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International Journal of Organic Chemistry 2015年第4期5卷 271-281页

作者： Thangavelu Saravanan Anju Chadha Tarur Konikkaledom Dinesh namasivayam palani Sengottuvelan Balasubramanian Laboratory of Bioorganic Chemistry Department of Biotechnology Indian Institute of Technology Madras Chennai India National Center for Catalysis Research Indian Institute of Technology Madras Chennai India Department of Inorganic Chemistry University of Madras Guindy Campus Chennai India ITC Life Sciences and Technology Centre ITC Limited Peenya Industrial Area Phase I Bangalore India

Enantiomerically enriched (R)-1-(2-bromocycloalkenyl)-3-buten-1-ol and its derivatives were obtained via enantioselective hydrolysis [resolution] with good enantioselectivities (E = 31 to >500) using Candida parapsilosis ATCC 7330. The various reaction parameters were optimized for enantioselective hydrolysis to achieve high enantiomeric excess (ee) and conversions. Among the substrates tested, (RS)-1-(2-bromocyclohex-1-en-1-yl) but-3-yn-1-yl acetate was hydrolysed by the biocatalyst in 12 h to the corresponding (R)-alcohol in 49% conversion and >99 ee. The optically pure allylic alcohol thus obtained was used as a chiral starting material for the synthesis of an enantiomerically enriched bicyclic alcohol effectively establishing achemoenzymatic route.

关键词： Chemoenzymatic Synthesis Enantioselective Hydrolysis Candida parapsilosis ATCC 7330 Hydrolases Bicyclic Carbocycle

A Novel Approach for the Synthesis of (R) and (S)-Nicotine

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International Journal of Organic Chemistry 2022年第4期12卷 189-199页

作者： Rohith Kumar Agarthimoole Sahir Gagan Sudesna Parida Tarur Konikkaledom Dinesh Maheswaran S. Karatholuvhu namasivayam palani Soumitra Mukherjee ITC Limited ITC Life Sciences and Technology Centre Peenya Industrial Area Phase I Bangalore India Presently at Department of Atmospheric Sciences Texas A&M University College Station Texas USA

Nicotine is an alkaloid mainly found in leaves of tobacco and is used therapeutically for patients seeking relief from tobacco dependence in the form of products such as gums, patches, lozenges etc. In these products, majorly nicotine derived from tobacco is used which is inherently contaminated with undesirable nicotine related substances as impurities at low levels and is difficult to remove. Hence, use of synthetic nicotine is considered as an option which will be devoid of such impurities. In this work, a short and efficient synthesis of (R) and (S) nicotine was achieved by leveraging a key esterification between racemic homoallylic alcohol intermediate (2) and (S)-Ibuprofen (3) to produce diastereomers (5a) and (5b) which were easily separable under standard column chromatography conditions. Use of (S)-Ibuprofen (3) as a chiral resolving agent constitutes a novel approach which was not reported earlier. A subsequent hydrolysis of the diastereomers furnished the homoallylic alcohol intermediates (S)-6a and (R)-6a with high enantiopurity, which was effectively translated to the corresponding (R)-nicotine and (S)-nicotine respectively.

关键词： Nicotine Ibuprofen Diastereomers Column Chromatography Chiral Purity

Effect of process parameters on springback behaviour during air bending of electrogalvanised steel sheet

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2011年第3期12卷 183-189页

作者： Durairaj VASUDEVAN Rajumani SRINIVASAN palani PADMANABHAN Department of Mechanical Engineering PSNA College of Engineering and Technology Department of Mechanical Engineering RVS College of Engineering and Technology Bharath Niketan Engineering College

This work aims to study the springback behaviour of electrogalvanised (EG) steel sheets during the air bending *** have been conducted to analyse the influence of various parameters such as coating thickness,orientation of the sheet,punch radius,die radius,die opening,punch velocity,and punch travel on springback *** is established that the springback increases with increasing coating thickness,punch radius,punch travel,die radius,die opening,and punch *** 90° orientation exhibits higher springback than 0° orientation.

