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Role of brahma-related gene 1/brahma-associated factor subunits in neural stem/progenitor cells and related neural developmental disorders

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World Journal of Stem Cells 2023年第4期15卷 235-247页

作者： nai-yu ke Tian-Yi Zhao Wan-Rong Wang yu-Tong Qian Chao Liu The First Clinical Medical College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Institute of Stem cells and Tissue Engineering School of Basic Medical SciencesAnhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Histology and Embryology School of Basic Medical SciencesAnhui Medical UniversityHefei 230032Anhui ProvinceChina

Different fates of neural stem/progenitor cells(NSPCs)and their progeny are determined by the gene regulatory network,where a chromatin-remodeling complex affects synergy with other ***,we review recent research progress indicating that the BRG1/BRM-associated factor(BAF)complex plays an important role in NSPCs during neural development and neural developmental *** studies based on animal models have shown that mutations in the BAF complex may cause abnormal neural differentiation,which can also lead to various diseases in *** discussed BAF complex subunits and their main characteristics in *** advances in studies of human pluripotent stem cells and the feasibility of driving their differentiation into NSPCs,we can now investigate the role of the BAF complex in regulating the balance between self-renewal and differentiation of *** recent progress in these research areas,we suggest that three approaches should be used in investigations in the near *** of whole human exome and genome-wide association studies suggest that mutations in the subunits of the BAF complex are related to neurodevelopmental *** insight into the mechanism of BAF complex regulation in NSPCs during neural cell fate decisions and neurodevelopment may help in exploiting new methods for clinical applications.

关键词： Neural stem/progenitor cell BRG1/BRM-associated factor complex Subunit Proliferation Differentiation Neural developmental disorde

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Actively tunable electromagnetically induced transparency in hybrid Dirac-VO2 metamaterials

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Optoelectronics Letters 2025年第1期21卷 13-20页

作者： DI ke XIE Meng XIA Huarong CHENG Anyu LIU yu DU Jiajia Department of Optoelectronic Engineering Chongqing University of Post and Telecommunications Chongqing key Laboratory of Autonomous Navigation and Microsystem Chongqing University of Posts and Telecommunications Department of Automation Chongqing University of Post and Telecommunications

In this paper, we present a metamaterial structure of Dirac and vanadium dioxide（VO2） and investigate its optical properties using the finite-difference time-domain（FDTD） technique. Using the phase transition feature of VO2, the design can realize active tuning of the plasmon induced transparency（PIT） effect at terahertz frequency, thereby converting from a single PIT to a double-PIT. When VO2is in the insulating state, the structure is symmetric to obtain a single-band PIT effect. When VO2is in the metallic state, the structure turns asymmetric to realize a dual-band PIT effect. This design provides a reference direction for the design of actively tunable metamaterials. Additionally, it is discovered that the transparent window's resonant frequency and the Fermi level in this structure have a somewhat linear relationship. In addition, the structure achieves superior refractive index sensitivity in the terahertz band, surpassing 1 THz/RIU. Consequently, the design exhibits encouraging potential for application in refractive index sensors and optical switches.

关键词： Transparency

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Stability and Stabilization of Sampled-Data Based LFC for Power Systems:A Data-Driven Method

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 291-293页

作者： yu-Long Fan Chuan-ke Zhang Yong He the School of Automation China University of Geosciences the Hubei key Laboratory of Advanced Control and Intelligent Automation for Complex Systems the Engineering Research Center of Intelligent Technology for Geo-Exploration Ministry of Education IEEE

Dear Editor,This letter is concerned with stability analysis and stabilization design for sampled-data based load frequency control(LFC) systems via a data-driven method. By describing the dynamic behavior of LFC systems based on a data-based representation, a stability criterion is derived to obtain the admissible maximum sampling interval(MSI) for a given controller and a design condition of the PI-type controller is further developed to meet the required MSI. Finally, the effectiveness of the proposed methods is verified by a case study.

