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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi Ye Runqing Liu Hangxing wang Aizhen Zuo Cen Jin nan wang Huiqi Sun Luqian Feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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Role of macrophage polarization in diabetic foot ulcer healing:A bibliometric study

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World Journal of Diabetes 2025年第1期16卷 169-186页

作者： You-Wen Zhang Lei Sun Yan-nan wang Shi-Yu Zhan Department of Peripheral Vascular Disease Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250014Shandong ProvinceChina Department of Surgery The Second Affiliated Hospital of Shandong University of Traditional Chinese MedicineJinan 250001Shandong ProvinceChina Department of Surgery Longkou Traditional Chinese Medicine HospitalYantai 265701Shandong ProvinceChina

BACKGROUND Diabetic foot ulcers(DFUs)are a significant contributor to disability and mortality in diabetic *** polarization and functional regulation are promising areas of research and show therapeutic potential in the field of DFU ***,the complex mechanism,the difficulty in clinical translation,and the large heterogeneity present significant ***,this study was to comprehensively analyze the publication status and trends of studies on macrophage polarization and DFU *** To examine the relevant literature on macrophage polarization in DFU *** A bibliometric analysis was conducted using the Web of Science *** literature was retrieved from the Web of Science Core Collection database between 2013 to 2023 using literature visualization and analysis software(VOSviewer and CiteSpace)and bibliometric online *** obtained literature was then subjected to visualization and analysis of different countries/regions,institutions,journals,authors,and keywords to reveal the research’s major trends and *** The number of publications on the role of macrophage polarization in DFU healing increased rapidly from 2013 to 2023,especially in the latter *** researchers were the most prolific in this field,with 217 publications,while American researchers had been engaged in this field for a longer *** Tan of nanjing Drum Tower Hospital and Qian Ding of nanjing University were the first to publish in this *** Jiao Tong University was the institution with the most publications(27).The keywords“bone marrow”,“adjustment,replacement,response,tissue repair”,and“activation,repair,differentiation”appeared more *** study of macrophage polarization in DFU healing focused on the regulatory mechanism,gene expression,and other *** This study through the bibliometric method reveals the research trends and development trends in this field of macrophage polar

关键词： Diabetic foot Wound healing Macrophage polarization Bibliometric analysis Research cooperation Research trend

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The discovery of a quantum Griffiths singularity in superconducting films

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National Science Review 2016年第4期3卷 395-396页

作者： nan-Lin wang International Center for Quantum Materials School of PhysicsPeking University

More than 40 years ago,Robert B Griffiths proposed that phase transitions can be dramatically changed by a disorder effect and,in particular,that it is possible for the dynamical critical exponent to diverge[1].Since that time,this theory has been applied to quantum phase transitions(QPTs)and has been developed into the concept of the quantum Griffiths ***,the primary

关键词： very SMT The discovery of a quantum Griffiths singularity in superconducting films

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Effect of phase-separated patterns on the formation of core-shell structure

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Journal of Materials Science & Technology 2020年第3期38卷 64-72页

作者： Yinli Peng nan wang MOE Key Laboratory of Materials Physics and Chemistry under Extraordinary Conditions School of Natural and Applied SciencesNorthwestern Polytechnical UniversityXi’an710072China

Revealing the mechanisms of self-organized core-shell(C-S)structure in immiscible systems has drawn considerable attentions,however,the further and fundamental understanding from the point of view of phase-separated pattern remains extremely *** this work,by realizing two phase-separated patterns in transparent immiscible system,namely nucleation-growth and spinodal decomposition,their effects on radius of minority-phase droplet(MPD)were examined,and subsequently the effect on C-S structure was further *** was found that compared with MPDs produced via nucleation-growth,the MPDs via spinodal decomposition are much larger and easier to form a C-S *** is mainly because the larger MPDs can migrate faster and are earlier to reach the sample’s *** addition,two pathways of core formation were observed during the formation of C-S structure:one evolves from a ringlike structure in the phase separation of spinodal decomposition;the other derives from the collision of numerous MPD at sample’s *** a difference is ascribed to the combination of different growth kinetics and the volume fractions of *** findings might provide an in-depth insight into the C-S structure formation in immiscible systems.