关键词： Springback Electrogalvanised (EG) steel Air bending

Readily available alkylbenzenes as precursors for the one-pot preparation of buta-1,3-dienes under DDQ visible-light photocatalysis in benzotrifluoride

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Organic Chemistry Frontiers 2022年第5期9卷 1395-1402页

作者： palani Natarajan Deachen Chuskit Priya Department of Chemistry&Centre for Advanced Studies in Chemistry Panjab UniversityChandigarh-160014India

Easily accessible alkylbenzenes are highly valuable starting materials and solvents in synthetic organic chemistry for the production of pharmaceuticals,plastics,synthetic rubber,dyes,etc.

关键词： alkyl visible rubber

Effects of magnetohydrodynamic flow past a vertical plate with variable surface temperature

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Applied Mathematics and Mechanics(English Edition) 2010年第3期31卷 329-338页

作者： Ibrahim A.ABBAS G.palani Department of Mathematics Faculty of Sciences and ArtsNajran University Department of Mathematics Faculty of ScienceSohag University Department of Mathematics S.S.Govt.Arts College

An analysis is performed to study the magnetohydrodynamic flow of an electrically conducting, viscous incompressible fluid past a semi-infinite vertical plate with variable surface temperature under the action of transversely applied magnetic field. The heat due to viscous dissipation and the induced magnetic field are assumed to be negligible. The dimensionless governing equations are unsteady, two-dimensional, coupled and non-linear governing equations. It is found that the magnetic field parameter has a retarding effect on the velocities of air and water.

关键词： finite element vertical plate skin friction velocity Nusselt number

Influence of magnetic field and thermal radiation by natural convection past vertical cone subjected to variable surface heat flux

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Applied Mathematics and Mechanics(English Edition) 2012年第5期33卷 605-620页

作者： G.palani K.Y.KIM Department of Mathematics Dr.Ambedkar Govt.Arts CollegeChennai 600039Tamil NaduIndia Department of Mechanical Engineering Inha UniversityIncheon 402751Republic of Korea

A numerical study is performed to examine the heat transfer characteristics of natural convection past a vertical cone under the combined effects of magnetic field and thermal radiation. The surface of the cone is subjected to a variable surface heat flux. The fluid considered is a gray, absorbing-emitting radiation but a non-scattering medium. With approximate transformations, the boundary layer equations governing the flow are reduced to non-dimensional equations valid in the free convection regime. The dimensionless governing equations are solved by an implicit finite difference method of Crank-Nicolson type which is fast convergent, accurate, and unconditionally stable. Numerical results are obtained and presented for velocity, temperature, local and average wall shear stress, and local and average Nusselt number in air and water. The present results axe compared with the previous published work and are found to be in excellent agreement.

关键词： apex magnetohydrodynamics radiation finite difference skin friction,vertical cone

Theoretical and Computational Analyses of LNG Evaporator

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Journal of Thermal Science 2017年第2期26卷 132-137页

作者： palani Kumar Chidambaram Yang Myung Jo Heuy Dong Kim FMTRC Daejoo Machinery Co Ltd Department Mechanical Engineering Andong National University

Theoretical and numerical analysis on the fluid flow and heat transfer inside a LNG evaporator is conducted in this work. Methane is used instead of LNG as the operating fluid. This is because; methane constitutes over 80% of natural gas. The analytical calculations are performed using simple mass and energy balance equations. The analytical calculations are made to assess the pressure and temperature variations in the steam tube. Multiphase numerical simulations are performed by solving the governing equations(basic flow equations of continuity, momentum and energy equations) in a portion of the evaporator domain consisting of a single steam pipe. The flow equations are solved along with equations of species transport. Multiphase modeling is incorporated using VOF method. Liquid methane is the primary phase. It vaporizes into the secondary phase gaseous methane. Steam is another secondary phase which flows through the heating coils. Turbulence is modeled by a two equation turbulence model. Both the theoretical and numerical predictions are seen to match well with each other. Further parametric studies are planned based on the current research.

