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Prospective comparison of prophylactic antibiotic use between intravenous moxifloxacin and ceftriaxone for high-risk patients with post-ERCP cholangitis

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Hepatobiliary & Pancreatic Diseases International 2017年第5期16卷 512-518页

作者： nam Hee kim Hong Joo kim Ki Bae Bang Department of Internal Medicine Sungkyunkwan University Kangbuk Samsung Hospital Department of Internal Medicine Dankook University Hospital

BACKGROUND: The use of prophylactic antibiotics before endoscopic retrograde cholangiopancreatography(ERCP) is recommended by all major international gastroenterological societies, especially in the presence of an obstructed biliary system. This study compared the occurrence rate of post-procedural complications, including cholangitis and septicemia between prophylactic intravenous moxifloxacin and ceftriaxone in patients with bile duct obstruction scheduled for therapeutic ***: From November 2013 to July 2015, 86 consecutive patients with biliary obstruction with one or more factors predicting benefits of antibiotic prophylaxis prior to ERCP were included in the current randomized open-label non-inferiority trial(Clinical *** identifier NCT02098486). Intravenous moxifloxacin(400 mg/day) or ceftriaxone(2 g/day)were given 90 minutes before ERCP, and were administered for more than 3 days if the patient developed symptoms and signs of cholangitis or septicemia. Recalcitrant cholangitis was defined as persistence of cholangitis for more than 5 days after ERCP or recurrence of cholangitis within 30 days after ***: Recalcitrant cholangitis occurred in 1(2.3%) and 2(4.8%) patients receiving intravenous moxifloxacin and ceftriaxone group, respectively(P=0.612). Septicemia was noted in1(2.3%) and 1(2.4%) patient in intravenous moxifloxacin and ceftriaxone group, respectively(P=1.0). The mean hospital stay was also not significantly different between the moxifloxacin and ceftriaxone groups(8.8±7.2 vs 9.1±9.4 days, P=0.867). Antibiotic resistance of the isolated pathogens by in vitro activity assay was noted in 1(2.3%) and 2(4.8%) patients in the moxifloxacin and ceftriaxone group, respectively(P=0.612). CONCLUSION: Intravenous moxifloxacin is not inferior to intravenous ceftriaxone for the prophylactic treatment of post-ERCP cholangitis and cholangitis-associated morbidity.

关键词： endoscopic retrograde cholangiopancreatography cholangitis moxifloxacin ceftriaxone recalcitrant cholangitis

Complete resection of a huge hypervascular inflammatory myofibroblastic tumor in right hemithorax after embolization

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World Journal of Pediatrics 2016年第4期12卷 498-500页

作者： Kyu-nam kim Dong-Won kim Department of Anesthesiology and Pain Medicine Hanyang University HospitalRepublic of Korea

Background:Inflammatory myofibroblastic tumor(IMT)is a rare and mostly benign tumor that has the possibility of malignant ***:Radiological findings revealed a huge mass that filled most of the right hemithorax of a 17-month-old female *** extirpation was stopped due to massive bleeding and limited exposure of the *** was conducted to obstruct the arteries feeding the *** resection was ***:Histopathologic examination led to the diagnosis of *** recovery was ***:Hypervascularity of IMT should be *** embolization can be effective to reduce intraoperative blood loss and facilitate the surgical procedure.

关键词： embolization granuloma mediastinal neoplasms plasma cell

Stability for Leipholz’s Type of Laminated Box Columns with Nonsymmetric Lay-Ups on Elastic Foundation

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Advances in Applied Mathematics and Mechanics 2015年第2期7卷 158-179页

作者： nam-Il kim Jaehong Lee Department of Architectural Engineering Sejong University98 Kunja DongKwangjin KuSeoul 143-747Korea

The stability behavior of the Leipholz’s type of laminated box columns with nonsymmetric lay-ups resting on elastic foundation is investigated using theﬁnite el-ement *** on the kinematic assumptions consistent with the Vlasov beam theory,a formal engineering approach of the mechanics of the laminated box column-s with symmetric and nonsymmetric lay-ups is *** extended Hamilton’s principle is employed to obtain the elastic stiffness and mass matrices,the Rayleigh damping and elastic foundation matrices,the geometric stiffness matrix due to dis-tributed axial force,and the load correction stiffness matrix accounting for the uni-formly distributed nonconservative *** evaluation procedures for the critical values of divergence andﬂutter loads with/without internal and external damping ef-fects are brieﬂy *** examples are carried out to validate the present theory with respect to the previously published ***,the inﬂuences of theﬁber angle change and damping on the divergence andﬂutter loads of the laminated box columns are parametrically investigated.

