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Neuropathological characteristics of abnormal white matter functional signaling in adolescents with major depression

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World Journal of Psychiatry 2024年第2期14卷 276-286页

作者： Xin-Lin Huang Ju Gao Yong-Ming wang Feng Zhu Jing qin qian-nan Yao Xiao-Bin zhang Hong-Yan Sun Imaging and Nuclear Medicine Jiamusi UniversityJiamusi 154000Heilongjiang ProvinceChina Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina School of Biology&Basic Medical Sciences Medical College of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Radiology Shanghai Anting HospitalShanghai 20000China Department of Radiology The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina

BACKGROUND Major depression disorder(MDD)constitutes a significant mental health *** surveys indicate that the lifetime prevalence of depression in adolescents is much higher than that in adults,with a corresponding increased risk of *** studying brain dysfunction associated with MDD in adolescents,research on brain white matter(WM)is *** researchers even mistakenly regard the signals generated by the WM as noise *** fact,studies have shown that WM exhibits similar blood oxygen level-dependent signal *** alterations in WM signals and their relationship with disease severity in adolescents with MDD remain *** To explore potential abnormalities in WM functional signals in adolescents with *** This study involved 48 adolescent patients with MDD and 31 healthy controls(HC).All participants were assessed using the Patient Health Questionnaire-9 Scale and the mini international neuropsychiatric interview(MINI)suicide *** addition,a Siemens Skyra 3.0T magnetic resonance scanner was used to obtain the subjects'image *** DPABI software was utilized to calculate the WM signal of the fractional amplitude of low frequency fluctuations(fALFF)and regional homogeneity,followed by a two-sample t-test between the MDD and HC *** component analysis(ICA)was also used to evaluate the WM functional ***’s correlation was performed to assess the relationship between statistical test results and clinical *** Compared to HC,individuals with MDD demonstrated a decrease in the fALFF of WM in the corpus callosum body,left posterior limb of the internal capsule,right superior corona radiata,and bilateral posterior corona radiata[Perror(FWE)voxel correction].The regional homogeneity of WM increased in the right posterior limb of internal capsule and left superior corona radiata,and decreased in the left superior longitudinal fasciculus(P<0.001,FWE voxel corre

关键词： White matter Regional homogeneity The fractional amplitude of low-frequency fluctuations Independent component analysis Adolescents Major depression disorders

Development and validation of a novel non-invasive test for diagnosing nonalcoholic fatty liver disease in Chinese children

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World Journal of Pediatrics 2024年第4期20卷 413-421页

作者： Zhe-Wen qin qian-nan Ren Hong-Xi zhang Ya-Ru Liu Ke Huang Wei Wu Guan-Ping Dong Yan Ni Jun-Fen Fu Division of Endocrinology National Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalDepartment of EndocrinologyNational Clinical Research Center for Child HealthNational Children’s Regional Medical CenterThe Children’s HospitalZhejiang University School of MedicineHangzhou310052China

With the exploding prevalence of obesity,many children are at risk of developing nonalcoholic fatty liver *** anthropometric and laboratory parameters,our study aimed to develop a model to quantitatively evaluate liver fat content(LFC)in children with *** A well-characterized cohort of 181 children between 5 and 16 years of age were recruited to the study in the Endocrinology Department as the derivation *** external validation cohort comprised 77 *** assessment of liver fat content was performed using proton magnetic resonance *** and laboratory metrics were measured in all subjects.B-ultrasound examination was carried out in the external validation *** Kruskal-Wallis test,Spearman bivariate correlation analyses,univariable linear regressions and multivariable linear regression were used to build the optimal predictive *** The model was based on indicators including alanine aminotransferase,homeostasis model assessment of insulin resistance,triglycerides,waist circumference and Tanner *** adjusted R^(2)of the model was 0.589,which presented high sensitivity and specificity both in internal[sensitivity of 0.824,specificity of 0.900,area under curve(AUC)of 0.900 with a 95%confidence interval:0.783–1.000]and external validation(sensitivity of 0.918 and specificity of 0.821,AUC of 0.901 with a 95%confidence interval:0.818–0.984).Conclusions Our model based on five clinical indicators was simple,non-invasive,and inexpensive;it had high sensitivity and specificity in predicting LFC in ***,it may be useful for identifying children with obesity who are at risk for developing nonalcoholic fatty liver disease.

