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The MING proposal at SHINE:megahertz cavity enhanced X‑ray generation

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Nuclear Science and Techniques 2023年第1期34卷 51-85页

作者： nan‑shun huang Zi‑Peng Liu Bang‑Jie Deng Zi‑Han Zhu Shao‑Hua Li Tao Liu Zheng Qi Jia‑Wei Yan Wei Zhang Sheng‑Wang Xiang Yang‑Yang Lei Ya Zhu Yong‑Zhou He Qi‑Bing Yuan Fei Gao Rong‑Bing Deng Sen Sun Zhi‑Di Lei Zhi‑Qiang Jiang Meng‑Qi Duan Yuan Zhuan Xue‑Fang huang Peng‑Cheng Dong Zhong‑Liang Li Shang‑Yu Si Lian Xue Si Chen Yong‑Fang Liu Ya‑Jun Tong Hai‑Xiao Deng Zhen‑Tang Zhao Zhangjiang Laboratory Shanghai 201210China School of Nuclear Science and Technology Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China European XFEL Schenefeld 22869Germany ShanghaiTech University Shanghai 201210China

The cavity-based X-ray free-electron laser(XFEL)has promise in producing fully coherent pulses with a bandwidth of a few meV and very stable intensity,whereas the currently existing self-amplified spontaneous emission(SASE)XFEL is capable of generating ultra-short pulses with chaotic *** general,a cavity-based XFEL can provide a spectral brightness three orders of magnitude higher than that of the SASE mode,thereby opening a new door for cutting-edge scientific *** the development of superconducting MHz repetition-rate XFEL facilities such as FLASH,European-XFEL,LCLS-II,and SHINE,practical cavity-based XFEL operations are becoming increasingly *** this study,megahertz cavity enhanced X-ray generation(MING)is proposed based on China’s first hard XFEL facility-SHINE,which we refer to as MING@SHINE.

关键词： X-ray free-electron laser Free electron laser oscillator Fully coherent X-ray

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao huang Xin-Yue Li Ming-Ke Wang Ji-shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Correlations in Werner States

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Communications in Theoretical Physics 2008年第2期49卷 327-328页

作者： LUO shun-Long LI nan Academy of Mathematics and Systems Science the Chinese Academy of Sciences Beijing 100080 China

Werner states are paradigmatic examples of quantum states and play an innovative role in quantum information theory. In investigating the correlating capability of Werner states, we find the curious phenomenon that quantum correlations, as quantified by the entanglement of formation, may exceed the total correlations, as measured by the quantum mutual information. Consequently, though the entanglement of formation is so widely used in quantifying entanglement, it cannot be interpreted as a consistent measure of quantum correlations per se if we accept the folklore that total correlations are measured （or rather upper bounded） by the quantum mutual information.

关键词： total correlations quantum correlations entanglement of formation Werner states

Firm embedding behavior of annular grooved projectiles impacting ductile metal targets

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Defence Technology（防务技术） 2019年第5期15卷 768-778页

作者： Qi huang shun-shan Feng Xu-ke Lan Chao-nan Chen Yong-xiang Dong Tong Zhou State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

Annular grooved projectiles(AGPs)have drawn ongoing concerns as an advanced penetrator for their excellent anti-rebound capability in impacting metal *** could become embedded solidly in the target surface during low-velocity *** this investigation,the firm embedding behavior of AGP was observed by impact *** numerical simulations provided a better understanding of this *** and numerical results indicated that the firm embedding behavior of AGP was mainly due to the filling-material in the groove rather than the friction between the projectile and target,unlike traditional shape such as conical *** to observation,firm embedding process can generally be subdivided into four stages:initial-cratering stage,groove-filling stage,fillingmaterial failure stage and rebound vibration ***,the damage mechanics of target material around crater was obtained through microscopic tests.A comparison of the cross-sectional figures between the experiment and simulation proved that the analysis and the proposed method were reasonable and feasible,which further demonstrated that the firm embedding behavior has application potential in new concept warheads.

关键词： Annular grooved projectile (AGP) Impact Firm embedding behavior Flow characteristics Microscopic tests

Mechanical formula for the plastic limit pressure of stent during expansion

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Acta Mechanica Sinica 2009年第6期25卷 795-801页

作者： Jie Yang nan huang School of Mechanics and Engineering Southwest Jiaotong University 610031 Chengdu China School of Material Science and Engineering Southwest Jiaotong University 610031 Chengdu China

The mechanics of cardiovascular stents during the process of expansion are very important for stent function and safety. In general, finite element method （FEM） or experi- ments are major methods used to ascertain mechanical prop- erties of the stent. In this paper, we develop a theoretical model of the tubular stent, derive formulas for the axial forces and moments on the stent end, and propose formu- las for the plastic limit pressure vs. the stent＇s radius during expansion. Examples covering different geometrical param- eters and material parameters are provided, and the plastic limit pressures calculated by FEM and the present method are compared, proving that the present formulas are acceptable and meaningful for the design and innovation of the stent.

