ALS） in the resistant biotype of G. aparine. Fragments that encode the ALS were amplified and cloned from susceptible （S） and resistant （R） biotypes of G. aparine to tribenuron-methyl and sequenced subsequently. The result showed that the nucleotide sequence of Rbiotype of G. aparine differed from that of the S biotype with three amino acid substitutions, of which, the amino acid substitution of Trp57-4 （TGG） to Gly （GGG） is located in the highly conserved region Domain B. The substitution of Trp574 might be responsible for the resistance to tribenuron-methyl in the R-biotype of G. aparine.

关键词： resistance Galium aparine L. acetolactate synthase gene mutation

DIFFUSING OF AN AMMONIA MOLECULE IN WATER IN A VERY SHORT TIME PERIOD

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Journal of Hydrodynamics 2012年第6期24卷 969-970页

作者： sheng nan TU Yu-song GUO Pan WAN Rong-zheng FANG Hai-ping Shanghai Institute of Applied Physics Chinese Academy of Science University of the Chinese Academy of Sciences Institute of Systems Biology Shanghai University

The diffusion of an ammonia molecule （NH3） in water was investigated by molecular dynamic simulations. It is found that the diffusion shows negative correlation with its dipole orientation.

关键词： diffusion ammonia correlation

Proteomics of the mediodorsal thalamic nucleus of rats with stress-induced gastric ulcer

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World Journal of Gastroenterology 2019年第23期25卷 2911-2923页

作者： sheng-nan Gong Jian-Ping Zhu Ying-Jie Ma Dong-Qin Zhao College of Life Sciences Shandong Normal University

BACKGROUND Stress-induced gastric ulcer(SGU) is one of the most common visceral complications after trauma. Restraint water-immersion stress(RWIS) can cause serious gastrointestinal dysfunction and has been widely used to study the pathogenesis of SGU to identify medications that can cure the disease. The mediodorsal thalamic nucleus(MD) is the centre integrating visceral and physical activity and contributes to SGU induced by RWIS. Hence, the role of the MD during RWIS needs to be *** To screen for differentially expressed proteins in the MD of the RWIS rats to further elucidate molecular mechanisms of *** Male Wistar rats were selected randomly and divided into two groups, namely, a control group and an RWIS group. Gastric mucosal lesions of the sacrificed rats were measured using the erosion index and the proteomic profiles of the MD were generated through isobaric tags for relative and absolute quantitation(iTRAQ) coupled with two-dimensional liquid chromatography and tandem mass spectrometry. Additionally, iTRAQ results were verified by Western blot *** A total of 2853 proteins were identified, and these included 65 dysregulated(31 upregulated and 34 downregulated) proteins(fold change ratio ≥ 1.2). Gene Ontology(GO) analysis showed that most of the upregulated proteins are primarily related to cell division, whereas most of the downregulated proteins are related to neuron morphogenesis and neurotransmitter regulation. Ingenuity Pathway Analysis revealed that the dysregulated proteins are mainly involved in the neurological disease signalling pathways. Furthermore, our results indicated that glycogen synthase kinase-3 beta might be related to the central mechanismthrough which RWIS gives rise to *** Quantitative proteomic analysis elucidated the molecular targets associated with the production of SGU and provides insights into the role of the MD. The underlying molecular mechanisms need to be further dissected.

关键词： Mediodorsal thalamic nucleus Proteome Restraint water-immersion stress Stress-induced gastric ulcer Glycogen synthase kinase-3 beta

Combining of chemotherapy with targeted therapy for advanced biliary tract cancer:A systematic review and meta-analysis

