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Fragmentation stability and retention time-shift obtained by LC-MS/MS to distinguish sialylated N-glycan linkage isomers in therapeutic glycoproteins

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Journal of Pharmaceutical Analysis 2023年第3期13卷 305-314页

作者： Chi soo Park Minju Kang Ahyeon kim Chulmin Moon Mirae kim Jieun kim Subin Yang Leeseul Jang Ji Yeon Jang Ha Hyung kim Department of Global Innovative Drugs Graduate School of Chung-Ang UniversitySeoul06974Republic of Korea

Sialylated N-glycan isomers withα2-3 orα2-6 linkage(s)have distinctive roles in glycoproteins,but are difficult to ***-type(WT)and glycoengineered(mutant)therapeutic glycoproteins,cytotoxic T lymphocyte-associated antigen-4-immunoglobulin(CTLA4-Ig),were produced in Chinese hamster ovary cell lines;however,their linkage isomers have not been *** this study,N-glycans of CTLA4-Igs were released,labeled with procainamide,and analyzed by liquid chromatography-tandem mass spectrometry(MS/MS)to identify and quantify sialylated N-glycan linkage *** linkage isomers were distinguished by comparison of 1)intensity of the N-acetylglucosamine ion to the sialic acid ion(Ln/Nn)using different fragmentation stability in MS/MS spectra and 2)retention time-shift for a selective m/z value in the extracted ion *** isomer was distinctively identified,and each quantity(>0.1%)was obtained relative to the total N-glycans(100%)for all observed ionization *** sialylated N-glycan isomers with onlyα2-3 linkage(s)in WT were identified,and each isomer's sum of quantities was 50.4%.Furthermore,39 sialylated N-glycan isomers(58.8%)in mono-(3 N-glycans;0.9%),bi-(18;48.3%),tri-(14;8.9%),and tetra-(4;0.7%)antennary structures of mutant were obtained,which comprised mono-(15 N-glycans;25.4%),di-(15;28.4%),tri-(8;4.8%),and tetra-(1;0.2%)sialylation,respectively,with onlyα2-3(10 N-glycans;4.8%),bothα2-3 andα2-6(14;18.4%),and onlyα2-6(15;35.6%)linkage(s).These results are consistent with those forα2-3 neuraminidase-treated *** study generated a novel plot of Ln/Nn versus retention time to distinguish sialylated N-glycan linkage isomers in glycoprotein.

关键词： Therapeutic glycoprotein Sialylation Linkage isomer LC-MS/MS

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Synthesis and characterization of red-emitting Yb/Ho-CaSiO3 upconversion phosphors

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Progress in Natural Science:Materials International 2022年第5期32卷 594-601页

作者： Bina Chaudhary Yuwaraj K.Kshetri Dhani Ram Dhakal soo Wohn Lee Tae-Ho kim Department of Fusion Science and Technology Sun Moon University Research Center for Green Advance Materials Sun Moon University Department of Environmental and Bio-Chemical Engineering Sun Moon University

Host material plays an important role in obtaining efficient photon upconversion and downshifting ***, fluoride and oxyfluoride glasses-based materials are used for high-efficiency photon ***, the poor thermal stability of fluoride glasses and the toxicity of fluorine ions limit their applications. In this report, Yb/Ho-doped CaSiO3wollastonite phosphors have been demonstrated as efficient red-emitting upconversion phosphors. The phosphors have been synthesized by microwave hydrothermal process followed by heat treatment at 1050°C in the air environment. 2M phase of the β-wollastonite has been confirmed by X-ray diffraction and Raman spectroscopy while the existence of the Yb and Ho dopants in the CaSiO3lattice has been confirmed by X-ray photoelectron spectroscopy. The synthesized samples showed strong red upconversion emission centered at 662 nm and near-infrared downshifting emissions at 2016 nm upon 980 nm excitation. The emissions were found to depend significantly on the Ho concentration. Temporal evolution of the main emission bands was investigated to show that the energy transfer upconversion from Yb to Ho ions was responsible for the efficient upconversion and downshifting phenomenon.

