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Biochemical and Immunochemical Characterization of Caenorhabditis elegans Metallothioneins I and II Induced by Cadmium

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Biomedical and Environmental Sciences 1990年第3期3卷 315-325页

作者： MASAOMI KONDO masayoshi IMAGAWA KOHJI MARUYAMA YOSHIHIRO OKADA SUSUMU TSUNASAWA TSUTOMU NISHIHARA Faculty of Pharmaceutical Sciences Institute for Protein Research Osaka University Suita Osaka 565Japan

Metallothioneins in Caenorhahditis elegans (CeMT-Ⅰ and Ⅱ) were punned by the combination of gel filtration ion-exchange *** high-performance liquid *** acid compositions and amino-terminal sequences of CeMT-Ⅰ and Ⅱ were slightly different from those of vertebrate MTs previously reported, although cysteine residue contents were relatively *** immunoassay using anti-CeMT-Ⅱ antibody showed the difference of antigenicity to rat MT-Ⅰ and Ⅱ and even to CeMT-Ⅰ. Immunohistochemical staining revealed the existence of CeMT-Ⅱ in the intestine and the eggs, suggesting the role of MT in detoxification and homeostasis of heavv metals. 1990 Academic ***.

关键词： Biochemical and Immunochemical Characterization of Caenorhabditis elegans Metallothioneins I and II Induced by Cadmium II

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六自由度磁浮微动台电磁场建模与计算

清华大学学报（自然科学版） 2010年第12期50卷 1978-1982页

作者：李广张鸣朱煜段广洪 masayoshi Tomizuka 清华大学精密仪器与机械学系摩擦学国家重点实验室中国北京100084 加州大学伯克利分校机械工程系美国伯克利94720

为了提高光刻机工件台中微动台的运动精度和加速度,设计了一种将支承和驱动在同一电磁单元中实现的新型Lorentz电机驱动、磁悬浮支承、并联、6自由度微动台结构,应用解析方法建立了微动台磁场模型和特定结构约束下的磁场分布。对微动台... 详细信息

为了提高光刻机工件台中微动台的运动精度和加速度,设计了一种将支承和驱动在同一电磁单元中实现的新型Lorentz电机驱动、磁悬浮支承、并联、6自由度微动台结构,应用解析方法建立了微动台磁场模型和特定结构约束下的磁场分布。对微动台电磁力-位移特性进行了分析。采用数值方法计算了微动台电磁单元绕组损耗引起的温升。结果表明:该微动台具有驱动力大、结构简单、散热方便等优点,可为我国自主产权光刻机微动台设计提供参考。

关键词：微动台电磁场计算温升光刻机

A Forecasting Model of Required Number of Wheat Bulk Carriers for Africa

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中国海洋经济评论 2008年第1期02卷 34-44页

作者： masayoshi Kubo Division of Maritime Logistics Sciences Graduate School of Maritime SciencesFaculty of Maritime SciencesKobe University

The ocean transportation of grain bulk carriers is promoted by development of ocean *** the development of coastal region,the cargo transportation wi11 become more and more important,especially for the resource such as grain,oil and *** this study,a model is built to estimate the number of grain bulk carriers needed for wheat based upon analyzing the relationships between Tons and Ton-miles of Africa wheat *** find that the agricultural policies greatly affect the wheat transportation to ***,using two scenarios, we predict how many ships are necessary for the maritime transportation of wheat from other places to Africa in the *** believe that this research is extremely useful to maritime transportation of wheat to Africa.

关键词： Maritime transportation coastal region development

基于终端滑模控制的四轮独立驱动汽车转矩分配方法(英文)

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2014年第9期15卷 681-693页

作者： Pan SONG Chang-fu ZONG masayoshi TOMIZUKA State Key Laboratory of Automotive Simulation and Control Jilin University Department of Mechanical Engineering University of California

研究目的:四轮独立驱动汽车四个车轮的电机转矩可以正、反向输出,有必要对其底盘集成控制系统进行针对性设计以保证各车轮间的协调运作。集成控制系统一般可以分为上层运动控制器和下层力分配器。对于运动控制器的设计,同类研究一般采... 详细信息

