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bioactive polymeric scaffolds for tissue engineering

bioactive Materials 2016年第2期1卷 93-108页

作者： Scott Stratton namdev b.shelke Kazunori Hoshino Swetha Rudraiah Sangamesh G.Kumbar Department of Orthopaedic Surgery UConn HealthFarmingtonCTUSA Institute for Regenerative Engineering UConn HealthFarmingtonCTUSA Department of biomedical Engineering University of ConnecticutStorrsCTUSA Department of Pharmaceutical Sciences School of PharmacyUniversity of Saint JosephHartfordCT06103USA

A variety of engineered scaffolds have been created for tissue engineering using polymers,ceramics and their *** has been adopted for majority of the three-dimensional(3D)scaffold design both in terms of physicochemical properties,as well as bioactivity for superior tissue *** fabricated via salt leaching,particle sintering,hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in *** systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and *** scaffold fabrication techniques often failed to create intricate structures with greater resolution,not reproducible and involved multiple *** 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug *** review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores,bioactivity and degradation rate to enable tissue *** highlights few examples of bioactive scaffold mediated nerve,muscle,tendon/ligament and bone *** of the efforts required for optimization,a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined.

关键词： bioactive biomaterials Scaffold Porosity biodegradable Tissue regeneration

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An Ensemble based Approach for Sentiment Classification in Asian Regional Language

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Computer Systems Science & Engineering 2023年第3期44卷 2457-2468页

作者： Mahesh b.shelke Jeong Gon Lee Sovan Samanta Sachin N.Deshmukh G.bhalke Daulappa Rahul b.Mannade Arun Kumar Sivaraman Department of Computer Science and Information Technology Dr.Babasaheb Ambedkar Marathwada UniversityAurangabadMaharashtra431004India Division of Applied Mathematics Wonkwang University460Iksan daeroIksan SiJeonbuk54538Korea Department of Mathematics Tamralipta MahavidyalayaTamlukWest Bengal721636India Department of Electronics and Telecommunication Engineering AISSMSCOEPuneMaharashtra411001India Department of Information Technology Govemment College of EngineeringAurangabadMaharashtra431005India School of Computer Science and Engineering Vellore Institute of TechnologyChennai600127India

In today’s digital world,millions of individuals are linked to one another via the Internet and social *** opens up new avenues for information exchange with *** analysis(SA)has gotten a lot of attention during the last *** analyse the challenges of Sentiment Analysis(SA)in one of the Asian regional languages known as Marathi in this study by providing a benchmark setup in which wefirst produced an annotated dataset composed of Marathi text acquired from microblogging websites such as *** also choose domain experts to manually annotate Marathi microblogging posts with positive,negative,and neutral *** addition,to show the efficient use of the annotated dataset,an ensemble-based model for sentiment analysis was *** contrast to others machine learning classifier,we achieved better performance in terms of accuracy for ensemble classifier with 10-fold cross-validation(cv),outcomes as 97.77%,f-score is 97.89%.

关键词： Sentiment analysis machine learning lexical resource ensemble classifier

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Ultrasound-assisted one-pot synthesis of 2,4,5-triarylimidazole derivatives catalyzed by ceric (Ⅳ) ammonium nitrate in aqueous media

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Chinese Chemical Letters 2009年第3期20卷 283-287页

作者： K.F.shelke S.b.Sapkal M.S.Shingare Organic Research Laboratory Department of ChemistryDr.Babasaheb Ambedkar Marathwada UniversityAurangabad(M.S.) 431004India

2,4,5-Triarylimidazoles could be obtained in excellent yields by the one-pot three-component condensation of benzil/benzoin, aldehydes and ammonium acetate in the presence of catalytic amount of the inexpensive, readily available and non-toxic ceric （IV） ammonium nitrate （CAN） in aqueous media under ultrasound at room temperature. In this reaction the products were obtained in short reaction time and easy operation under mild conditions.