关键词： Wollastonites Upconversion Downshifting Red-emitting phosphors

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A Review on Interface Engineering of MXenes for Perovskite Solar Cells

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Nano-Micro Letters 2023年第8期15卷 270-308页

作者： Srikanta Palei G.Murali Choong‑Hee kim Insik In Seul‑Yi Lee soo‑Jin Park Department of Chemistry Inha University100 InharoIncheon 22212South Korea Department of Polymer Science and Engineering Department of IT‑Energy Convergence(BK21 Four)Chemical Industry InstituteKorea National University of TransportationChungju 27469South Korea

With an excellent power conversion efficiency of 25.7%,closer to the Shockley–Queisser limit,perovskite solar cells(PSCs)have become a strong candidate for a next-generation energy ***,the lack of stability and reliability in PSCs remained challenging for ***,such as interfacial and structural engineering,have a more critical influence on enhanced ***,two-dimensional materials,have emerged as promising materials in solar cell applications due to their metallic electrical conductivity,high carrier mobility,excellent optical transparency,wide tunable work function,and superior mechanical *** to different choices of transition elements and surface-terminating functional groups,MXenes possess the feature of tuning the work function,which is an essential metric for band energy alignment between the absorber layer and the charge transport layers for charge carrier extraction and collection in ***,adopting MXenes to their respective components helps reduce the interfacial recombination resistance and provides smooth charge transfer paths,leading to enhanced conductivity and operational stability of *** review paper aims to provide an overview of the applications of MXenes as components,classified according to their roles as additives(into the perovskite absorber layer,charge transport layers,and electrodes)and themselves alone or as interfacial layers,and their significant importance in PSCs in terms of device performance and ***,we discuss the present research status and future directions toward its use in PSCs.

关键词： MXenes Perovskite solar cells Additives Interfacial layer Electrodes

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Uterine rupture due to adenomyosis in an adolescent:A case report and review of literature

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World Journal of Clinical Cases 2023年第32期11卷 7888-7894页

作者： Nah Ihm kim Ji Shin Lee Jong Hee nam Department of Pathology Chonnam National University HospitalGwangju 61469South Korea Department of Pathology Chonnam National University Hwasun HospitalHwasun 58128South Korea Department of Pathology Chonnam National University Medical SchoolGwangju 61469South Korea

BACKGROUND Uterine rupture is a fatal medical complication with a high mortality *** cases of uterine rupture occur in late pregnancy or during labor and are mainly related to uterine scarring due to previous surgical *** is a possible risk factor for uterine ***,spontaneous uterine rupture due to severe adenomyosis in a non-gravida-teenaged female has not been reported in the literature to *** SUMMARY A 16-year-old girl was referred to our hospital for acute abdominal pain and hypovolemic shock with a blood pressure of 90/50 *** studies revealed a huge endometrial mass with multiple nodules in the lung,suggesting lung *** patient underwent an emergency total hysterectomy and wedge resection of the lung ***,the uterus showed diffuse adenomyosis with glandular and stromal *** nodules were endometrioma with massive *** demonstrated that the tumor cells were positive for PAX8,ER,and PR expression,leading to a final diagnosis of pulmonary endometriosis and uterine *** surgery,the patient remains in good condition without *** This is the first case of spontaneous uterine rupture due to adenomyosis in a nongravida adolescent.

关键词： Uterus Adenomyosis Malignancy Endometrioma Case report

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A new analytical approach for identifying market contagion

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Financial Innovation 2022年第1期8卷 1097-1131页

作者： Hee soo Lee Tae Yoon kim Department of Business Administration Sejong University209 Neungdong-ro Gwangjin-guSeoul 05006Korea Department of Statistics Keimyung University1095 Dalgubeol-daeroDaegu 704-701Korea.

This study proposed a new analytical approach to identify the excessive comovement of two markets as *** goal is achieved by linking latent-factor and single-equation error correction models and evaluating the breaks in the short-and long-term relationships and correlatedness in the linked *** results demonstrated that a short-term relationship representing the market speed ratio between two markets plays a key role in contagion *** a long-term relationship or correlatedness is broken(comovement change)due to a break in the short-term relationship(market speed ratio),contagion is highly likely and should be formally *** posterior probabilities were calculated to determine the ***,this study applied this analytical Bayesian approach to empirically test the contagion effects of the *** market during the global financial crisis between 2007 and 2009 using 22 developed equity markets.