关键词： LNG Evaporator Analytical Calculation Numerical Simulation

Synthesis of silver nanoparticles by Lactobaciluus acidophilus 01 strain and evaluation of its in vitro genomic DNA toxicity

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Nano-Micro Letters 2010年第3期2卷 160-163页

作者： S.Karthick Raja namasivayam Gnanendra Kumar E Reepika R Department of Biotechnology Sathyabama University

Silver nanoparticles synthesized by dried biomass of Lactobaciluus acidophilus 01 strain was evaluated against toxicity of genomic DNA isolated from bacteria(***) fungi(Beauveria bassiana) algae(Seenedesmus acutus) and human blood adopting standard condition was discussed in the present *** silver nanoparticles were characterized by UV-Vis spectroscopy and *** UV-Vis spectroscopy revealed the formation of silver nanoparticles by yielding the typical silver plasmon absorption maxima at 430 nm and SEM micrograph indicates the uniform spherical particles within the size range of 45?60 *** energy dispersive X-ray spectroscopy(EDX) of the nanoparticle confirmed the presence of elemental silver signal as strong *** above synthesized silver nanoparticles didn't cause any toxic effect on all the tested genomic DNA at all tested concentrations which reveals nil genomic nanoparticles induced toxicity.

关键词： Lactobacillus acidophilus Silver nanoparticles Antibacterial activity Biosynthesis

Solar photovoltaic fed dual input LED lighting system with constant illumination control

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Frontiers in Energy 2016年第4期10卷 473-478页

作者： Kinattingal SUNDARESWARAN Kevin Ark KUMAR Payyalore Raman VENKATESWARAN Sankaran palani Department of Electrical and Electronics Engineering National Instituteof Technology Tiruchirappalli 620015 India Bharat Heavy Electricals Limited Tiruchirappalli 620014 India Sudharsan Engineering College Pudukkottai 622501 India

A dual input LED lighting scheme with constant illumination is proposed in this paper. The scheme employs a photovoltaic array as the first input and a battery as the second one. A microcontroller is programmed to operate a changeover switch as well as a DC-DC converter for uninterrupted and constant illumina- tion in work place. The scheme is suitable for conference halls, laboratories, clean rooms, marriage halls, theaters, etc. The complete modeling, design and experimentation of the proposed scheme are explained and the economic viability of the scheme is justified.

关键词： photovoltaic LED light dual input P&O algorithm

Anti-diabetic activity of quercetin extracted from Phyllanthus emblica ***: In silico and in vivo approaches

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Journal of Pharmaceutical Analysis 2018年第2期8卷 109-118页

作者： Prabhu Srinivasan S.Vijayakumar Swaminathan Kothandaraman Manogar palani Computational Phytochemistry Lab PG and Research Department of Botany and Microbiology A. V. V. M Sri Pushpam College (Autonomous) Department of Physics RKM Vivekananda College (Autonomous)

In this study, molecular interactions of the ligands, quercetin, gallic acid, and metformin with various diabetes mellitus-related protein targets, such as glycogen phosphorylase and peroxisome proliferatoractivated receptor gamma, were assessed. It was revealed that quercetin possesses good binding affinity to both targets. Quercetin is a major constituent of methanolic extracts of Phyllanthus emblica fruit. The antihyperglycemic effect of quercetin in streptozotocin(STZ)-induced diabetic rats was examined. The isolated quercetin administered at a dose of 75 mg/kg body weight produced a maximum decrease of14.78% in blood glucose levels in the diabetic rats after 7 days of treatment. Furthermore, quercetin doses of 50 and 75 mg/kg were shown to significantly improve the profiles of triglycerides, high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein, and total cholesterol at the end of the study in STZ-induced diabetic rats. The administration of quercetin(25, 50, and 75 mg/kg body weight)daily for 28 days in STZ-induced diabetic rats resulted in a significant decrease in blood glucose and urine sugar levels, with a considerable rise in plasma insulin and hemoglobin levels. Therefore, quercetin is a potential drug with antidiabetic and antihyperglycemic action mediated by changes in the levels of glucose, cholesterol, and triglycerides as indicated by in silico and in vivo studies.

关键词： Bioactive molecules Glycogen phosphorylase Molecular docking Phyllanthus emblica Quercetin Albino Wister male rats