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Folic Acid-Functionalized Nanocrystalline Cellulose as a Renewable and Biocompatible Nanomaterial for Cancer-Targeting Nanoparticles

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Journal of Renewable Materials 2024年第1期12卷 29-43页

作者： Thean Heng Tan najihah mohd hashim Wageeh Abdulhadi Yehya Dabdawb Mochamad Zakki Fahmi Hwei Voon Lee Nanotechnology&Catalysis Research Center(NANOCAT) Universiti MalayaKuala Lumpur50603Malaysia Department of Pharmaceutical Chemistry Faculty of PharmacyUniversiti MalayaKuala Lumpur50603Malaysia Department of Chemistry Faculty of Science and TechnologyUniversitas AirlanggaCampus CMulyorejoSurabaya60115Indonesia

The study focuses on the development of biocompatible and stable FA-functionalized nanocrystalline cellulose(NCC)as a potential drug delivery system for targeting folate receptor-positive cancer *** FA-functionalized NCCs were synthesized through a series of chemical reactions,resulting in nanoparticles with favorable properties for biomedical *** microstructural analysis revealed that the functionalized NCCs maintained their rod-shaped morphology and displayed hydrodynamic diameters suitable for evading the mononuclear phagocytic system while being large enough to target tumor ***,these nanoparticles possessed a negative surface charge,enhancing their stability and repelling potential *** binding specificity of FA-functionalized NCCs to folate receptor-positive cancer cells was demonstrated through various *** free folic acid inhibition assay showed approximately 30%decrease in the binding of functionalized NCCs in the presence of just 5 mM free FA,confirming their selectivity for folate receptor-positive *** microscopy further validated this specificity,as only cancer cells displayed significant binding of functionalized ***,biocompatibility tests revealed that both NCCs and FA-functionalized NCCs had minimal effects on red blood cells,and they did not induce erythrocyte ***,cell viability assays demonstrated functionalized NCCs have selective cytotoxicity against colorectal cancer cells HT-29 and SW-620(68%–88%cell viability)while sparing noncancerous colon cells CCD-18Co(81%–97%cell viability).In summary,FA-functionalized NCCs exhibit promising characteristics for targeted drug delivery in cancer *** biocompatibility,stability,and selective cytotoxicity make them an attractive option for delivering therapeutic agents to folate receptor-positive cancer cells,potentially improving the effectiveness of cancer treatments while minimizing harm to healthy tissues.

关键词： Agricultural wastes sustainable nanocarrier blood biocompatibility folic acid receptor drug delivery system nanomedicine

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Exploring Nutritional Compositions,Volatile Compounds,Health Benefits,Emerging Processing Technologies,and Potential Food Products of Glutinous Rice:A Review

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Rice science 2024年第3期31卷 251-268页

作者： Maimunah mohd ALI Norhashila hashim Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaBangi 43600SelangorMalaysia Department of Biological and Agricultural Engineering Faculty of EngineeringUniversiti Putra MalaysiaSerdang 43400SelangorMalaysia SMART Farming Technology Research Centre Faculty of EngineeringUniversiti Putra MalaysiaUPM Serdang 43400SelangorMalaysia Innovation Center for Confectionary Technology(MANIS) Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaUKM Bangi 43600Selangor Darul EhsanMalaysia

Glutinous rice(Oryza sativa ***)stands out as one of the most popular rice varieties globally,amidst thousands of rice *** increasing popularity is attributed to its rich nutritional compositions and health *** review aims to summarize the nutritional compositions,volatile compounds,and health benefits of glutinous ***,in-depth studies are necessary to explore the utilization of glutinous rice in enhancing processing technologies and developing new food *** rice has been shown to possess numerous health benefits,including antioxidant activity,bioactive compounds,anti-cancer properties,anti-inflammatory effects,anti-diabetic potential,and cholesterol-lowering *** its nutritional compositions,the major volatile compounds identified in glutinous rice could serve as a functional food for human *** processing technologies related to glutinous rice are elaborated to improve the latest developments for incorporating them into various food products.

关键词： glutinous rice health benefit volatile compound nutritional composition processing technology

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Can the Bass innovation diffusion model describe adsorption breakthrough curves of pharmaceutical contaminants?

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Green Chemical Engineering 2024年第2期5卷 145-149页

作者： Khim Hoong Chu mohd Ali hashim Department of Chemical Engineering Faculty of EngineeringUniversity of MalayaKuala Lumpur50603Malaysia

*** Fixed bed adsorption is a widely used separation process in the chemical industry for the processing of liquids and *** performance of fixed bed adsorption systems is often evaluated by analyzing the breakthrough curves,which represent the variation of the solute concentration in the effluent stream as a function of time or bed volume.

关键词： adsorption breakthrough curves

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Smart Farming for Sustainable Rice Production:An Insight into Application,Challenge,and Future Prospect

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Rice science 2024年第1期31卷 47-61页

作者： Norhashila hashim Maimunah mohd ALI Muhammad Razif MAHADI Ahmad Fikri ABDULLAH Aimrun WAYAYOK Muhamad Saufi mohd KASSIM Askiah JAMALUDDIN Department of Biological and Agricultural Engineering/SMART Farming Technology Research Centre Faculty of EngineeringUniversiti Putra MalaysiaSelangor 43400Malaysia Department of Food Sciences Faculty of Science and TechnologyUniversiti Kebangsaan MalaysiaSelangor 43600Malaysia Department of Resource Management&Consumer Studies Faculty of Human EcologyUniversiti Putra MalaysiaSelangor 43400Malaysia

Rice has a huge impact on socio-economic growth,and ensuring its sustainability and optimal utilization is *** review provides an insight into the role of smart farming in enhancing rice *** applications of smart farming in rice production including yield estimation,smart irrigation systems,monitoring disease and growth,and predicting rice quality and classifications are *** challenges of smart farming in sustainable rice production to enhance the understanding of researchers,policymakers,and stakeholders are *** efforts have been exerted to combat the issues in rice production in order to promote rice sector *** effective implementation of smart farming in rice production has been facilitated by various technical advancements,particularly the integration of the Internet of Things and artificial *** future prospects of smart farming in transforming existing rice production practices are also *** the utilization of smart farming,the rice industry can attain sustainable and resilient production systems that could mitigate environmental impact and safeguard food ***,the rice industry holds a bright future in transforming current rice production practices into a new outlook in rice smart farming development.

关键词： rice production smart farming food security agriculture sustainability

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A review of salivary composition changes induced by fasting and its impact on health

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Food Science and Human Wellness 2024年第1期13卷 50-64页

作者： Nurul Fadhilah Kamalul Aripin NIdayu Zahid mohd Aizat Abdul Rahim hashim Yaacob Parvez I.Haris Zubaidah Haji AbdRahim Rauzah hashim School of Chemical Engineering College of EngineeringUniversiti Teknologi MARAShah Alam 40450Malaysia Centre for Fundamental and Frontier Sciences in Nanostructure Self-Assembly Department of ChemistryFaculty of ScienceUniversiti MalayaKuala Lumpur 50603Malaysia Department of Oral and Craniofacial Sciences Faculty of DentistryUniversiti MalayaKuala Lumpur 50603Malaysia UMSC Dental Specialist Clinic UM Dentistry TowerUniversiti MalayaMedical CentreKuala Lumpur 50603Malaysia Leicester School of Allied Health Sciences De Montfort UniversityLeicester LE19BHUnited Kingdom Chancellery(Research and Innovation) Universiti MalayaKuala Lumpur 50603Malaysia

Human saliva is an indispensable fluid that maintains a healthy oral cavity which otherwise can lead to oral diseases(dental caries and periodontitis).In addition,salivary metabolites and microbiome profile provide early detection of systemic diseases such as cancer and *** diagnostic has gained popularity due to its non-invasive sampling ***(abstinence from food or drink or both)research for weight loss and improve health is common,but studies using fasting saliva are *** metabolites in fasting saliva have been reported with interesting results,which can be enhanced by considering different confounding *** example,fasting saliva contains higher salivary nitrite,which is related to nitric oxide(NO).NO is a vasodilator supporting the healthy function of endothelial cells and its deficiency is connected to many *** timely supply of NO through exogenous and endogenous means is highlighted and the potential advantage of fasting salivary composition changes in relation to COVID-19 infection is *** review aims to provide a general discussion on the salivary composition,properties,and functions of the whole saliva,including the health benefits of fasting.