关键词： Phase separation Immiscible system Nucleation Spinodal decomposition Core-shell structure

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Shape Coexistence for ^179Hg in Relativistic Mean-Field Theory

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Communications in Theoretical Physics 2005年第4X期44卷 675-678页

作者： wang nan College of Science Shenzhen University Shenzhen 518060 China Institute of Theoretical Physics the Chinese Academy of Sciences Beijing 100080 China School of Physics Peking University Beijing 100871 China Center of Theoretical Nuclear Physics National Laboratory of Heavy Ion AcceleratorLanzhou 730000 China

The potential energy surface of179 Hg is traced and the multi-shape coexistence phenomenon in that nucleus is studied within the relativistic mean-field theory with quadrupole moment constraint. The calculation result... 详细信息

关键词： relativistic mean-field theory shape coexistence binding energy

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Images of Azurin Protein Studied by AFM

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Chemical Research in Chinese Universities 2004年第4期20卷 437-439页

作者： wang nan wang Yuan-liang Biomedical Engineering Department Chongqing UniversityChongqing 400044P.R.China Inorganic Chemistry Department South Parks RoadUniversity of OxfordOX13QRUK

Azurins, a wild type and a genetically mutant K27 altered one, were immobilized on annealed gold surface and investigated by means of atomic force microscopy. It was found that the surface coverage and height distribution of the adsorbed protein molecules are different from each other, which is possibly the result of the different orientation on the surface. It is believed that the wild type azurin is connected to gold surface by the disulphide bridge; while the mutant, K27C, might be through the thiol groups of the cysteine residues on their surface.

关键词： Atomic force microscopy Protein Azurin Topography

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Flexible double narrowband near-infrared photodetector based on PMMA/core-shell upconversion nanoparticle composites

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Journal of Rare Earths 2022年第2期40卷 211-217,I0002页

作者： Ya’nan Ji Donglei Zhou nan wang nan Ding Wen Xu Hongwei Song State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

Flexible narrowband near infrared(NIR)photodetectors(PDs)are urgently in demand in the fastdeveloping era of flexible electronics,due to their crucial roles in various innovative ***,we designed and synthesized the core-shell structured NaYF4:Yb^(3+),Er^(3+)@NaYF4:Nd^(3+)upconversion nanoparticles(UCNPs),which can be pumped by the 808 and 980 nm *** upconversion luminescence(UCL)are significantly enhanced after being assembled with the opal photonic crystals(OPCs)due to the photonic crystal effect,with 55 and 48 folds of enhancement factors under illuminations of 808 and 980 nm lights,*** on this hybrid,the flexible narrowband PDs were successfully fabricated on the PET substrate with the structure of OPCs/NaYF4:Yb^(3+),Er^(3+)@Nd^(3+)/MAPbl3,which displays excellent detection performance to double narrowband NIR light(808 and 980 nm)benefiting from the amplified UCL,with responsivity of 8.79 and 7.39 A/W,detectivity of 3.01×10^(11)and2.68×10^(11)cm·Hz^(1/2)/W for 808 and 980 nm lights detection respectively,along with short response time in the range of 120-160 ***,the OPCs/NaYF4:Yb^(3+),Er^(3+)@NaYF4:Nd^(3+)/MAPbI3 double narrowband PDs display low photodetection power threshold(0.05 W/cm2),outstanding flexibility,prominent moisture resistance,and good long-time *** work displays a new concept of narrowband NIR PDs,which open a new field for specific NIR light detections.