关键词： Leipholz column laminate stability divergence ﬂutter ﬁnite element analysis

Appetite for Natech Risk Information in Japan:Understanding Citizens'Communicative Behavior Towards Risk Information Disclosure Around Osaka Bay

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International Journal of Disaster Risk Science 2022年第3期13卷 372-390页

作者： Dimitrios Tzioutzios Jeong-nam kim Ana Maria Cruz Department of Urban Management Graduate School of EngineeringKyoto UniversityKyoto615-8540Japan Gaylord College of Journalism and Mass Communication University of OklahomaNormanOK73019USA Disaster Prevention Research Institute Kyoto UniversityKyoto611-0011Japan

Effective risk communication is essential for disaster risk *** from empowering communities to make informed risk choices,risk information disclosure can also drastically enhance their disaster preparedness,especially concerning conjoint scenarios of technological and natural hazards(Natech).A fundamental precondition is the actual demand for such *** study ventures to assess whether residents around Osaka Bay have this demand,or"appetite,"for risk information disclosure,as well as to understand their communicative behavior and perceived challenges in the Japanese context through the prism of the Situational Theory of Problem *** test this framework under realistic conditions,data were collected through a household questionnaire survey from two urban areas near industrial complexes in Osaka *** results show that identifying Natech risk information deficiency as a problem was not a statistically significant predictor for individuals'motivation to ***,their motivation increased as their perceived personal involvement with the situation rose,while the perceived obstacles in doing something about it exerted a negative influence on their ***'motivation intensified their communicative actions to solve this *** segmentation underscored the elevated public perceptions concerning the issue of risk information deficiency in nearly nine out of ten *** findings indicate a strong community appetite for chemical and Natech risk information,which subsequently led to high situational motivation to engage in communicative action,particularly information *** management policy is suggested to focus on introducing chemical risk information disclosure regulatory initiatives to encourage citizen engagement.

关键词： Japan Natech risk information Participatory risk management Risk communication Situational Theory of Problem Solving(STOPS)

INVERTING GENERATING FUNCTIONS WITH INCREASED NUMERICAL PRECISION-A COMPUTATIONAL EXPERIENCE

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Journal of Systems Science and Systems Engineering 2011年第4期20卷 475-494页

作者： nam K. kim Mohan L. CHAUDHRY Bong K. YOON Kilhwan kim Department of Industrial Engineering Chonnam National University Department of Mathematics and Computer Science Royal Military College of Canada Defense Management College Korea National Defense University Internet Research Lab. Electronics and Telecommunications Research Institute

In this paper, we consider the numerical inversion of a variety of generating functions （GFs） that arise in the area of engineering and non-engineering fields. Three classes of GFs are taken into account in a comprehensive manner： classes of probability generating functions （PGFs） that are given in rational and non-rational forms, and a class of GFs that are not PGFs. Among others, those PGFs that are not explicitly given but contain a number of unknowns are largely considered as they are often encountered in many interesting applied problems. For the numerical inversion of GFs, we use the methods of the discrete （fast） Fourier transform and the Taylor series expansion. Through these methods, we show that it is remarkably easy to obtain the desired sequence to any given accuracy, so long as enough numerical precision is used in computations. Since high precision is readily available in current software packages and programming languages, one can now lift, with little effort, the so-called Laplacian curtain that veils the sequence of interest. To demonstrate, we take a series of representative examples： the PGF of the number of customers in the discrete-time Geo^X/Geo/c queue, the same in the continuous-time M^X/D/c queue, and the GFs arising in the discrete-time renewal process.

关键词： Queuing applied probability numerical inversion generating function

Stud welding for fixation of cryogenic insulation of membrane tanks in LNG ship building

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中国有色金属学会会刊：英文版 2009年第B9期19卷 271-275页

作者： Jeong-Soo LEE Young-Soo RYU nam-In kim Bong-Joon kim Yoo-Kyung kim Myung-Hyun kim Hanjin Heavy Industries & Construction Co. Ltd Department of Naval Architecture and Ocean Engineering Pusan National University

The support plates including all of the inner hulls such as E grade steel, weld seams and SUS304L were considered to establish the optimal stud welding condition in LNG ship building. The stainless steel plate was especially applied to the bracket on the liquid dome. The polished and etched surfaces of the welded stud and support plate were examined if the bead was properly formed. With the micrographic examination, the fusion boundary of metal weld zone formed by stud welding was analyzed to optimize the welding parameters. And also the analysis of the unacceptable welding faults such as cold and hot weld were performed. The mechanical tests such as tensile tests and bending tests were carried out to reveal any abnormal variation in the relationship of process parameters and the strength.

关键词：螺柱焊接 LNG船绝缘膜优化工艺参数低温坦克不锈钢板最佳条件

A Unified Buffering Management with Set Divisible Cache for PCM Main Memory

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Journal of Computer Science & Technology 2016年第1期31卷 137-146页

作者： Mei-Ying Bian Su-Kyung Yoon Jeong-Geun kim Sangjae nam Shin-Dug kim Department of Computer Science Yonsei University Seoul 120-749 Korea

This research proposes a phase-change memory （PCM） based main memory system with an effective combi- nation of a superblock-based adaptive buffering structure and its associated set divisible last-level cache （LLC）. To achieve high performance similar to that of dynamic random-access memory （DRAM） based main memory, the superblock-based adaptive buffer （SABU） is comprised of dual DRAM buffers, i.e., an aggressive superblock-based pre-fetching buffer （SBPB） and an adaptive sub-block reusing buffer （SBRB）, and a set divisible LLC based on a cache space optimization scheme. According to our experiment, the longer PCM access latency can typically be hidden using our proposed SABU, which can significantly reduce the number of writes over the PCM main memory by 26.44%. The SABU approach can reduce PCM access latency up to 0.43 times, compared with conventional DRAM main memory. Meanwhile, the average memory energy consumption can be reduced by 19.7%.