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu yu Wang Hanlin Huang Jun ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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[Research advances in the transplacental transfer efficiencies of environmental pollutants]

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Se pu = Chinese journal of chromatography 2025年第1期43卷 13-21页

作者： ke-yu yuan Jun Xiong Bi-Feng yuan School of Public Health Wuhan University Wuhan 430071 China.

Industrialization has led to significant increases in the types and quantities of pollutants, with environmental pollutants widely present in various media, including the air, food, and everyday items. These pollutants can enter the human body via multiple pathways, including ingestion through food and absorption through the skin; this intrusion can disrupt the production, release, and circulation of hormones in the body, resulting in a range of illnesses that affect the reproductive, endocrine, and nervous systems. Consequently, these pollutants pose substantial risks to human health. In particular, fetuses are highly sensitive to environmental pollutants during critical stages of development, and exposure during periods of growth and development can result in more-obvious and severe health hazards that can lead to preterm birth, low birth weight, and fetal malformations. The placenta acts as a barrier between the mother and fetus, and selectively filters certain pollutants. While some pollutants remain in the maternal bloodstream, others cross the placental barrier into the fetal umbilical blood through passive diffusion, placental transport proteins, or endocytosis. The transplacental transfer efficiency (TTE) is the ratio of the level of the pollutant in the umbilical blood to that in the maternal blood, and is a valuable metric for evaluating the ability of a pollutant to breach the placental barrier. A higher TTE implies that a larger proportion of pollutants are transferred from the mother to the fetus, thereby amplifying the potential risks to the fetus. Mass spectrometry-based detection methods are extensively used in the chemical and environmental sciences because they are exceptionally sensitive and highly resolving. This analytical technique involves ionizing compounds within a sample and identifying them based on their distinct mass-to-charge ratios; it enables both qualitative and quantitative analyses of various environmental pollutants. Current metho

关键词： chromatography-mass spectrometry environmental pollutants organochlorine pesticides (OCPs) per- and polyfluoroalkyl substances (PFASs) polybrominated diphenyl ethers (PBDEs) polychlorinated biphenyls (PCBs) review transplacental transfer efficiency (TTE)

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Role of nutrition in diabetes mellitus and infections

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World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu yu Li-yun Zhou Xiao Huang Xin-yue Li Ming-ke Wang Ji-Shun Yang Naval Medical Center of PLA Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

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Surface micro-arrays enhancing electromagnetic interference shielding of polydimethylsiloxane/multiwalled carbon nanotubes nanocomposites

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Nano Research 2025年第1期18卷 508-519页

作者： ke Jiang Zhi Chen Ji yu Chen Zheng Shan Huang Ming Wang Chongqing key Laboratory of Soft-Matter Material Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China School of Mechanics Civil Engineering and ArchitecturesNorthwestern Polytechnical UniversityXi’an 710072China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Herein,the electromagnetic shielding performance of surface concave-convex(SC)and zig-zag micro-arrays was studied by using a simulation prediction and a three-dimensional(3D)printing custom ***,surface stripe concaveconvex(SSC)and surface cylindrical concave-convex(SCC)micro-arrays with or without zig-zag micro-arrays are designed,and their shielding performance is simulated in multi-bands(C-,X-band).The multiwalled carbon nanotubes/polydimethylsiloxane composites(MWCNT/PDMS)with different SC structures and different electrical conductivity are molded in acrylonitrile-butadiene-styrene copolymer(ABS)molds which are printed by a 3D *** results show that the electromagnetic interference shielding effectiveness(EMI SE)of the samples can be enhanced by constructing the SC micro-arrays with zig-zag micro-arrays,and improving with the increase of conductivity and *** addition,the shielding mechanism of the SC-MWCNT/PDMS composites is investigated and discussed by an electromagnetic simulation.