关键词： Upconversion luminescence Upconversion enhancement Narrow-band near-infrared photodetection Flexible photodetectors Rare earths

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Emerging low-dimensional materials for mid-infrared detection

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nano Research 2021年第6期14卷 1863-1877页

作者： Jiangbin Wu nan wang Xiaodong Yan Han wang Ming Hsieh Department of Electrical and Computer Engineering University of Southern CaliforniaLos AngelesCA90089USA Mork Family Department of Chemical Engineering and Material Science University of Southern CaliforniaLos AngelesCA90089USA

Mid-infrared(IR)detectors based on the emerging low-dimensional(two-dimensional and quasi one-dimensional)materials offer unique characteristics including large bandgap tunability,optical polarization sensitivity and integrability with typical silicon process,which are not available in the mid-IR detectors based on traditional compound ***,we review the recent progress in study of mid-IR detectors based on the low-dimensional materials,including black phosphorus,black arsenic phosphorus,tellurene and BaTiS3,from the perspectives of crystal structure,material synthesis,optical properties,and the detector *** detector gain and detectivity are benchmarked,and the unique properties,such as the polarization sensitivity,are *** also provide our perspective about key future research directions in this field.

关键词： mid-infrared detector anisotropy low-dimensional gain detectivity

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Covalent flavoproteins:types,occurrence,biogenesis and catalytic mechanisms

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Chinese Journal of Natural Medicines 2022年第10期20卷 749-760页

作者： wang Minjun ZHANG Wenyuan wang nan Ocean College Zhejiang UniversityZhoushan 316021China

Flavoproteins are proteins that contain a nucleic acid derivative of riboflavin:flavin adenine dinucleotide(FAD)or flavin mononucleotide(FMN).Flavoproteins are involved in a wide array of biological processes,such as photosynthesis,DNA repair and natural product *** should be noted that 5%-10%of flavoproteins have a covalently linked flavin prosthetic *** covalent linkages benefit the holoenzyme in several ways including improving the stability and catalytic *** the past decade,significant progress has been made in covalent flavoproteins,especially with respect to enzyme-dependent biogenesis and discovery of novel linkage *** present review gives a condensed overview of investigations published from March 2009 to December 2021,with emphasis on the discovery,biogenesis and their catalytic role in natural product biosynthesis.

关键词： Flavoprotein Covalent linkage Biosynthesis Natural products

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A mathematical model of cortical bone remodeling at cellular level under mechanical stimulus

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Acta Mechanica Sinica 2012年第6期28卷 1678-1692页

作者： Qing-Hua Qin Ya-nan wang Research School of Engineering The Australian National University

A bone cell population dynamics model for cor- tical bone remodeling under mechanical stimulus is devel- oped in this paper. The external experiments extracted from the literature which have not been used in the creation of the model are used to test the validity of the model. Not only can the model compare reasonably well with these ex- perimental results such as the increase percentage of final values of bone mineral content （BMC） and bone fracture en- ergy （BFE） among different loading schemes （which proves the validity of the model）, but also predict the realtime devel- opment pattern of BMC and BFE, as well as the dynamics of osteoblasts （OBA）, osteoclasts （OCA）, nitric oxide （NO） and prostaglandin E2 （PGE2） for each loading scheme, which can hardly be monitored through experiment. In conclusion, the model is the first of its kind that is able to provide an in- sight into the quantitative mechanism of bone remodeling at cellular level by which bone cells are activated by mechan- ical stimulus in order to start resorption/formation of bone mass. More importantly, this model has laid a solid foun- dation based on which future work such as systemic control theory analysis of bone remodeling under mechanical stimu- lus can be investigated. The to-be identified control mecha- nism will help to develop effective drugs and combined non- pharmacological therapies to combat bone loss pathologies. Also this deeper understanding of how mechanical forces quantitatively interact with skeletal tissue is essential for the generation of bone tissue for tissue replacement purposes in tissue engineering.

关键词： Cortical bone remodeling Cell population dy-namics Mechanotransduction Mechanosensitivity Bonefracture energy - Bone mineral content

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