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Integrated Genomic and Network-Based Analyses of Complex Diseases and Human Disease Network

Journal of Genetics and Genomics 2016年第6期43卷 349-367页

作者： Olfat Al-Harazi Sadiq Al Insaif Monirah A.Al-Ajlan namik kaya Nduna Dzimiri Dilek Colak Department of Biostatistics Epidemiology and Scientific ComputingKing Faisal Specialist Hospital and Research Centre College of Computer and Information Sciences King Saud University Department of Genetics King Faisal Specialist Hospital and Research Centre

A disease phenotype generally reflects various pathobiological processes that interact in a complex network. The highly interconnected nature of the human protein interaction network（interactome） indicates that, at the molecular level, it is difficult to consider diseases as being independent of one another. Recently, genome-wide molecular measurements, data mining and bioinformatics approaches have provided the means to explore human diseases from a molecular basis. The exploration of diseases and a system of disease relationships based on the integration of genome-wide molecular data with the human interactome could offer a powerful perspective for understanding the molecular architecture of diseases. Recently, subnetwork markers have proven to be more robust and reliable than individual biomarker genes selected based on gene expression profiles alone, and achieve higher accuracy in disease classification. We have applied one of these methodologies to idiopathic dilated cardiomyopathy（IDCM） data that we have generated using a microarray and identified significant subnetworks associated with the disease. In this paper, we review the recent endeavours in this direction, and summarize the existing methodologies and computational tools for network-based analysis of complex diseases and molecular relationships among apparently different disorders and human disease network. We also discuss the future research trends and topics of this promising field.

关键词： Proteineprotein interaction Subnetwork marker Diseasome Network medicine Systems biology Genomics

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Evaluation of penile hemodynamic status and adjustment of treatment alternatives in Peyronie's disease

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Asian Journal of Andrology 2002年第3期4卷 187-190页

作者： Tibet Erdogru Murat Savas namik Yilmaz Mustafa Faruk Usta Turker Koksal Mutlu Ates Mehmet Baykara Department of Urology Akdeniz University Faculty of Medicine Kampus 07059 TurkeyDepartment of Urology Akdeniz University Faculty of Medicine Kampus 07059 TurkeyDepartment of Urology Akdeniz University Faculty of Medicine Kampus 07059 TurkeyDepartment of Urology Akdeniz University Faculty of Medicine Kampus 07059 TurkeyDepartment of Urology Akdeniz University Faculty of Medicine Kampus 07059 TurkeyDepartment of Urology Akdeniz University Faculty of Medicine Kampus 07059 TurkeyDepartment of Urology Akdeniz University Faculty of Medicine Kampus 07059 Turkey

Aim: Erectile dysfunction may be observed in up to 80% of patients with Peyronie's disease. An objective evaluation of the erectile function is attempted to work out in patients with Peyronie's disease. Methods: Penile deformity, sexual function and penile vascular status were analyzed in 123 patients with Peyronie's disease, who had not received any pertinent treatment. Results: Penile deformity, palpable plaque and pain on erection were seen in 112 (91%), 97(78.8%) and 27 (21.9%) of the 123 patients, respectively. Of the 76 patients evaluated by color Doppler ultrasounography, veno-occlusive dysfunction as the vascular component for erectile dysfunction was found in 17 (22.3%), arterial insufficiency in 10(13.1%) and a mixed picture in 23 (30.2%). Conclusion: The documentation of penile erectile function and the determination of the vascular status using color Doppler ultrasonography can guide the appropriate therapeutic choice.

关键词： Peyronie's disease sexual function penile vascular status color Doppler ultrasonography

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The Transcriptional Response of Arabidopsis thaliana L. Genes AtKu70, AtRAD51 and AtRadl to X-Ray Radiation

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Journal of Agricultural Science and Technology(A) 2017年第1期7卷 52-60页

作者： Sergey Litvinov namik Rashydov Institute of Cell Biology and Genetic Engineering National Academy of Sciences of Ukraine 148 Zabolotnogo Kiev-03143 Ukraine

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Quantic approach to mind-matter interaction

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Life Research 2020年第2期3卷 78-90页

作者： namik Kemal mahallesi Kampus caddesi Cengiz Mordeniz Department of Anesthesiology and Intensive Care Pain MedicineTraditional and Complementary MedicineTekirdag Namik KemalUniversity

The human mind-body possesses an innate ability,based upon the evolutionarily conserved brain and body systems to promote health and *** there is a bidirectional influence of psychological and physiological variables on health,modern allopathic medicine,that addresses the disease in the body and disorder in the mind,should be reconceptualized for more holistic *** mindbody dualism is re-evaluated in the light of quantum information theory from different scientific findings such as energy and electromagnetic wave,information,quantum theories,and placebo effect.

