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Omnidirectional color wavelength tuning of stretchable chiral liquid crystal elastomers

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Light(Science & Applications) 2024年第6期13卷 1062-1074页

作者： Seungmin nam Wontae Jung Jun Hyuk Shin su Seok Choi Department of Electrical Engineering Pohang University of Science and Technology(POSTECH)PohangKorea

Wavelength-tunable structural colors using stimuli-responsive materials,such as chiral liquid crystals(CLCs),have attracted increasing attention owing to their high functionality in various tunable photonic ***,on-demand omnidirectional wavelength control is highly desirable from the perspective of wavelength-tuning ***,despite numerous previous research efforts on tunable CLC structural colors,only mono-directional wavelength tuning toward shorter wavelengths has been employed in most studies to *** this study,we report the ideally desired omnidirectional wavelength control toward longer and shorter wavelengths with significantly improved tunability over a broadband wavelength *** using areal expanding and contractive strain control of dielectric elastomer actuators(DEAs)with chiral liquid crystal elastomers(CLCEs),simultaneous and omnidirectional structural color-tuning control was *** breakthrough in omnidirectional wavelength control enhances the achievable tuning freedom and versatility,making it applicable to a broad range of high-functional photonic applications.

关键词： tuning tunable directional

Catalpa bignonioides extract improves exercise performance through regulation of growth and metabolism in skeletal muscles

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 47-54页

作者： Hoibin Jeong Dong-joo Lee sung-Pil Kwon SeonJu Park Song-Rae Kim Seung Hyun Kim Jae-Il Park Deug-chan Lee Kyung-Min Choi WonWoo Lee Ji-Won Park Bohyun Yun su-Hyeon Cho Kil-nam Kim Seoul Center Korea Basic Science InstituteSeoul 02841Republic of Korea Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Research&Development Center Chungdam CDC JNPharm LLC.Chuncheon 24341Republic of Korea Department of Biomedical Technology Kangwon National UniversityChuncheon 24341Republic of Korea Yonsei Institute of Pharmaceutical Sciences College of PharmacyYonsei UniversityIncheon 21983Republic of Korea Gwangju Center Korea Basic Science InstituteGwangju 61751Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do58762Republic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To evaluate the effects of Catalpa bignonioides fruit extract on the promotion of muscle growth and muscular capacity in vitro and in ***:Cell viability was measured using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide *** proliferation was assessed using a 5-bromo-2’-deoxyuridine(BrdU)assay *** blot analysis was performed to determine the protein expressions of related *** effects of Catalpa bignonioides extract were investigated in mice using the treadmill exhaustion test and whole-limb grip strength *** composition analysis was performed using high-performance liquid chromatography(HPLC).Results:Catalpa bignonioides extract increased the proliferation of C2C12 mouse myoblasts by activating the Akt/mTOR signaling *** also induced metabolic changes,increasing the number of mitochondria and glucose metabolism by phosphorylating adenosine monophosphate-activated protein *** an in vivo study,the extract-treated mice showed improved motor abilities,such as muscular endurance and grip ***,HPLC analysis showed that vanillic acid may be the main component of the Catalpa bignonioides extract that enhanced muscle ***:Catalpa bignonioides improves exercise performance through regulation of growth and metabolism in skeletal muscles,suggesting its potential as an effective natural agent for improving muscular strength.

关键词： Catalpa bignonioides Skeletal muscle Cell proliferation Mitochondria Energy metabolism C2C12

The NAC transcription factor LuNAC61 negatively regulates fiber development in flax (Linum usitatissimum L.)

