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Rapid Magnetic 3D Printing of Cellular Structures with MCF-7 Cell Inks

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Research 2019年第1期2019卷 1183-1195页

作者： S.Mishriki A.R.Abdel Fattah t.Kammann R.P.Sahu F.Geng I.K.Puri School of Biomedical Engineering McMaster UniversityHamiltonOntarioCanada Department of Mechanical Engineering McMaster UniversityHamiltonOntarioCanada Faculty of Biological Sciences Friedrich-Schiller-University JenaGermany

A contactless label-free method using a diamagnetophoretic ink to rapidly print three-dimensional(3D)scafold-free multicellular structures is *** inks consist of MCF-7 cells that are suspended in a culture medium to which a paramagnetic salt,diethylenetriaminepentaacetic acid gadolinium(III)dihydrogen salt hydrate(Gd-DtPA),is *** a magnetic feld is applied,the host fuid containing the paramagnetic salt is attracted towards regions of high magnetic feld gradient,displacing the ink towards regions with a low *** this method,3D structures are printed on ultra-low attachment(ULA)*** a tissue culture treated(tCt)surface,a 3D printed spheroid coexists with a two-dimensional(2D)cell monolayer,where the composite is termed as a 2.5D *** 3D structures can be magnetically printed within 6 hours in a medium containing 25 mM *** infuence of the paramagnetic salt on MCF-7 cell viability,cell morphology,and ability of cells to adhere to each other to stabilize the printed structures on both ULA and tCt surfaces is *** expressions of hypoxia-inducible factor 1-alpha(HIF1�)and vascular endothelial growth factor(VEGF)allow comparison of the relative stresses for the printed 3D and 2.5D cell geometries with those for 3D spheroids formed without magnetic *** magnetic printing method can be potentially scaled to a higher throughput to rapidly print cells into 3D heterogeneous cell structures with variable geometries with repeatable dimensions for applications such as tissue engineering and tumour formation for drug discovery.

关键词： structure culture dimensions

Using mixed integer programming and airborne laser scanning to generate forest management units

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Journal of Forestry Research 2022年第1期33卷 217-226页

作者： Adrián Pascual Sándor Ftóth Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349-017 LisboaPortugal School of Forest Sciences University of Eastern FinlandP.O.Box 11180101 JoensuuFinland School of Environmental and Forest Sciences University of WashingtonSeattleWAUSA

Airborne laser scanning(ALS)has been widely applied to estimate tree and forest attributes,but it can also drive the segmentation of forest *** algorithms are the dominant technique in segmentation but spatial optimization using exact methods remains *** study presents a novel approach to segmentation based on mixed integer programming to create forest management units(FMUs).this investigation focuses on using raster information derived from ALS *** mainstream clustering algorithms were compared to the new MIP formula that simultaneously accounts for area and adjacency restrictions,FMUs size and homogeneity in terms of vegetation *** optimal problem solution was found when using less than 150 cells,showing the problem formulation is *** results for MIP were better than for the clustering algorithms;FMUs were more compact based on the intravariation of canopy height and the variability in size was *** MIP model allows the user to strictly control the size of FMUs,which is not possible in heuristic optimization and in the clustering algorithms *** definition of forest management units based on remote sensing data is an important operation and our study pioneers the use of MIP ALS-based optimal segmentation.

关键词： Segmentation Precision forestry Optimization Mathematical programming Airborne laser scanning

the complexity of providing humanitarian surgical care in armed conflict: a framework to help categorize needs

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Emergency and Critical Care Medicine 2022年第2期2卷 41-44页

作者： Kevin Gianaris Barclay t.Stewart Sherry M.Wren Adam L.Kushner Indiana University School of Medicine IndianapolisINUSA Department of Surgery University of WashingtonSeattleWAUSA Harborview Injury Prevention and Research Center University of WashingtonSeattleWAUSA Department of Surgery Stanford UniversityPalo AltoCAUSA Surgeons OverSeas New York CityNYUSA Department of International Health Bloomberg School of Public HealthJohns Hopkins UniversityBaltimoreMDUSA

Armed conflicts are increasing globally due to political unrest and the broader effects of climate *** resources to provide quality surgical care,it becomes nearly impossible to provide quality emergency surgery and trauma care similar to that in high-income *** understand and help aid organizations provide resources and address the surgical needs of populations facing armed conflict,a matrix to identify variables and help with interventions was *** published global surgery matrix based on the PIPES(Personnel,Infrastructure,Procedures,Equipment and Supplies)surgical capacity tool was adapted to this *** novel matrix incorporates 108 *** variables are grossly divided into local and international agency components to address the issue of who is providing *** a time continuum of pre-conflict,conflict,and post-conflict allows organizations to concentrate on when during the conflict to target their *** addition to the previously used personnel,infrastructure,procedures,equipment,and supplies categories,a sixth category called standards was included that addresses the issues such as information technology,data systems,quality improvement programs,and patient *** testing of this matrix to obtain feedback from end users is the next step in ***,peri-conflict preparedness should increase and improve surgical outcomes and reduce in death and disabilities around the world.

