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Open Journal of Medical Imaging 2024年第3期14卷 106-113页

作者： Siddick Oumar Kenza Fathallah Hassan Ahmed Aicha Merzem Hasnaa Belgadir Omar Amriss Nadia Moussali naima el benna Department of Radiology University Hospital Center Ibn Rochd Casablanca Morocco

Median arcuate ligament syndrome (MALS), is a rare abdominal vascular compression syndrome caused by the compression of the proximal celiac trunk by the median arcuate ligament. According to many authors, a low insertion of the diaphragmatic crura or an abnormally high origin of the celiac trunk from the aorta can cause compression of the celiac artery. Usually, patients with MALS are asymptomatic. Computed tomography (CT) angiography of the abdomen is the main imaging modality to confirm the diagnosis. The coexistence of celiac trunk and superior mesenteric artery compression by the median arcuate ligament is rarely described in the literature. To our knowledge, until now, a simultaneous combination of three abdominal vascular compressions by the median arcuate ligament has never been described. From this case, we report a simultaneous compression of the celiac trunk, superior mesenteric artery, and renal arteries by the median arcuate ligament.

关键词： Median Arcuate Ligament Syndrome (MALS) Celiac Trunk Compression Superior Mesenteric Artery and Renal Arteries Compression Computed Tomography Angiography

Autosomal Dominant Polycystic Kidney Disease: Epidemiological, Clinical Aspects and Predictive Factors of Poor Renal Prognosis (About 300 Cases)

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Open Journal of Nephrology 2024年第2期14卷 275-293页

作者： Rihab Dkhissi Nada el Kadiri Tarik Bouattar Loubna Benamar naima Ouzeddoun Department of Nephrology-Dialysis-Renal Transplantation IbnSina Hospital Mohammed V University Rabat Morocco

Introduction: Autosomal dominant polycystic kidney disease (ADPKD) is a common, multisystemic, and progressive hereditary disease. It accounts for 6 to 8% of incident cases of end-stage chronic renal disease (ESRD) in developed countries. The aim of this study is to describe the predictive factors for the development of end-stage chronic kidney disease (CKD) in the course of this disease. Material and Methods: This is a retrospective, descriptive, and analytical study including 300 cases of ADPKD collected at the Nephrology Department of Ibn-Sina Hospital in Rabat over a period of 30 years (1993 to 2023). Included in the study are all patients with ADPKD meeting the ultrasound diagnostic criteria. The analysis focused on demographic, clinical, paraclinical, evolutionary data, as well as prognostic factors associated with renal function deterioration. Results: The mean age of patients at diagnosis is 51.53 +/− 17 years [16 - 93] with a male predominance. The median serum creatinine at diagnosis is 15.5 mg/l [10 - 34]. 21% of patients had ESRD (eGFR 300 mg/24h (21%). The most common cystic complication is hemorrhage (12.3%). 21.3% of patients had hepatorenal polycystic disease. In adjusted analysis, the predictive risk factors for the occurrence of ESRD were smoking (p = 0.019), anemia (p Conclusion: ADPKD can progress insidiously to ESRD. Identification and early treatment of predictive factors for poor renal prognosis could contribute to a better outcome for this disease.

关键词： ADPKD ESRD Factors of Poor Renal Prognosis Renal and Extra-Renal Manifestations

Primary Hyperoxaluria Type 1 in Adulthood: Case Series

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Open Journal of Nephrology 2024年第3期14卷 350-360页

作者： Sara el Maakoul Nada el Kadiri Nabil Hmaidouch Salma Belmokadem Loubna Benamar Tarik Bouattar naima Ouzeddoun Department of Nephrology Dialysis Renal Transplantation Ibn Sina University Hospital-Rabat Rabat Morocco Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco

Introduction: Primary hyperoxaluria type 1 (HP1) is a rare lithiasis with systemic involvement, due to the accumulation of calcium oxalate crystals. In the absence of therapeutic management, it progresses to end-stage chronic renal failure. The aim of this study is to describe and analyse the observations of our patients with HP1. Patients and methods: This is a retrospective study carried out between 2014 and 2023 in the Nephrology-Dialysis Transplant Department of the Ibn Sina University Hospital in Rabat. The clinical, paraclinical and evolutionary elements were taken from the patients’ medical records. Results: We collected 11 cases, with a mean age of 27 ± 8.5 years and a M/F sex ratio of 1.7. The diagnosis of HP1 was made on the basis of genetic analysis in 8 patients, morphological and spectro-photometric analysis of the calculus in one patient, biopsy of the graft in one patient and crystalluria and a family history of PH1 in one patient. Two patients died, and 8 patients were on chronic haemdialysis with systemic damage. Only one patient maintained a stable GFR at 60 ml/min. Conclusion: Early diagnosis combined with conservative treatment is the only way to limit the rapid progression of this disease. This requires awareness and collaboration between nephrologists, urologists and biologists within a specialised team.

关键词： Primary Hyperoxaluria Adulthood Kidney Disease

Renal Vein Thrombosis Suggestive of Extramembranous Glomerulonephritis Associated with Sjögren’s Syndrome (Case Report)

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Open Journal of Internal Medicine 2024年第2期14卷 181-187页

作者： Mariam el Galiou Mina Agrou Rihab Dkhissi Loubna Benamar naima Ouzeddoun Lamyae Rouass Tarik Bouattar Department of Nephrology Dialysis and Transplantation IbnSina University Hospital Mohamed V University Rabat Morocco Department of Pathological Anatomy IbnSina University Hospital Mohammed V University Rabat Morocco

Introduction: Glomerular damage during Gougerot-Sjgren syndrome is much rarer than interstitial damage, and is essentially extra-membranous and membrano-proliferative glomerulonephritis. Observation: We report the case of a 44-year-old woman with primary Sjgrens syndrome, confirmed by clinical dryness syndrome, positive anti-SSA and anti-SSB antibodies, and a salivary gland biopsy revealing grade 4 lymphocytic sialadenitis according to CHISHOLMs classification. Later, the patient developed nephrotic syndrome, along with hypertension. Renal function remained normal with a creatinine level of 9.3 mg/l, and hematuria was absent. Only antinuclear antibodies tested positive, while anti-PLA2R antibodies were negative. A renal biopsy was performed, which was complicated on the same day by hemodynamic instability with hematuria. Renal CT scan with contrast injection revealed a posterior perirenal hematoma without contrast extravasation. Additionally, bilateral renal vein thrombosis was incidentally discovered, suggesting extramembranous glomerulonephritis. The patients hemodynamic status stabilized after fluid resuscitation with isotonic saline solution (0.9%), without the need for blood transfusion. Renal biopsy confirmed extramembranous glomerulonephritis with interstitial fibrosis and minimal tubular atrophy. The initial etiological assessment was negative. The patient was started on oral corticosteroids, angiotensin-converting enzyme inhibitors, and therapeutic anticoagulation for renal vein thrombosis. The patients condition improved, with the disappearance of the syndrome and spontaneous regression of the hematoma. Discussion: The association of nephrotic syndrome and renal vein thrombosis primarily suggests glomerulopathy, in particular extra-membranous glomerulonephritis. Sjgrens syndrome can be associated with extra-membranous glomerulonephritis without being its direct cause. Like, it is possible that it is a cause of glomerulonephritis, essentially extra membrano

关键词： Sjögren’s Syndrome Extramembranous Glomerulonephritis Nephrotic Syndrome Anti-PLA2R Antibodies

Prognostic Factors in Cardiorenal Syndrome Type 1: Retrospective Observational and Analytical Study

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World Journal of Cardiovascular Diseases 2024年第7期14卷 435-445页

