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National guidelines for diagnosis and treatment of cervical cancer 2022 in China(English version)

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Chinese Journal of Cancer Research 2022年第3期34卷 256-269页

作者：无 naiyi zhang Yidi Yuan National Health Commission of the People's Republic of China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Peking University Cancer Hospital&Institute

Contents *** *** 2.1 HPV infection 2.2 Behavioral risk factors *** manifestations 3.1 Symptoms 3.2 Signs *** examination 4.1 Cervical/vaginal cytology examination and HPV test 4.2 Cervical colposcopy 4.3 Gynecological... 详细信息

关键词： diagnosis Cervical Clinical

Immunocytochemical examination of PTEN and Ki-67 for endometrial carcinoma using thin-layer endometrial preparations

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BIOCELL 2021年第4期45卷 923-932页

作者： XI YANG KE MA RUI CHEN naiyi zhang YITING MENG JIA WEN QINPING LIAO Department of Obstetrics and Gynecology Beijing Tsinghua Changgung HospitalMedical Center of Tsinghua UniversityBeijing102218China Department of Gynecology Beijing Cancer HospitalBeijing100142China Department of Pathology Beijing Tsinghua Changgung HospitalMedical Center of Tsinghua UniversityBeijing102218China

The current study is designed to evaluate certain immunocytochemical(ICC)biomarkers to gain a better *** this purpose,85 patients from March 2016 to March 2019 who planned to get a hysteroscopy assay were *** sampling was conducted by scratching the uterus cavity using SAP-1,and the samples were processed as liquid-based smears,using SurePath technology.36 patients diagnosed with EC or atypical endometrial hyperplasia were recruited in this study.33 cases were diagnosed with EC,and 3 cases were diagnosed with atypical endometrial hyperplasia,allocated with EC or precancerous lesions group.26 cases were diagnosed with benign lesions *** these cases,9 cases were diagnosed with endometrial simple hyperplasia,2 cases were diagnosed with complicated hyperplasia,5 cases were diagnosed with an irregular proliferation of endometrium and 10 cases were diagnosed with endometrial *** were 23 cases in the healthy *** in thin-layer endometrial preparations by ICC and using H-score or counting the percentage of stained *** presentation of PTEN in normal endometrium,benign lesions,and EC/precancerous lesions were different(p<0.01).Taking the cut-off value of 50(Youden’s index:0.698)PTEN expression for the diagnosis of EC/precancerous lesion,the sensitivity and specificity were 83.7%and 86.1%.The presentation of Ki-67 in normal endometrium,benign lesions,and EC/precancerous lesions were different(p<0.01).Taking the cut-off value of 15%(Youden’s index:0.76)Ki-67 expression for the diagnosis of EC/precancerous lesion,the sensitivity and specificity were 94.4%and 81.6%.In this study,the use of different cut-off values for Ki-67 and PTEN helped differentiate endometrial *** in the ECT detection of PTEN and Ki-67 can improve the diagnostic capabilities of endometrial cancer and precancerous lesions.

关键词： Immunocytochemical expression PTEN Ki-67 Endometrial carcinoma Thin-layer endometrial preparation

血清人附睾分泌蛋白4及CA125在子宫内膜癌术前评估和预后判断中的应用

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中国妇产科临床杂志 2019年第5期20卷 392-394页

作者：张乃怿高雨农高敏北京大学肿瘤医院暨北京市肿瘤防治研究所肿瘤妇科 100142 北京大学恶性肿瘤发病机制及转化研究重点实验室 100142

目的评估血清HE4和CA125在术前预估是否需行淋巴结切除的作用。方法入组患者145例,术前留取血液样本行HE4和CA125检测。HE4和CA125与病理学特征和预后的比较采用Mann-Whitney U检验。绘制ROC曲线选择HE4最佳的诊断界限值,计算灵敏度、... 详细信息

目的评估血清HE4和CA125在术前预估是否需行淋巴结切除的作用。方法入组患者145例,术前留取血液样本行HE4和CA125检测。HE4和CA125与病理学特征和预后的比较采用Mann-Whitney U检验。绘制ROC曲线选择HE4最佳的诊断界限值,计算灵敏度、特异度。结果平均随访40.7个月。HE4在深肌层浸润、卵巢转移、盆腔淋巴结转移及腹主动脉旁淋巴结转移的患者中明显增高。以HE4>61.2 pmol/L作为深肌层浸润的诊断指标时,灵敏度为80.0%,特异度为69.1%。以HE4>61.2 pmol/L作为判断腹主动脉旁淋巴结转移的诊断指标时,灵敏度为87.5%,特异度为56.6%。结论血清HE4与内膜癌的高危病理因素和不良预后有密切关联,HE4检测有助于术前预估内膜癌是否需行淋巴结切除和判断预后。

