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营商环境何以优化?——企业行政负担的视角

公共行政评论 2024年第3期17卷 159-174,199,200页

作者：姜楠曹现强山东大学政治学与公共管理学院

优化营商环境的核心在于降低企业行政负担和提升企业获得感,然而企业行政负担如何生成、如何优化等问题仍然不甚明晰。以A市优化营商环境的实践为例,以通过深度访谈、公开政策文本与新闻报道等途径收集而来的质性资料作为支撑,论文重新... 详细信息

优化营商环境的核心在于降低企业行政负担和提升企业获得感,然而企业行政负担如何生成、如何优化等问题仍然不甚明晰。以A市优化营商环境的实践为例,以通过深度访谈、公开政策文本与新闻报道等途径收集而来的质性资料作为支撑,论文重新审视并深入挖掘了企业行政负担的成因,结合优化营商环境治理实践,提出了降低企业行政负担的本土解释框架。研究发现,政企互动过程中,企业所背负的服从成本缘于申请材料冗杂、流程与环节复杂、材料内容不明晰等方面,学习成本缘于涉企政策来源多样且分散、涉企政策解读不明晰、涉企政策精准推送难等方面,心理成本缘于政企沟通不畅、政策稳定性差、政策普惠程度不高等方面。基于组织学视角,论文进一步从横向政府部门间的流程重塑、纵向政府部门间的考核问责以及外部场域环境中的需求回应三个方面,对降低行政负担的方式进行了学理建构。具体来说,降低企业的行政负担应当以营商环境优化全局观为基础,在坚持底线监管、审慎监管的基础上识别行政负担与管理的边界。在政企互动初期,应当侧重以技术治理推动涉企政策信息公开、集成与精准推送,以界面治理推动部门协同提升涉企事项的管理效率。随着政企互动程度的不断深入,应当提升审管协同与城市政务热线等治理水平,通过建立容错机制鼓励政府创新,从而支持政府部门为企业主动提供服务,有效回应企业需求。

关键词：行政负担政企互动优化营商环境

基于线性结构模型的古塔刚度中心识别方法研究

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工程力学 2024年第6期41卷 154-163,201页

作者：曹笑楠杨娜白凡北京交通大学土木建筑工程学院北京100044 结构风工程与城市风环境北京市重点实验室北京100044

基于动力测试的古塔结构状态评估是其预防性保护工作的重要一环。该文结合动力测试方法,提出了一种基于线性结构模型进行古塔刚度中心识别的方法。基于偏心结构动力学理论凝练了非同轴刚度偏心的古塔计算模型与特征方程;基于Bayesian理... 详细信息

基于动力测试的古塔结构状态评估是其预防性保护工作的重要一环。该文结合动力测试方法,提出了一种基于线性结构模型进行古塔刚度中心识别的方法。基于偏心结构动力学理论凝练了非同轴刚度偏心的古塔计算模型与特征方程;基于Bayesian理论线性结构识别模型的推导及Gibbs抽样开展了结构物理参数识别,并结合经典算例对识别结果进行了验证;将该方法应用到我国重点保护文物开元寺塔的刚度中心识别中。

关键词：古塔结构刚度中心线性结构识别模型 Bayesian理论物理参数识别

Effect of Cr_(2)O_(3) on properties of cao-SiO_(2)-Fe_(t)O-MgO system and dissolution behavior of lime

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Journal of Iron and Steel Research(International) 2024年第4期31卷 870-881页

作者： Shan-nan Li Jian-li Li Yue Yu Hang-yu Zhu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The productivity of the chrome-containing semi-steel converter smelting process is directly affected by the slag-forming speed during the converter preliminary stage.The effects of Cr_(2)O_(3) content on the physicochemical properties of the cao-SiO_(2)-Fe_(t)O-MgO system,such as melting temperature,solidification behavior,mineral composition,and lime dissolution rate,were studied.The results showed that the slag was an amorphous phase at 1500℃.When Cr_(2)O_(3) was added,Ca(Fe,Mg)Si_(2)O_(6) and spinel were formed in the slag.With the increase in Cr_(2)O_(3) content,the amount of spinel precipitation increased,and the dendritic FegO_(4) crystal gradually changed into the granular(Fe,Mg)(Fe,Cr)2O_(4) crystal.As the Cr_(2)O_(3) content increased from O to 2.91 wt.%,the melting temperature of the slag rose,and the melting range of the slag expanded slightly,but the lime dissolution rate did not change.When the Cr_(2)O_(3) content further increased to 9.09 wt.%,the melting temperature continued to rise,the melting range rapidly expanded,and the lime dissolution rate decreased.