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Journal of Integrative Agriculture 2024年第3期23卷 795-805页

作者： Dongwei Xie Jing Li Wan Li Lijun sun Zhigang Dai Wenzhi Zhou Jianguang su Jian sun School of Life Sciences Nantong UniversityNantong 226019China Institute of Crop Cultivation and Tillage Heilongjiang Academy of Agricultural SciencesHarbin 150086China Institute of Bast Fiber Crops Chinese Academy of Agricultural SciencesChangsha 410221China Jiangsu Sanshu Biotechnology Co.Ltd. Nantong 226001China

Flax is a crucial fiber crop that exhibits excellent textile properties and serves as a model plant for investigating phloem fiber development. The regulation of multiple genes significantly influences fiber development, notably involving NAC(nam, ATAF1/2, CUC2) transcription factors in forming the fiber secondary cell wall(SCW).Overexpression of LuNAC61 in flax resulted in sparse top meristematic zone leaves and significantly reduced stem cellulose content. Scanning electron microscopy and staining observations revealed a significant reduction in fiber bundles. β-Glucuronidase(GUS) staining analysis demonstrated high activity of the LuNAC61 promoter in the bast fibers of the flax stem. Additionally, several members of the LuPLATZ and LuCesA families exhibited significant coexpression with LuNAC61. subcellular localization indicated the presence of LuPLATZ24 protein in the nucleus and cytoplasm, LuNAC61 protein exclusively in the nucleus, and LuCesA10 in the nucleus and endoplasmic reticulum. LuPLATZ24 positively regulates LuNAC61, whereas LuNAC61 negatively affects LuCesA10, suggesting the involvement of a metabolic network in regulating flax fiber development. In conclusion, this study provides a critical opportunity for a comprehensive and in-depth analysis of the mechanisms governing flax fiber development and the potential use of biotechnology to enhance flax fiber yield.

关键词： flax fiber development Lu NAC61 gene function gene interaction

UBP12/UBP13-mediated deubiquitination of salicylic acid receptor NPR3 suppresses plant immunity

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Molecular Plant 2023年第1期16卷 232-244页

作者： Yu Zhou su-Hyun Park nam-Hai Chua Temasek Life Sciences Laboratory National University of Singapore1 Research LinkSingapore 117604Singapore Disruptive&sustainable Technologies for Agricultural Precision Singapore-MIT Alliance for Research and Technology1 CREATE WaySingapore 138602Singapore

Salicylic acid(SA),a defense hormone produced after pathogen challenge,is critical for plant *** NONEXPRESSER OF PR GENES 1(NPR1)and its paralogs NPR3 and NPR4 can bind SA and mediate SA signal ***1 functions as a transcriptional co-activator to promote defense gene expression,whereas NPR3 and NPR4 have been shown to function as negative regulators in the SA signaling *** the mechanism about NPR1 regulation has been well studied,how NPR3/NPR4 proteins are regulated in immune responses remains largely ***,we show that the stability of NPR3/NPR4 is enhanced by *** the absence of pathogen challenge,NPR3/NPR4 are unstable and degraded by the 26S proteasome,whereas the increase in cellular SA levels upon pathogen infection suppresses NPR3/NPR4 *** found that UBP12 and UBP13,two homologous deubiquitinases from a ubiquitin-specific protease subfamily,negatively regulate plant immunity by promoting NPR3/NPR4 *** genetic results further showed that UBP12/UBP13-mediated immunity suppression is partially dependent on NPR3/NPR4 *** interacting with NPR3 in the nucleus in an SA-dependent manner,UBP12 and UBP13 remove ubiquitin from polyubiquitinated NPR3 to protect it from being *** stabilization of NPR3/NPR4 promoted by UBP12/UBP13 is essential for negative regulation of basal and SA-induced immunity.

关键词： plant immunity salicylic acid NPR3 UBP12/UBP13

Evaluation of immobilizing agents as soil quality conditioners in addition to their metal(loid) immobilizing effect

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Pedosphere 2022年第2期32卷 307-316页

作者： Chaw su LWIN Mina LEE Young-nam KIM Gary OWENS Kwon-Rae KIM Department of Soil and Water Science Yezin Agricultural UniversityYezinNaypyitaw 15013Myanmar Department of Smart-Agro Industry Gyeongsang National UniversityJinju 52725Korea Institute of Agriculture and Life Science(IALS) Gyeongsang National UniversityJinju 52828Korea Environmental Contaminants Group Future Industries InstituteUniversity of South AustralianMawson Lakes SA 5095Australia