关键词：附睾分泌蛋白4 CA125 子宫内膜癌淋巴结清扫术

阿瑞匹坦联合地塞米松及昂丹司琼预防妇科肿瘤患者顺铂化疗引起的恶心呕吐的效果观察

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实用妇产科杂志 2017年第1期33卷 57-61页

作者：张乃怿高雨农北京大学肿瘤医院暨北京市肿瘤防治研究所恶性肿瘤发病机制及转化研究教育部重点实验室北京100142

目的:通过前瞻性观察评价阿瑞匹坦联合地塞米松及昂丹司琼预防妇科肿瘤患者接受含顺铂化疗引起的恶心呕吐(CINV)的效果。方法:采用前瞻性研究方法选择2013年12月1日至2014年9月30日收治的妇科肿瘤患者70例,均接受含有顺铂的单日或多日... 详细信息

目的:通过前瞻性观察评价阿瑞匹坦联合地塞米松及昂丹司琼预防妇科肿瘤患者接受含顺铂化疗引起的恶心呕吐(CINV)的效果。方法:采用前瞻性研究方法选择2013年12月1日至2014年9月30日收治的妇科肿瘤患者70例,均接受含有顺铂的单日或多日化疗方案,并给予阿瑞匹坦联合地塞米松及昂丹司琼的三联预防性止吐治疗。在整个研究期间通过患者研究日志记录其对治疗的反应。主要研究终点为完全缓解率,次要研究终点包括急性期完全缓解率、延迟期完全缓解率、完全保护率、完全控制率、危险因素和预期因素对完全缓解率的影响以及CINV对日常生活的影响。结果:70例患者中完全缓解率为80.0%,急性期完全缓解率为94.3%,延迟期完全缓解率为84.3%;完全保护率为42.9%,完全控制率为25.7%;71.4%的患者表示CINV对日常生活影响极小。结论:阿瑞匹坦联合地塞米松及昂丹司琼可有效预防妇科肿瘤患者接受含顺铂的化疗引起的呕吐,但三药联合方案对预防恶心的作用仍欠满意,用于多日化疗的最佳用药方案尚需进一步研究。接受顺铂化疗的妇科肿瘤患者,在应用三联止吐方案后,CINV对多数患者生活质量的影响很小。

关键词：化疗引起的恶心呕吐预防性治疗顺铂阿瑞匹坦地塞米松昂丹司琼

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论高等教育基本职能的法律制度化

职业技术教育 2006年第14期27卷 10-12页

作者：张乃翼沈阳师范大学

对高等教育的基本规律进行立法确认是高等教育法制化发展的必然要求。而高等教育的社会公共职能、产业服务职能、社会精神财富的传承与创新职能等是高等教育立法的客观依据。高等教育的基本关系和管理关系是高等教育法的调整对象。

关键词：高等教育基本职能基本规律基本关系管理关系法律制度化

46XY单纯性腺发育不全合并恶性混合性生殖细胞肿瘤一例

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中华肿瘤杂志 2016年第12期38卷 951-952页

作者：张乃怿曹登峰郑虹高雨农北京大学肿瘤医院暨北京市肿瘤防治研究所肿瘤妇科恶性肿瘤发病机制及转化研究教育部重点实验室 100142

患者社会性别为女性，15岁，因发热、下腹痛、发现腹部巨大包块于2012年6月29日在外院行开腹右卵巢肿物剥除术＋左卵巢活检术。术中见：右卵巢22cm×18cm×16cm多房囊实性肿物，左卵巢条索状，子宫幼稚型。术后6d查甲胎蛋白（AFP）为571... 详细信息

患者社会性别为女性，15岁，因发热、下腹痛、发现腹部巨大包块于2012年6月29日在外院行开腹右卵巢肿物剥除术＋左卵巢活检术。术中见：右卵巢22cm×18cm×16cm多房囊实性肿物，左卵巢条索状，子宫幼稚型。术后6d查甲胎蛋白（AFP）为5710ng／ml，CA125为45．6U／ml。

关键词：肿瘤生殖细胞和胚胎性性腺发育不全染色体

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十三陵水库工程修建始末

科学文化评论 2020年第6期17卷 101-111页

作者：张志辉张乃乙不详中国科学技术大学科技史与科技考古系

十三陵水库于1958年1月21日开工,6月30日宣布竣工,是当时的样板工程之一,其决策和修建过程具有鲜明的时代特征。目前史学界尚未见有对十三陵水库建设过程的深入研究。依据相关档案文献和当事人的访谈,系统梳理了十三陵水库工程的修建始... 详细信息

十三陵水库于1958年1月21日开工,6月30日宣布竣工,是当时的样板工程之一,其决策和修建过程具有鲜明的时代特征。目前史学界尚未见有对十三陵水库建设过程的深入研究。依据相关档案文献和当事人的访谈,系统梳理了十三陵水库工程的修建始末,发现,它是以特殊的"三边"(边勘测、边设计、边施工)方式修建。工程修建期间,毛泽东、周恩来等多位国家领导人亲赴工地参加劳动,产生了巨大的社会影响。但是,水库工程完工后发生严重的漏水问题,甚至多年干涸见底,无法发挥正常功能,后经多年反复改造才得以解决。十三陵水库的决策和建设过程是特殊历史时期的典型案例,对于研究中华人民共和国成立初期水利工程建设的历史具有重要意义。