关键词： Cr_(2)O_(3) Vanadium-titanium magnetite Converter Slag Lime dissolution

A CNN-Based Single-Stage Occlusion Real-Time Target Detection Method

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Journal of Intelligent Learning Systems and Applications 2024年第1期16卷 1-11页

作者： Liang Liu nan Yang Saifei Liu Yuanyuan cao Shuowen Tian Tiancheng Liu Xun Zhao Rizhao Power Supply Company State Grid Shandong Electric Power Company Rizhao China School of Automation Beijing Information Science and Technology University Beijing China

Aiming at the problem of low accuracy of traditional target detection methods for target detection in endoscopes in substation environments, a CNN-based real-time detection method for masked targets is proposed. The method adopts the overall design of backbone network, detection network and algorithmic parameter optimisation method, completes the model training on the self-constructed occlusion target dataset, and adopts the multi-scale perception method for target detection. The HNM algorithm is used to screen positive and negative samples during the training process, and the NMS algorithm is used to post-process the prediction results during the detection process to improve the detection efficiency. After experimental validation, the obtained model has the multi-class average predicted value (mAP) of the dataset. It has general advantages over traditional target detection methods. The detection time of a single target on FDDB dataset is 39 ms, which can meet the need of real-time target detection. In addition, the project team has successfully deployed the method into substations and put it into use in many places in Beijing, which is important for achieving the anomaly of occlusion target detection.

关键词： Real-Time Mask Target CNN (Convolutional Neural Network) Single-Stage Detection Multi-Scale Feature Perception

Two sex pheromone receptors for sexual communication in the American cockroach

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Science China(Life Sciences) 2024年第7期67卷 1455-1467页

作者： Na Li Renke Dong Huanchao Zeng Yan Zhang Run Huang Wei Liu Fengming cao Jincong Yu Mingtao Liao Jingyou Chen Wenlei Zhang Zejian Huang Jiahui Wang Li Li Shen Zhu Danyan Huang Zining Li Xiaoshuai Zhang Dongwei Yuan nan Chen Yongliang Fan Guirong Wang Coby Schal Yufeng Pan Sheng Li Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology Institute of Insect Science and TechnologySchool of Life SciencesSouth China Normal UniversityGuangzhou 510631China Guangmeiyuan R&D Center Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied TechnologySouth China Normal UniversityMeizhou 514589China Lingnan Guangdong Laboratory of Modern Agriculture Genome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518000China State Key Laboratory of Crop Stress Biology for Arid Areas and Key Laboratory of Integrated Pest Management on the Loess Plateau of Ministry of AgricultureNorthwest A&F UniversityYangling 712100China Department of Entomology and Plant Pathology North Carolina State UniversityRaleigh 27695USA The Key Laboratory of Developmental Genes and Human Disease School of Life Science and TechnologySoutheast UniversityNanjing 210096China

Volatile sex pheromones are vital for sexual communication between males and females.Females of the American cockroach,Periplaneta americana,produce and emit two sex pheromone components,periplanone-A(PA)and periplanone-B(PB).Although PB is the major sex attractant and can attract males,how it interacts with PA in regulating sexual behaviors is still unknown.In this study,we found that in male cockroaches,PA counteracted PB attraction.We identified two odorant receptors(ORs),OR53 and OR100,as PB/PA and PA receptors,respectively.OR53 and OR100 were predominantly expressed in the antennae of sexually mature males,and their expression levels were regulated by the sex differentiation pathway and nutrition-responsive signals.Cellular localization of OR53 and OR100 in male antennae further revealed that two types of sensilla coordinate a complex two-pheromone-two-receptor pathway in regulating cockroach sexual behaviors.These findings indicate distinct functions of the two sex pheromone components,identify their receptors and possible regulatory mechanisms underlying the male-specific and age-dependent sexual behaviors,and can guide novel strategies for pest management.

