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Risk factors for bleeding after endoscopic mucosal resection

World Journal of Gastroenterology 2005年第46期11卷 7335-7339页

作者： Masatsugu Shiba Kazuhide Higuchi Kaori Kadouchi Ai Montani Kazuki Yamamori Hirotoshi Okazaki Makiko Taguchi tomoko Wada Atsushi Itani Toshio Watanabe Kazunari Tominaga Yoshihiro Fujiwara Tomoshige Hayashi Kei Tsumura Tetsuo Arakawa Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of Preventive Medicine and Environmental HealthOsaka City University Medical SchoolOsakaJapan Department of GastroenterologyOsaka City University Medical School OsakaJapan Department of CardiologyOsaka City University Medical SchoolOsakaJapan

AIM： To clarify the risk factors for bleeding after endoscopic mucosal resection （EMR）. METHODS： A total of 297 consecutive patients who underwent EMR were enrolled. Some of the patients had multiple lesions. Bleeding requiring endoscopic treatment was defined as bleeding after EMR. Odds ratios （OR） with 95% confidence intervals （CI）, calculated by logistic regression with multivariate adjustments for covariates, were the measures of association. RESULTS： Of the 297 patients, 57 （19.2%） patients with bleeding after EMR were confirmed. With multivariate adjustment, the cutting method of EMR, diameter, and endoscopic pattern of the tumor were associated with the risk of bleeding after EMR. The multivariate-adjusted OR for bleeding after EMR using endoscopic aspiration mucosectomy was 3.07 （95%CI, 1.59-5.92） compared with strip biopsy. The multiple-adjusted OR for bleeding after EMR for the highest quartile （16-50 mm） of tumor diameter was 5.63 （95%CI, 1.84-17.23） compared with that for the lowest （4-7 mm）. The multiple-adjusted OR for bleeding after EMR for depressed type of tumor was 4.21 （95%CI, 1.75-10.10） compared with elevated type. CONCLUSION： It is important to take tumor charactedstics （tumor size and endoscopic pattern） and cutting method of EMR into consideration in predicting bleeding after EMR.

关键词： Endoscopic mucosal resection Bleeding Tumor characteristics Cutting method

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Effects of UV Irradiation on the Locomotor Activity and Body Temperature Rhythms in Hairless Mice

Effects of UV Irradiation on the Locomotor Activity and Body...

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The 3rd Asian and Oceanian Conference on Photobiology

作者： Eri Chikamori tomoko Sudo Atsuko Masuda Kanako Muramatsu Morihiro Yoneda tomoko Wakamura Hiromi Tokura Tadashi Oishi Faculty of Science Faculty of Science Faculty of Science KYOUSEI Science Center for Life and Nature Faculty of Human Life and Environment Nara Women’s UniversityNara 630-8506Japan Faculty of Medicine Kyoto UniversityKyoto 606-8501Japan Institute of Textiles ＆ Clothing The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Faculty of Science Nara Saho College Rokuyaon-cho 806Nara 630-8566Japan

＜正＞Effects of ultra violet light （UV） irradiation on the skin physiology have been studied well. However, other effects than the skin physiology have not been investigated so much. On the other hand, visible light is reported to be most important as a zeitgeber to entrain circadian rhythms in animals. However, effects of UV on the circadian rhythms such as locomotor activity and body temperature rhythms have not been investigated well. Therefore, in this study, we examined the effects of UV irradiation on the circadian rhythms of locomotor activity and body temperature in hairless mice.

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The Group A Streptococcus Interleukin-8 Protease SpyCEP Promotes Bacterial Intracellular Survival by Evasion of Autophagy

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Infectious Microbes & Diseases 2022年第3期4卷 116-123页

作者： RenéBergmann Giuseppe Gulotta Federica Andreoni tomoko Sumitomo Shigetada Kawabata Annelies S.Zinkernagel Gursharan S.Chhatwal Victor Nizet Manfred Rohde Satoshi Uchiyama Central Unit for Microscopy(ZEIM) Helmholtz Centre for Infection ResearchBraunschweigGermany Division of Infectious Diseases and Hospital Epidemiology University Hospital ZurichZurichSwitzerland Department of Oral and Molecular Microbiology Osaka University Graduate School of DentistrySuita-OsakaJapan Division of Host-Microbe Systems and Therapeutics Department of PediatricsUniversity of CaliforniaSan DiegoLa JollaCalifornia

Autophagy serves an innate immune function in defending the host against invading bacteria,including group A Streptococcus(GAS).Autophagy is regulated by numerous host proteins,including the endogenous negative regulator calpain,a cytosolic *** disseminated serotypeM1T1 GAS strains associated with high invasive disease potential express numerous virulence factors and resist autophagic *** in vitro infection of human epithelial cell lines with representative wild-type GAS M1T1 strain 5448(M1.5448),we observed increased calpain activation linked to a specific GAS virulence factor,the interleukin-8 protease *** activation inhibited autophagy and decreased capture of cytosolic GAS in *** contrast,the serotype M6 GAS strain JRS4(***4),which is highly susceptible to host autophagy-mediated killing,expresses low levels of SpyCEP and does not activate *** of SpyCEP in ***4 stimulated calpain activation,inhibited autophagy,and significantly decreased bacterial capture in *** paired loss-and gain-of-function studies reveal a novel role for the bacterial protease SpyCEP in enabling GAS M1 evasion of autophagy and host innate immune clearance.

