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“北京科技冬奥”关于智能场馆建设的探索

智能建筑与智慧城市 2024年第2期 10-12页

作者：王飞飞张刘引张淏楠陈冰凌北京清华同衡规划设计研究院有限公司

场馆是冬奥会、残奥会举办的基础,更是运动竞技、观赛和展示城市发展水平的窗口,其担负着建筑行业智能化先行示范的使命。2019-2022年系列北京冬奥场馆均进行了新建或升级智能化,围绕建筑智能管理、建筑与用户服务、建筑与城市互动等方... 详细信息

场馆是冬奥会、残奥会举办的基础,更是运动竞技、观赛和展示城市发展水平的窗口,其担负着建筑行业智能化先行示范的使命。2019-2022年系列北京冬奥场馆均进行了新建或升级智能化,围绕建筑智能管理、建筑与用户服务、建筑与城市互动等方面做出了创新探索,突破了建筑智能化发展的行业瓶颈,为大型建筑智能化改造和社区智能化改造提供了新样板。

关键词：科技冬奥智能场馆智能建筑

维普期刊数据库博看期刊

胎盘碱性磷酸酶在子宫内膜样腺癌与子宫内膜增生性疾病中的表达及临床意义

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中国妇幼保健 2024年第10期39卷 1854-1857页

作者：郭祎男宣可张海雁张瑜杜红雁翟江萍邹雪婷宋双敏郭春利西安交通大学附属西北妇女儿童医院陕西西安710000 西安新长安妇产医院

目的分析胎盘碱性磷酸酶(PLAP)表达阳性部位的差异及对子宫内膜非典型增生与子宫内膜样腺癌鉴别诊断的意义。方法选取2015年1月-2022年12月西北妇女儿童医院病理科和西安新长安妇产医院病理科共140例子宫内膜标本,包括20例增殖期子宫... 详细信息

目的分析胎盘碱性磷酸酶(PLAP)表达阳性部位的差异及对子宫内膜非典型增生与子宫内膜样腺癌鉴别诊断的意义。方法选取2015年1月-2022年12月西北妇女儿童医院病理科和西安新长安妇产医院病理科共140例子宫内膜标本,包括20例增殖期子宫内膜,20例子宫内膜简单性增生,20例子宫内膜复杂性增生,20例子宫内膜非典型增生及60例不同分化程度的子宫内膜样腺癌。进行免疫组化染色,采用H-score评分法观察PLAP表达情况并记录;收集TCGA、GEO、ArrayExpress、Oncomine数据库提供的子宫内膜样腺癌相关数据,对PLAP mRNA在子宫内膜样腺癌组织中的表达及诊断效能进行Meta分析。结果 PLAP在各类子宫内膜标本中的阳性表达情况:子宫内膜样腺癌(高分化)中阳性率为46.7%,子宫内膜样腺癌(中分化)中阳性率为66.7%,子宫内膜样腺癌(低分化)中阳性率为66.7%,子宫内膜非典型增生中阳性率为65.0%,子宫内膜复杂性增生中阳性率为15.0%,子宫内膜简单性增生中阳性率为10.0%,增殖期子宫内膜中阳性率为10.0%。子宫内膜样腺癌、子宫内膜非典型增生、增殖期子宫内膜+子宫内膜简单性增生+子宫内膜复杂性增生中PLAP表达的H-score比较,差异有统计学意义(P<0.05)。结论 PLAP的免疫组化染色有助于子宫内膜非典型增生与子宫内膜样腺癌的诊断及鉴别诊断。

关键词：子宫内膜非典型增生子宫内膜样腺癌胎盘碱性磷酸酶

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污泥处理与资源化虚拟仿真实验的设计与实践

造纸技术与应用 2024年第2期52卷 60-65页

作者：罗邯予李正朴海燕张兰河张庭东北电力大学化学工程学院吉林吉林132012

阐述了污泥处理与资源化虚拟仿真实验体系的设计背景、构建、实验环境及教学效果。针对好氧发酵和脱水焚烧工艺建立了虚拟仿真模块。学生操作具体分为构建工艺路线、设计计算、运行与调试仿真实验、提交操作4部分。虚拟仿真实验可以使... 详细信息

阐述了污泥处理与资源化虚拟仿真实验体系的设计背景、构建、实验环境及教学效果。针对好氧发酵和脱水焚烧工艺建立了虚拟仿真模块。学生操作具体分为构建工艺路线、设计计算、运行与调试仿真实验、提交操作4部分。虚拟仿真实验可以使学生熟悉好氧发酵和脱水焚烧工艺相关的基础知识、主要设备及工艺流程,弥补实体实验的不足。