关键词： sex pheromone odorant receptor sexual attraction sex differentiation cockroach

Effect of rotor-mounted protrusion on sealing performance and flow structure in rotor-stator cavity

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Chinese Journal of Aeronautics 2018年第11期31卷 2057-2072页

作者： nan cao Xiang LUO Zeyu WU Jie WEN National Key Laboratory of Science and Technology on Aero-Engine Aero-Thermodynamics School of Energy and Power EngineeringBeihang UniversityBeijing 100083China Collaborative Innovation Center for Advanced Aero-Engine Beijing 100083China

This paper presents an experimental investigation on the effect of protrusion radial position and height on the sealing performance and flow structure in the rotor-stator cavity. The rotormounted protrusions are assembled at three radial positions and are set to three heights. The cavity is equipped with three rim seals: a radial seal, an axial seal and a seal with double fins on the stator.The annulus Reynolds number is set at 4:39 ×10;and the rotational Reynolds number ranges from 7:51×10;to 1:20×10;. Heat and mass transfer analogy is applied. Pressure and CO;concentration are measured. The experimental results show that in cavities with different rim seals, radial distributions of the sealing efficiency, pressure and swirl ratio are basically the same. The sealing performance is improved by protrusions compared with the cavity without protrusion and improves with the increase of protrusion radial position and height. The effect of protrusion increases with the increase of the rotational Reynolds number. The windage loss and the flow resistance introduced by protrusions are investigated. It is found that induced windage loss and flow resistance decrease with the increase of protrusion radial position but increase with the protrusion height.

关键词： Height Protrusion Radial position Rim seal Sealing performance

双联拱隧道爆炸时程分析和动力响应:以甘肃省奤盖隧道为例

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科学技术与工程 2024年第14期24卷 6034-6042页

作者：王楠曹小平兰州交通大学土木工程学院兰州730070

考虑现实生活中隧道面临易燃易爆气体的爆炸和偶发车辆碰撞的爆炸,以甘肃省卓尼县柳林镇附近的奤盖隧道为工程背景,运用有限元软件Midas/GTS NX进行隧道爆炸模拟数值分析,分析了在静力荷载和炸药当量条件下,双联拱隧道的受力影响,对隧... 详细信息

考虑现实生活中隧道面临易燃易爆气体的爆炸和偶发车辆碰撞的爆炸,以甘肃省卓尼县柳林镇附近的奤盖隧道为工程背景,运用有限元软件Midas/GTS NX进行隧道爆炸模拟数值分析,分析了在静力荷载和炸药当量条件下,双联拱隧道的受力影响,对隧道围岩及衬砌进行了位移、速度、加速度和应力时程分析和响应研究。结果表明:当发生爆炸作用时,隧道横向和径向受到应力冲击波以及反射冲击波的影响最为显著,当超过一定值的时候,隧道就会发生局部剪切破坏或剥落破坏;由于反射波的存在,围岩和衬砌的速度和加速度均会呈现出多个峰值,且距爆源位置越近,衬砌的结构损伤也越严重;隧道应力集中区域表现出明显的抗拉抗压,迎爆面应力响应最为显著。

关键词：爆炸冲击衬砌响应数值模拟双联拱隧道变形特征

FMRP通过激活RAS/MAPK信号通路抑制结直肠肿瘤细胞的铁死亡

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南方医科大学学报 2024年第5期44卷 885-893页

作者：王南石斌马小兰吴伟超曹佳宁夏医科大学总医院硕士培养站宁夏银川750004 宁夏医科大学总医院急诊科宁夏银川750004 银川市第一人民医院耳鼻喉科宁夏银川750004 宁夏医科大学总医院医学科学研究院外科学研究室宁夏银川750004

目的探讨脆性X智力障碍蛋白(FMRP)调控结直肠肿瘤(CRC)细胞逃避铁死亡的作用机制。方法使用RT-qPCR和Western blotting方法验证FMRP在CRC细胞中的表达;利用TCGA数据库分析FMRP参与调控CRC进展的生物功能及信号通路;采用慢病毒表达系统和... 详细信息

