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Agnuside Reduces Visceral Adipocyte Size,Improves Insulin Sensitivity and Reverses Hepatic Steatosis in Ovariectomized Rats

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Journal of Pharmacy and Pharmacology 2019年第4期7卷 133-147页

作者： Franciele Neves Moreno Eduardo Hideo Gilglioni Rosangela Fernandes Garcia naiara cristina lucredi Sandra Mara Ferreira Nilton Almeida Brito Marcia do Nascimento Brito Emy Luiza Ishii-Iwamoto Clairce Luzia Salgueiro-Pagadigorria Laboratory of Experimental Steatosis Department of BiochemistryState University of MaringaMaringa 87020-900PRBrazil Laboratory of Biological Oxidations Department of BiochemistryState University of MaringaMaringa 87020-900PRBrazil Department of Physiological Sciences State University of MaringaMaringa 87020-900PRBrazil Laboratory of Biological oxidations Department of BiochemistryFederal University of Santa CatarinaFlorianopolis 88040-900SCBrazil Department of Structural and Functional Biology Institute of BiologyState University of Campinas(UNICAMP)Campinas 13083-970SPBrazil

This study aimed to investigate the effects of agnuside(AGN),a phytoestrogen in Vitex agnus-castus,on cellular and metabolic alterations induced by ovariectomy in ***(OVX)Wistar rats were used as an animal model of postmenopausal metabolic *** visceral and subcutaneous adipocyte sizes,the peripheral insulin sensitivity and the occurrence of nonalcoholic fatty liver disease(NAFLD)and liver oxidative damage were *** results were compared with those obtained from control rats(sham-operated)and OVX rats treated daily with *** OVX rats exhibited visceral adipocyte hypertrophy and developed glucose intolerance,hyperinsulinemia,NAFLD and *** exerted beneficial effects on several metabolic parameters in OVX rats,including the improvement in glucose intolerance,hyperinsulinemia and ***,AGN promoted a general improvement in the liver redox *** the reduction of the mesenteric adipocyte size is very likely to be an important mode of action of AGN,some actions of AGN could also involve the interaction with estrogen receptors.

关键词： Metabolic syndrome ovariectomized rats adipocyte size NAFLD agnuside

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Simultaneous analysis of the intestinal parasites and diet through eDNA metabarcoding

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Integrative Zoology 2023年第3期18卷 399-413页

作者： Xabier CABODEVILLA Benjamín Juan GÓMEZ-MOLINER naiara ABAD María JoséMADEIRA Department of Zoology and Animal Cell Biology Faculty of PharmacyUniversity of the Basque Country(UPV/EHU)AlavaSpain Instituto de Investigación en Recursos Cinegéticos(IREC)(CSIC-UCLM-JCCM) Ciudad RealSpain

Agricultural expansion and intensiﬁcation are having a huge impact on plant and arthropod diversity and abun-dance,affecting food availability for farmland ***ﬁcult food access,in turn,can lead to immunosuppression and a higher incidence of *** the studies designed to examine changes in the diet of birds and their par-asites,metabarcoding is proving particularly *** technique requires mini-barcodes capable of amplifying the DNA of target organisms from fecal environmental *** help to understand the impact of agricultural expansion on biodiversity,this study sought to design and identify mini-barcodes that might simultaneously as-sess diet and intestinal parasites from the feces of farmland *** capacity to identify diet and parasites of 2 existing and 3 newly developed mini-barcodes was tested“in silico”in relation to the behavior of a reference eukaryotic *** the newly designed mini-barcodes,MiniB18S_81 showed the higher taxonomic cover-age of eukaryotic taxa and a greater ampliﬁcation and identiﬁcation capacity for diet and parasite ***,when it was tested on fecal samples from 5 different steppe bird species,MiniB18S_81 showed high taxonomic resolution of the most relevant diet and parasite phyla,Arthropoda,Nematoda,Platyhelminthes,and Apicomplexa at the order ***,the mini-barcode developed emerges as an excellent tool to simultaneously provide detailed information regarding the diet and parasites of birds,essential for conservation and management.