关键词：污泥资源化利用虚拟仿真固体废物环境工程

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普通高等农林院校生物化学教学改革探索

教育教学论坛 2024年第12期 75-78页

作者：郑悦亭张维王江褚贝贝河南农业大学动物医学院河南郑州450046

“生物化学”是生命科学研究领域的重要基础课程之一,是从化学的角度解释生命现象和生命体内的反应过程,也是学好其他专业课程的基础。在信息爆炸的时代背景下,传统的知识已经难以满足学生的好奇心和求知欲,在全面深化教学改革的今天,... 详细信息

“生物化学”是生命科学研究领域的重要基础课程之一,是从化学的角度解释生命现象和生命体内的反应过程,也是学好其他专业课程的基础。在信息爆炸的时代背景下,传统的知识已经难以满足学生的好奇心和求知欲,在全面深化教学改革的今天,普通高等农林院校“生物化学”课程教学必须与时俱进,进行相应的改革和发展,才能传承和发展生物化学。主要从教学内容改革和教学方法改革两个方面提出建议,希望能够通过更新教学内容、创新教学方法推动教学改革,调动学生的学习积极性,提高学生的学习兴趣,促进普通高等农林院校“生物化学”课程的教与学,实现从“以教为中心”向“以学为中心”的转变,从而带领学生学好“生物化学”,为专业课的学习奠定坚实的基础。

关键词：生物化学教学改革学习积极性学习兴趣

New diterpenoids isolated from Leonurus japonicus and their acetylcholinesterase inhibitory activity

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Chinese Journal of Natural Medicines 2017年第11期15卷 860-864页

作者： WU Han-Kui SUN ting ZHAO Feng zhang Li-Ping LI Gang zhang Jie College of Chemistry and Chemical Engineering Anyang Normal University Key Laboratory of Natural Medicine and Immuno-Engineering Henan University

Three new labdane diterpenoids, leojaponicone A(1), isoleojaponicone A(2) and methylisoleojaponicone A(3), were isolated from the herb of Leonurus japonicus. The chemical structures of these secondary metabolites were elucidated on the basis of 1 D and 2 D NMR, including HMQC, and HMBC spectroscopic techniques. All the new compounds were tested in vitro for their acetylcholinesterase and α-glucosidase inhibitory activity. Compounds 1-3 exhibited low inhibitory effects on α-glucosidase with respect to acarbose and exhibited high inhibitory effects on acetylcholinesterase with respect to huperzine A.

关键词： Leonurus japonicus Leojaponicone Acetylcholinesterase Labdane diterpenoid

Structure,Calculation,Optical Properties and Bioimaging of an Organic Fluorescence Compound

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Chinese Journal of Structural Chemistry 2021年第10期40卷 1291-1297页

作者： JIN Feng XIONG Qi-Juan LIU Zhuo-Ni XIAO Ya-ting YANG Fang CHENG ting-ting zhang Lin TAO Dong-Liang LIAO Rong-Bao LIU Yong College of Chemical and Material Engineering Fuyang Normal UniversityFuyang 236037China College of Biological and Food Engineering Fuyang Normal UniversityFuyang 236037China

A π-conjugated optical functional organic compound comprising an electron donor(D) and acceptor(A) was synthesized. The crystal structure was determined through single-crystal X-ray diffraction analysis. It crystallizes in monoclinic, space group P2_(1) with a = 9.6610(5), b = 8.9093(4), c = 26.303(1)Å, β = 96.262(4)°, V = 2250.5(2)Å^(3), Z = 4, D_(c)= 1.220 Mg/m^(3), F(000) = 872, Μr = 413.50, μ = 0.072 mm^(-1), the final R = 0.0569 and wR = 0.1700 for 8976 observed reflections with I > 2σ(I). Optical properties were studied in detail through theoretical calculation and experimental study. The result reveals that the compound exhibits excellent fluorescence performance and it can be compatible in the cytoplasm of NIH/3T3 cells, showing potential in fluorescence microscopy bioimaging.