In trace metal (TM)-contaminated agricultural soils,management of TM availability is important for safe crop *** addition,maintenance or improvement of soil quality is vital for sustainable crop *** TM phytoavailability and increased soil quality can be achieved by the application of various immobilizing agents to soil,which can supply both macronutrients and organic *** study investigated the long-term influences of four common immobilizing agents on soil biogeochemical properties and the phytoavailability of TMs in mixed metal-contaminated soil from a cultivated upland near an abandoned mining *** (L),gypsum (G),fly ash (F),and animal manure-based compost (C) were applied to pots containing contaminated soil,either individually or in *** incubation for three years under sequential cultivation of two crops and fallow,soil biogeochemical properties were determined,and Brassica rapa plant bioassay was *** phytoavailability of all TMs (both cationic metals and anionic metalloids) remained significantly lower in soils treated with immobilizing agents even after three years,when compared with the no-agent control (CK) *** addition,the soil quality was significantly improved by treatment with immobilizing *** instance,the C and L+C treatments were the most effective in improving soil physical (bulk density,porosity,and water-resistant aggregate stability),chemical (pH,organic matter,total nitrogen,cation exchange capacity,and plant-available phosphorus,magnesium,and potassium),and biological (microbial biomass carbon and dehydrogenase activity) *** improvement of soil properties and lowering of TM bioavailability were also consistent with the most significant increase in *** biomass production observed in the C treatment,followed by the L+C,G+F,L,G,F,and L+G treatments,as compared with that in *** results indicate that the function of the TM-immobilizing agent as a soil qualit

关键词： crop production metal bioavailability metal immobilization metal phytoavailability soil amendments soil biogeochemical properties soil remediation trace metals

Effect of solid-solution strengthening on deformation mechanisms and strain hardening in medium-entropy V_(1-x)Cr_(x)CoNi alloys

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Journal of Materials Science & Technology 2022年第13期108卷 270-280页

作者： Hyun Chung Dae Woong Kim Woo Jin Cho Heung nam Han Yuji Ikeda Shoji Ishibashi Fritz Körmann Seok su Sohn Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea Center for High Entropy Alloys Pohang University of Science and TechnologyPohang 37673South Korea Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National UniversitySeoul 08826South Korea Institute for Materials Science University of StuttgartPfaffenwaldring 55Stuttgart 70569Germany Computational Materials Design Max-Planck-Institut für Eisenforschung GmbHMax-Planck-Strabe 1Düsseldorf 40237Germany Research Center for Computational Design of Advanced Functional Materials(CD-Fmat) National Institute of Advanced Industrial Science and Technology(AIST)TsukubaIbaraki 305-8568Japan Department of Materials Science and Engineering Delft University of TechnologyMekelweg2Delft 2628 CDthe Netherlands

High-and medium-entropy alloys(HEAs and MEAs)possess high solid-solution *** investigations have been conducted on its impact on yield strength,however,there are limited reports regarding the relation between solid-solution strengthening and strain-hardening *** addition,no attempt has been made to account for the dislocation-mediated plasticity;most works focused on twinning-or transformation-induced plasticity(TWIP or TRIP).In this work we reveal the role of solidsolution strengthening on the strain-hardening rate via systematically investigating evolutions of deformation structures by controlling the Cr/V ratio in prototypical V_(1-x)Cr_(x)CoNi *** the TWIP of CrCoNi with the dislocation slip of V_(0.4)Cr_(0.6)CoNi,the hardening rate of CrCoNi was superior to slip-band refinements of V_(0.4)Cr_(0.6)CoNi due to the dynamic Hall-Petch ***,as V content increased further to V_(0.7)Cr_(0.3)CoNi and VCoNi,their rate of slip-band refinement in V_(0.7)Cr_(0.3)CoNi and VCoNi with high solid-solution strength surpassed that of *** it is generally accepted in conventional alloys that deformation twinning results in a higher strain-hardening rate than dislocation-mediated plasticity,we observed that the latter can be predominant in the former under an activated huge solid-solution strengthening *** high solid-solution strength lowered the cross-slip activation and consequently retarded the dislocation rearrangement rate,i.e.,the dynamic *** delay in the hardening rate decrease,therefore,increased the strain-hardening rate,results in an overall higher strain-hardening rate of V-rich alloys.