作者： Mariam el Galiou Amal Zniber Hajar Fitah naima Ouzeddoun Tarik Bouattar Nawal Doghmi Laila Lahlou Loubna Benamar Nephrology-Dialysis-Renal Transplantation Department Ibn Sina University Hospital Mohamed V University Rabat Morocco Department of Cardiology B Ibn Sina University Hospital Mohamed V University Rabat Morocco Laboratory of Biostatistics Clinical Research and Epidemiology Department of Public Health Mohamed V University Rabat Morocco

Introduction: Type 1 cardiorenal syndrome (CRS 1) is characterized by acute impairment of cardiac function leading to acute renal dysfunction. CRS1 is present in 25% of patients admitted for heart failure. The objective of our study is to analyze the epidemiological, clinical, therapeutic profile and the risk and prognostic factors of these patients. Materials and Methods: We identified 120 patients with cardiorenal syndrome (CRS) over a one-year period to determine the prevalence and risk factors for developing CRS 1. We analyzed the clinical, biological, and evolutionary profiles of patients with CRS 1 and determined the risk factors for the occurrence of acute kidney injury (AKI) as well as the mortality factors in these patients. Résultats: The average age of our patients with CRS1 is 58 ± 9 years, with a sex ratio of 1.4. The average eGFR of our patients is 35 ± 6.5 ml/min/1.73m2. Diabetes was found in 17% of our patients and hypertension in 14%. The etiology of cardiac impairment is predominantly acute coronary syndrome (ACS), followed by rhythm disorders. Renally, all our patients have acute kidney injury (AKI), with 86% having functional acute renal failure and 14% having acute tubular necrosis. Therapeutically, 50% of our patients are on diuretics, 42% receive beta-blocker treatment, and RAAS blockers are used in 29% of cases. Renal replacement therapy (RRT) sessions were required in 13.8% of cases. In univariate analysis, male gender, tachyarrhythmia, and hypertension are associated with the early onset of acute kidney injury (AKI). The use of diuretics, anemia, and low left ventricular ejection fraction (LVEF) are linked to a higher risk of developing CRS 1 (p = 0.021, p = 0.037, p = 0.010 respectively). In multivariate analysis, advanced age is significantly associated with increased mortality risk in CRS 1 patients (p = 0.030), while beta-blocker use is considered a protective factor (p = 0.014). Conclusion: Our study identifies several key factors asso

关键词： Acute Kidney Injury Type 1 Cardiorenal Syndrome Acute Heart Failure Diuretics

Antioxidant activities and total phenol content of Inula viscosa extracts selected from three regions of Morocco

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Asian Pacific Journal of Tropical Biomedicine 2015年第3期5卷 228-233页

作者： naima Chahmi Jaouad Anissi Sanae Jennan Abdellah Farah Khalid Sendide Mohammed el Hassouni Laboratory of Biotechnology Faculty of Sciences Dhar El Mehraz.Sidi Mohammed Ben Abdellah University Laboratory of Medicinal and Aromatic Plants and Natural Substances.National Institute of Medicinal and Aromatic Plants Al Akhawayn university School of Science and EngineeringLaboratoty of Biotechnology

Objective:To investigate antioxidant activity,total phenolic and flavonoid content of ethanol(E) and ethyl acetate(A) extracts of Inula viscosa aerial parts selected from three regions of Morocco(*** and Taounate).Methods:Antioxidants properties were measured by three different test systems of assay namely free radical scavenging activities against 2,2-diphenyI-1-picrylhydrazyl,total antioxidant capacity and iron-reducing *** phenolic content was measured by FolinCiocalteu ***:All the extracts showed significant antioxidant activities and contained important levels of *** ethanol extract(0.3 mg/mL) from Sefrou showed the greatest antioxidant capacity in the three systems of assay,which was probably due to its high content of polyphenols(274.39±6.94) mg gallic acid equivalent/g dry *** flavonoid content was found equal for all ***:Our results of antioxidant assays were justified and partially supported the popular usage of the tested *** high antioxidant activity found in the plant from Sefrou and its great biomass in this region suggested that Inula viscosa is a good source of natural antioxidants compounds which might have benefits for health.

