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Detection of fucosylated haptoglobin using the 10-7G antibody as a biomarker for evaluating endoscopic remission in ulcerative colitis

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World Journal of Gastroenterology 2021年第2期27卷 162-175页

作者： Kei Motooka Koichi Morishita nami ito Shinichiro Shinzaki Taku Tashiro Satoshi Nojima Kayoko Shimizu Mutsuhiro Date Natsumi Sakata Momoko Yamada Shinji Takamatsu Yoshihiro Kamada Hideki Iijima Tsunekazu Mizushima Eiichi Morii Tetsuo Takehara Eiji Miyoshi Department of Molecular Biochemistry and Clinical Investigation Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan Department of Gastroenterology and Hepatology Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan Department of Pathology Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan FUJIFILM Wako Pure Chemical Corporation Amagasaki 661-0963HyogoJapan Department of Gastroenterological Surgery Osaka University Graduate School of MedicineSuita 565-0871OsakaJapan

BACKGROUND Inflammatory bowel disease(IBD)is a chronic,relapsing inflammation of the digestive *** fecal and serum biomarkers have been extremely important and supportive for monitoring of IBD,their low sensitivity and high variability characteristics limit clinical ***,the establishment of better biomarkers is *** is one of the most important glycosylation modifications of *** haptoglobin(Fuc-Hpt)is used as a biomarker for several cancers and inflammation-related *** recently established a novel glycan monoclonal antibody(mAb),designated 10-7G,which recognizes *** developed an enzyme-linked immunosorbent assay(ELISA)to measure serum levels of Fuc-Hpt(10-7G values).AIM To investigate the usefulness of the serum 10-7G values as a potential biomarker for monitoring disease activity in *** This was a case control *** tissues of IBD patients(n=10)were examined immunohistochemically using the 10-7G *** determined 10-7G values using serum from patients with ulcerative colitis(UC,n=110),Crohn’s disease(n=45),acute enteritis(AE,n=11),and healthy volunteers(HVs)who exhibited normal(n=20)or high(n=79)C-reactive protein(CRP)levels at medical *** investigated the correlation between the 10-7G value and various clinical parameters of IBD patients by correlation *** operating characteristic(ROC)curve analysis was performed to evaluate the usefulness of the 10-7G values as a biomarker for clinical and endoscopic remission of UC compared to conventional serum *** In the immunohistochemical analysis,positive 10-7G mAb staining was observed in lymphocytes infiltrating into inflammatory sites of the mucosal layer and lymphoid *** 10-7G values were significantly higher in patients with IBD(P<0.001)and AE(P<0.05)compared with *** addition,10-7G values were correlated with clinical examination parameters related to inflammation in patients with

关键词： Inflammatory bowel disease Biomarkers Glycosylation Fucosylated haptoglobin Prohaptoglobin Endoscopic remission

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Influence of a Program Combining Amusement and Exercise on Subjective Well-Being: Six-Month Intervention Study with a Complex-Type Program for Community-Dwelling Elderly Subjects

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Open Journal of Preventive Medicine 2018年第8期8卷 266-281页

作者： nami Kawabata Tadayuki Iida Hideki Miyaguchi Masafumi Kunishige Chinami Ishizuki Hiroko Hashimoto Yasuhiro ito Toshihide Harada Program in Biological System Sciences Graduate School of Comprehensive Scientific Research Prefectural University of Hiroshima Shobara Japan Department of Rehabilitation/Occupational Therapist Faculty of Health Sciences Hiroshima Cosmopolitan University Hiroshima Japan Department of Physical Therapy Faculty of Health and Welfare Prefectural University of Hiroshima Mihara Japan Department of Human Behavior Science of Occupational Therapy Health Sciences Major Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Division of Occupational Therapy Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Occupational Therapy Faculty of Health Sciences Morinomiya University of Medical Sciences Osaka Japan School of Health Sciences Fujita Health University Toyoake Japan

Background: Health promotion for the elderly mainly targets improvements in physical function, and a lack of strengthening of subjective well-being as well as the creation of interaction-providing opportunities for activity and participation has been reported. Evaluations of positive and negative aspects for subjective well-being are needed. Elderly subjects were intervened through a 6-month complex-type program combining amusement and exercise and its influences on subjective well-being and physical and physiological functions were investigated. Methods: Subjects in this survey were 37 healthy elderly females living in M city, Hiroshima Prefecture (age: 69.7 ± 5.9 years old), and the survey was performed between September 2016 and March 2017. The complex-type program comprised amusement and exercise programs. The survey was performed at 4 time points during the intervention period: before the intervention and 1, 3, and 6 months during the intervention. Subjective well-being (Japanese version of the Subjective Well-being Inventory (SUBI): Mental health scores, Mental fatigue scores), salivary amylase levels, and the locomotive syndrome risk test (two-step test, stand-up test, and 25-question risk assessment) were surveyed at each time point. Regarding the duration of the intervention as a factor, changes in salivary amylase levels were analyzed using repeated measures one-way ANOVA and SUBI was tested using the Friedman test (EZR Ver 1.32). In addition, the relationship between the locomotive syndrome risk level and duration of the intervention was examined using Fisher’s test. Results: SUBI and the locomotive syndrome risk level significantly differed with time during the intervention. Slight changes were observed in salivary amylase levels during the intervention. Conclusion: The present results suggest that the complex-type program promoted interactions among community-dwelling elderly subjects and positively influenced the maintenance of and improvements in phys

关键词： Subjective Well-Being SUBI The Elderly Amusement Exercise

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