关键词： biomonitoring broad-spectrum primers eukaryotic mini-barcodes fecal eDNA farmland birds parasitology

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Modelling policy combinations of vaccination and transmission suppression of SARS-CoV-2 in Rio de Janeiro,Brazil

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Infectious Disease Modelling 2022年第1期7卷 231-242页

作者： naiara C.M.Valiati Daniel A.M.Villela Universidade Federal Rural do Rio de Janeiro SeropedicaRJBrazil Programa de Computaçao Científica Fundaçao Oswaldo CruzRio de JaneiroRJBrazil

COVID-19 vaccination in Brazil required a phased program,with priorities for age groups,health workers,and vulnerable *** distancing and isolation interventions have been essential to mitigate the advance of the pandemic in several *** developed a mathematical model capable of capturing the dynamics of the SARS-CoV-2 dissemination aligned with social distancing,isolation measures,and *** data from the city of Rio de Janeiro provided a case study to analyze possible scenarios,including non-pharmaceutical interventions and vaccination in the epidemic *** results demonstrate that the combination of vaccination and policies of transmission suppression potentially lowered the number of hospitalized cases by 380þand 66þthousand cases,respectively,compared to an absence of such *** top of transmission suppressiononly policies,vaccination impacted more than 230þthousand averted hospitalized cases and 43þthousand averted ***,health surveillance activities should be maintained along with vaccination planning in scheduled groups until a large vaccinated coverage is ***,this analytical framework enables evaluation of such scenarios.

关键词： SARS-CoV-2 Vaccination COVID-19

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Terrain radiometric calibration of airborne UAVSAR for forested area

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Geo-Spatial Information Science 2012年第4期15卷 229-240页

作者： CHENG Xiaoguang naiara PINTO GONG Jianya State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan University129 Luoyu RoadWuhan 430079China Department of Geographical Sciences University of MarylandCollege ParkMD 20770USA NASA/Caltech Jet Propulsion Laboratory PasadenaCAUSA

In the field of biomass estimation,terrain radiometric calibration of airborne polarimetric SAR data for forested areas is an urgent *** area correction ofσ-naught could not completely remove terrain *** by Small and Shimada,this paper tested gamma-naught on one mountainous forested area using airborne Uninhabited Aerial Vehicle Synthetic Aperture Radar data and found it could remove most terrain ***,a systematic increasing trend from far range to near range is found in airborne SAR *** paper made an attempt to use the relationship between distance to SAR sensor andγ-naught to calibrateγ-*** quantitative evaluation methods are *** results demonstrate that variation ofγ-naught can be constrained to a limited extent from near range to far *** this method is based on ground range images,it avoids complicated orthorectification.

关键词： terrain radiometric calibration UAVSAR sigma-naught γ-naught

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World Journal of Psychiatry 2021年第12期11卷 1247-1258页

作者： Joana Jaureguizar Iratxe Redondo Nuria Galende naiara Ozamiz Developmental and Educational Psychology University of the Basque CountryLejona 48940BizkaiaSpain

The coronavirus pandemic has affected all facets of our lives and all ages and social strata *** have been taken to protect against the spread of the virus,such as more rigorous hand hygiene,the use of face masks and social ***,the focus has often been on young people,who have been seen as a group lacking sufficient respect for government-imposed *** review outlines the preventive measures that have been taken in different countries and discusses their specific impact on young people and adolescents,taking into account the developmental stage and concrete needs of this age *** summarizes those studies that have provided information on compliance with preventive measures by young people and adolescents,concluding that although compliance levels among this age group are lower than among older adults,the general view of youths as non-compliant is not consistent with real,objective *** review also summarizes different views regarding the possible reasons for this lower level of compliance,taking into account both social(gender and age)and personal factors(personality,empathy,prosociality,self-control,cognitive styles and motivations),and discusses the practical implications of these findings for the future.

关键词： COVID-19 Health regulations Compliance Young people Adolescents

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NiWO4 powders prepared via polymeric precursor method for application as ceramic luminescent pigments

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Journal of Advanced Ceramics 2020年第1期9卷 55-63页

作者： naiara A.LIMA Lorena D.S.ALENCAR Máximo SIU-LI Carlos A.C.FEITOSA Alexandre MESQUITA Jean-Claude M’PEKO Maria I.B.BERNARDI Instituto de Física de Sao Carlos Universidade de Sao Paulo13560-970 Sao CarlosSPBrazil Instituto Federal de Mato Grosso do Sul IFMS79200-000 AquidauanaMSBrazil Departamento de Física Centro de Ciências Exatas e TecnologiaUniversidade Federal do MaranhaoUFMA65080-805Sao LuisMABrazil Instituto de Geociências e Ciências Exatas Departamento de FísicaUniversidade Estadual Paulista13506-900Rio ClaroSPBrazil

Ni WO4 was prepared using the polymeric precursor method and studied in terms of physical and chemical properties to verify its stability for industrial applications as *** characterization was accomplished using thermal analyses,X-ray diffraction(XRD),scanning electron microscopy(SEM),photoluminescence(PL)and UV–Vis spectroscopies,colorimetric coordinates,and Raman *** the temperature,successive exothermic reactions were observed and they are related with thermal decomposition of the organic *** stability was reached at^700℃.The material is verified to become completely free of second phase at^800℃.The end Ni WO4 powders showed an intense charge transfer(CT)-related tail centered in the ultraviolet region,resulting in a yellow *** addition,the powders exhibited broad excitation band and broad deep blue–green emission band,which were enhanced with increasing powders’crystallinity.