关键词： memory hierarchy memory structure,cache memory buffer management

Pharmacokinetics and tissue distribution of a novel PDE5 inhibitor,SK-3530,in rats

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Acta Pharmacologica Sinica 2007年第8期28卷 1247-1253页

作者： Hye-hyun YOO nam-sun kim Guang-jin Im Dong-hyun kim Bioanalysis and Biotransformation Research Center Korea Institute of Science & Technology Seoul 136-791Korea Life Science RD Center SK ChemicalsGyeonggi-do 440-300Korea

Aim:To investigate the pharmacokinetic profile and tissue distribution of a novelphosphodiesterase type 5 inhibitor,5-ethyl-2-{5-[4-（2-hydroxy-ethyl）-piperazine-1-sulfonyl]-2-propoxy-phenyl}-7-propyl-3,5-dihydro-pyrrolo（3,2-d）pyrimidin-4-one（SK-3530）,in rats after administration of the14C-labeled ***:The pharmacokinetic parameters of SK-3530 were measured based on the totalradioactivity and parent SK-3530 concentration in rat plasma after intravenousand oral *** tissue distribution of total radioactivity after a singleoral administration of[14C]SK-3530 at a dose of 40 mg/kg was *** protein binding rates of SK-3530 were assessed by in vitro and ex ***:The total radioactivity profiles showed linear *** maximum plasma concentration and area under the curve of the parent SK3530were 10%-20% compared to those of the total *** the oral admin-istration of[14C]SK-3530,the radioactivity was widely distributed in all tissues,and the tissue/plasma ratio of the radioactivity 1 h after administration was calcu-lated as 0.5-2.6 with the exception of excretory organs.A relatively high penetra-tion was shown in the adrenal glands,liver,and *** vitro and ex vivo plasmaprotein binding assay by ultrafiltration showed a considerably high binding rateof more than 97%.Conclusion:SK-3530 was relatively well absorbed in the gas-trointestinal tract and showed linear pharmacokinetics over the investigated ***-3530 had low oral bioavailability due to a high,first-pass metabolism.

关键词： SK-3530 PDE5 inhibitor pharmacokinetics tissue distribution rats

Evaluation of immobilizing agents as soil quality conditioners in addition to their metal(loid) immobilizing effect

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Pedosphere 2022年第2期32卷 307-316页

作者： Chaw Su LWIN Mina LEE Young-nam kim Gary OWENS Kwon-Rae kim Department of Soil and Water Science Yezin Agricultural UniversityYezinNaypyitaw 15013Myanmar Department of Smart-Agro Industry Gyeongsang National UniversityJinju 52725Korea Institute of Agriculture and Life Science(IALS) Gyeongsang National UniversityJinju 52828Korea Environmental Contaminants Group Future Industries InstituteUniversity of South AustralianMawson Lakes SA 5095Australia

In trace metal (TM)-contaminated agricultural soils,management of TM availability is important for safe crop *** addition,maintenance or improvement of soil quality is vital for sustainable crop *** TM phytoavailability and increased soil quality can be achieved by the application of various immobilizing agents to soil,which can supply both macronutrients and organic *** study investigated the long-term influences of four common immobilizing agents on soil biogeochemical properties and the phytoavailability of TMs in mixed metal-contaminated soil from a cultivated upland near an abandoned mining *** (L),gypsum (G),fly ash (F),and animal manure-based compost (C) were applied to pots containing contaminated soil,either individually or in *** incubation for three years under sequential cultivation of two crops and fallow,soil biogeochemical properties were determined,and Brassica rapa plant bioassay was *** phytoavailability of all TMs (both cationic metals and anionic metalloids) remained significantly lower in soils treated with immobilizing agents even after three years,when compared with the no-agent control (CK) *** addition,the soil quality was significantly improved by treatment with immobilizing *** instance,the C and L+C treatments were the most effective in improving soil physical (bulk density,porosity,and water-resistant aggregate stability),chemical (pH,organic matter,total nitrogen,cation exchange capacity,and plant-available phosphorus,magnesium,and potassium),and biological (microbial biomass carbon and dehydrogenase activity) *** improvement of soil properties and lowering of TM bioavailability were also consistent with the most significant increase in *** biomass production observed in the C treatment,followed by the L+C,G+F,L,G,F,and L+G treatments,as compared with that in *** results indicate that the function of the TM-immobilizing agent as a soil qualit

关键词： crop production metal bioavailability metal immobilization metal phytoavailability soil amendments soil biogeochemical properties soil remediation trace metals