关键词： Mind-body medicine Quantum mechanics Nonlocality Entanglement Mind Perception

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Field workshop of IGCP 499

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Episodes 2007年第3期30卷 229-230页

作者： Peter Konigshof Silvio H. Peralta namik Yalcin Forschungsinstitut und Naturmuseum Senckenberg Senckenberganlage 25 D-60325 Frankfurt am Main GERMANY Peter National University of San Juan 1. De la Roza Ave and Meglioli St. 5400 Rivadavia San Juan ARGENTINA Department of Geological Engineering Istanbul University TR-34850 Avcilar Istanbul TURKEY

A field workshop of the International Geoscience Programme (IGCP) Project 499 entifled 'Devonian Land-- Sea Interaction: Evolution of Ecosystems and Climate' (DEVEC)was held between 14 and 22 May 2007 in San Juan, Argentina. The Devonian of the San Juan and Mendoza Precordillera and the San Rafeal Block are of special interest for the project due to the palaeogeographic and biostratigraphic importance in the Devonian Malvinokaffric Realm, but also in the tecto-sedimentary evolution of the Precordillera terrane.

关键词：国际地理项目会议研究工作会议国际组织

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Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis,oxidative damage and apoptosis in rats

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World Journal of Gastroenterology 2008年第8期14卷 1222-1230页

作者： Alper Akcan Sebahattin Muhtaroglu Hulya Akgun Hizir Akyildiz Can Kucuk Erdogan Sozuer Alper Yurci namik Yilmaz Department of General Surgery ErciyesUniversity School of Medicine Kayseri 38039 Turkey Department of Biochemistry ErciyeUniversity School of Medicine Kayseri 38039 Turkey Department of Pathology Erciyes University School of Medicine Kayseri 38039 Turkey Department of Gastroenterology Erciyes University School of Medicine Kayseri 38039 Turkey

AIM:To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. METHODS:In this study, a total of 50 rats were divided equally into 5 groups. In the control group, no colitis induction or drug administration was performed. Colitis was induced in all other groups. Following the induction of colitis, BBS, NTS or both were applied to three groups of rats. The remaining group (colitis group) received no treatment. On the 11th d after induction of colitis and drug treatment, blood samples were collected for TNF-α and IL-6 level studies. Malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO) and caspase-3 activities, as well as histopathological findings, evaluated in colonic tissues. RESULTS:According to the macroscopic and microscopic findings, the study groups treated with BBS, NTS and BBS + NTS showed significantly lower damage and inflammation compared with the colitis group (macroscopic score, 2.1 ± 0.87, 3.7 ± 0.94 and 2.1 ± 0.87 vs 7.3 ± 0.94;microscopic score, 2.0 ± 0.66, 3.3 ± 0.82 and 1.8 ± 0.63 vs 5.2 ± 0.78, P < 0.01). TNF-α and IL-6 levels were increased significantly in all groups compared with the control group. These increases were significantly smaller in the BBS, NTS and BBS + NTS groups compared with the colitis group (TNF-α levels, 169.69 ± 53.56, 245.86 ± 64.85 and 175.54 ± 42.19 vs 556.44 ± 49.82;IL-6 levels, 443.30 ± 53.99, 612.80 ± 70.39 and 396.80 ± 78.43 vs 1505.90 ± 222.23, P < 0.05). The colonic MPO and MDA levels were significantly lower in control, BBS, NTS and BBS + NTS groups than in the colitis group (MPO levels, 24.36 ± 8.10, 40.51 ± 8.67 and 25.83 ± 6.43 vs 161.47 ± 38.24;MDA levels, 4.70 ± 1.41, 6.55 ± 1.12 and 4.51 ± 0.54 vs 15.60 ± 1.88, P < 0.05). Carbonyl content and caspase-3 levels were higher in the colitis and NTS groups than in control, BBS and BBS + NTS groups (carbonyl levels, 553.99 ± 59.58 and 336.26 ± 35.72 vs 209.76 ± 30.92, 219.76 ± 25.77 and 220.34 ± 36.95

关键词：结肠炎氧化损伤细胞凋亡三硝基苯磺酸

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Retraction Note: Quantic approach to mind-matter interaction

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Life Research 2020年第3期3卷 140-140页

作者： namik Kemal mahallesi 不详

Retraction of:Life Research https://***/lr/EN/10.12032/life2020-0422-401,published online 25 April 2020 The Editors have retracted this article because significant portions of the text were taken from publications and internet source without attribution[1].The following parts of the paper are copied verbatim or are adapted from those appearing in the thesis:description of mind-body therapies;definition of quantum mechanics and quantum theory and subsequent sentences;definition of nonlocality;the principle of entanglement;discussion of phase locking/*** these issues,we wish to retract the article in its *** deeply regret this circumstance and apologize to the community.