研究目的:四轮独立驱动汽车四个车轮的电机转矩可以正、反向输出,有必要对其底盘集成控制系统进行针对性设计以保证各车轮间的协调运作。集成控制系统一般可以分为上层运动控制器和下层力分配器。对于运动控制器的设计,同类研究一般采用滑模控制方法来处理汽车运动的非线性特征,其中终端滑模控制因具有高的稳态精度和有限时间收敛的特点而成为研究热点。对于力分配器的设计,通常方法不能在保证运算效率的同时考虑到执行器的约束,从而很难应用于实际。本文采用终端滑模控制方法来设计运动控制器,通过分析驾驶员操作行为从而更好地追踪理想的车辆运动目标;并提出一种简单有效的转矩分配控制策略,通过考虑轮胎附着极限从而将运动总力分配至四个车轮上。创新要点:本文创新性地将终端滑模控制应用到底盘集成控制系统以实现车辆纵向、侧向及横摆运动的联合控制;本文提出了一种新颖的转矩分配控制策略,将复杂的有约束控制分配问题分解至若干个简单的无约束分配子问题。研究方法:本文采用分层式协调控制方案(图1),应用非奇异和全局快速终端滑模控制方法设计运动控制器,提出一种基于伪逆矩阵的有约束转矩分配策略,应用驾驶员最优预瞄加速度模型来描述和分析人-车闭环系统的运动响应,通过MATLAB/Simulink和CarSim的联合仿真对所设计的四轮独立驱动汽车转矩分配方法进行对比验证。所设定的三个仿真工况包括:开环方向盘角阶跃输入(图6、7及表2)、闭环双移线工况(图8–10)和闭环对开路面制动(图11–15),分别用以测试车辆横摆、侧向及纵向方向上的动力学响应。重要结论:本文提出的基于终端滑模控制的四轮独立驱动汽车转矩分配方法将车辆的稳态转向特性由不足转向转变为中性转向,驾驶员从而能更容易地操纵车辆而不需要对汽车的非线性响应做出额外的转向补偿。与此同时,该分配方法在不影响车辆侧向稳定性的前提下可以准确地响应驾驶员的加速/制动意图。仿真结果表明终端滑模控制器相比传统滑模控制方法在车辆纵向、侧向、横摆方向上的运动控制效果均有一定程度地提高,而有约束的力分配器更可以明显地提高车辆的操纵性和稳定性。综合评价表明,所提出的基于终端滑模控制的四轮独立驱动汽车转矩分配方法获得了最佳的控制性能,符合设计要求。

关键词：汽车动力学底盘集成控制驾驶员模型终端滑模控制控制分配

Factors Associated with District Tsunami Victim Rate by Age Class in Ishinomaki City： 2011 Great East Japan Earthquake and Tsunami

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Journal of Civil Engineering and Architecture 2018年第3期12卷 235-244页

作者： masayoshi Tanishita The Department of Civil and Environmental Engineering Chuo University 1-13-27 Kasuga Bunkyo-ku Tokyo 112-8551 Japan

This paper analyzes the factors associated with the district tsunami victim rate in 2011 by age class/group in Ishinomaki city, Japan. Sea or river visibility and evaluation potential from the temporary facilities to higher hills are factors associated with victim rate in addition to tsunami depth. In addition, victim rate, especially for elder people, is low in the districts that have higher aging rate. The characteristics of these districts are：（1） many people are engaged in fishery related jobs and know each other and （2） higher hills are behind the beach.

关键词： District victim rate age class tsunami sea visibility.

Corticospinal excitability during motor imagery is diminished by continuous repetition-induced fatigue

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Neural Regeneration Research 2021年第6期16卷 1031-1036页

作者： Akira nakashima Takefumi Moriuchi Daiki Matsuda Takashi Hasegawa Jirou Nakamura Kimika Anan Katsuya Satoh Tomotaka Suzuki Toshio Higashi Kenichi Sugawara Department of Rehabilitation Juzenkai HospitalNagasakiJapan Graduate School of Biomedical Sciences Nagasaki UniversityNagasakiJapan School of Rehabilitation Kanagawa University of Human ServicesYokosukaJapan

Application of continuous repetition of motor imagery can improve the performance of exercise ***,there is a lack of more detailed neurophysiological evidence to support the formulation of clear standards for interventions using motor ***,identification of motor imagery intervention time is necessary because it exhibits possible central ***,the purpose of this study was to elucidate the development of fatigue during continuous repetition of motor imagery through objective and subjective *** study involved two *** experiment 1,14 healthy young volunteers were required to imagine grasping and lifting a 1.5-L plastic bottle using the whole *** participant performed the motor imagery task 100 times under each condition with 48 hours interval between two conditions:500 mL or 1500 mL of water in the bottle during the demonstration *** fatigue and a decrease in pinch power appeared under the 1500-mL *** were changes in concentration ability or corticospinal excitability,as assessed by motor evoked potentials,between each set with continuous repetition of motor imagery also under the 1500-mL ***,in experiment 2,12 healthy volunteers were required to perform the motor imagery task 200 times under the 1500-mL *** concentration ability and corticospinal excitability *** is the first study to show that continuous repetition of motor imagery can decrease corticospinal excitability in addition to producing mental *** study was approved by the Institutional Ethics Committee at the Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121302)on January 30,2019.