关键词： Armed conflict Emergency care Global surgery Humanitarian assistance trauma care

Percutaneous coronary interventions in the elderly:a 10-year experience in Northern New England

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Journal of Geriatric Cardiology 2005年第1期2卷 17-22页

作者： David J.Malenka James t.DeVries Samuel J.Shubrooks for the Northern New England Cardiovascular Disease Study Group Section of Cardiology Dartmouth-Hitchcock Medical Center LebanonNH Center for the Evaluative Clinical Sciences Dartmouth Medical SchoolHanoverNHUSA for the Northern New England Cardiovascular Disease Study Group Section of Cardiology Dartmouth-Hitchcock Medical Center LebanonNHUSA for the Northern New England Cardiovascular Disease Study Group Division of Cardiology Beth Israel-Deaconess Medical Center BostonMAUSA Jr

Background there is a paucity of information available for clinical decision making applying to the elderly patient population. therefore, data of percutaneous coronary interventions (PCI) including demographic information on the elderly patients, procedural practices, and outcomes are needed. Objectives and Methods From consecutive PCIs of participating institutions, demographics data, clinical, angiographic success and adverse clinical outcomes were collected. Standard statistical methods were used to compare crude differences in patient and procedural characteristics across age groups. Results At baseline, the prevalence of comorbid conditions ( renal failure and heart failure) increased with age. Unstable angina or a non-St elevation MI were the most common indications for PCI across all age groups. Fewer patients ≥ 80 years old were undergoing primary PCI and older patients were somewhat less likely to receive a Ⅱb/Ⅲa receptor blocker. Slightly more patients ≥ 80 years old underwent a 2-vessel PCI ( consistent with them having more multivessel disease) and these patients were more likely to have an intervention on a type C lesion. Compared to patients ＜ 50 years old, those aged ≥ 70 years old had a significantly increased risk of death, MI, stroke, or vascular complications at the access site. Conclusions this study suggests increasing age is associated with increasing risk for an adverse outcome following PCI. this is in part attributable to case-mix but likely, also related to the changing physiology of aging. Despite the increased risk of the procedure, the clinical success rate for PCI is quite high and makes it a reasonable alternative for the treatment of CAD in the elderly.

关键词： coronary artery disease elderly percutaneous coronary intervention

MORPHOtROPIC PHASE BOUNDARY AND DIELECtRIC RELAXAtION StUDY OF(Bi_(0.5)Na_(0.5))tiO_(3)-BatiO_(3)LEAD-FREE CERAMIC

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Journal of Advanced Dielectrics 2012年第3期2卷 34-46页

作者： B.PARIJA S.PANIGRAHI t.BADAPANDA t.P.SINHA Department of Physics National Institute of Technology Rourkela-769008India C.V.Raman College of Engineering Bhubaneswar Department of Physics Bose Institute 93/1 A.P.C.RoadKolkata-700009India

We report the temperature and frequency dependence impedance spectroscopy of(1-x)(Bi_(0.5)Na_(0.5))tiO_(3-x)BatiO_(3)(abbreviated as BNt-Bt)ceramics with 0≤x≤0.07 prepared by conventional solid-state route.X-ray diffraction analysis indicated that a solid solution is formed when BatiO_(3)diffuses into the(Bi_(0.5)Na_(0.5))tiO_(3)lattice and a morphotropic phase boundary between rhombohedral and tetragonal locates at x=*** microstructure indicated that the grain size reduces and the shape changes from rectangular to quasi-spherical with increase in BatiO_(3)*** Impedance Spectroscopy analysis suggested the presence of temperature-dependent relaxation process in the *** modulus mechanism indicated the nonDebye type of conductivity relaxation in the materials,which is supported by impedance *** activation energies have been calculated from impedance,electric modulus studies and dc conductivity which suggests that the conductions are ionic in *** activation energy increases with increase of Bt content up to x=0.05 and decreases at x=0.07 which also indicates the presence of morphotropic phase boundary at x=0.07.

关键词： Morphtropic phase boundary(MPB) impedance spectroscopy electrical modulus relaxations conductivity

Modern imaging of the tracheo-bronchial tree

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World Journal of Radiology 2010年第7期2卷 237-248页

作者： Archana t Laroia Brad H thompson Sandeep t Laroia Edwin JR van Beek Department of Radiology University of Iowa Hospitals and Clinics Clinical Research Imaging Centre Queen's Medical Research InstituteUniversity of Edinburgh

Recent state-of-the-art computed tomography and improved three-dimensional(3-D) postprocessing techniques have revolutionized the capability of visualizing airway pathology,offering physicians an advanced view of pathology and allowing for appropriate management *** article is a comprehensive review of trachea and main bronchi imaging,with emphasis on the dynamic airway anatomy,and a discussion of a wide variety of diseases including,but not limited to,congenital large airway abnormalities,tracheobronchial stenoses,benign and malignant neoplasms and *** importance of multiplanar reconstruction,3-D reconstruction and incorporation of dynamic imaging for non-invasive evaluation of the large airways is stressed.

