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Augmentation of tumor necrosis factor family-induced apoptosis by E3330 in human hepatocellular carcinoma cell lines via inhibition of NFκB

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World Journal of Gastroenterology 2005年第40期11卷 6258-6261页

作者： Yukiko Saitou Katsuya Shiraki Takenari Yamanaka Kazumi Miyashita tomoko Inoue Yutaka Yamanaka Yumi Yamaguchi Naoyuki Enokimura Norihiko Yamamoto Keiichi Itou Kazushi Sugimoto Takeshi nakano First Department of Internal Medicine

AIM- To investigate the reduction of cell viability in human hepatocellular carcinoma （HCC） cell lines induced by inhibition of nuclear factor kB （NFkB）. METIIOI）S： HLE, SKHep1, and HepG2 were incubated and E3330 was used to compare the stimulation of some chemotherapeutic drugs with that of TNF family, Fas ligand, TNF（x and TNF-related apoptosis-inducing ligand （TRAIL） at the point of the reduction of cell viability by inhibiting NFkB. RESULTS： E3330 decreased NFKB levels in HLE cells stimulated by TNF and TRAIL. The cytotoxicity of the combination of TRAIL, TNFa, Fas ligand, and E3330 increased synergistically in a dose-dependent manner compared to either E3330 alone in all HCC cell lines by MTT assay. However, the combination of some chemotherapeutic drugs and E3330 did not decrease the cell viability. CONCLUSION： Inhibition of NFd3 sensitizes human HCC cell lines to TNF-mediated apoptosis including TRAIL, and TRAIL-based tumor therapy might be a powerful potential therapeutic tool in the treatment of human HCC.

关键词： E3330 NFkB inhibitor Cytotoxicity TRAIL TNFa Fas ligand Doxorubicin Camptotecin

Adenosine triphosphate maintenance by branched chain amino acids as a novel neuroprotective strategy for retinal neurodegenerative diseases

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Neural Regeneration Research 2019年第1期14卷 82-84页

作者： tomoko Hasegawa Hanako Ohashi Ikeda Department of Ophthalmology and Visual Sciences Kyoto University Graduate School of Medicine Department of Experimental Therapeutics Institute for Advancement of Clinical and Translational Science Kyoto University Hospital

Retinal neuronal cell death is caused in many incurable eye diseases such as retinitis pigmentosa(RP)and glaucoma,which are leading causes of adult *** RP,progressive loss of photoreceptor cells leads to visual *** established treatments are available to date for this condition,although potential treatments,including regenerative medicine,gene therapy,and neurotropic factor therapy are being *** glaucoma。

关键词：眼睛疾病视网膜氨基酸基因治疗腺苷分叉维护光敏电阻器

A Rice Phytochrome A in Arabidopsis： The Role of the N-terminus under red and far-red light

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Molecular Plant 2008年第1期1卷 84-102页

作者： Julia Kneissl tomoko Shinomura Masaki Furuya Cordelia Bolle Ludwig-Maximilians-Universitat Munchen Bereich Botanik Menzinger Str. 67 80638 Munchen Germany Hitachi Advanced Research Laboratory Hatoyama Saitama 350-0395 Japan

The phytochrome （phy）A and phyB photoreceptors mediate three photobiological response modes in plants; whereas phyA can mediate the very-low-fluence response （VLFR）, the high-irradiance response （HIR） and, to some extent, the low fluence response （LFR）, phyB and other type U phytochromes only mediate the LFR. To investigate to what level a rice phyA can complement for Arabidopsis phyA or phyB function and to evaluate the role of the serine residues in the first 20 amino acids of the N-terminus of phyA, we examined VLFR, LFR, and HIR responses in phyB and phyAphyB mutant plants transformed with rice PHYA cDNA or a mutant rice PHYA cDNA in which the first 10 serine residues were mutated to alanines （phyA SA）. Utilizing mutants without endogenous phyB allowed the evaluation of red-light-derived responses sensed by the rice phyA. In summary, the WT rice phyA could complement VLFR and LFR responses such as inhibition of hypocotyl elongation under pulses of FR or continuous R light, induction of flowering and leaf expansion, whereas the phyA SA was more specific for HIR responses （e.g. inhibition of hypocotyl elongation and anthocyanin accumulation under continuous far-red light）. As the N-terminal serines can no longer be phosphorylated in the phyA SA mutant, this suggests a role for phosphorylation discriminating between the different phyA-dependent responses. The efficacy of the rice phyA expressed in Arabidopsis was dependent upon the developmental age of the plants analyzed and on the physiological response, suggesting a stage-dependent downstream modulation of phytochrome signaling.