关键词： group A Streptococcus SpyCEP virulence factor epithelial cells intracellular survival autophagy xenophagy calpain

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Necessity of Magnetic Resonance Imaging (MRI) using an appropriate sequence for diagnosis of trigeminal neuralgia associated with intracranial tumor

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Open Journal of Stomatology 2013年第9期3卷 510-514页

作者： Yoko Yamazaki tomoko Niimi Yuko Ando Daisuke Tomizawa Masahiko Shimada Orofacial Pain Clinic Tokyo Medical and Dental University Dental Hos-pital Tokyo Japan Orofacial Pain Management Oral Restitution Oral Health Sciences Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan

Aims: Trigeminal neuralgia is generally caused by neurovascular compression. In rare cases intracranial tumors may also lead to this condition. The present study was conducted to identify clinical symptoms and testing methods that are useful for early detection of trigeminal neuralgia associated with intracranial tumor. Methods: Five patients with trigeminal neuralgia suspected to be due to intracranial tumor, who visited our department for the first time during the period between February 2007 and March 2009, were examined. We analyzed the medical records and MRI findings of these patients. The clinical symptoms of subjects were compared to those presented at the International Classification of Headache Disorders. Results: There were no feature symptoms to trigeminal neuralgia caused by intracranial tumors compared with trigeminal neuralgia in general. None of the patients complained of spontaneous headache and nausea, which are clinical symptoms characteristic of brain tumor. Head MRI at our hospital was the most accurate method to detect intracranial tumors. Finally four of five patients received brain surgery to remove tumors. Conclusion: Small tumors and roots of the trigeminal nerve may not create accurate images by regular head MRI. Therefore, MRI using the imaging sequence which enables accurate visualization of roots of the trigeminal nerve is essential to confirm the presence of tumors in patients with suspected trigeminal neuralgia.

关键词： Trigeminal Neuralgia Intracranial Tumor Benign Tumor MRI Neurosurgery

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Negative Pressure Wound Therapy with Multiple Drainage Holes for the Treatment of Pressure Ulcer with Undermining: Case Reports

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第1期3卷 107-109页

作者： Hiroyuki Miura Yumiko Ito tomoko Matsuda Ayano Abe Syun Kitaba Department of Dermatology Kinki Central Hospital Itami Japan

Noninvasive treatment of pressure ulcers with undermining is often difficult. To decrease the risk of bleeding in such conditions, negative pressure wound therapy (NPWT) has been applied. We treated a pressure ulcer with wide undermining using NPWT after opening drainage holes in the undermined area. This method can reduce the risk of bleeding and promote the rapid closure of the undermined area.

关键词： Negative Pressure Wound Therapy Pressure Ulcer Undermining

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Changes in Nurses'Ethical Practices in Organ Transplant Nursing Using Action Research

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Health 2021年第4期13卷 323-333页

作者： Nami Tanimizu Yuko Hayashi Chiharu Akazawa Akihiro Shuda Kuniko Hagiwara tomoko Imanishi Faculty of Nursing Kansai Medical University Osaka Japan Faculty of Nursing Osaka Medical College Osaka Japan Graduate School of Human Health Sciences Tokyo Metropolitan University Tokyo Japan Department of Nursing Osaka University Hospital Osaka Japan Department of Nursing Kyoto University of Advanced Science Kyoto Japan

The purpose of this study is to investigate how participation in action research will change nursing activities in dealing with ethical issues experienced in daily nursing settings of organ transplantation. The action research here is comprised of four types of sessions: clarification of wishes (1st session), meetings to talk about matters experienced, study meetings, and reflections (final session). In the first and final sessions, group interviews about ethical practices were conducted. Recorded data from the interviews and 4th meeting to talk about experiences were analyzed using WordMiner1.5. Participants had the individual need, “wish to improve understanding of ethics in their own skills to promote ethical practices and ethical interests”. Then, they became aware of “ethical practice in placing importance on the relationship with patients/their families and ethics attitudes as nurses”. This awareness was connected to “sharing ideas and information with medical staff, awareness of and action suitable for ethics issues, and increased interest in ethics issues”. Like this, the awareness of ethical practices has expanded from individuals to the relationship with patients/their families and sharing ideas with medical staff, and this has developed into self-development. The findings suggest the importance of an organizational culture that addresses ethics to improve practical ethics skills. The findings also suggest that it would be necessary for an organization to take long-term actions to addresses ethical issues in wards or hospitals.