目的探讨脆性X智力障碍蛋白(FMRP)调控结直肠肿瘤(CRC)细胞逃避铁死亡的作用机制。方法使用RT-qPCR和Western blotting方法验证FMRP在CRC细胞中的表达;利用TCGA数据库分析FMRP参与调控CRC进展的生物功能及信号通路;采用慢病毒表达系统和siRNA干扰技术,分别构建FMRP过表达载体(Lv-FMRP)和敲低载体(siFMRP-1、siFMRP-2、siFMRP-3),细胞实验设Control组、NC组、siFMRP-1组、siFMRP-2组、siFMRP-3组、Lv-NC组、Lv-FMRP组;采用CCK8和平板克隆实验检测细胞增殖;采用MDA/ROS/GSH/Fe^(2+)试剂盒检测细胞铁死亡水平;采用JC-1荧光染色法检测线粒体膜电位变化;采用Western blot检测铁死亡相关蛋白及RAS/MAPK信号通路相关蛋白表达;利用裸鼠皮下成瘤实验观察FMRP对肿瘤生长的影响。结果与正常肠粘膜上皮细胞NCM460相比,FMRP在CRC细胞中明显高表达(P<0.05);TCGA数据库联合生信分析显示FMRP与活性氧调控、氧化应激诱导细胞死亡、线粒体呼吸等生物过程相关,与谷胱甘肽代谢通路相关;体外实验结果显示,与Control组相比,FMRP敲低组细胞增殖能力降低,GSH含量降低,MDA和ROS含量升高,Fe^(2+)荧光强度增强(P<0.05),SLC7A11/GPX4蛋白表达降低,线粒体膜电位JC-1荧光强度升高,而FMRP过表达组与上述结果相反;体内实验结果显示,敲低FMRP抑制瘤体生长,抑制SLC7A11表达(P<0.01);进一步检测RAS/MAPK信号通路,发现敲低FMRP导致ERK、MEK、MAPK、RAS蛋白磷酸化水平降低,过表达FMRP上述蛋白磷酸化水平升高(P<0.05)。结论FMRP通过激活RAS/MAPK信号通路抑制细胞铁死亡促进CRC恶性进展。

关键词： FMRP 铁死亡 RAS/MAPK信号通路结直肠肿瘤

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习近平文化思想:核心要义、理论贡献与实践指引——以乡村建设为视角

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新疆社会科学 2024年第3期 1-9,176页

作者：王杰曹兹纲聂楠西北农林科技大学人文社会发展学院西北农林科技大学黄河流域乡村振兴研究与评估中心陕西杨凌712100 新疆中国特色社会主义理论体系研究中心新疆乌鲁木齐830011 新疆大学中国语言文学学院中国文艺评论(新疆大学)基地办公室新疆乌鲁木齐840046

习近平文化思想是习近平新时代中国特色社会主义思想的文化篇章。基于乡村建设视角对习近平文化思想进行解读和诠释,对于实现乡村全面振兴具有重大理论价值。从乡村振兴层面来看,习近平文化思想规定了乡村全面振兴的文化使命;从乡村治... 详细信息

习近平文化思想是习近平新时代中国特色社会主义思想的文化篇章。基于乡村建设视角对习近平文化思想进行解读和诠释,对于实现乡村全面振兴具有重大理论价值。从乡村振兴层面来看,习近平文化思想规定了乡村全面振兴的文化使命;从乡村治理层面来看,习近平文化思想为推进乡村治理现代化提供了文化指引;从乡村生活层面来看,习近平文化思想表达了乡村美好生活的文化诉求。习近平文化思想为新时代乡村意识形态建设奠定了思想根基;为巩固文化强国建设的乡村之基提供了理论指导;为推进中国式乡村文化现代化提供了科学方法论。在乡村建设进程中,习近平文化思想的实践指引在于坚持党在乡村基层的文化领导权,坚持以人民为中心推动乡村文化繁荣兴盛,坚持在守正创新中提升乡村文化建设水平。

关键词：习近平文化思想乡村视角核心要义理论贡献实践指引