关键词： Contagion test Market integration Bayesian approach Comovement Market speed ratio

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Effects of electroacupuncture on the functionality of NG2-expressing cells in perilesional brain tissue of mice following ischemic stroke

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Neural Regeneration Research 2022年第7期17卷 1556-1565页

作者： Hong Ju Lee Da Hee Jung nam Kwen kim Hwa Kyoung Shin Byung Tae Choi Department of Korean Medical Science School of Korean MedicinePusan National UniversityYangsanRepublic of Korea Graduate Training Program of Korean Medicine for Healthy Aging Pusan National UniversityYangsanRepublic of Korea Department of Korean Ophthalmology Otolaryngology and DermatologySchool of Korean MedicinePusan National UniversityYangsanRepublic of Korea

Neural/glial antigen 2(NG2)-expressing cells has multipotent stem cell activity under cerebral *** study examined the effects of electroacupuncture(EA)therapy(2 Hz,1 or 3 mA,20 minutes)at the Sishencong acupoint on motor function after ischemic insult in the brain by investigating the rehabilitative potential of NG2-derived cells in a mouse model of ischemic *** stimulation alleviated motor deficits caused by ischemic stroke,and 1 mA EA stimulation was more efficacious than 3 mA EA stimulation or positive control treatment with edaravone,a free radical *** properties of NG2-expressing cells were altered with 1 mA EA stimulation,enhancing their survival in perilesional brain tissue via reduction of tumor necrosis factor alpha *** stimulation robustly activated signaling pathways related to proliferation and survival of NG2-expressing cells and increased the expression of neurotrophic factors such as brain-derived neurotrophic factor,tumor growth factor beta,and neurotrophin *** the perilesional striatum,EA stimulation greatly increased the number of NG2-expressing cells double-positive for oligodendrocyte,endothelial cell,and microglia/macrophage markers(CC1,CD31,and CD68).EA therapy also greatly activated brain-derived neurotrophic factor/tropomyosin receptor kinase B and glycogen synthase kinase 3 beta *** results indicate that EA therapy may prevent functional loss at the perilesional site by enhancing survival and differentiation of NG2-expressing cells via the activation of brain-derived neurotrophic factor-induced signaling,subsequently ameliorating motor *** animal experiments were approved by the Animal Ethics Committee of Pusan National University(approval ***2019-2199 and PNU2019-2884)on April 8,2019 and June 19,2019.

关键词： brain-derived neurotrophic factor differentiation electroacupuncture motor function neural/glial antigen 2 perilesional striatum stroke survival

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Novel extended C-m models of flow stress for accurate mechanical and metallurgical calculations and comparison with traditional flow models

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Journal of Magnesium and Alloys 2022年第9期10卷 2516-2533页

作者： Man soo Joun Mohd Kaswandee Razali Jae Dong Yoo Min Cheol kim Jeong Muk Choi ReCAFT Gyeongsang National UniversityGraduate School of Mechanical and Aerospace EngineeringJinju 52828South Korea Gyeongsang National University Graduate School of Mechanical and Aerospace EngineeringJinju 52828South Korea MFRC Research CenterJinju 52818South Korea Jinhap Daejeon 34302South Korea

Here,we developed novel extended piecewise bilinear power law(C-m)models to describe flow stresses under broad ranges of strain,strain rate,and temperature for mechanical and metallurgical calculations during metal forming at elevated *** traditional C-m model is improved upon by formulating the material parameters C and m,defined at sample strains and temperatures as functions of the strain *** coefficients are described as a linear combination of the basis functions defined in piecewise patches of the sample strain and temperature domain.A comparison with traditional closed-form function flow models revealed that our approach using the extended piecewise bilinear C-m model is superior in terms of accuracy,ease of use,and adaptability;additionally,the extended C-m model was applicable to numerical analysis of mechanical,metallurgical,and microstructural ***,metallurgy-related values can be calculated directly from the flow stress *** the proposed model was developed for materials at elevated temperatures,it can be applied over a broad temperature range.

关键词： Flow stress Power law model Piecewise bilinear function Numerical analysis Microstructural prediction Peak strain

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Expert recommendation system based on analyzing expertise and networks of human resources in National Science & Technology Information Service

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Journal of Central South University 2013年第8期20卷 2212-2218页

作者： YANG Myung-seok KANG nam-kyu kim Yun-jeong kim Jae-soo CHOI Kwang-nam kim Young-kuk NTIS Center Korea Institute of Science and Technology Information Department Of Computer Science and Engineering Chungnam National University

This work aims to implement expert and collaborative group recommendation services through an analysis of expertise and network relations NTIS. First of all, expertise database has been constructed by