关键词： Biochemical markers Children Magnetic resonance spectroscopy Nonalcoholic fatty liver disease Pediatric obesity

Reduction of Nitric Oxide over Rutile-supported Cu Surfaces： A Quantum Chemical Study

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Chinese Journal of Chemistry 2005年第11期23卷 1479-1482页

作者： TAN, Kai LIN, Meng-Hai wang, nan-qin zhang, qian-er Department of Chemistry University of Xiamen Xiamen Fujian 361005 China

The adsorption and decomposition of NO on the stoichiometric rutile-supported Cu surfaces have been studied by means of density functional calculations with an embedded cluster model. The calculation results indicate that NO is favorably adsorbed as O-down and could easily attach another NO molecule to form N2O intermediate or directly be dissociated into N2 and O2. On the basis of the calculated energetics, possible mechanism of NO decomposition reaction has been proposed.

关键词： DFT Cu/TiO2 embedded cluster model

Interatomic Potentials for NiZr Alloys from Experimental and Ab initio Calculations

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Chemical Research in Chinese Universities 2002年第1期18卷 38-41页

作者： TAN Kai, LIN Meng-hai , wang nan-qin and zhang qian-er Department of Chemistry,Xiamen University,Xiamen 361005,P.R.China Department of Chemistry Xiamen University Xiamen 361005

We applied an approach to the development of many-body interatomic potentials for NiZr alloys,gaining an improved accuracy and *** functional form of the potential is that of the embedded method,but it has been improved as follows. (1) The database used for the development of the potential includes both experimental data and a large set of energies of different structures of the alloys generated by Fab initio calculations. (2) The optimum parametrization of the potential for the given database is obtained by fitting. Using this approach we developed reliable interatomic potentials for Ni and Zr. The potential accurately reproduces basic equilibrium properties of the alloys.

关键词： Ab initio NiZr alloy Many-body interatomic potential

滞育时间对豆天蛾幼虫营养成分及代谢酶活性的影响

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江苏农业学报 2024年第1期40卷 149-155页

作者：钱蕾秦毅张佳李宗男邓盼周刚李情怡廖怀建江苏省农业科学院休闲农业研究所江苏南京210014 扬州大学植物保护学院江苏扬州225009 淮安市农业科学院徐淮地区淮阴农业科学研究所江苏淮安223001 江苏科技大学生物技术学院江苏镇江212100

为了明确不同滞育时间对豆天蛾幼虫的影响,本研究测定了豆天蛾幼虫体内营养物质(包括蛋白质、氨基酸和脂肪酸)含量及肠道代谢酶活性的变化。结果表明,不同滞育时间的豆天蛾幼虫体内蛋白质含量均显著高于对照,且在滞育后期(150 d)达到最... 详细信息

为了明确不同滞育时间对豆天蛾幼虫的影响,本研究测定了豆天蛾幼虫体内营养物质(包括蛋白质、氨基酸和脂肪酸)含量及肠道代谢酶活性的变化。结果表明,不同滞育时间的豆天蛾幼虫体内蛋白质含量均显著高于对照,且在滞育后期(150 d)达到最高值。滞育150 d的豆天蛾幼虫体内18种氨基酸含量均显著高于对照。与对照相比,滞育60 d豆天蛾幼虫体内亚油酸含量降低0.030个百分点(P<0.05),滞育30 d、90 d、120 d、150 d豆天蛾幼虫体内亚麻酸含量分别高于对照0.140个百分点、0.060个百分点、0.060个百分点、0.080个百分点(P<0.05)。滞育30 d豆天蛾幼虫肠道碱性磷酸酶、己糖激酶活性显著低于对照(P<0.05),滞育120 d时达到最高值;海藻糖酶、丙酮酸激酶活性在滞育90 d达到最高值;滞育120 d山梨醇脱氢酶活性最高,比对照高18.37%(P<0.05)。综上所述,滞育期的豆天蛾幼虫营养价值提高,代谢酶活性波动明显。

关键词：豆天蛾滞育代谢酶蛋白质氨基酸脂肪酸

Bondings and Interactions in Fe-CO:Pairing versus Unpairing Mechanism

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Chinese Chemical Letters 1997年第5期8卷 443-446页