关键词： Inula viscosa Folk medicine Flavonoids contents Polyphenols DPPH Reducing power

Autosomal Dominant Polycystic Kidney Disease: Epidemiological, Clinical Aspects and Predictive Factors of Poor Renal Prognosis (About 300 Cases)

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Assessment of Phytochemical Analysis,Nutritional Composition and Antimicrobial Activity of Moringa oleifera

Open Journal of Nephrology（肾脏病） 2024年第2期 275页

作者： Rihab Dkhissi Nada el Kadiri Tarik Bouattar Loubna Benamar naima Ouzeddoun

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Phyton-International Journal of Experimental Botany 2022年第8期91卷 1817-1829页

作者： naima Asghar Abida Aziz Muhammad Farooq Azhar Mohamed el-Sharnouby Uzma Irfan Iqra Rafiq Husnain Farooq Muhammad Ishaq Asif Rehmani Mohamed I.Sakran A.Altalhi Fahad M.Alzuaibr Ayman el Sabagh Department of Botany The Women UniversityMultan66000Pakistan Department of Forestry and Range Management Bahauddin Zakariya UniversityMultan60800Pakistan Department of Biotechnology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Environmental Sciences University of CaliforniaRiverside92521USA Department of Forestry Rangeand WildlifeGhazi UniversityDera Ghazi Khan32200Pakistan Department of Agronomy Ghazi UniversityDera Ghazi Khan32200Pakistan Biochemistry Department Faculty of ScienceUniversity of TabukTabuk47512Saudi Arabia Biology Department Faculty of ScienceTaif UniversityTaif21944Saudi Arabia Department of Biology Faculty of ScienceUniversity of TabukTabuk71491Saudi Arabia Department of Agronomy Faculty of AgricultureUniversity of KafrelsheikhKafr Elsheikh33516Egypt

Moringa oleifera is a miracle plant rich in nutrients,antioxidants,and antibiotic *** study was designed to evaluate various biochemical attributes of leaves and flowers of *** parts(leaves,flowers)of ***,collected from different roadsides of Multan district,Punjab,Pakistan,were used as experimental *** indicates that alkaloids,saponin,carbohydrates,fats,and protein had a high value in the aqueous extract of both leaves and flowers of *** phenol content was high in methanolic leaves extract and the phenol contents were high in aqueous extract of *** extract yield of *** leaves and flowers both showed a higher percentage in aqueous extract(57.5%),followed by methanol extract and lowest in ethyl acetate *** contents were higher in ethyl acetate extract of leaves(33.67%)and aqueous extract of flowers(53.71%).While crude fiber was high in methanolic extract of leaves(12.40%)and in flowers crude fiber was high in ethyl acetate extract(15.86%).The moisture contents were higher in leaves(8.87%)than flowers(7.3%)and similarly,ash percentage in flowers(52.60%)than leaves(41.84%).Ethyl acetate extracts of *** leaves show antibacterial activity against Pseudomonas aeruginosa while methanolic extract of *** flowers shows antibacterial activity against Xanthomonas *** growth inhibits show in all extracts of leaves against Aspergillus flavus,***,and *** except for the concentrated aqueous extract of *** in flowers maximum growth inhibits all extracts against ***,***,and *** except the diluted ethyl acetate *** present in different parts of moringa have significant edible and commercial *** extracts exhibited significant antimicrobial activity,therefore have applications in pharmaceuticals.

关键词： Antifungal antioxidants phytochemical antibacterial phenolics plant extract medicinal properties

Renal Vein Thrombosis Suggestive of Extramembranous Glomerulonephritis Associated with Sjögren’s Syndrome (Case Report)

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Prognostic Factors in Cardiorenal Syndrome Type 1: Retrospective Observational and Analytical Study

Open Journal of Internal Medicine（内科学期刊） 2024年第2期 181页

作者： Mariam el Galiou Mina Agrou Rihab Dkhissi Loubna Benamar naima Ouzeddoun Lamyae Rouass Tarik Bouattar

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