关键词：专业知识网络分析推荐系统人力资源专家基础学分权值计算

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Boost Up the Mechanical and Electrical Property of CNT Fibers by Governing Lyotropic Liquid Crystalline Mesophases with Aramid Polymers for Robust Lightweight Wiring Applications

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Advanced Fiber Materials 2023年第2期5卷 514-526页

作者： Ki‑Hyun Ryu Jeong‑Gil kim Dongju Lee Seo Gyun kim Bon‑Cheol Ku Jun Yeon Hwang Kwang‑Un Jeong nam Dong kim Dae‑Yoon kim Functional Composite Materials Research Center Korea Institute of Science and TechnologyWanju 55324Republic of Korea Carbon Composite Materials Research Center Korea Institute of Science and TechnologyWanju 55324Republic of Korea Department of Polymer‑Nano Science and Technology Department of Nano Convergence EngineeringJeonbuk National UniversityJeonju 54896Republic of Korea Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and TechnologyDaejeon 34141Republic of Korea

Monofilament type of polyaromatic amide(PA)and carbon nanotube(CNT)composite fibers is presented.A concept of a lyotropic liquid crystal(LLC)constructed via a spontaneous self-assembly is introduced to mitigate the extremely low com-patibility between PA and *** approaches provide an effective co-processing route of PA and CNT simultaneously to fabricate the uniform,continuous,and reliable composite fibers through a ***,the addition of a small amount PA into the dope solution of CNT governs the LLC mesophase not only in a spinneret stage but also in a coagulant ***,the developed PA/CNT composite fibers have the high uniaxial orientational order and the close interfacial packing compared to the pure CNT *** PA/CNT composite fibers achieve the outstanding tensile strength,electrical conductivity,and electrochemical response,while maintaining a *** also exhibit the chemical,mechanical,and thermal *** of these advantages can make flexible,sewable,and washable PA/CNT composite fibers ideal nanocomposite materials for use in next-generation information and energy transporting system by replacing conventional metal electrical conductors.

关键词： Carbon nanotube Aramid polymer Liquid crystal Composite fiber Electrical wire

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Neotectonic transpressional intraplate deformation in eastern Eurasia: Insights from active fault systems in the southeastern Korean Peninsula

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Geoscience Frontiers 2023年第4期14卷 123-136页

作者： namgwon kim Seung-Ik Park Chang soo Cho Youngbeom Cheon Alexander L.Peace Department of Geology Kyungpook National UniversityDaegu 41566Republic of Korea Earthquake Research Center Korea Institute of Geosciences and Mineral ResourcesDaejeon 34132Republic of Korea Active Tectonics Research Center Korea Institute of Geosciences and Mineral ResourcesDaejeon 34132Republic of Korea School of Earth Environment and SocietyMcMaster UniversityHamiltonON L8S 4K1Canada

Transpression occurs in response to oblique convergence across a deformation zone in intraplate regions and plate *** Korean Peninsula is located at an intraplate region of the eastern Eurasian Plate and has been deformed under the ENE–WSW maximum horizontal compression since the late *** this study,we analyzed short-term instrumental seismic(focal mechanism)and long-term paleoseis-mic(Quaternary fault outcrop)data to decipher the neotectonic crustal deformation pattern in the south-eastern Korean ***(paleo-)seismic data acquired from an NNE–SSW trending deformation zone between the Yangsan and Ulleung fault zones indicate spatial partitioning of crustal deformation by NNW–SSE to NNE–SSW striking reverse faults and NNE–SSW striking strike-slip faults,supporting a strike-slip partitioned transpression *** instantaneous and finite neotectonic strains,estimated from the focal mechanism and Quaternary outcrop data,respectively,show discrepan-cies in their axes,which can be attributed to the switching between extensional and intermediate axes of finite strain during the accumulation of wrench-dominated ***,some major faults,including the Yangsan and Ulsan fault zones,are relatively misoriented to slip under the current stress condition but,paradoxically,have more(paleo-)seismic records indicating their role in accommodating the neotectonic transpressional *** propose that fluids,heat flow,and lithospheric structure are potential factors affecting the reactivation of the relatively misoriented major *** findings provide insights into the accommodation pattern of strain associated with the neotectonic crustal extrusion in an intraplate region of the eastern Eurasian Plate in response to the collision of the Indian Plate and the sub-duction of the Pacific/Philippine Sea Plates.

关键词： Transpression Strike-slip partition Intraplate strain accommodation Fault-slip analysis Slip tendency analysis

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