关键词： Action Research Transplant Nursing Ethical Practice

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Highly-Efficient Conversion of Primary Amides to Nitriles Using Indium(III) Triflate as the Catalyst

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International Journal of Organic Chemistry 2014年第1期4卷 1-6页

作者： tomoko Mineno Mamika Shinada Kazuki Watanabe Hitoshi Yoshimitsu Hiroyuki Miyashita Hisao Kansui Laboratory of Medicinal Chemistry Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Natural Medicines Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan Laboratory of Organic Chemistry for Life Sciences Faculty of Pharmacy Takasaki University of Health and Welfare Takasaki Japan Laboratory of Organic Chemistry Faculty of Pharmaceutical Sciences Sojo University Kumamoto Japan

Indium(III) triflate, a trivalent indium reagent, was shown to be a highly-efficient catalyst for the conversion of primary amides to the corresponding nitriles. The successful reactions required 5 mol% of indium(III) triflate, and toluene was proved to be the most suitable solvent. Various amides were subjected to this method, and each produced the corresponding nitriles in excellent yields.

关键词： Indium(III) Triflate Primary Amides Nitriles

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利用基于CRC技术的ICP-MS对环境和地质类型样品进行快速准确的多元素分析

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环境化学 2012年第5期31卷 760-762页

作者： Julian Wills Shona McSheehy tomoko Oki Meike Hamester Bill Spence 赛默飞世尔科技德国不来梅赛默飞世尔科技英国温斯福德

相比于传统元素分析技术而言,ICP-MS具备多元素同时测定能力、极高的灵敏度、优越的检测限及宽泛的线性动态范围和对同位素比值测定的能力,这一系列的核心优势都是ICP-MS技术的不断普及的主要原因.固体和液体样品均可以使用ICP-MS进行... 详细信息

相比于传统元素分析技术而言,ICP-MS具备多元素同时测定能力、极高的灵敏度、优越的检测限及宽泛的线性动态范围和对同位素比值测定的能力,这一系列的核心优势都是ICP-MS技术的不断普及的主要原因.固体和液体样品均可以使用ICP-MS进行测定分析.由于ICP-MS分析范围从ppt级（万亿分之一）至ppm级（百万分之一）,所以每次仅需提供极少量的样品即可满足ICP-MS测定的要求．不同雾化和校正技术的联合使用，使得ICP—MS同时适用于液体和固体样品的分析．

关键词： ICP-MS技术多元素分析液体样品地质类型多元素同时测定 CRC 环境利用

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Intention Formation Process for the Use of Tracheostomy and Invasive Ventilation in Patients with Amyotrophic Lateral Sclerosis

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Open Journal of Nursing 2017年第10期7卷 1101-1114页

作者： Woojung Shin tomoko Inoue Yuki Nakayama Takanori Yokota Hide Yoshino Makoto Tanaka Department of Critical and Invasive-Palliative Care Nursing Graduate School of Health Care Sciences Tokyo Medical and Dental University Tokyo Japan National College of Nursing Tokyo Japan ALS Nursing Care Project Tokyo Metropolitan Institute of Medical Science Tokyo Japan Department of Neurology and Neurological Science Graduate School of Medical and Dental Sciences Tokyo Medical and Dental University Tokyo Japan Yoshino Neurology Clinic Chiba Japan

Background: Little is known about the intention formation process regarding the use of tracheostomy and invasive ventilation (TIV) in amyotrophic lateral sclerosis (ALS) patients in the course of disease progression. Objective: To clarify the intention formation process in the use of TIV in ALS patients for the purpose of providing decision-making support. Methods: We conducted a follow-up study of 14 patients using semi-structured interviews, participant observation, and medical records review. Results: The patients’ various intentions regarding the use of TIV were formed as their symptoms progressed (e.g., declining motor, swallowing, and respiratory functions). Other factors influencing their decision were their considerations, such as their ability to communicate after receiving TIV treatment, the degree of support they would receive from professionals after TIV treatment, palliative care for physical distress, value of life after TIV treatment, and to what degree they would be a burden on their families. Conclusion: Patients’ intentions regarding the use of TIV were diverse and changeable. The decision of whether or not to use TIV was made out of conviction as well as considering individual experiences of symptom progression and quality of life after TIV use.

关键词： Amyotrophic Lateral Sclerosis Tracheostomy and Invasive Ventilation Decision-Making Case Study Research Design Qualitative Approach

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Bipedicled Mini V-Y Advancement Flap for Skin Defect of the Face

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Modern Plastic Surgery 2018年第2期8卷 15-20页

作者： Mikiko Ooshima Mariko Kochi Daichi Morioka Towa Miyamoto tomoko Tsuda Koichi Kadomatsu Department of Plastic and Reconstructive Surgery Showa University Tokyo Japan

In young patients, even small circular facial defects after the excision of benign skin tumors present a reconstructive challenge. The usefulness of a V-Y advancement flap for reconstructing such defects is well documented. We refined this technique as a mini V-Y advancement flap consisting of two subcutaneous pedicles that vascularize the skin island via subdermal plexus lateral bridges. This technique was used for 21 middle-aged or younger patients with a small benign skin lesion. None of them experienced any postoperative complications. Aesthetically excellent results were found in all patients. This small advancement flap could be attempted as an alternative to fusiform excision of small skin lesions, particularly in younger patients.

关键词： Facial Skin Tumor Skin Defect Advancement Flap Subdermal Plexus

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