关键词： nickel tungstate yellow pigment colorimetric coordinate optical property structural characterization

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CIS controls the functional polarization of GM-CSF-derived macrophages

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Cellular & Molecular Immunology 2023年第1期20卷 65-79页

作者： Shengbo Zhang Jai Rautela naiara G.Bediaga Tatiana B.Kolesnik Yue You Junli Nie Laura F.Dagley Justin Bedo Hanqing Wang Li Sun Robyn Sutherland Elliot Surgenor Nadia Iannarella Rhys Allan Fernando Souza-Fonseca-Guimaraes Yi Xie Qike Wang Yuxia Zhang Yuekang Xu Stephen L.Nutt Andrew M.Lew Nicholas D.Huntington Sandra E.Nicholson Michaël Chopin Yifan Zhan Walter and Eliza Hall Institute of Medical Research ParkvilleVICAustralia Department of Medical Biology University of MelbourneParkvilleVICAustralia Department of Biochemistry and Molecular Biology Biomedicine Discovery InstituteMonash UniversityClaytonVICAustralia oNKo-Innate Pty Ltd Moonee PondsVICAustralia Department of Computing and Information Systems University of MelbourneParkvilleVICAustralia Department of Respiratory Medicine Guangzhou Institute of PediatricsGuangzhou Women and Children’s Medical CentreState Key Laboratory of Respiratory DiseasesGuangzhou Medical UniversityGuangzhouGuangdongChina College of Biological Science Anhui Normal UniversityHefeiChina University of Queensland Diamantina Institute University of QueenslandTranslational Research InstituteBrisbaneQLDAustralia Program in Cardiovascular and Metabolic Disorders Duke-NUS Medical SchoolDukeSingapore Drug Discovery Shanghai Huaota BiopharmShanghaiChina

The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macrophages (MØs) with opposing functions, namely, proinflammatory M1-like MØs and immunosuppressive M2-like MØs. Despite the importance of these opposing biological outcomes, the intrinsic mechanism that regulates the functional polarization of MØs under GM-CSF signaling remains elusive. Here, we showed that GM-CSF-induced MØ polarization resulted in the expression of cytokine-inducible SH2-containing protein (CIS) and that CIS deficiency skewed the differentiation of monocytes toward immunosuppressive M2-like MØs. CIS deficiency resulted in hyperactivation of the JAK-STAT5 signaling pathway, consequently promoting downregulation of the transcription factor Interferon Regulatory Factor 8 (IRF8). Loss- and gain-of-function approaches highlighted IRF8 as a critical regulator of the M1-like polarization program. In vivo, CIS deficiency induced the differentiation of M2-like macrophages, which promoted strong Th2 immune responses characterized by the development of severe experimental asthma. Collectively, our results reveal a CIS-modulated mechanism that clarifies the opposing actions of GM-CSF in MØ differentiation and uncovers the role of GM-CSF in controlling allergic inflammation.

关键词： CIS GM-CSF Macrophage M2 M1

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Safety of digoxin in nonagenarian patients with atrial fibrillation:lessons from the Spanish Multicenter Registry

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Journal of Geriatric Cardiology 2021年第10期18卷 809-815页

作者： Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi María Cespón-Fernández David Alonso-Rodríguez Santiago Jesús Camacho-Freire naiara Cubelos-Fernández Álvaro López-Masjuán Ríos María Melendo-Viu AndrésÍñiguez-Romo Department of Cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain Department of Cardiology University Hospital of LeónLeónSpain Department of Cardiology University Hospital Juan Ramón JiménezHuelvaSpain