关键词： Computed tomography trachea Bronchial tree Airways Advanced imaging

Binding Reaction of Hemin with Chloroquine, Quinine and Quinidine in Water-propylene Glycol Mixture

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Chinese Journal of Chemistry 2003年第8期21卷 1022-1025页

作者： MAVAKALA B. K. NLANDU B. B. MPIANA P. t. GUSHIMANA Z. Y. 尉志武 Ministry of Education Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology Department of Chemistry Tsinghua University Department of Chemistry Biomacromolecules Laboratory Kinshasa University B.P. 190 Kinshasa R. D. Congo

the interaction of hemin with chloroquine, quinine and quini-dine wasinvestigated in 50% water-propylene glycol mixture at pH = 9, 8.1, 7.4 and 6.8 using aspectrophotometric method. the data could be well fitted into a model consistent with the formationof a 1:1 complex between the reacting partners. In addition, the results indicated that hemincomplexed more strongly with quinidine than with chloroquine and quinine, and the binding constantswere pH-dependent. Moreover, it was proved that the water-propylene glycol mixture is well suitableto the study of the systems containing hemin and quinoline-based drugs.

关键词： hemin antimalarial drug complex pH-depen- dence propylene glycol

Heterocyclic benzoxazole-based liquid crystals:Synthesis and mesomorphic properties

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Chinese Chemical Letters 2011年第10期22卷 1191-1194页

作者： Sie tiong Ha Kok Leei Foo Ramesh t.Subramaniam Masato M.Ito S.Sreehari Sastry Siew teng Ong Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul RahmanJln UniversitiBandar Barat31900 KamparPerakMalaysia Center for Ionics University Malaya Department of Physics Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia Faculty of Engineering Soka University1-236 Tangi-choHachiojiTokyo 192-8577Japan Department of Physics Acharya Nagarjuna UniversityNagarjuna Nagar 522 510India

New Schiff base liquid crystals containing benzoxazole core and alkanoyloxy chain at the end group of the molecules （C_（n-1）H_（2n-1）COO-,n=14,16,18） was *** present compounds are enantiotropic smectic A liquid *** was also found that the end groups of the molecules and polar chloro substituent at the benzoxazole fragment had effect on the mesomorphic properties.

关键词： Schiff bases Benzoxazoles Mesomorphic Smectic A Structure-property relationship

Hepatitis C virus treatment with glecaprevir and pibrentasvir in patients co-prescribed carbamazepine:three case reports

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World Journal of Gastrointestinal Pharmacology and therapeutics 2023年第4期14卷 33-38页

作者： Michael Braude Dilip t Ratnam Louise Marsh Joshua H Abasszade Anouk t Dev Department of Gastroenterology and Hepatology Monash HealthClayton 3168VICAustralia General Practice Margaret River Medical CentreMargaret River 6285Australia

BACKGROUND Highly effective and well-tolerated direct-acting antiviral(DAA)therapies have revolutionised the management of hepatitis C virus(HCV);however,niche populations face treatment *** co-prescribed with several firstgeneration anti-epileptic drugs(AEDs)are contraindicated due to drug-drug interactions.A common example is carbamazepine whereby steady-state carbamazepine reduces the maximum concentration and area under the curve of velpatasvir,glecaprevir and pibrentasvir due to potent cytochrome P450(CYP)3A4 *** also induces P-glycoprotein which reduces glecaprevir and pibrentasvir’s area under curve to infinite *** and glecaprevir-pibrentasvir are contraindicated in patients who are co-prescribed carbamazepine due to the risk of reduced DAA therapeutic effect and consequently,virological treatment *** presents a challenge for patients in whom carbamazepine substitution is medically unfeasible,impractical or ***,the properties of current generation DAA therapies,including high-potency non-structural protein 5A inhibitory effect,may be sufficient to overcome reduced bioavailability arising from carbamazepine related CYP 3A4 and P-glycoprotein *** SUMMARY We present a case series of three patients with non-cirrhotic,treatment-naïve,genotype 1a,1b,and 3a HCV who were treated with a 12 wk course of glecaprevir-pibrentasvir,while co-prescribed carbamazepine for seizure ***-pibrentasvir combination therapy was chosen due to its potent in vitro activity and low barrier to pan-genotypic resistance associated *** therapy was dose-separated from carbamazepine to maximise time to peak concentration,and taken with meals to improve *** virological response at 12 wk was achieved in each patient with no adverse *** DAA therapies,including glecaprevir-pibrentasvir,warrant consideration as a therapeutic agent in people with HCV w

关键词： Antiepileptic drugs Drug interactions Hepatitis C virus Sustained virological response Health care access Case repor