关键词： Medium-entropy alloy Tensile property Solid-solution strength Strain-hardening rate Stacking fault energy

Reliability, Accuracy, and Use Frequency of Evaluation Methods for Amount of Tongue Coating

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Chinese Journal of Integrative Medicine 2019年第5期25卷 378-385页

作者： su-Ryun Kim Dong-Hyun nam Department of Biofunctional Medicine and Diagnosis College of Korean MedicineSangji UniversityWonju 26339Republic of Korea

Objective: To classify the evaluation methods for amount of tongue coating(TC) and investigate their reliability, accuracy, and frequency of use. Methods: Articles published from 1985 to 2015 were searched for evaluation methods for the amount of TC in PubMed and the Cochrane Library. Only clinical researches were included except protocol articles. The methods were classi?ed according to their characteristics. Results: Finally,113 articles were selected. The evaluation method for the amount of TC from the articles was classi?ed into 4 types: intuitive, specificative, computerized, and weighing TC. The reliability in the intuitive and specificative methods(κ=0.33–0.92) showed varying levels among the studies. In general, the amount of TC calculated by the speci?cative method(Spearman's r=0.68–0.80) was more strongly related to the directly measured value than to the value estimated by the computerized method(Pearson's r=0.442). The number of articles published on this topic has increased consistently, and the speci?cative method was the most frequently used. Despite the higher reliability of the computerized method, it has not been widely used. Conclusions: The high prevalence of the speci?cative method would continue in clinical practice because of its convenience and accuracy. However,to establish higher reliability, the limitation of the subjectivity of the assessors should be overcome through calibration training. In the computerized method, novel algorithms are needed to obtain a higher accuracy so that it can help the practitioners con?dently estimate the amount of TC.

关键词： tongue coating evaluation methods reliability accuracy frequency

SYNCRIP controls miR-137 and striatal learning in animal models of methamphetamine abstinence

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3281-3297页

作者： Baeksun Kim sung Hyun Tag Eunjoo nam suji Ham sujin Ahn Juhwan Kim Doo-Wan Cho Sangjoon Lee Young-su Yang Seung Eun Lee Yong Sik Kim Il-Joo Cho Kwang Pyo Kim su-Cheol Han Heh-In Im Convergence Research Center for Diagnosis Treatment and Care System of Dementia(DTC)Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Division of Bio-Medical Science&Technology KIST SchoolKorea University of Science and Technology(UST)Seoul 02792Republic of Korea Center for Neuroscience KISTSeoul 02792Republic of Korea Animal Model Research Center Jeonbuk Department of Inhalation ResearchKorea Institute of Toxicology(KIT)Korea Research Institute of Chemical Technology(KRICT)Jeongeup 56212Republic of Korea Research Animal Resource Center KISTSeoul 02792Republic of Korea Department of Pharmacology Seoul National University College of MedicineSeoul 03080Republic of Korea Center for BioMicrosystems KISTSeoul 02792Republic of Korea Department of Applied Chemistry Kyung Hee UniversityGyeonggi-do 17104Republic of Korea