关键词： surface micro-arrays electrical properties electromagnetic interference(EMI)shielding three-dimensional(3D)printing

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Populations of Ethanol Conformers in Liquid CCI4 and CS2 by Raman Spectra in OH Stretching Region

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Chinese Journal of Chemical Physics 2015年第3期28卷 245-252,I0001页

作者： nai-yin Hu ke Lin Xiao-guo Zhou Shi-lin Liu Hefei National Laboratory for Physical Sciences at the Microscale Department of Chemical PhysicsUniversity of Science and Technology of China Hefei 230025 China Synergetic Innovation Center of Quantum Information & Quantum Physics University of Science and Technology of China Hefei 230026 China

Combining Raman spectroscopy with density functional theory, the populations of the trans- and gaucheethanol conformers are investigated in carbon tetrachloride （CC14） and carbon disulfide （CS2）. The spectral contributions of two ethanol conformers are identified in OH stretching region. The energy difference between both conformers is estimated with the aid of the calculated Raman cross sections. It can be seen that the trans- ethanol is more stable in CC14 and CS2 solutions. The spectra are also obtained at different temperatures, and it is found the van＇t Hoff analysis is invalid in these solutions. By taking accounts of the Boltzmann distribution and theoretical Raman cross section, the energy difference is found to be increased with temperature, which shows the weak intermolecular interactions can enhance the population of transethanol.

关键词： Raman spectroscopy Ethanol Conformer Energy difference

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A multiwavelength study of the star forming HⅡ region Sh2-82

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Research in Astronomy and Astrophysics 2012年第6期12卷 651-660页

作者： nai-Ping yu Jun-Jie Wang National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China NAOC-TU Joint Center for Astrophysics Lhasa 850000 China

Based on a multiwavelength study, the interstellar medium and young stel- lar objects （YSOs） around the H II region Sh2-82 have been analyzed. Two molecular clumps were found from the archival data of the Galactic Ring Survey, and using the Two Micron All-Sky Survey catalog, we found two corresponding young clusters embedded in the molecular clumps. The very good relations between CO emission, infrared shells and YSOs suggest that it is probably a triggered star formation region from the expansion of Sh2-82. We further used the data from the Galactic Legacy Infrared Mid-Plane Survey Extraordinaire from Spitzer to study the YSOs within the two clumps, confirming star formation in this region. By spectral energy distribution fits to each YSO candidate with infrared excess, we derived the slope of the initial mass function. Finally, comparing the H II region＇s dynamical age and the fragmenta- tion time of the molecular shell, we discard the ＂collect and collapse＂ process as being the triggering mechanism for YSO formation. Sh2-82 can be a mixture of other pro- cesses such as radiative-driven implosion and/or collisions with pre-existing clumps.

关键词： ISM: clouds -- nebulae: HII region -- individual: Sh2-82 -- stars:formation

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Molecular outflows and gas rotation associated with G20.08–0.14N

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Research in Astronomy and Astrophysics 2013年第11期13卷 1295-1306页

作者： nai-Ping yu Jun-Jie Wang National Astronomical Observatories Chinese Academy of Sciences NAOC-TU Joint Center for Astrophysics

We present the results of a high-resolution study with the Submillimeter Array （SMA） toward the massive star-forming complex G20.08-0.14N. With the SMA data, we have detected and analyzed the transitions in the 12CO （3-2） and 12CO （2-1） molecular lines as well as CHaCN. The millimeter observations reveal highly collimated bipolar molecular outflows, traced by high-velocity 12CO （2-1） and 12CO （3-2） emissions. Using a rotation temperature diagram, we derive that the rota- tional temperature and the column density of CHaCN are 244 K and 1.2 ~ 1015 cm-2, respectively. We also suggest that the minor outflow is probably driven by the hy- percompact （HC） HII region A that is inside. We find the molecular gas （traced by ClrO, SO, CH3OH and SO2） surrounding G20.08-0.14N appears to be undergoing bulk rotation. The HCHII region A that is inside is most probably the main source of accretion and heating for G20.08-0.14N.

关键词： ISM: individual objects (G20.08-0.14N) -- ISM: molecules -- radiolines: ISM -- stars: formation-- ISM: kinematics and dynamics

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