关键词： central nervous system concentration continuous repetition of motor imagery corticospinal excitability mental fatigue motor evoked potential motor imagery muscle fatigue neurophysiology transcranial magnetic stimulation

A method for using video presentation to increase the vividness and activity of cortical regions during motor imagery tasks

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Neural Regeneration Research 2021年第12期16卷 2431-2437页

作者： Kengo Fujiwara Masatomo Shibata Yoshinaga Awano Koji Shibayama Naoki Iso Moemi Matsuo Akira nakashima Takefumi Moriuchi Wataru Mitsunaga Toshio Higashi Department of Clinical Services Nagasaki Rehabilitation HospitalNagasakiJapan Graduate School of Biomedical Sciences Nagasaki UniversityNagasakiJapan Department of Rehabilitation Faculty of Health SciencesTokyo Kasei UniversityTokyoJapan

In recent years,mental practice(MP)using laterally inverted video of a subject’s non-paralyzed upper limb to improve the vividness of presented motor imagery(MI)has been shown to be effective for improving the function of a paralyzed upper ***,no studies have yet assessed the activity of cortical regions engaged during MI task performance using inverse video presentations and neurophysiological *** study sought to investigate changes in MI vividness and hemodynamic changes in the cerebral cortex during MI performance under the following three conditions in near-infrared spectroscopy:MI-only without inverse video presentation(MI-only),MI with action observation(AO)of an inverse video presentation of another person’s hand(AO+MI(other hand)),and MI with AO of an inverse video presentation of a participant’s own hand(AO+MI(own hand)).Participants included 66 healthy right-handed adults(41 men and 25 women;mean age:26.3±4.3 years).There were 23 patients in the MI-only group(mean age:26.4±4.1 years),20 in the AO+MI(other hand)group(mean age:25.9±5.0 years),and 23 in the AO+MI(own hand)group(mean age:26.9±4.1 years).The MI task involved transferring 1 cm×1 cm blocks from one plate to another,once per second,using chopsticks held in the non-dominant *** on a visual analog scale(VAS),MI vividness was significantly higher in the AO+MI(own hand)group than in the MI-only group and the AO+MI(other hand)group.A main effect of condition was revealed in terms of MI vividness,as well as regions of interest(ROIs)in certain brain areas associated with motor *** data suggest that inverse video presentation of a person’s own hand enhances the MI vividness and increases the activity of motor-related cortical areas during *** study was approved by the Institutional Ethics Committee of Nagasaki University Graduate School of Biomedical and Health Sciences(approval No.18121303)on January 18,2019.

关键词： action observation cortical activity inverse video presentation mental practice motor imagery motor palsy paralysis recovery rehabilitation stroke

Cytapheresis for pyoderma gangrenosum associated with inflammatory bowel disease:A review of current status

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World Journal of Clinical Cases 2020年第11期8卷 2092-2101页

作者： Kentaro Tominaga Kenya Kamimura Hiroki Sato masayoshi Ko Yuzo Kawata Takeshi Mizusawa Junji Yokoyama Shuji Terai Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8510Japan

Pyoderma gangrenosum(PG)is a neutrophilic dermatosis clinically characterized by the presence of painful skin ulcerations with *** it is frequently associated with inflammatory bowel diseases,including ulcerative colitis,gastroenterologists should be familiar with the disease including therapeutic ***,we have conducted a review focusing on the cytapheresis for PG in cases of inflammatory bowel diseases.A literature search was conducted to extract studies published in the last 20 years,with information on demographics,clinical symptoms,treatment,and the clinical course from a total of 22 cases reported and our recent *** most patients,cytapheresis was associated with improvement or resolution of PG after failure of conventional therapeutic options such as corticosteroids,antibiotics,immunosuppressive agents and *** on the information summarized,cytapheresis is helpful in the majority of patients with PG refractory to medical treatment associated with inflammatory bowel diseases and could be further studied in a multicenter,randomized trial.

关键词： Granulocytapheresis Leucocytapheresis Cytapheresis Inflammatory bowel diseases Pyoderma gangrenosum Complications

Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases

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World Journal of Gastroenterology 2012年第28期18卷 3673-3680页

作者： Yoshiki Naito Hironori Kusano Osamu nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano Departments of Pathology Kurume University School of Medicine Kurume 830-0011 Japan Biostatistics Center Kurume University Kurume 830-0011 Japan Department of Diagnostic Pathology Kurume University Hospital Kurume 830-0011 Japan Division of Gastroenterology Department of Medicine Kurume University School of Medicine Kurume 830-0011 Japan Department of Pathology Omuta City General Hospital Omuta 836-8567 Japan Department of Pathology Asakura Medical Association Hospital Fukuoka 838-0069 Japan Department of Pathology National Hospital Organization Kyushu Medical Center Fukuoka 810-8563 Japan Department of Pathology Shin-Koga Hospital Tenjinkai 120 Tenjincho Kurume 830-0033 Japan Department of Pathology Kurume University Medical Center 155-1 Kokubumachi Kurume 839-0863 Japan Department of Surgery Japanese Red Cross Kumamoto Hospital Kumamoto 861-8520 Japan Department of Pathology Japanese Red Cross Kumamoto Hospital Kumamoto 861-8520 Japan Division of Surgery Saiseikai Kumamoto Hospital Kumamoto 861-4193 Japan Department of Pathology St Mary's Hospital Kurume 830-8543 Japan Department of Surgery Kurume University School of Medicine Kurume 830-0011 Japan

AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy.

关键词： Intraductal biliary neoplasm Intraductal papillary neoplasm of the bile duct Intraductal tubular neoplasm of the bile duct Intraductal tubulopapillary neoplasm of the bile duct Mucin expression