关键词： phytochrome (phy) high-irradiance response (HIR) very-low-fluence response (VLFR)

ECA39 is a novel distant metastasis-related biomarker in colorectal cancer

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World Journal of Gastroenterology 2006年第36期12卷 5884-5889页

作者： Reigetsu Yoshikawa Hidenori Yanagi Chun-Shen Shen Yoshinori Fujiwara Masafumi Noda Toshihiko Yagyu Makoto Gega Tsutomu Oshima Takehira Yamamura Haruki Okamura Yoshiro nakano Tomonori Morinaga tomoko Hashimoto-Tamaoki Second Department of Surgery Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Institute for Advanced Medical Sciences Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Dermatology Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan Department of Genetics Hyogo College of Medicine Nishinomiya Hyogo 663-8501 Japan

AIM: To investigate the possible role of polysaccharide-K (PSK) -related markers in predicting distant metastasis and in the clinical outcome of colorectal cancer (CRC).METHODS: Firstly, we used protein microarrays to analyze the in vitro expression profiles of potential PSK-related markers in the human colorectal adenocarcinoma cell line SW480, which carries a mutant p53 gene. Then, we investigated the clinical implications of these markers in the prognosis of CRC patients. RESULTS: ECA39, a direct target of c-Myc, was identi-fied as a candidate protein affected by the anti-metastat-ic effects of PSK. Immunohistochemistry revealed that ECA39 was expressed at significantly higher levels in tumor tissues with distant metastases compared to those without (P < 0.00001). Positive ECA39 expression was shown to be highly reliable for the prediction of distant metastases (sensitivity: 86.7%, specificity: 90%, posi-tive predictive value: 86.7%, negative predictive value: 90%). A significantly higher cumulative 5-yr disease free survival rate was observed in the ECA39-negative patient group (77.3%) compared with the ECA39-positive patient group (25.8%) (P < 0.05). CONCLUSION: Our results suggest that ECA39 is a dominant predictive factor for distant metastasis in pa-tients with advanced CRC and that its suppression by PSK might represent a useful application of immuno-therapy as part of a program of integrated medicine.

关键词： ECA39 Distant metastasis Colorectal cancer Polysaccharide-K Integrated medicine

Lateral olfactory tract usher substance(LOTUS) protein,an endogenous Nogo receptor antagonist,converts a non-permissive to permissive brain environment for axonal regrowth

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Neural Regeneration Research 2018年第7期13卷 1193-1194页

作者： tomoko Hirokawa Kohtaro Takei Molecular Medical Bioscience Laboratory Yokohama City University Graduate School of Medical Life Science

It is well known that primates,including humans,hardly recover motor function after spinal cord injury（SCI）when compared with non-primate mammals such as *** limited functional recovery is in part due to a non-permi... 详细信息

关键词： MAG Lateral olfactory tract usher substance protein,an endogenous Nogo receptor antagonist,converts a non-permissive to permissive brain environment for axonal regrowth LOTUS SCI CNS

Improvement of Glacial Lakes Detection under Shadow Environment Using ASTER Data in Himalayas, Nepal

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Chinese Geographical Science 2013年第2期23卷 216-226页

作者： CHEN Wenbo FUKUI Hiromichi DOKO tomoko GU Xingfa Graduate School of Media and Governance Keio University Chubu Institute for Advanced Studies Chubu University Research Institute of Environment and Information Sciences Yokohama National University JSPS Research Fellow Institute of Remote Sensing Applications Chinese Academy of Sciences

The detection of glacial lake change in the Himalayas, Nepal is extremely significant since the glacial lake change is one of the crucial indicators of global climate change in this area, where is the most sensitive area of the global climate changes. In the Hima- layas, some of glacial lakes are covered by the dark mountains＇ shadow because of their location. Therefore, these lakes can not be de- tected by conventional method such as Normalized Difference Water Index （NDWI）, because the reflectance feature of shadowed glacial lake is different comparing to the ones which are located in the open flat area. The shadow causes two major problems： 1） glacial lakes which are covered by shadow completely result in underestimation of the number of glacial lakes; 2） glacial lakes which are partly iden- tified are considered to undervalue the area of glacial lakes. The aim of this study is to develop a new model, named Detection of Shadowed Glacial Lakes （DSGL） model, to identify glacial lakes under the shadow environment by using Advanced Space-borne Ther- mal Emission and Reflection Radiometer （ASTER） data in the Himalayas, Nepal. The DSGL model is based on integration of two dif- ferent modifications of NDWI, namely NDWls model and NDWIshe model. NDWI~ is defined as integration of the NDWI and slope analysis and used for detecting non-shadowed lake in the mountain area. The NDWIshe is proposed as a new methodology to overcome the weakness of NDWI~ on identifying shadowed lakes in highly elevated mountainous area such as the Himalayas. The first step of the NDWIshe is to enhance the data from ASTER 1B using the histogram equalization （HE） method, and its outcome product is named AS- TERho. We used the ASTERhe for calculating the NDWIhc and the NDWIshe. Integrated with terrain analysis using Digital Elevation Model （DEM） data, the NDWIshe can be used to identify the shadowed glacial lakes in the Himalayas. NDWIs value of 0.41 is used to identify the glacier lake （NDWI~ 〉 0.

