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Crohn's disease and risk of fracture: does thyroid disease play a role?

World Journal of Gastroenterology 2003年第3期9卷 615-618页

作者： nakechand pooran Pankaj Singh Simmy Bank Division of Gastroenterology Albert Einstein College of Mcdicine-Long Island Jewish Medical Center New Hyde Park New YorkUSA

AIM: To assess the role of thyroid disease as a risk for fractures in Crohn's ***: A cross-sectional study was conducted from 1998 to 2000. The study group consisted of 210 patients with Crohn's disease. A group of 206 patients without inflammatory bowel disease served as controls. Primary outcome was thyroid disorder. Secondary outcomes included use of steroids, immunosuppressive medications, surgery and incidence of ***: The prevalence of hyperthyroidism was similar in both groups. However, the prevalence of hypothyroidism was lower in Crohn's patients (3.8 % vs 8.2 %, P=0.05).Within the Crohn's group, the use of immunosuppressive agents (0 % vs11 %), steroid usage (12.5 % vs37 %), small bowel surgery (12.5 % vs 28 %) and large bowel surgery (12.5 % vs27 %) were lower in the hypothyroid subset as compared to the euthyroid subset. Seven (3.4 %) Crohn'spatients suffered fracture, all of whom were ***: Thyroid disorder was not found to be associated with Crohn's disease and was not found to increase the risk for fractures. Therefore, screening for thyroid disease is not a necessary component in the management of Crohn's disease.

关键词： Adult Aged Crohn Disease Cross-Sectional Studies Fractures, Bone Humans Hyperthyroidism Hypothyroidism Incidence Middle Aged Retrospective Studies Risk Factors

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