关键词： 2,4,5-Triarylimidazole One-pot Ceric (IV) ammonium nitrate Aqueous media Ultrasound

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An efficient synthesis of benzofuran derivatives under conventional/non-conventional method

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Chinese Chemical Letters 2010年第12期21卷 1439-1442页

作者： Suryakant b.Sapkal Kiran F.shelke bapurao b.Shingate Murlidhar S.Shingare Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad(M.S.)431004India

l-Methyl-3-ethyl imidazolium bromide[meim]br/basic alumina（Al2O3） has been found to promote the cyclocondensation of chloroacetone/chloroethyl acetate with salicylaldehydes under conventional as well as microwave ir... 详细信息

关键词： [meim]br/Al2O3 benzofuran Cyclocondensation Conventional Non-conventional methods

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Ascorbic acid and curcumin alleviate abnormal estrous cycle and morphological changes in cells induced by repeated ultraviolet b radiations in female Wistar rats

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Asian pacific Journal of Reproduction 2020年第3期9卷 142-147页

作者： Gayatri Rai Narendra namdev Payal Mahobiya Department of Zoology Dr Harisingh Gour(A Central University)VishwavidhyalayaSagar(M.P.)India

Objective: To study the protective effect of ascorbic acid and curcumin against the abnormal estrous cycle and morphological changes in cells induced by repeated ultraviolet b(UVb)radiation in female Wistar ***: Sixteen female sexually mature Wistar rats weighing 130-150 g and aged 12-16 weeks were randomly divided into four *** control group received normal food and water ad *** UVb group was exposed to a dose of 280 nm of UVb radiation for 2 h *** UVb+curcumin group received a dose of 280 nm of UVb radiation for 2 h daily and also an oral dose of curcumin(25 mg/kg body weight)*** UVb+ascorbic acid group received a dose of 280 nm of UVb radiation for 2 h daily and also an oral dose of ascorbic acid(250 mg/kg body weight)*** the treatments last for 15 consecutive *** and ovary weight and gonadosomatic index were *** stages(proestrus,estrus,metaestrus and diestrus)of the estrous cycle were determined by the cell types observed in the vaginal ***: UVb radiation caused irregular alterations on the estrous cycle and morphological changes of the female Wistar rat as compared with the control *** acid and curcumin protected UVb-induced estrous phases and their *** curcumin showed greater protection than ascorbic ***: Ascorbic acid and curcumin at low doses can alleviate abnormal estrous cycle and morphological changes in cells induced by UVb radiations in female Wistar rats.

关键词： Estrous cycle Ultraviolet-b radiation Vaginal smear Ascorbic acid Curcumin

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boric acid as an efficient catalyst for the synthesis of 1,1-diacetate under solvent-free condition

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Chinese Chemical Letters 2009年第12期20卷 1453-1456页

作者： K.F shelke S.b.Sapkal G.K.Kakade P.V.Shinde b.b.Shingate M.S.Shingare Organic Research Laboratory Department of ChemistryDr.Babasaheb Ambedkar Marathwada University

boric acid （bO3H3） is an inexpensive, efficient and mild catalyst for the synthesis of 1,1-diacetate （acylal） from the various aromatic and heteroaryl aldehydes with acetic anhydride at room temperature under solvent-free condition. The present method does not involve any hazardous organic solvents or catalysts. This method gives notable advantages such as excellent chemoselectivity, mild reaction condition, short reaction times and excellent yield.

关键词： Aromatic and heteroaryl aldehyde boric acid 1,1-Diacetate Solvent-free

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Alum:An efficient catalyst for one-pot synthesis of α-aminophosphonates

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Chinese Chemical Letters 2009年第9期20卷 1042-1046页

作者： Swapnil S.Sonar Kiran F.shelke Gopal K.Kakade bapurao b.Shingate Murlidhar S.Shingare Department of Chemistry Dr.Babasaheb Ambedkar Marathwada UniversityAurangabad 431004 MSIndia National Chemical Laboratory Pune 411008 MSIndia