关键词： Saliva Fasting Nitrate Nitrite Nitric oxide

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Modeling sprawl of unauthorized development using geospatial technology: case study in Kuantan district, Malaysia

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International Journal of Digital Earth 2011年第3期4卷 223-238页

作者： Mazlan hashim Norzailawati mohd Noor Maged Marghany Institute of Geospatial Science&Technology(INSTEG) Faculty of Geoinformation Sciences and EngineeringUniversiti Teknologi Malaysia81300 UTM SkudaiJohor BahruMalaysia

The paper explores a framework combining remote sensing and GIS-cellular automata(CA)concepts aimed at improving the modeling of unauthorized land use *** sensing data have been used in urban modeling and analysis,the use of high-resolution remote sensing data in assessing unauthorized development is quite *** work has demonstrated systematic combination utilization of geospatial analyses tools to acquire a new level of information to enable urban modeling and sprawl analysis in assisting urban sustainable *** this study,Kuantan city,Malaysia was selected in simulation of the unauthorized land use with CA concept for a period of 15 years(20002015),with main input time-series land use observation from 1995 to *** 2000 and 2005 land use input was also used as calibrated and test assessment of the *** results show excellent agreement between in-situ changes of the unauthorized land use classes and the corresponding simulated classes within the same *** conclusion,CA model can lead to new levels of understanding of how urban areas grow and change as in view of digital earth aspiration.

关键词： cellular automata sprawl remote sensing GIS urban simulation

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Dye-tolerant marine Acinetobacter baumannii-mediated biodegradation of reactive red

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Water Science and Engineering 2018年第4期11卷 265-275页

作者： Sneha Unnikrishnan mohd hashim Khan Karthikeyan Ramalingam School of Life Sciences B.S.Abdur Rahman Crescent Institute of Science and Technology

The objective of this study was to isolate a potent dye-degrading microbe that can be used to reduce the pollution caused by industrial *** red 198 is an extensively used textile dye and is a major environmental pollutant in water bodies. In this study, a bacterial strain was isolated from sea sediments and identified as Acinetobacter baumannii with 16S rRNA sequencing. The isolated bacteria were immobilized in calcium alginate and decolorization studies were carried out to determine the optimum pH, temperature, dye concentration, inoculum volume,and static/agitated condition using the one factor at a time(OFAT) approach. The Box-Behnken design, a type of response surface methodology,was adopted to improve the degradation efficiency. At 37℃ using an inoculum volume of six beads, 96.20% decolorization was observed in 500 mg/L of reactive red 198 after 72 h. Dye degradation was confirmed with UV-visible spectroscopy and Fourier-transform infrared(FTIR)spectroscopy studies of the dye and degraded metabolites. Microbial toxicity studies using Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa and phytotoxicity studies using Vigna radiata proved that the toxicity of the dye was significantly reduced after degradation. We can conclude that the isolated A. baumannii strain is an efficient dye-degrading microbe that can be used to reduce the pollution caused by industrial dyes.

关键词： Immobilization Box-Behnken design Response surface methodology Microbial toxicity Dye degradation

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Low-energy X-ray attenuation characteristics of Rhizophora ***

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Nuclear Science and Techniques 2021年第3期32卷 11-29页

作者： Damilola Oluwafemi Samson Ahmad Shukri mohd Zubir Mat Jafri Rokiah hashim mohd Zahri Abdul Aziz Sylvester Jande Gemanam mohd Fahmi mohd Yusof School of Physics Universiti Sains Malaysia11800 GelugorPenangMalaysia School of Industrial Technology Universiti Sains Malaysia11800 GelugorPenangMalaysia Advanced Medical and Dental Institute Universiti Sains Malaysia13200 BertamPenangMalaysia School of Health Sciences Universiti Sains Malaysia16150 Kota BharuKelantanMalaysia

Photon absorption parameters such as mass attenuation coefficients(μ_m),molar extinction coefficients(ε),total molecular(σ_(t,m)),atomic(σ_(t,a))and electronic(σ_(t,el))cross sections,half-value layers(X_(1/2)),tenth-value layers(X_(1/10)),mean free paths(λ),effective atomic numbers(Z_(eff)),and effective electron densities(N_(el))were estimated for defatted soy flour(DSF),soy protein concentrate(SPC),and soy protein isolate(SPI)-based Rhizophora *** composites substituted with 10 wt%sodium hydroxide(NaOH)and 0,5,10,and 15 wt%itaconic acid polyamidoamine-epichlorohydrin(IA-PAE)*** composition was assessed using ultrahigh-resolution field emission scanning electron microscopy-energy dispersive X-ray spectrometry(UHR-FESEM-EDX).The interaction parameters were evaluated for K_(α1)photons at16.59,17.46,21.21,and 25.26 keV,employing a low-energy germanium(LEGe)detector system and an~(241)Amγ-ray source.X-ray diffraction characterization revealed an amorphous phase in the developed particleboard *** DSF15',SPC15',and SPI15'exhibited the highest values ofμ_m,ε,σ_(t,m),Zeff,and N_(el)among all of the studied particleboard samples,within the range of measured photon *** addition,all of the modified samples exhibited lower X_(1/2),X_(1/10),λ,σ_(t,a),andσ_(t,el)than the unmodified samples,with DSF-,SPC-,and SPI/NaOH/Rhizophora spp./IA-PAE(15 wt%),indicating insignificant *** current results of the particleboard samples'analysis can be useful for medical radiation applications and shielding research.