关键词： quantum subsequent adapted

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Detection of *** Antigen in the Stool Samples of Children,in Tekirdag,Turkey

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Health 2014年第10期6卷 865-869页

作者： Ayse Demet kaya Dumrul Gülen Mine Aydin Gamze Varol Saracoglu Aslihan Uzun Department of Medical Microbiology Medical FacultyNamik Kemal UniversityTekirdagTurkey Department of Public Health Medical FacultyNamik Kemal UniversityTekirdagTurkey Tekirdag State Hospital TekirdagTurkey

Introduction: Helicobacter pylori (H. pylori) is an important bacterial pathogen, predominantly in undeveloped countries and regions. We conducted this study to investigate the presence of H. pylori antigen in the stool specimens of children, in Tekirdag, Turkey. Material and Methods: Stool specimens of 1441 children aging between 0 month to 15 years, with the complaints of abdominal pain, anemia, gastroenteritis, nausea and vomiting were included in the study. The subjects were divided into three groups based on their ages: Group A (0 month - 5 years), Group B (6 - 10 years) and Group C (11 - 15 years). All specimens were tested for H. pylori antigen with HP Ag (***, Diagnostic Bioprobes, Italy). Results were evaluated statistically. Results: The median age of children with H. pylori positive samples was 6.6 ± 4.1 and 47.9% were girls. Overall positivity of H. pylori stool antigen was 6.6%. Positivity rates due to ages in Groups A, B and C were: 8.9%, 5.8%,? 5.2% respectively (x2 = 9.3, p = 0.01). No difference was observed due to gender (x2 = 0.17, p = 0.68). Conclusion: Higher antigen positivity obtained in 0 - 5 years group, indicates the risk of acquiring the infection in early years of life. Preventive measures for the development of H. pylori infection gain importance, especially in developing countries.

关键词： Helicobacter pylori Stool Antigen Children

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The Evaluation of the Knee Joint in Terms of Magnetic Resonance Imaging Measurements in Osteoarthritis Patients:A Comparative Study Comprising a Control Group

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Open Journal of Radiology 2014年第1期4卷 111-119页

作者： Bozkurt Gulek Gokhan Soker Ertugrul Erken Yakup Yesilkaya Behice Durgun Nazan Alpaslan Eda Soker Omer kaya Eren Erken Department of Radiology Namik Kemal UniversityTekirdagTurkey Department of Radiology Numune Teaching and Research HospitalAdanaTurkey Department of Nephrology Gaziosmanpasa UniversityTokatTurkey Department of Radiology Kirsehir State HospitalKirsehirTurkey Department of Anatomy Cukurova UniversityAdanaTurkey Department of Biostatistics Cukurova UniversityAdanaTurkey Department of Physical Therapy and Rehabilitaiton Numune Teaching and Research HospitalAdanaTurkey Department of Rheumatology and Immunology Cukurova UniversityAdanaTurkey

The aim of this study was to assess the knee joints of osteoarthritis patients in terms of clinical and magnetic resonance imaging (MRI) measurements and draw definitive conclusions from these quantimetric data. In order to achieve the above-mentioned goal, the knees of individuals from two distinct groups were examined by MRI. One group consisted of osteoarthritis patients while the other comprised the control individuals. All individuals from both groups underwent clinical and MRI measurements concerning their knees. These data were compared by using the statistical software from the Statistical Package for Social Sciences (SPSS) v.15 program. Statistically significant differences were found between the control and patients groups in terms of the measurements of the second (short) diameter of the medial femoral condyle, and the intercondylar distance (p < 0.05). In addition to these findings, the Receiver Operating Characteristics (ROC) curve analysis gave statistically significant results for both of these measurements. The cutoff values for these criteria were as follows in sequence order: a sensitivity of 75% and a specificity of 52% for the medial femoral condyle, and a sensitivity of 70% and a specificity of 70% for the intercondylar distance. The ROC curve data may not be a deterministic outcome alone for this study. But it may in fact have a significant meaning when it is evaluated together with other statistically significant data. The t-test for Equality of Means, for example, gave significant results, concerning the measurements of the short axis of the medial femoral condyle and the intercondylar distance. It is well known that it is the medial portion of the knee joint which deteriorates the most during the process of osteoarthritis of the knee (OAK), and this complies with the results of this study.

关键词： Osteoarthritis Knee MRI

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Joint IGCP 499/SDS Meeting

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Episodes 2006年第2期29卷 134-134页

作者： Peter konigshof Eberhard Schidler Volker Wilde Jurga Lazauskiene M.namik Yalicn Forschungsinstitut and Naturmuseum Senckenber Senckenberganlage 25D-60325 Frakfurt am Main GERMANY Geological Sruvey of Lithuania Department of Lithostratigraphy and Tectonics Konaskio35LT-2009 Vilnius LITHUANIA Istanbul University Engineering FacultyDepartment of Geological EngineeringTR-34850 Avcilar-Istanbul TURKERY

A major event of IGCP 499 in 2005 took place in Southern Siberia. In the tradition of successful joint meetings and field trips of Devonian IGCP projects and the international Subcommission on Devonian Stratigraphy (SDS), a very successful meeting was held at the Institute of Petroleum Geology,United Institute of Geology and Mineralogy of the Russian Academy of Sciences, Siberian Branch in Novosibirsk.

关键词：石油地质特征西伯利亚俄罗斯

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