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2061-2076页

作者： Xue-Song Bai sheng-nan Zhou Yi-Qun Jin Xiao-Dong He Department of General Surgery Peking Union Medical College HospitalChina Academy of Medical Science&Peking Union Medical CollegeBeijing 100730China Affiliated Hangzhou First People’s Hospital Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Targeted therapy(TT)has resulted in controversial efficacy as first-line treatment for biliary tract cancer(BTC).More efficacy comparisons are required to clarify the overall effects of chemotherapy(CT)combined with TT and CT alone on advanced *** To conduct a meta-analysis of the available evidence on the efficacy of CT combined with TT for advanced *** The PubMed,EMBASE,ClinicalTrials,Scopus and Cochrane Library databases were systematically searched for relevant studies published from inception to August *** randomized clinical trials(RCTs)including comparisons between the combination of gemcitabine-based CT with TT and CT alone as firstline treatment for advanced BTC were eligible(PROSPERO-CRD42022313001).The odds ratios(ORs)for the objective response rate(ORR)and hazard ratios(HRs)for both progression-free survival(PFS)and overall survival(OS)were calculated and *** analyses based on different targeted agents,CT regimens and tumor locations were *** Nine RCTs with a total of 1361 individuals were included and *** overall analysis showed a significant improvement in ORR in patients treated with CT+TT compared to those treated with CT alone(OR=1.43,95%CI:1.11-1.86,P=0.007)but no difference in PFS or *** trends were observed in the subgroup treated with agents targeting epidermal growth factor receptor(OR=1.67,95%CI:1.17-2.37,P=0.004)but not in the subgroups treated with agents targeting vascular endothelial growth factor receptor or mesenchymal-epithelial transition ***,patients who received a CT regimen of gemcitabine+oxaliplatin in the CT+TT arm had both a higher ORR(OR=1.75,95%CI:1.20-2.56,P=0.004)and longer PFS(HR=0.83,95%CI:0.70-0.99,P=0.03)than those in the CT-only ***,patients with cholangiocarcinoma treated with CT+TT had significantly increased ORR and PFS(ORR,OR=2.06,95%CI:1.27-3.35,PFS,HR=0.79,95%CI:0.66-0.94).CONCLUSION CT+TT is a potential first-line treat

关键词： Advanced biliary tract cancer Targeted therapy Chemotherapy Meta-analysis Randomized controlled trial First-line treatment

A single pulse study of PSR J1752+2359

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Research in Astronomy and Astrophysics 2021年第9期21卷 262-268页

作者： sheng-nan Sun Wen-Ming Yan Na Wang Rai Yuen Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Xinjiang Key Laboratory of Radio Astrophysics 150 Science 1-StreetUrumqi 830011China

The single pulse observation of PSR J1752+2359 at 1250 MHz made using the Five-hundredmeter Aperture Spherical radio Telescope(FAST)is *** show that the pulsar exhibits two distinct emission states:a normal state with continuous normal pulse emission and a rotating radio transient(RRAT)-like state with sporadic *** makes PSR J1752+2359 the third pulsar that exhibits switching between RRAT-like and pulsar-like *** data show that,during the observation,20 per cent of the time for this pulsar was in the normal state and 80 per cent in the RRAT-like state.A quasiperiodic switching,with a periodicity of around 568 spin periods,between the two states was *** pulse energies for the two states both follow log-normal *** demonstrate that the polarization profiles and the linear polarization position angle(PA)swings differ significantly between the two *** is a phase offset of about 0°.35 between the pulse profile peaks of the two *** argue that the emission geometry in the magnetosphere may be different for the two states.

关键词： stars neutron-pulsars general-pulsars individual(PSR J1752+2359)

LARGE EDDY SIMULATION OF FREE SURFACE TURBULENT CHANNEL FLOW WITH HEAT TRANSFER

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Journal of Hydrodynamics 2002年第1期14卷 16-22页

作者： Zhong, Feng-Quan Liu, nan-sheng Lu, Xi-Yun Zhuang, Li-Xian Dept. of Modern Mech. Univ. of Sci. and Technol. of China Hefei 230026 China

The Large Eddy Simulation (LES) was used to study the free-surface turbulent channel flow with passive heat transfer. The three-dimensional filtered incompressible Navier-Stokes equations and energy equation were numerically solved with dynamic Subgrid Scale (SGS) models for modeling turbulent stresses and heat flux. To compare the turbulent behavior of the free-surface and two-walled channel flows, the LES of two-walled turbulent channel flow was performed. The statistical quantities and flow structures of the free-surface turbulence with heat transfer in the vicinity of the free-surface were investigated. The results are also in good agreement with theoretical analysis and available results by Direct Numerical Simulation (DNS).

关键词： Computer simulation Heat transfer Mathematical models