关键词： Photon interaction parameters Shielding DSF–SPC–SPI Particleboards NaOH/IA-PAE

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Mesoscale surface circulation and variability of Southern Indian Ocean derived by combining satellite altimetry and drifter observations

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Acta Oceanologica Sinica 2015年第9期34卷 12-22页

作者： BENNY N.Peter SHENBAKAVALLI Ranjan MAZLAN hashim mohd Nadzri Reba mohd Razali Mahmud Department of Coastal and Offshore Engineering School of Ocean Engineering and Underwater TechnologyKerala University of Fisheries and Ocean Studies Department of Geomatic Engineering Faculty of Geoinformation and Real EstateUniversity of Technology Malaysia Institute of Geospatial Science & Technology Faculty of Geoinformation and Real EstateUniversity of Technology Malaysia

High resoultion Eulerian mean velocity field has been derived by combining the satellite tracked surface drifter data with satellite altimetry and ocean surface winds. The drifter data used in this study includes Argos and surface drifter data from Global Drifter Program. Maps of Sea Level Anomaly （MSLA） weekly files with a resolution of （1/3）° in both Latitude and Longitude for the period 1993-2012 have been used. The Ekman current is computed using ocean surface mean wind fields from scatterometers onboard ERS 1/2, Quikscat and ASCAT. The derived mean velocity field exhibits the broad flow of Antarctic Circumpolar Current with speeds up to 0.6 m/s. Anomalous field is quite significant in the western part between 20~ and 40~E and in the eastern part between 80~E and 100~E with velocity anomaly up to 0.3 m/s. The estimated mean flow pattern well agrees with the dynamic topography derived from in-situ observations. Also, the derived velocity field is consistent with the in-situ ADCP current measurements. Eddy kinetic energy illustrates an increasing trend during 1993-2008 and is in phase coherence with the Southern Annular Mode by three month lag. Periodic modulations are found in the eddy kinetic energy due the low frequency Antarctic Circumpolar Wave propagation.

关键词： Antarctic Ocean circulation satellite altimetry eddy kinetic energy Southern Indian Ocean antarctic circumpolar wave

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Comparison of a plant based natural surfactant with SDS for washing of As(V) from Fe rich soil

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Journal of Environmental Sciences 2013年第11期25卷 2247-2256页

作者： Soumyadeep Mukhopadhyay mohd. Ali hashim Jaya Narayan Sahu Ismail Yusoff Bhaskar Sen Gupta Department of Chemical Engineering University of Malaya Department of Geology University of Malaya School of Planning Architecture and Civil Engineering Queen's University Belfast

This study explores the possible application of a biodegradable plant based surfactant, obtained from Sapindus mukorossi, for washing low levels of arsenic （As） from an iron （Fe） rich soil. Natural association of As（Ⅴ） with Fe（Ⅲ） makes the process difficult. Soapnut solution was compared to anionic surfactant sodium dodecyl sulfate （SDS） in down-flow and a newly introduced suction mode for soil column washing. It was observed that soapnut attained up to 86% efficiency with respect to SDS in removing As. Full factorial design of experiment revealed a very good fit of data. The suction mode generated up to 83 kPa pressure inside column whilst down-flow mode generated a much higher pressure of 214 kPa, thus making the suction mode more efficient. Micellar solubilisation was found to be responsible for As desorption from the soil and it followed 1st order kinetics. Desorption rate coefficient of suction mode was found to be in the range of 0.005 to 0.01, much higher than down-flow mode values. Analysis of the PT-IR data suggested that the soapnut solution did not interact chemically with As, offering an option for reusing the surfactant. Soapnut can be considered as a soil washing agent for removing As even from soil with high Fe content.

关键词： soil washing soapnut Sapindus mukorossi arsenic plant based surfactant

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