BACKGROUND The association between digoxin and mortality is an unclear *** older patients with atrial fibrillation(AF),where use of digoxin is frequent,the evidence of its safety is *** aim is to assess the safety of digoxin in nonagenarian patients with *** We evaluated data from 795 nonagenarian patients with non-valvular AF from the Spanish Multicenter *** analyzed the relationship between digoxin and all-cause mortality with the Cox proportional-hazards *** Follow-up was 27.7±18.3 *** age was 92.5±3.8 years,and 71%of nonagenarian patients were *** was not associated with increased risk of mortality[adjusted hazard ratio(aHR)=1.16,95%CI:0.96−1.41,P=0.130].However,we found a significant increase in mortality in the subgroup with estimated glomerular filtration rate(eGFR)<30 mL/min per 1.73 m^(2)(aHR=2.01,95%CI:1.13−3.57,P=0.018),but not in the other subgroups of eGFR(30−59 mL/min per 1.73 m^(2) and≥60 mL/min per 1.73 m^(2)).When exploring the risk of mortality according to sex,male subgroup was associated with an in-crease in mortality(aHR=1.48,95%CI:1.02−2.14,P=0.041).This was not observed in females subgroup(aHR=1.03,95%CI:0.81−1.29,P=0.829).Based on the presence or absence of heart failure,we did not find significant differences(aHR=1.20,95%CI:0.87−1.65,P=0.268 ***=1.15,95%CI:0.90−1.47,P=0.273,respectively).CONCLUSIONS In our large registry of nonagenarian patients with AF,we did not find an association between digoxin and mortality in the total ***,in the subgroup analyses,we found an increase in mortality with the use of digoxin in men and in patients with an eGFR<30 mL/min per 1.73 m^(2).

关键词： patients digoxin fibrillation

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Optimization of the porcine adult skin-derived precursor cell isolation protocol

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Stem Cell Discovery 2013年第1期3卷 72-76页

作者： Haizea Iribar Begona Castro-Feo Iker Azcoitia-Ramsden naiara de Paz-Alonso Ander Izeta Araika Gutiérrez-Rivera Tissue Engineering Lab Department of BioengineeringInstituto BiodonostiaHospital Universitario DonostiaSan SebastiánSpain Histocell Tissue Engineering Parque Tecnológico de BizkaiaDerioSpain

Neuronal and glial differentiation potential of skin-derived precursors is of great interest for clinical application in the treatment of neurodegenerative disease. In this sense, the pig model is a great candidate for the development of preclinical models. To the date, skin-derived precursor spheres have not been isolated from adult porcine skin. In order to optimize the protocol for isolating dermal precursor spheres from adult porcine skin, 15 porcine skin biopsies were subjected to three different processing protocols. Liberase-based digestion of ventral porcine skin gave rise to more cells with spherogenic capacity than other protocols and these spheres presented phenotypic and differentiation potential consistent with bona fide skin-derived precursor cells.

关键词： Porcine Dermal Precursors SKPs Clinical Application

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Comparative study of quality of life after hospital-at-home or in-patient admission for acute decompensation of chronic heart failure

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World Journal of Cardiovascular Diseases 2013年第1期3卷 174-181页

作者： Angel García-Soleto naiara Parraza-Diez Felipe Aizpuru-Barandiaran Fernando Aros-Borau Humberto Mendoza-Ruiz de Zuazu Maria Jesus Martin-Gudino Jose Regalado de los Cobos Hospital-at-Home Service Araba University HospitalVitoriaSpain Araba Research Unit Araba University HospitalVitoriaSpain Department of Cardiology Araba University HospitalVitoriaSpain Department of Internal Medicine Nuestra Senora de Sonsoles HospitalAvilaSpain Emergency Department Araba University HospitalVitoriaSpain

AIMS: Hospitalisation at home (HaH) achieves comparable health outcomes to conventional in-patient care, in terms of cost-effectiveness and quality of life. Our objective was to assess the impact of episodes of acute decompensation of heart failure (ADCHF) on functional status and quality of life, in patients under HaH care compared with a matched group receiving conventional in-patient care at a Cardiology ward (CW). Methods: Randomised clinical trial in 71 patients with ADCHF attending the Emergency Department. Patients were either admitted to the hospital’s CW or to the HaH service. The functional status and health related quality of life (HRQOL) were assessed using the Barthel Index (BI) and the EQ-5D, Short Form-36 (SF-36) and Minnessota Living with Heart Failure (MLHFQ) questionnaires, administered at admission and, depending on the test, at discharge and 1, 3, 6 and 12 months after discharge. Results: MLHFQ and SF-36 experienced significant improvement in most domains with respect to the initial values at discharge and 6 months after only in the HaH group;though by 12-months there were no significant differences. Barthel Index and EQ-5D value scores showed improvement with respect to initial values in both arms. The improvement could be appreciated in more components and for longer among the HaH patients. Conclusions: Functional independence and quality of life improve at discharge compared to admission, after both home-based and in-patient hospitalisation, outcomes being better in various respects over the first year of follow-up after hospital-at-home care.

关键词： Heart Failure Health-Related Quality of Life Hospital at Home

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