Alum （KAl（SOa）E.12H2O） is an inexpensive, efficient, non-toxic and mild catalyst for the one-pot synthesis of α-aminopho- sphonates. A three component reaction of an aldehyde/ketone, an amine and triethyl phosphite was carried out under solvent-free conditions to afford the corresponding α-aminophosphonates in short reaction times and high yields with the green aspects by avoiding toxic catalysts and solvents. 2009 Murlidhar S. Shingare. Published by Elsevier b.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Alum α-Aminophosphonates Aldehyde/ketone Amine Triethyl phosphite Solvent-free

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Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats

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Asian Pacific Journal of Tropical biomedicine 2012年第12期2卷 992-998页

作者： Urmila M Aswar Padmaja P Kalshetti Suhas M shelke Sharad H bhosale Subhash L bodhankar Department of Pharmacology STES's Sinhgad Institute of Pharmacy Department of Pharmacology Maharashtra Institute of Pharmacy Department of Pharmacology Poona College of PharmacyBharati Vidyapeeth Deemed University

Objective:To study the derivatives of 1,2,4-triazino[5,6-b]indole-3-thione for antidepressant activity in olfactory bulbectomized(ObX)*** of various derivatives tested for acute tail suspension test,the two derivatives showiug prominent action *** for bilateral olfactory bulbeetomy rsodel of ehronic depression in ***:The sub aeute effects of 14-day oral pretreatment of two derivatives labeled as 3a(70 mg/kg)and 3r(70 mg/kg),imipramine(20 mg/kg),fluoxetiue(30 mg/kg)and moclobemide(15 mg/kg)were evaluated on bilateral bulbectomy induced rise in body weight,hyperphagia,hyperactivity,and on sexual *** serum sodium concentration,body temperature,and heart rate were also ***:The derivatives3a and 3r showed reversal of drop in body weight,reversed ObX indueed hyperactivity,normalized body temperature,heart rate,and serum sodium *** elevated maze test,moclobemide,3a,3r treatment significantly redueed time spent in open arm as compared to ObX rats.3a and 3r also irsproved sexual behavior ***:The present study shows promising antidepressant action and provides a proof of concept for the chronic treatrsent of 3a,3r to treat depression.

关键词： 1,2,4-triazino-[5,6-b]indole-3-thione Olfactory bulbectomy Antidepressant activity

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Influence of Thickness on the Photosensing Properties of Chemically Synthesized Copper Sulfide Thin Films

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World Journal of Condensed Matter Physics 2015年第1期5卷 1-9页

作者： Abhiman Dattatray Dhondge Sunil Rameshgir Gosavi Narayani Madhukar Gosavi Chatur Pundlik Sawant Amar Maruti Patil Abhijeet Ravsaheb.shelke Nishad Gopal Deshpande C. H. C. Arts S. G. P. Commerce and B. B. J. P. Science College Taloda India Government College of Engineering Jalgaon India G. T. Patil College Nandurbar India q-SpinTech & Nanomaterials Laboratory Department of Physics Shivaji University Kolhapur India

We report here the influence of thickness on the photosensing properties of copper sulfide (CuS) thin films. The CuS films were deposited onto glass substrate by using a simple and cost effective chemical bath deposition method. The changes in film thickness as a function of time were monitored. The films were characterized using X-ray diffraction technique (XRD), field emission scanning electron microscopy (FE-SEM), optical measurement techniques and electrical measurement. X-ray diffraction results indicate that all the CuS thin films have an orthorhombic (covellite) structure with preferential orientation along (113) direction. The intensity of the diffraction peaks increases as thickness of the film increases. Uniform deposition having nanocrystalline granular morphology distributed over the entire glass substrate was observed through FE-SEM studies. The crystalline and surface properties of the CuS thin films improved with increase in the film thickness. Transmittance (except for 210 nm thick CuS film) together with band gap values was found to decrease with increase in thickness. I-V measurements under dark and illumination condition show that the CuS thin films give a good photoresponse.

关键词： Copper Sulfide (CuS) Chemical bath Deposition (CbD) Thin Film X-Ray Diffraction (XRD) Field Emission Scanning Electron Microscopy (FESEM) Photosensitivity

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