关键词： glacial lake shadow environment DSGL model ASTER remote sensing Himalayas Nepal

Influence of normal to high stroke volume on congestive heart failure development after transcatheter aortic valve implantation:case series

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Journal of Geriatric Cardiology 2021年第1期18卷 83-88页

作者： tomoko Tomioka Tomohiro Ito Ryokichi Takahasi Shuhei Tanaka Department of Cardiology South Miyagi Medical CenterShibataJapan

Aortic stenosis(AS)is the most common valvular disease in the older adults'population,and its prevalence will likely continue to increase with the aging society.[1]Surgical aortic valve replacement(SAVR)for elderly patients is known as a high-risk procedure.[2-4]Transcatheter aortic valve implantation(TAVI)is a reasonable alternative to SAVR for older and inoperable patients with AS,and TAVI significantly improves outcomes in elderly patients with severe AS and serious comorbidities,[5,6]TAVI achieves a 20%relative reduction in mortality compared with SAVR.

关键词： aortic mortality implantation

Gamete Dialogs in Green Lineages

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Molecular Plant 2015年第10期8卷 1442-1454页

作者： Toshiyuki Mori Hiroko Kawai-Toyooka tomoko Igawa Hisayoshi Nozaki Department of Biological Sciences Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Graduate School of Horticulture Chiba University 648 Matsudo Matsudo Chiba 271-8510 Japan

Gamete fusion is a core process of sexual reproduction and, in both plants and animals, different sex gametes fuse within species. Although most of the molecular factors involved in gamete interaction are still unknown in various sex-possessing eukaryotes, reports of such factors in algae and land plants have been increasing in the past decade. In particular, knowledge of gamete interaction in flowering plants and green algae has increased since the identification of the conserved gamete fusion factor GENERATIVE CELL SPECIFIC 1/HAPLESS 2 （GCS1/HAP2）. GCSl was first identified as a pollen generative cell-specific transmembrane protein in the lily （Lilium Iongiflorum）, and was then shown to function not only in flowering plant gamete fusion but also in various eukaryotes, including unicellular protists and metazoans. In addition, although initially restricted to Chlamydomonas, knowledge of gamete attachment in flowering plants was also acquired. This review focuses on recent progress in the study of gamete interaction in volvocine green algae and flowering plants and discusses conserved mechanisms of gamete recognition, attachment, and fusion leading to zygote formation.

关键词： sexual reproduction gamete fusion flowering plants green algae evolution

Rosuvastatin Reduces Plasma Small Dense Ldl-Cholesterol Predominantly in Non-Diabetic Hypercholesterolemic Patients

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Pharmacology & Pharmacy 2012年第1期3卷 72-78页

作者： Gen Yoshino Saburo nakano tomoko Matsumoto Eiichi Murakami Toshisuke Morita Koji Kuboki 不详

Aims: Small dense LDL (sdLDL) cholesterol is considered a cardiovascular risk. Our purpose in this study was to evaluate the efficacy of rosuvastatin in reducing sdLDL and large buoyant LDL (lbLDL-C) in hypercholesterolemia. Methods: Fifty-six patients with a mean baseline LDL-cholesterol (LDL-C) concentration of 173.9 ± 40.5 mg/dL were treated with rosuvastatin 2.5 mg/day for 12 weeks. LDL-C, sdLDL-C, and apolipoprotein (apo) B were assessed and l lbLDL-C was calculated (LDL-C minus sdLDL-C). Results: After 12-week treatment with rosuvastatin 2.5mg, sdLDL-C and lbLDL-C were significantly reduced from 62.1 ± 23.8 mg/dL to 34.0 ± 13.4 mg/dL, p <0.001 and 112.7 ± 34.9 mg/dL to 77.2± 29.2 mg/dL, p < 0.001 respectively, and sdLDL-C/lbLDL-C ratio and apo B also decreased significantly, from 0.36 ± 0.02 to 0.32 ± 0.02, p < 0.005 and 134.2 ± 4.3 to 93.6 ± 3.5 mg/dl, p < 0.001, respectively. In diabetic subjects there was significant correlation between percent reductions in the plasma triglyceride and sdLDL-C/ lbLDL-C ratio (r = 0.58, p < 0.005), but not between the percentage decrease in plasma triglyceride and sdLDL-C. Conclusions: Treatment with rosuvastatin is associated with significant reduction in sdLDL, lbLDL and sdLDL/lbLDL ratio.

关键词： Rosuvastatin Small Dense LDL-Cholesterol (sdLDL) Large Buoyant LDL-C (lbLDL-C) Apolipoprotein (apo) B Small Dense LDL-Cholesterol (sdLDL)/Large Buoyant LDL-C (lbLDL-C) Ratio