Abstinence from prolonged psychostimulant use prompts stimulant withdrawal *** adaptations within the dorsal striatum have been considered the main hallmark of stimulant abstinence. Here we explored striatal miRNA-target interaction and its impact on circulating miRNA marker as well as behavioral dysfunctions in methamphetamine(MA) abstinence. We conducted miRNA sequencing and profiling in the nonhuman primate model of MA abstinence, followed by miRNA qPCR,LC-MS/MS proteomics, immunoassays, and behavior tests in mice. In nonhuman primates, MA abstinence triggered a lasting upregulation of miR-137 in the dorsal striatum but a simultaneous downregulation of circulating miR-137. In mice, aberrant increase in striatal miR-137-dependent inhibition of SYNCRIP essentially mediated the MA abstinence-induced reduction of circulating miR-137. Pathway modeling through experimental deduction illustrated that the MA abstinence-mediated downregulation of circulating miR-137 was caused by reduction of SYNCRIP-dependent miRNA sorting into the exosomes in the dorsal striatum. Furthermore, diminished SYNCRIP in the dorsal striatum was necessary for MA abstinence-induced behavioral bias towards egocentric spatial learning. Taken together, our data revealed circulating miR-137 as a potential blood-based marker that could reflect MA abstinence-dependent changes in striatal miR-137/SYNCRIP axis, and striatal SYNCRIP as a potential therapeutic target for striatum-associated cognitive dysfunction by MA withdrawal syndrome.

关键词： Methamphetamine Abstinence Withdrawal Striatum miR-137 SYNCRIP Biomarker Behavior

Changing trends and characteristics of peptic ulcer disease:A multicenter study from 2010 to 2019 in Korea

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World Journal of Gastroenterology 2023年第44期29卷 5882-5893页

作者： Yoon Jin Choi Tae Jun Kim Chang Seok Bang Yong Kang Lee Moon Won Lee su Youn nam Woon Geon Shin Seung In Seo Department of Internal Medicine National Cancer CenterGoyang-si 13620South Korea Department of Internal Medicine Samsung Medical CenterSeoul 06351South Korea Department of Internal Medicine Chuncheon Sacred Heart HospitalChuncheon 24253South Korea Department of Internal Medicine National Health Insurance Service Ilsan HospitalGoyang-si 10444South Korea Department of Internal Medicine Pusan National University School of MedicineBusan 50463South Korea Division of Gastroenterology and Hepatology Department of Internal MedicineKyungpook National University Chilgok HospitalDaegu 41404South Korea Department of Internal Medicine Kangdong Sacred Heart HospitalHallym University College of MedicineSeoul 05355South Korea Institute for Liver and Digestive Diseases Hallym UniversityChuncheon 24253South Korea Division of Gastroenterology Department of Internal MedicineKangdong Sacred Heart HospitalSeoul 05355South Korea

BACKGROUND The clinical trend and characteristics of peptic ulcer disease(PUD)have not fully been investigated in the past *** To evaluate the changing trends and characteristics of PUD according to age and METHODS We analyzed seven hospital databases converted into the Observational Medical Outcomes Partnership-Common Data Model between 2010 and *** classified patients with PUD who underwent rapid urease tests or Helicobacter pylori(***)serology into three groups:***-related,drug[nonsteroidal anti-inflammatory drugs(NSAIDs)or aspirin]-related,and idiopathic(***/NSAID/aspirin-negative)PUD and compared the yearly trends and characteristics among the three *** We included 26785 patients in 7 databases,and the proportion of old age(≥65 years)was 38.8%.The overall number of PUD exhibited no decrease,whereas PUD in old age revealed an increasing trend(P=0.01 for trend).Of the 19601 patients,41.8%had ***-related,36.1%had drug-related,and 22.1%had idiopathic *** PUD exhibited a decreasing trend after 2014(P=0.01),drug-related PUD demonstrated an increasing trend(P=0.04),and idiopathic PUD showed an increasing trend in the old-age group(P=0.01)during 10 *** with drug-related PUD had significantly more comorbidities and concomitant ulcerogenic *** idiopathic PUD group had a significantly higher number of patients with chronic liver *** With the aging population increase,the effects of concomitant ulcerogenic drugs and preventive strategies should be investigated in drug-induced *** studies are required to clarify the relationship between idiopathic PUD and chronic liver disease.

关键词： Peptic ulcer disease Drug Idiopathic Trend Characteristics