作者： Xin XU nan qin wang Xin LU qian er zhang(State Key taloratory of Physical CheAnsny on Solid Surface, Institute of Physical Chethestry,Department of Chendstry, Xiamen 361005) State Key Lab. Phys. Chem. Solid S. Institute of Physical Chemistry Department of Chemistry Xiamen 361005 China

Four micro states of Fe-CO with 3d(sigma)-4s and 3d(delta)-3d(delta) electrons spin-paired or unpaired are examined to investigate the influence of pairing versus unpairing mechanism upon the bondings and interactions in Fe-CO. The calculation results show that the Fe-CO bondings and interactions are determined by a balance between the bonding stabilization and the exchange stabilization with or without 3d(sigma)-4s electron spin-pairing. The 3d(delta)-3d(delta) electron spin-pairing versus unpairing has a surprising large effect on the Fe-CO bonding properties, even though the 3d(delta) orbitals are usually considered as being nonbonding.

关键词： CO Fe Bondings and Interactions in Fe-CO

ASSIGNMENTS FOR THE GROUND STATES OF METAL MONOCARBONYLS

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Chinese Chemical Letters 1995年第10期6卷 887-890页

作者： Xin XU nan qin wang Xin LU qian er zhang(State Key Laboratory for Physical Chemistry of the Solid Surface,Department of Chemistry,Xiamen University,Fujian 361005) Xiamen Univ Dept Chem State Key Lab Phys Chem Solid Surface Xiamen 361005 Peoples R China

The bonding mechanisms between the first-row transition metal and carbon monoxide were discussed. Three basic rules have been drawn up to determine the ground states of the metal monocarbonyls. The theoretical assignm...

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MECHANISM OF METHANOL DECOMPOSITION ON CLEAN AND OXYGEN-MODIFIED Fe,Cu SURFACES:BOND-ORDer CONSerVATION APPROACH

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Journal of Energy Chemistry 1993年第3期 185-194页

作者： wang nan-qin XIA Wen-Sheng zhang qian-er Department of Chemistry, Xiamen University Xiamen, Fujian 361005

Bond-order conservation-Morse potential （BOC-MP） approach hasbeen used to study the mechanism of methanol decomposition on the clean andoxygen-modified Fe（100）, Cu （100） surfaces. On the clean Cu （100） surfacemethanol was adsorbed in molecular forms and desorbed without dissociation,but on the clean Fe（100） surface it decomposed via a methoxy （CH3O） inter-mediate into carbon monoxide （CO） and hydrogen （H2） mainly, or into methyl（CH3） and hydroxyl （OH） species directly. The thermal stability of methoxyincreased in the presence of pre-adsorbed oxygen（O3）. Hollow site O3poisonedthe decomposition of methanol, but non-hollow site O3promoted the decomposi-tion of methanol into the methoxy, which decomposed and selectively led to theformation of formaldehyde （H2CO） on oxygen-modified Cu surfaces. The for-mation of formaldehyde via a disproportionation reaction of methoxy is also dis-cussed.

关键词： Fe MECHANISM OF METHANOL DECOMPOSITION ON CLEAN AND OXYGEN-MODIFIED Fe,Cu SURFACES OHC Cu

DECOMPOSITION OF METHANOL ON METAL SURFACES:BOND-ORDer CONSerVATION APPROACH

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Journal of Energy Chemistry 1993年第2期 100-108页

作者： XIA Wen-Sheng wang nan-qin zhang qian-er Department of Chemistry,Xiamen University,Xiamen,Fujian 361005

Bond-Order Conservation-Morse Potential（BOC-MP）approach hasbeen used to study the decomposition of methanol（CH3OH）onFe（111）,Pd（111）,Pt（111）and Cu（111）*** result shows:The scission of O-H,C-O bond in methanol occurs on Fe,but O-H bond is activated on Cu,andO-H,C-O bonds are activated on Pd,Pt.O-H bond is broken into methoxy（CH3Os）,up to the final product（CO）.C-O bond is broken into(CH2.+H2O3),then leads to the formation of hydrogenated species CH3.2,CH4.8on Ptand Pal,while broken into either(CH2,s+H2Os)or(CH3,s+OHs)on *** selectivity of methanol decomposition and the thermal stability of methoxyincrease in the order of Fe更多还原AbstractFilter('ChDivSummary', 'ChDivSummaryMore', 'ChDivSummaryReset');

关键词： Pt