关键词：十三陵水库水利工程修建始末 “三边”工程

Diatomic Pd catalyst with conjugated backbone for synergistic electrochemical CO_(2)reduction

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Nano Research 2024年第6期17卷 4850-4855页

作者： Wenxuan zhang Mengran zhang Hongjuan Wang Wen zhang Min zhang MOE International Joint Laboratory of Materials Microstructure Institute for New Energy Materials and Low Carbon TechnologiesSchool of Materials Science and EngineeringTianjin University of TechnologyTianjin 300384China Tianjin Key Laboratory of Organic Solar Cells and Photochemical Conversion School of Chemistry and Chemical EngineeringTianjin University of TechnologyTianjin 300384China

Double-site catalysts have attracted widespread attention in the field of electrocatalysis due to their high metal loading,adjustable active centres,and electronic valence ***,the development of bimetallic sites catalysts that coordinate with definite atoms is still in the exploratory ***,we designed and synthesized a bimetallic palladium complex(BPB-Pd_(2))with conjugated *** supported BPB-Pd_(2)was applied to electrochemical CO_(2)reduction reaction(CO_(2)RR)for the first *** as-obtained BPB-Pd_(2)gives an exceptional Faradaic efficiency of CO(FECO)of 94.4%at−0.80 V *** hydrogen electrode(RHE),which is significantly superior to monoatomic palladium catalyst(BPB-Pd1).The density functional theory(DFT)calculations revealed that the essential reason for the outstanding activity of BPB-Pd_(2)toward CO_(2)RR was that the electronic effect between diatomic palladium reduces the free energy change for CO_(2)RR ***,BPB-Pd_(2)exhibits moderate free energy change to form COOH*intermediate,which was beneficial for the generation of CO in CO_(2)RR.

关键词： synthesis electrocatalysis CO_(2)reduction bimetallic palladium complex synergistic catalysis

N-doped graphene quantum dot-decorated N-TiO2/P-doped porous hollow g-C_(3)N_(4) nanotube composite photocatalysts for antibiotic photodegradation and H2 production

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International Journal of Minerals,Metallurgy and Materials 2024年第1期31卷 165-178页

作者： Jingshu Yuan Yao zhang Xiaoyan zhang Junjie zhang Shen’gen zhang Institute for Advanced Materials and Technology University of Science and Technology BeijingBeijing 100083China Xi’an Fanyi University Xi’an 710105China Shunde Graduate School of University of Science and Technology Beijing Foshan 528399China State Key Laboratory of Lunar and Planetary Sciences Macao University of Science and TechnologyMacao SAR 820000China

Exclusive responsiveness to ultraviolet light (~3.2 eV) and high photogenerated charge recombination rate are the two primary drawbacks of pure TiO_(2). We combined N-doped graphene quantum dots (N-GQDs), morphology regulation, and heterojunction construction strategies to synthesize N-GQD/N-doped TiO_(2)/P-doped porous hollow g-C_(3)N_(4) nanotube (PCN) composite photocatalysts (denoted as G-TPCN). The optimal sample (G-TPCN doped with 0.1wt% N-GQD, denoted as 0.1% G-TPCN) exhibits significantly enhanced photoabsorption, which is attributed to the change in bandgap caused by elemental doping (P and N), the improved light-harvesting resulting from the tube structure, and the upconversion effect of N-GQDs. In addition, the internal charge separation and transfer capability of0.1% G-TPCN are dramatically boosted, and its carrier concentration is 3.7, 2.3, and 1.9 times that of N-TiO_(2), PCN, and N-TiO_(2)/PCN(TPCN-1), respectively. This phenomenon is attributed to the formation of Z-scheme heterojunction between N-TiO_(2) and PCNs, the excellent electron conduction ability of N-GQDs, and the short transfer distance caused by the porous nanotube structure. Compared with those of N-TiO_(2), PCNs, and TPCN-1, the H2 production activity of 0.1%G-TPCN under visible light is enhanced by 12.4, 2.3, and 1.4times, respectively, and its ciprofloxacin (CIP) degradation rate is increased by 7.9, 5.7, and 2.9 times, respectively. The optimized performance benefits from excellent photoresponsiveness and improved carrier separation and migration efficiencies. Finally, the photocatalytic mechanism of 0.1% G-TPCN and five possible degradation pathways of CIP are proposed. This study clarifies the mechanism of multiple modification strategies to synergistically improve the photocatalytic performance of 0.1% G-TPCN and provides a potential strategy for rationally designing novel photocatalysts for environmental remediation and solar energy conversion.

关键词： N-doped TiO_(2) N-doped graphene quantum dots P-doped g-C_(3)N_(4) porous hollow nanotube heterojunction photocatalysis