关键词： crystal structure theoretical calculation organic fluorescence material bioimaging

Interactive Web-based Annotation of Plant MicroRNAs with iwa-miRNA

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Genomics, Proteomics & Bioinformatics 2022年第3期20卷 557-567页

作者： ting zhang Jingjing Zhai Xiaorong zhang Lei Ling Menghan Li Shang Xie Minggui Song Chuang Ma State Key Laboratory of Crop Stress Biology for Arid Areas Center of BioinformaticsCollege of Life SciencesNorthwest A&F UniversityYangling 712100China Key Laboratory of Biology and Genetics Improvement of Maize in Arid Area of Northwest Region Ministry of Agriculture and Rural AffairsNorthwest A&F UniversityYangling 712100China College of Plant Science Tibet Agricultural and Animal Husbandry UniversityLinzhi 860006China College of Information Engineering Northwest A&F UniversityYangling 712100China

MicroRNAs(miRNAs) are important regulators of gene expression. The large-scale detection and profiling of miRNAs have been accelerated with the development of highthroughput small RNA sequencing(sRNA-Seq) techniques and bioinformatics tools. However,generating high-quality comprehensive miRNA annotations remains challenging due to the intrinsic complexity of sRNA-Seq data and inherent limitations of existing miRNA prediction tools. Here,we present iwa-miRNA, a Galaxy-based framework that can facilitate miRNA annotation in plant species by combining computational analysis and manual curation. iwa-miRNA is specifically designed to generate a comprehensive list of miRNA candidates, bridging the gap between already annotated miRNAs provided by public miRNA databases and new predictions from sRNA-Seq datasets. It can also assist users in selecting promising miRNA candidates in an interactive mode,contributing to the accessibility and reproducibility of genome-wide miRNA annotation. iwamiRNA is user-friendly and can be easily deployed as a web application for researchers without programming experience. With fexible, interactive, and easy-to-use features, iwa-miRNA is a valuable tool for the annotation of miRNAs in plant species with reference genomes. We also illustrate the application of iwa-miRNA for miRNA annotation using data from plant species with varying genomic complexity. The source codes and web server of iwa-miRNA are freely accessible at http://***/.

关键词： Galaxy Interactive annotation Manual inspection MicroRNA Platform

Theoretical Analysis of the Mechanism of Cationic Pd(Ⅱ)-catalyzed Fujiwara-Moritani Reaction

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Chinese Journal of Structural Chemistry 2021年第5期40卷 576-587,528页

作者： REN Ying WANG Tao zhang ting-ting JIA Jian-Feng WU Hai-Shun Key Laboratory of Magnetic Molecules and Magnetic Information Materials of Ministry of Education School of Chemistry and Materials ScienceShanxi Normal UniversityLinfen 041000China

A systematic theoretical investigation has been studied on Fujiwara-Moritani reaction between 3-methoxyacetanilide with n-butyl acrylate by means of density functional theory(DFT) calculations when two types of Pd(Ⅱ) catalysts are employed. In [Pd(MeCN)_4](BF_4)_2 catalytic cycle, a 1,4-benzoquinone(BQ)-induced C-H activation of trans-(MeCN)_2Pd(BQ)~(2+) with 3-methoxyacetanilide occurs as the first step to give DC-4_(MeCN), facilitating the insertion of n-butyl acrylate and β-hydride elimination, followed by recycling of catalyst through hydrogen abstraction of monocationic BQ fragment. In Pd(OAc)_(2) catalytic cycle, it is proposed that the most favored reaction pathway should proceed in dicationic mechanism involving a BQ-assisted hydrogen transfer for C-H activation by Pd active catalyst(HOAc)_(2)Pd(BQ)^(2+) to generate DC-4_(HOAc), promoting acrylate insertion and β-hydride elimination, followed by the regeneration of catalyst to give the final product. The calculations indicate that the rate-determining step in [Pd(MeCN)_(4)](BF_4)_(2) catalytic system is the acrylate insertion, while it is the regeneration of catalyst in the Pd(OAc)_(2) catalytic system. In particular, the roles of BQ and ligand effects have also been investigated.

关键词： C-H bond activation DFT studies Pd(Ⅱ)catalyst reaction mechanism

Effective synthesis of benzyl halides triggered by in situ prepared hypervalent halides

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Chinese Chemical Letters 2013年第1期24卷 45-48页

作者： Xue-Ge Ling Yan Xiong Shu-ting zhang Ruo-Feng Huang Xiao-Hui zhang School of Chemistry and Chemical Engineering Chongqing University

An effective approach for the direct benzylhalogenation with in situ generation of hypervalent halides has been developed. A variety of benzyl halides are produced in moderate to excellent yields （up to 99%） with hi... 详细信息

关键词： Benzyl halidesBrominationHypervalentlodination