关键词： Stent. Expansion . Inter forcePlastic limit pressure . FEM

OPTIMAL AND INCENTIVE COMPATIBLE PRICING FOR HETEROGENEOUS PERIODS

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Journal of Systems Science and Systems Engineering 2008年第1期17卷 50-65页

作者： Jian CHEN nan ZHANG Shuo huang Research Center for Contemporary Management Key Research Institute of Humanities and Social Sciences at Universities School of Economics and Management Tsinghua University Beijing 100084 China

This paper studies a service firm whose business time can be divided into several periods, each providing different value to customers. Heterogeneous service is a major reason resulting in imbalances between supply and demand. Since customers differ in their degree of impatience, firrns can use differential pricing mechanisms to optimize their objectives and match supply with demand in each period, by inducing customers to choose different periods. We study two types of firrns, an internal firm, the objective of which is to maximize the system＇s （including the f＇nan and all the customers） total net value, and a commercial firm, which aims to optimize its own profit. Though impatience factors are customers＇ private information, for each type of firm, we derive the optimal incentive compatible pricing policy, under which all the coming customers will follow the firm＇s assignment, that is, patient customers will buy the service in high-value periods, but their waiting time will be longer, while impatient customers will enter into the low-value periods, but they will be compensated by shorter waiting times. Furthermore, in the internal firm, we also prove that this mechanism enables the decentralization of decisions, while maintaining centralized system-wide optimality. Numerical analysis shows that when there is sufficient capacity, the internal firm does not always need to set lower prices than the commercial firm in every period.

关键词： Delay cost queuing differential pricing information asymmetry incentive compatibility

Convergence of a Non-interior Continuation Algorithm for the Monotone SCCP

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Acta Mathematicae Applicatae Sinica 2010年第4期26卷 543-556页

作者： nan Lu Zheng-Hai huang Department of Mathematics School of ScienceTianjin UniversityTianjin 300072China

It is well known that the symmetric cone complementarity problem（SCCP） is a broad class of optimization problems which contains many optimization problems as special *** on a general smoothing function,we propose in this paper a non-interior continuation algorithm for solving the monotone *** proposed algorithm solves at most one system of linear equations at each *** using the theory of Euclidean Jordan algebras,we show that the algorithm is globally linearly and locally quadratically convergent under suitable assumptions.

关键词： Symmetric cone complementarity problem non-interior continuation method global linear convergence local quadratic convergence

Seismic Imaging of the Sedimentary System of the Upper Cretaceous Nenjiang Formation in the Northern Songliao Basin

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Journal of Earth Science 2019年第4期30卷 788-798页

作者： Wuling Mo Chaodong Wu nan Su shun Zhang Mingzhen Wang School of Earth and Space Sciences Peking UniversityBeijing 100871China PetroChina Exploration and Development Research Institute Langfang 257000China Exploration and Development Research Institute of Daqing Oilfield Co. Ltd. Daqing 163712China

This paper studied seismic imaging of the sedimentary system of the Nenjiang Formation in the Northern Songliao Basin based on seismic sedimentology. An accurate and detailed depiction and explanation is provided for underground geological bodies within a relative geological period using the stratal slice technology,based on three-order sequence correlations of well logging and seismic data for the purpose of obtaining high-resolution pictures of the sedimentary system. Research results have revealed that the sedimentary system of the Upper Cretaceous Nenjiang Formation in the Northern Songliao Basin includes meandering streams,anastomosing streams,lake deltas,and sediment gravity flow channels. Based on seismic imaging analysis,the genesis and seismic geomorphology of the sedimentary system of the Nenjiang Formation are explored in order to understand the spatial distribution of typical sedimentary bodies and the evolution of streams in the Nenjiang Formation. According to the research results,the sedimentation of the Nenjiang Formation was subject to the delta system in the east and northeast of the formation. The provenance in the northeastern part played a dominant role during the deposition of the Nenjiang Formation for some time;after the earlier maximum flooding in the second and third members of the Nenjiang Formation,the northeastern system began to decline and was gradually replaced by the eastern system. Stratal slices have revealed that a well-developed gravity flow channel system was developed in the first member of the Nenjiang Formation,and massive slip blocks occurred in the second and third members of the formation. The research results indicated that the large gravity flow channel system in the first member of the Nenjiang Formation was formed by streams that emptied directly into the lake;and the slip blocks in the second and third members were the results of gravity sliding of sediments along steep slopes at the delta front.

关键词： seismic sedimentology stratal slice sedimentary system Nenjiang Formation Songliao Basin