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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu Huiming Xu Changyong tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

手术室执行预防性抗菌药物的影响因素及改进效果分析

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继续医学教育 2015年第4期29卷 87-88页

作者：宋春钱雪茹唐乃梅新疆医科大学第二附属医院手术室新疆乌鲁木齐830000

目的探讨影响手术室执行抗菌药物的原因及相关改进措施。方法汇总手术室术前抗菌药物的执行情况,并进行总结分析。结果对手术室执行抗菌药物的影响因素进行总结,并提出对策。结论手术室预防性抗菌药物的执行情况直接影响药物效果,有效... 详细信息

目的探讨影响手术室执行抗菌药物的原因及相关改进措施。方法汇总手术室术前抗菌药物的执行情况,并进行总结分析。结果对手术室执行抗菌药物的影响因素进行总结,并提出对策。结论手术室预防性抗菌药物的执行情况直接影响药物效果,有效执行是关键。

关键词：手术室执行预防性抗菌药物影响因素及改进效果分析

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目视管理方法在剖宫产手术隔离技术中的应用

新疆医科大学学报 2019年第5期42卷 652-655,662页

作者：宋春唐乃梅闫泓霖新疆医科大学第二附属医院乌鲁木齐830063

目的观察目视管理方法实施剖宫产手术隔离技术的应用效果。方法将实施剖宫产手术的160例患者随机分为对照组和观察组,对照组按常规实施剖宫产手术隔离技术,观察组应用目视管理方法实施剖宫产手术隔离技术,采用剖宫产术中隔离措施实施评... 详细信息

目的观察目视管理方法实施剖宫产手术隔离技术的应用效果。方法将实施剖宫产手术的160例患者随机分为对照组和观察组,对照组按常规实施剖宫产手术隔离技术,观察组应用目视管理方法实施剖宫产手术隔离技术,采用剖宫产术中隔离措施实施评价表观察2组手术隔离技术实施情况,比较目视管理方法实施剖宫产手术隔离技术的效果。结果 (1)剖宫产手术隔离防范措施实施情况比较:剖宫产手术12项隔离措施中,第3项破膜弯钳妥善隔离放置,第8项缝合子宫使用的手术器械隔离放置,观察组剖宫产手术隔离防范措施实施执行优于对照组(P0.05),第二助手隔离情况差异有统计学意义(P<0.05),器械护士隔离情况差异有统计学意义(P<0.01)。结论目视管理方法有效管理剖宫产手术隔离技术实施,促进手术人员对术中的隔离技术的关注,有利于参与手术人员之间的协同合作,确保隔离技术的执行效果,降低医源性种植的几率。

关键词：目视管理方法剖宫产隔离医源性种植

Industrial Control Anomaly Detection Based on Distributed Linear Deep Learning

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Computers, Materials & Continua 2025年第1期82卷 1129-1150页

作者： Shijie tang Yong Ding Huiyong Wang School of Computer Science and Information Security Guilin University of Electronic TechnologyGuilin541004China School of Electronic Engineering and Automation Guilin University of Electronic TechnologyGuilin541004China Guangxi Engineering Research Center of Industrial Internet Security and Blockchain Guilin University of Electronic TechnologyGuilin541004China Institute of Cyberspace Technology HKCT Institute for Higher EducationHong Kong999077China School of Mathematics&Computing Science Guilin University of Electronic TechnologyGuilin541004China

As more and more devices in Cyber-Physical Systems(CPS)are connected to the Internet,physical components such as programmable logic controller(PLC),sensors,and actuators are facing greater risks of network attacks,and fast and accurate attack detection techniques are *** key problem in distinguishing between normal and abnormal sequences is to model sequential changes in a large and diverse field of time *** address this issue,we propose an anomaly detection method based on distributed deep *** method uses a bilateral filtering algorithm for sequential sequences to remove noise in the time series,which can maintain the edge of discrete *** use a distributed linear deep learning model to establish a sequential prediction model and adjust the threshold for anomaly detection based on the prediction error of the validation *** method can not only detect abnormal attacks but also locate the sensors that cause *** conducted experiments on the Secure Water Treatment(SWAT)and Water Distribution(WADI)public *** experimental results show that our method is superior to the baseline method in identifying the types of attacks and detecting efficiency.

关键词： Anomaly detection CPS deep learning MLP(multi-layer perceptron)

Soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew Gregory Chengyun tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population drug

GM3对J6-2细胞的促分化作用及对鞘糖脂与磷脂组分的影响

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生物化学与生物物理进展 1992年第2期19卷 123-127页

作者：张新波崔肇春汤乃梅朱正美大连医学院生化教研室大连市116023

本文在用形态学与组化手段证实神经节苷脂GM3促进国人白血病细胞系J6-2分化的基础上,研究了分化前后细胞鞘糖脂及磷脂组分的变化。作者用自行提纯的GM3表明,J6-2细胞在分化前后没有显著的神经节苷脂组分的改变,中性鞘糖脂组分CMH在分化... 详细信息

本文在用形态学与组化手段证实神经节苷脂GM3促进国人白血病细胞系J6-2分化的基础上,研究了分化前后细胞鞘糖脂及磷脂组分的变化。作者用自行提纯的GM3表明,J6-2细胞在分化前后没有显著的神经节苷脂组分的改变,中性鞘糖脂组分CMH在分化后明显增多。GM3使LPC、SPM及PI+PS等磷脂组分减少,但使PC组分增多。此项结果提示了神经节苷脂的一个新的功能——调节磷脂代谢,但其具体机制尚待阐明。

关键词：白血病细胞鞘糖脂神经节苷脂

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无菌物品有效期影响因素的调查

中华现代护理杂志 2017年第19期23卷 2518-2521页

作者：崔海丽唐乃梅谢晴晴新疆医科大学第二附属医院手术室乌鲁木齐830028

目的探讨影响一次性材料包装的无菌物品有效期的相关因素.方法将同一批次清洗灭菌后的无菌物品,存放于符合标准储存条件的消毒供应室和与标准储存条件不同的神经病区治疗室、普外病区换药室、门急诊注射室、洁净手术室,每个储存点120... 详细信息

目的探讨影响一次性材料包装的无菌物品有效期的相关因素.方法将同一批次清洗灭菌后的无菌物品,存放于符合标准储存条件的消毒供应室和与标准储存条件不同的神经病区治疗室、普外病区换药室、门急诊注射室、洁净手术室,每个储存点120件.定期对各储存环境下储存的同一批次的无菌物品进行细菌培养.结果灭菌后90 d,门急诊注射室的纸塑包装的3件样本有细菌生长;灭菌后105 d,普外病区换药室的纸塑包装的2件样本有细菌生长;灭菌后150 d,普外病区换药室的无纺布包装的1件样本有细菌生长;至180 d实验结束,存放于消毒供应中心、神经病区治疗室、洁净手术室的实验样本均无细菌生长.结论影响无菌物品的有效期与时间因素相关,还应从多方面对影响无菌物品有效期相关因素进行评估,将规范、行业标准、规定执行到位,才能确保物品质量,防止院内感染发生.

关键词：一次性包装材料无菌物品有效期影响因素

Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian tang Jiaying He Huihang Sun Jingjia Luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi Han tang Jianian Hu Siying Kang Song Qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte